ORIGINAL_ARTICLE
The Prevalence of Coronary Artery Diseases Risk Factors in Four Regions of Kerman City
Abstract Background and Aims: Cardiovascular diseases (CADs) are the most important causes of mortality and morbidity in the world and in Iran. These diseases are not completely curable but factors affecting them are preventable. The aim of this study was investigation of CAD risk factors in four municipal regions of Kerman city. Methods: From the city postal codes, 250 postal codes (as clusters) were selected randomly. Research coordinator team attended households in clusters and all the eligible members were recruited to the study. The recruitment was continued to reach 24 subjects in each cluster. The sample size was 5900 individuals aged from 15 to 75 years old. The prevalence of CAD risk factors including diabetes, hypertension, overweight and obesity, low physical activity, hyperlipidaemia, cigarette and opium smoking, depression and anxiety, oral and dental hygiene were assessed. Results: Overweight with overall prevalence of 30.5% in the city, showed significant different prevalence rates in four regions (region 1: 29.9%, region 2: 33.8%, region 3: 29.7% and region 4: 30.5%, P<0.001). Overall, diabetes and hypertension had prevalence rates of 8.1% and 11.3%, both with similar distribution in the four regions. However, in diabetic patients, the prevalence of abnormal HbA1C was 67.3%, 50.2%, 70.4% and 45.1% in regions one to four respectively (P<0.0005). The region four with 15.4% opium consumption had the highest rank among the four regions. Depression and anxiety had the highest prevalence in region 4 and the lowest in region 2 (P<0.01). The gingival score index was 72.6% in men and 68.1% in women with region four having the maximum prevalence of 80.1%. Conclusion: Overall, the prevalence of CADs in Kerman is relatively high and differs based on the region. Therefore, it is recommended that in designing educational programs for improving health behaviours, those differences are considered. It is suggested that these educations persist on reduction of obesity, opium consumption and improvement of mental health in region 4, on weight and LDL reduction in region 2, on diabetes control in regions 1 and on mental health improvement in region 3.
https://jkmu.kmu.ac.ir/article_16618_7b537d9fae1312ed25eb8c24da16e063.pdf
2016-08-01
406
420
risk factors
Coronary Artery Disease
Prevalence
Municipal regions
Kerman
Iran
Hamid
Najafipour
1
Professor of Physiology, Physiology Research Center and Department of Physiology, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Majid
Askaripour
2
PhD Candidate of Physiology, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Ali
Hosseinzadeh
3
PhD Candidate of Epidemiology, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Zahra
Sadeghi
4
Gasteroentrology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997;349(9063):1436-42.
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18
Najafipour H, Masoomi M, Shahesmaeili A, Haghdoost AA, Afshari M, Nasri HR, et al. Effects of opium consumption on coronary artery disease risk factors and oral health: Results of Kerman Coronary Artery Disease Risk factors Study a population-based survey on 5900 subjects aged 15-75 years. Int J Prev Med 2015;6(1):42.
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25
Rosmond R, Björntorp P. The hypothalamic–pituitary–adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. J Int Med 2000;247(2):188-97.
26
Najafipour H, Nasri HR, Afshari M, Moazenzadeh M, Shokoohi M, Foroud A, et al. Hypertension: diagnosis, control status and its predictors in general population aged between 15 and 75 years: a community-based study in southeastern Iran. Int J Public Health 2014; 59(6): 999-1009.
27
Najafipour H, Sanjari M, Shokoohi M, Haghdoost AA, Afshari M, Shadkam M, et al. Epidemiology of diabetes mellitus, pre‐diabetes, undiagnosed and uncontrolled diabetes and its predictors in general population aged 15 to 75 years: A community‐based study (KERCADRS) in southeastern Iran. J Diabetes 2015; 7(5): 613-21
28
Najafipour H, Moazenzadeh M, Afshari M, Nasri HR, Khaksari Hadad M, Forood A, Mirzazadeh A. Epidemic of low physical activity in an urban population and its relationship with other cardiovascular risk factors: Findings of a community-based study (KERCADRS) in South East of Iran. ARYA Atherosclerosis, 2016 [in press].
29
Najafipour H, Yousefzadeh G , Forood A, Karamozian M, Shadkam farokhi M, Mirzazadeh A. Overweight and Obesity Prevalence and its Predictors in a General Population Aged 15 to 75 Years: A Community-based Study in Southeastern Iran (KERCADR Study). ARYA Atherosclerosis 2016; 12(1): 18-27
30
Najafipour H, Banivaheb G, Sabahi A, Naderi N, Nasirian M, Mirzazadeh A. Prevalence of anxiety and depression symptoms and their relationship with other coronary artery disease risk factors: A population-based study on 5900 residents in Southeast Iran. Asian J Psychiatr 2016; 20: 55-60
31
Joukar S, Najafipour H, Malekpour-Afshar R, Mirzaeipour F, Nasri HR. The effect of passive opium smoking on cardiovascular indices of rabbits with normal and ischemic hearts. Open Cardiovasc Med J 2010; 4:1-6
32
ORIGINAL_ARTICLE
Improvement of Spinal Cord Injury in Rat Model via Transplantation of Neural Stem Cells Derived From Bone Marrow
Abstract Background & Aims: Cell therapy is among the novel therapeutic methods effective in the treatment of spinal cord injuries. The aim of the present study was using neural stem cells (NSCs) in treating contusion spinal cord injury in rat model. Methods: Bone marrow stromal cells (BMSCs) were isolated from adult rats. After three passages, these cells were transdifferntiated to neurospheres and subsequently to neural stem cells (NSCs). At in vivo studies, 43 adult female rats were divided into 5 groups. For the first group or Sham, laminectomy was the only procedure performed, whereas for the other four groups, after laminectomy, a contusion Spinal Cord Injury (SCI) was induced, as well. In group 2, no treatment was performed. In the other groups, injection was performed 7 days after SCI, as such: in groups 3, 4, and 5 normal saline, BMSCs, and NSCs were injected, respectively. The injections were administered intraspinally (IS). Motor improvement was assessed via BBB test one day before SCI and continued up to 12 weeks afterwards in all groups. Results: The current study revealed that a considerable percentage of the cells were BMSCs after the fourth passage. These cells were then transformed into neurospheres and NSCs. In all the experimental cell-therapy groups, a significant motor improvement was observed in comparison with that in the control group. This healing was more obvious during the period between the 2nd and the 4th weeks and less prominent during the period between the 4th and the 12th weeks. Conclusion: Transplantation of NSCs leads to partial motor improvement in contusive rat models.
https://jkmu.kmu.ac.ir/article_16619_0143297a038cdb7e80f0813b62e85dd7.pdf
2016-08-01
421
435
Bone marrow stromal cell
differentiation
Neural stem cells
Spinal cord injury
Hojjat-allah
Abbaszadeh
1
Assistant Professor, Hearing Disorders Research Center & Department of Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Taki
Tiraihi
2
Professor, Department of Anatomical Science, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran and Shefa Neuroscience Research Center, Khatam Al-Anbia Hospital, Tehran, Iran
LEAD_AUTHOR
Majid
Sadeghizade
3
Professor, Department of Genetics, Faculty of Sciences, Tarbiat Modares University, Tehran, Iran
AUTHOR
Alireza
Delshad
4
Associate Professor, Department of Anatomical Science, School of Medical Science, Shahed University, Tehran, Iran
AUTHOR
Taher
Taheri
5
Shefa Neuroscience Research Center, Khatam Al-Anbia Hospital, Tehran, Iran
AUTHOR
Ali Asghar
Peyvandi
6
Professor, Hearing Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
AUTHOR
Donnelly EM, Lamanna J, Boulis NM.Stem cell therapy for the spinal cord. Stem Cell Res Ther 2012; 3(4):24.
1
Anderson AJ, Robert S, Huang W, Young W, Cotman CW. Activation of complement pathways after contusion-induced spinal cord injury. J Neurotrauma 2004; 21(12):1831-46.
2
Wright KT, El-Masri W, Osman A, Chowdhury J, Johnson WE. Concise review: Bone marrow for the treatment of spinal cord injury: mechanisms and clinical applications. Stem Cells 2011; 29(2):169-78.
3
Rabchevsky AG, Streit WJ. Grafting of cultured microglial cells into the lesioned spinal cord of adult rats enhances neurite outgrowth. J Neurosci Res 1997; 47(1):34-48.
4
Li W, Maeda Y, Ming X, Cook S, Chapin J, Husar W, Dowling P. Apoptotic death following fas activation in human oligodendrocyte hybrid cultures. J Neurosci Res 2002; 69(2): 189–196.
5
Abbaszadeh HA, Tiraihi T, Delshad AR, SadeghiZadeh M Taheri, T. Bone marrow stromal cell transdifferentiation into oligodendrocyte-like cells using triiodothyronine as a inducer with expression of platelet-derived growth factor α as a maturity marker. Iran Biomed j 2013; 17(2): 62-70.
6
Ronaghi M, Erceg S, Moreno-Manzano V, Stojkovic M. Challenges of stem cell therapy for spinal cord injury: human embryonic stem cells, endogenous neural stem cells, or induced pluripotent stem cells. Stem Cells 2010; 28(1):93-9.
7
Chen MS, Huber AB, van der Harr ME, Frank M, Schnell L, Spillmann AA, et al. Nogo-A is a myelin associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1. Nature 2000; 403: 434-9.
