@article { author = {Parsirad, Mahdokht and aletaha, najmeh and Alborzi Avanaki, Foroogh and Farahvash, Mohammad Jafar and Fazeli, Mohammad Sadegh and Zebardast, Jayran}, title = {Investigating the Relationship between Red Blood Cell Distribution Width and Early Detection of Colorectal Cancer and Colonic Polyps}, journal = {Journal of Kerman University of Medical Sciences}, volume = {27}, number = {2}, pages = {134-140}, year = {2020}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2020.90616}, abstract = {Background: Colorectal cancer is a common cancer and has a high rate of mortality and morbidity. This can be reduced by screening tests. Some of the studies have recently referred to Red Cell Distribution Width (RDW) as a marker for early detection of various cancers. The aim of this study was to investigate the RDW and early detection of colorectal cancer and polyp. Methods:A total of 90 patients were divided into three groups. One group included patients with colon cancer, another group with colon polyps, and the third group with normal colonoscopy as a control group. Blood samples were taken from patients and mean corpuscular volume (MCV), hemoglobin (HB), platelet (PLT), red blood cell distribution width (RDW), ferritin, serum iron, and total iron-binding capacity (TIBC) values were recorded. Transferrin saturation (Tsat) was also calculated. Statistical analysis was performed to remove the anemia effect of patients who had Tsat less than 20%, which was compared to patients who had Tsat over 20%. For the relationship between RDW and colon cancer, a receiver operating characteristic (ROC) curve was used. Results: The area under the receiver-operating characteristic curve (AUC) of the RDW for predicting colon cancer was 0.698, with cut off >14 which had 80% sensitivity and 60% specificity. Conclusions: RDW can be considered as a parameter for predicting colorectal cancer.}, keywords = {Red cell distribution width,colorectal cancer,Colonic polyps,Early detection of cancer}, url = {https://jkmu.kmu.ac.ir/article_90616.html}, eprint = {https://jkmu.kmu.ac.ir/article_90616_9c6802e8e5461f1f2a6b3b2050891355.pdf} }