@article { author = {Mirzaii-Dizgah, Mohammad-Reza and Mirzaii-Dizgah, Mohammad-Hosein and Mirzaii-Dizgah, Iraj}, title = {Reduction of Saliva and Serum 25-Hydroxycholecalciferol in Multiple Sclerosis}, journal = {Journal of Kerman University of Medical Sciences}, volume = {27}, number = {2}, pages = {106-112}, year = {2020}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2020.90613}, abstract = {Methods:The prevalence of multiple sclerosis (MS) is high in patients suffering from 25-hydroxyvitamin D3 [25(OH)D] deficiency. The aim of this study was to investigate the possible association of saliva and serum 25(OH)D concentrations with MS in women. Methods: Serum and saliva 25(OH)D levels of 30 MS women and 30 matched healthy controls in this case-control study were measured by ELISA. Data were analyzed by unpaired two-tailed student’s t-test, Pearson correlation test and Receiver operating characteristic (ROC). Results: The mean levels of 25(OH)D in serum and in both stimulated and unstimulated saliva were significantly lower in patients with MS. Serum levels of 25(OH) significantly correlated with stimulated (r = 0.575; P=0.003) and unstimulated saliva (r = 0.548; P=0.004). The mean (±SD) EDSS was 3.6±1.9 in the MS group. EDSS was not significantly correlated with 25(OH)D in serum or in stimulated and unstimulated saliva. The cut-off points of 25(OH)D in serum and saliva were 18 ng/ml and 65 pg/ml, respectively. Conclusions:25(OH)D level in saliva like in serum was low in MS women. Serum 25(OH)D levels correlated positively with saliva 25(OH)D in women suffering from MS.}, keywords = {Multiple sclerosis 25,Hydroxycholecalciferol Saliva}, url = {https://jkmu.kmu.ac.ir/article_90613.html}, eprint = {https://jkmu.kmu.ac.ir/article_90613_c265edcb66032ed98856148a55e5dbe2.pdf} }