8
Xue M, Hollenberg MD, Yong VW. Combination of Thrombin and Matrix Metalloproteinase-9 Exacerbates Neurotoxicity in Cell Culture and Intracerebral hemorrhage in mice. J Neurosci 2006; 26(40): 10281-91
9
Zhang N, Yan H, Wen X. Tissue-engineering approaches for axonal guidance. Brain Res Brain Rev 2005; 49(1):48-64.
10
Hou SY, Zhang HY, Quan DP, Liu XL, Zhu JK. Tissue-engineered peripheral nerve grafting by differentiated bone marrow stromal cells. Neuroscience 2006; 140(1):101-10.
11
Marshall GP, Reynolds BA, Laywell ED. sings the neurosphere assay to quantify neural stem cells in vivo. Curr Pharm Biotechnol. 2007 Jun; 8(3):141-5.
12
Darabi S, Tiraihi T, Ruintan A, Abbaszadeh HA, Delshad A, Taheri T.Polarized neural stem cells derived from adult bone marrow stromal cells develop a rosette-like structure. In Vitro Cell Dev Biol Anim 2013; 49(8): 638-
13
Kaka GR, Tiraihi T, Delshad A, Arabkheradmand J, Kazemi H. In vitro differentiation of bone marrow stromal cells into oligodendrocyte-like cells using triiodothyronine as inducer. Int J Neurosci. 2012 May; 122(5):237-47.
14
Deng W1, Obrocka M, Fischer I, Prockop DJ. In vitro differentiation of human marrow stromal cells into early progenitors of neural cells by conditions that increase intracellular cyclic AMP. Biochem Biophys Res Commun. 2001 Mar 23; 282(1):148-52.
15
Darabi S, Tiraihi T, Delshad A, Sadeghizadeh M. A new multistep induction protocol for the transdifferentiation of bone marrow stromal stem cells into GABAergic neuron-like cells. Iran Biomed J. 2013; 17(1):8-14.
16
Abbaszadeh HA, Tiraihi T, Delshad A, Saghedizadeh M, Taheri T, Kazemi H. Differentiation of neurosphere-derived rat neural stem cells into oligodendrocyte-like cells by repressing PDGF-α and Olig2 with triiodothyronine. Tissue Cell 2014; 46(6): 462-9.
17
Gharibani PM, Tiraihi T, Arabkheradmand J. In vitro differentiation of GABAergic cells from bone marrow stromal cells using potassium chloride as inducer. Restor Neurol Neurosci. 2010;28(3):367-77
18
Kuhn HG, Palmer TD, Fuchs T. Adult neurogenesis: a compensatory mechanism for neuronal damage. Eur Arch Psychiatry Clin Neurosci 2001; 251(4):152-8.
19
Ankeny D.P. McTigue D.M. Jakeman L.B. Bone marrow transplants provide tissue protection and directional guidance for axons after contusive spinal cord injury in rats. Exp. Neurol. 2004; 190:17-31.
20
Abbaszadeh HA, Tiraihi T, Noori-Zadeh A, Delshad AR, Sadeghizade M, Taheri T. Human ciliary neurotrophic factor–overexpressing stable bone marrow stromal cells in the treatment of a rat model of traumatic spinal cord injury. Cytotherapy 2015; 17(7): 912-21.
21
Cloutier F, Siegenthaler MM, Nistor G, Keirstead HS.Transplantation of human embryonic stem cell-derived oligodendrocyte progenitors into rat spinal cord injuries does not cause harm. Regen Med. 2006 Jul; 1(4):469-79.
22
Ankeny DP, McTigue DM, Guan Z, Yan Q, Kinstler O, Stokes BT, Jakeman LB. Pegylated brain-derived neurotrophic factor shows improved distribution into the spinal cord and stimulates locomotor activity and morphological changes after injury. Exp Neurol. 2001 Jul; 170(1):85-100.
23
Keirstead HS, Nistor G, Bernal G, Totoiu M, Cloutier F, Sharp K, Steward O. Human embryonic stem cell-derived oligodendrocyte progenitor cell transplants remyelinate and restore locomotion after spinal cord injury. J Neurosci. 2005 May 11; 25(19):4694-705.
24
ORIGINAL_ARTICLE
Frequency Assessment of the H817Q (2451T→A) Variant of von Willebrand Gene in Individuals without Hemorrhagic Signs
Abstract Background and Aims: Von Willebrand disease is a bleeding disorder caused by quantitative or functional defects in von Willebrand factor. The disease is found in up to 1 percent of the population. The most common symptom is mucocutaneous bleeding. Recently, studies conducted on healthy people showed that the H817Q mutation that previously known to cause von Willebrand disease was seen in the normal individuals. This study aimed to evaluate the frequency of H817Q variant of von Willebrand gene in Iranian healthy individuals. Methods: 200 DNA samples from different Iranian ethnicities were tested. The subjects were interviewed for bleeding history and other relative symptoms. DNA was extracted from 5 ml blood samples using salting out method, following written informed consent. Using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, the samples were genotyped by Hin1II enzyme and the results were confirmed via sequencing. Results: The desired fragments were obtained using PCR-RFLP. One individual without any bleeding history was found to carry this allele in a heterozygote manner. The allele frequency was calculated as 0.25%. Conclusion: The calculated allele frequency was below 1% and thereby could not be considered as a polymorphism. Von Willebrand gene contains various mutation and polymorphisms which are population specific. To understand the Iranian pattern, more studies should be done to reveal this characteristic.
https://jkmu.kmu.ac.ir/article_16622_b224ad6a479296c9d9ab05ab64a81ebc.pdf
2016-08-01
436
445
Von Willebrand factor
Coagulation
Mutation
Polymorphism
Mansoureh
Bakhtiari
1
Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Shirin
Shahbazi
2
Assistant Professor, Department of Medical Genetics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
LEAD_AUTHOR
Mehrdad
Hashemi
3
Associate Professor, Department of Molecular Genetics, Tehran Medical Branch, Islamic Azad University, Tehran, Iran
AUTHOR
Yee A, Kretz CA. Von Willebrand factor: form for function. Semin Thromb Hemost 2014; 40(1): 17-27.
1
Springer TA. Von Willebrand factor, Jedi knight of the bloodstream. Blood 2014; 124(9): 1412-25.
2
Sadler JE. Von Willebrand disease type 1: a diagnosis in search of a disease. Blood 2003; 101(6): 2089-93.
3
Shahbazi S, Mahdian R, Ala FA, Lavergne JM, Denis CV, Christophe OD. Molecular characterization of Iranian patients with type 3 von Willebrand disease. Haemophilia 2009; 15(5): 1058-64.
4
James PD, Lillicrap D. von Willebrand disease: clinical and laboratory lessons learned from the large von Willebrand disease studies. Am J Hematol 2012; 87(Suppl 1): S4-11.
5
Mancuso DJ, Tuley EA, Westfield LA, Lester-Mancuso TL, Le Beau MM, Sorace JM, et al. Human von Willebrand factor gene and pseudogene: structural analysis and differentiation by polymerase chain reaction. Biochemistry 1991; 30(1): 253-69.
6
Kroner PA, Foster PA, Fahs SA, Montgomery RR. The defective interaction between von Willebrand factor and factor VIII in a patient with type 1 von Willebrand disease is caused by substitution of Arg19 and His54 in mature von Willebrand factor. Blood 1996; 87(3): 1013-21.
7
Rick ME, Krizek DM. Identification of a His54Gln substitution in von Willebrand factor from a patient with defective binding of factor VIII. Am J Hematol 1996; 51(4): 302-6.
8
Bellissimo DB, Christopherson PA, Flood VH, Gill JC, Friedman KD, Haberichter SL, et al. VWF mutations and new sequence variations identified in healthy controls are more frequent in the African-American population. Blood 2012; 119(9): 2135-40.
9
Wang QY, Song J, Gibbs RA, Boerwinkle E, Dong JF, Yu FL. Characterizing polymorphisms and allelic diversity of von Willebrand factor gene in the 1000 Genomes. J Thromb Haemost 2013; 11(2): 261-9.
10
Laffan MA, Lester W, O'Donnell JS, Will A, Tait RC, Goodeve A, et al. The diagnosis and management of von Willebrand disease: a United Kingdom Haemophilia Centre Doctors Organization guideline approved by the British Committee for Standards in Haematology. Br J Haematol 2014; 167(4): 453-65.
11
Shahbazi S, Baniahmad F, Zakiani-Roudsari M, Raigani M, Mahdian R. Nonsense mediated decay of VWF mRNA subsequent to c.7674-7675insC mutation in type3 VWD patients. Blood Cells Mol Dis 2012; 49(1): 48-52.
12
Shahbazi S, Alavi S, Mahdian R. Classification of exon 18 linked variants of VWF gene in von Willebrand disease. Int J Mol Epidemiol Genet 2012; 3(1): 77-83.
13
Tosetto A, Rodeghiero F, Castaman G, Goodeve A, Federici AB, Batlle J, et al. A quantitative analysis of bleeding symptoms in type 1 von Willebrand disease: results from a multicenter European study (MCMDM-1 VWD). J Thromb Haemost 2006; 4(4): 766-73.
14
Genin E, Feingold J, Clerget-Darpoux F. Identifying modifier genes of monogenic disease: strategies and difficulties. Hum Genet 2008; 124(4): 357-68.
15
Franchini M, Crestani S, Frattini F, Sissa C, Bonfanti C. ABO blood group and von Willebrand factor: biological implications. