@article { author = {Pourshah-Nazari, A.A and Ataei, H and Sepehri, GH.R and Rafati, A}, title = {Effects of 5,7 dihyroxytryptamine injection in dorsal and median raphe nuclei on morphine dependenc}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {184-190}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {previous studies have shown that morphine addiction is caused by abnormality in neurotransmission system.serotonin is one of the most important neurotransmiters involved in addiction.the dorsal and median raphe nuclei are the important sites that synthesize and release this neurotransmiters in this study we have injected 5,7  dihyroxytryptamine a serotonergic neurotoxin into the dorsal and median raphe nuclei followed of evaluation of craving behaviour for morphine.behavioural and electrophysiological studies(EEG) were conducted for the evaluation of morphine dependence.the results evaluated by self-administration method showed that,5,7 dihyroxytryptamine increased craving for morphine in comparison with sham group.furthermore the results of withdrawal syndrome syndrome sihns showed that 5,7 dihyroxytryptamine increased dependency to morphine compared to the sham group.electrophysiological study revealed that total power of EEG in 5,7 dihyroxytryptamine receiving group was less than the control group(p<0.05) by conclusion it seems that 5,7 dihyroxytryptamine can increase craving to morphine,by destroying serotonergic system.therefore in patients who must receive morphine as an analgesic,prescription of drugs that interact with serotonergic system should be avoided.}, keywords = {5,7 DHT,raphe nucleus,morphine dependence,Rat}, url = {https://jkmu.kmu.ac.ir/article_34261.html}, eprint = {https://jkmu.kmu.ac.ir/article_34261_a8c6a747f6362e14049b1dd46ac99aa0.pdf} } @article { author = {Khaksari, M and Sajadi, M.A}, title = {Effects of verapamil and nifedipine on carrageenan-induced inflammation in the rat paw}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {191-198}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {the extracardiac actions of calcium-channel belockers has little been studied.in fact,it has been demonstrated in a number of in viro studies,that calcium-channel belockers are involved in inflammation.here,we evaluated the dose-dependent Effects of verapamil and nifedipine on carrageenan-induced, acute inflammation in the rat paw compared to the anti-inflammatory activites of ibuprofen.the adult male rats were divided into two groups.paw edema was induced by intraplantar injection of 0.1 ml of 0.5% carrageenan solution.different doses of infedipine(10,25,100,200,mg/kg) and verapamil(25,100,400,mg/lg) and ibuprofen 12 mg/lg given intrapritoneally after carrageenan injection.assessment of edema performed by calculation of volume changes and by extravasation of evans blue in test grop compared to the control,one hour after injection of carrageen.verapamil and infedipine showed significantly inhibitory effect on increased edema.maximum inhibition(83+_10%) were induced by infedipine at 100mg/kg and verapamil at 25mg/kg.nifedipine inhibited  paw edema in a dose-dependent manner.the inflammation was significantly reduced(37+_5.2%) by infedipine at 200mg/lg,whereas verapamil did not have any effect.Ibuprofen reduced increased volume of paw and evans blue content by 83+_11.5% and 42+_6.3% respectively.no signifigant differences were found between inhibitory effects of nifedipine and ibuprofen.according to this results,calcium-channel blockers can inhibit acute flammatory responses in the paw,and these effects are comparable to ibuoprpfen.}, keywords = {Verapamil,nifedipine,acute flammation,calcium channels blockers}, url = {https://jkmu.kmu.ac.ir/article_34262.html}, eprint = {https://jkmu.kmu.ac.ir/article_34262_74dd7382eb7b05c0f7cd3a214a056237.pdf} } @article { author = {Jahanbani, J and Salarpour, F}, title = {The evaluation of oral precancerous lesions in factory workers of Kerman city in 1998}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {199-204}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {  leukoplakia,erythroplakia and palatal changes due to reversed smoking(R.S) are considered as precancerous lesions .oral lichen planus has been considered as a precancerous condition.to evaluate  precancerous lesions in factory workers of Kerman city,a cross sectional study was designed in which 1167 workers(1070 men,97 women,mean age=31.8) were participated.dental mirrors,explorers and flashlight were used for oral examinations and all the workers were examined by one person.overall 115 persons 9.9% had red and white lesions and among them 43 cases (3.7%) of precancerous lesion and 6 cases (0.5%) of lichen planus were diagnosed.all biopsy speciemen showed nondysplastic leukoplakia.direct relationship was observed between cigarrette smoking habits and loukoplakia(p<0.001).there was also a reverse relationship between educational level and leukoplakia(p<0.001).loukoplakia and lichen planus were most prevalenced in the age group of 20-40 years(p<0.001). also most of the lesions were detected in buccal mucosa and vestibule.Erythroplakia and R.S were not observed at all.the study showed a high rate of precancerous lesions among the workers (3.7%).further epidemiological studies of oral precancerous lesions and the inclusion of intraoral examinations in health care programs are recommended.}, keywords = {oral precancerous lesions .tobacco products,leukoplakia,Erythroplakia}, url = {https://jkmu.kmu.ac.ir/article_34263.html}, eprint = {https://jkmu.kmu.ac.ir/article_34263_ea8335c2b9f5c7e33d14589df0f72a91.pdf} } @article { author = {Ataei, R.A and Behzadian nejhad, GH}, title = {The effect of clostridium difficile Toxins Aand B on ligated rabbit IIeal loop and cultured cell link BK}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {205-213}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {clostridium difficile has been recognized as the major cause of pseudomembranous colitis.this bacterium produces two toxins(an enterotoxin -cytotoxin and a potent cytotoxin called toxin A and toxin B erespectively).these toxins have implicated in pathogenesis of the disease.however,histopathological effects of their molecular mass less than 100KDa have been essayed.in the persent study,we examined the dose repsonse and time course of these toxins in ligated rebbit ileal loop and cell culture link BK (boving kidney).the 1-10 mg/ml toxin A, with molecullar weight of 25 KDa,in ligated rabbit ileal loop(6 rabbits with maximum of 15 loopes in each animals) showed a series of histopathological changes leading to inflammation,fluid or bloody fluid accumulation,mucous and villi disraotion in lammina properia.different concentration of toxin B(MW=60 KDa) had no effect on fluid accumulation in striped rabbit ileal loop but caused driness and necrosis intensively.cultured cells exposed to 1mg/ml toxin B showed a series of cytopathologic changes  leading to cell retraction and rounding accompanied by the marginalization of the cell membrane.Enhancement of toxin concentration caused increament of cytopathic effects.}, keywords = {clostridium difficile,pseudomembranouse coltitis,Toxin Aand B,rabbit ligated ileal loop,cell culture}, url = {https://jkmu.kmu.ac.ir/article_34264.html}, eprint = {https://jkmu.kmu.ac.ir/article_34264_8fa2cbf6cd6f8886dcfbfb73b8db0489.pdf} } @article { author = {Heidarnia, A.R and Jalili, Z and Dabiri, SH and Farahmandi nia, Z and Alizadeh, M}, title = {The prevalence of iron deficiency anemia in 1-5 years old children referring to Kerman medical care and health centers in 1998}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {214-221}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Iron deficiency anemia(IDA) is one of the most common nutritional problems in the world.children under 5 years old are considerd as the high risk group consisting a high proportion of IDA patients.in this group,due to the specific conditions,the complication of anemia may lead to serious consequences.this study was designed to determine the prevalence of IDA in 1-5 years old children.A total of 320 of the subjects were selected by two-stage sampling method and the levels of Hb,Hct,MCV,MCH,MCHC, serum ferritin,serum iron,TIBC,and percentage of transferrin saturation were determined.results revealed that 22.5% of children had depleted iron stores(as defined by serum ferritin less than 10mg/ml).7.2% had Hb less than 11mg/ml,and 35% of them had percentage of transferrin saturation less than 15%.in this study a significant correlation was observed between iron deficiency(determined by serum ferretin level).percent of transferin saturation and variables such as age,sources of nutritional diet adivve and iron.significant correlation were also seen between anemia based on hemoglobin deficiency and the sources of nutritional advice(p<0.05).}, keywords = {iron deficiency,Anemia,iron supplementation,children aged 1-5}, url = {https://jkmu.kmu.ac.ir/article_34265.html}, eprint = {https://jkmu.kmu.ac.ir/article_34265_284e0e1ab46d60b86e69e37c872b3864.pdf} } @article { author = {Eskandarizadeh, A and Naderi nejhad, M.A}, title = {Determination of the caries free prevalence in 12 year-old students in Guidance schools in sirjan city in 1996}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {222-228}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Caries ferr is  an epidemiologic index for prevalence of dental caries in a society and it means that persons who do not have any dental caries,in other words,that equal to DMF=0.to determine the prevalence of caries ferr in 12 year-old student in Guidance school in sirjan city,this study was carried out with the method of WHO index in 1996.on the bases of a pilot study the of sample size was determined to be 300 persons(150 girls and 150 boys).this sample was selected by stratified cluster sampling.after dental examination and filling the WHO forms,the obtained data were statistically analyzed and the results were as follows.34.7 percent of 12 year-old(boy and girl) adolsent were caries ferr.39.3 percent of boys and 30 percent of girls in this study were caries free.according to WHO index caries prevalence was 65.3% in 12-year-old adolesents in sirjan which is considered relatively low.}, keywords = {Dental Caries,caries free,sirjan city}, url = {https://jkmu.kmu.ac.ir/article_34266.html}, eprint = {https://jkmu.kmu.ac.ir/article_34266_4f83f75218b9ef29dc93f5697f12020d.pdf} } @article { author = {Zare-Mehrjardi, A}, title = {The study of 13 cases of Gastrointestinal stromal tumors in Kerman}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {229-234}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {13 cases of  gastrointestinal stromal tumors (GIST) diagnosed in Kerman university hospitals between 1370-1376 are reviewed.of these cases,6 were male and 7 were female.patients, age ranged between 19 to 70 years with a median of 47.8 years. in 8 cases tumor developed in stomach and in 5 cases it originated from small intestine.all available H & E stained slides were reviewed and PAS and masson,s trichrome stains and immunohistochemical staining for smooth muscle actin and S-100 protein were performed.positive reaction was observed in 8 cases for actin and in 2 cases for S-100 protein.immunohistochemical findings did not corroborate primary histopathologic diagnoses in 7 cases.these findings confirm this notion that routine histopathologic stains are not reliable for diagnosis of line of differentiaton in GIST.moreover, median age of our patients are significantly lower than that of other studies(p<0.0005) but this needs further study.}, keywords = {gastrointestinal stromal tumors (GIST),leiomyoma,schwannoma,immunohistochemistry}, url = {https://jkmu.kmu.ac.ir/article_34267.html}, eprint = {https://jkmu.kmu.ac.ir/article_34267_d0161f139a9ebe707ec38709228ff2f2.pdf} } @article { author = {GHafarinejhad, A.R}, title = {Report of an extensive speech disorder in a paranoid schizophrenic patient}, journal = {Journal of Kerman University of Medical Sciences}, volume = {6}, number = {2}, pages = {235-240}, year = {1999}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Neologism and private usage of stock words have long been considered as uncommon disorders of schizophrenic thought and speech.however,,a review of current literature and psychiatric textbooks reveals few clinical examples.in this article a paranoid  schizophrenic patient with extensive speech disorder has been presented and his neologistic production,private meaning of stoch words and other speech abnormalities have been discussed.}, keywords = {paranoid schizophrenia,neologism,Speech disorder}, url = {https://jkmu.kmu.ac.ir/article_34268.html}, eprint = {https://jkmu.kmu.ac.ir/article_34268_46b4882364a9beb3124a82340ae9e36f.pdf} }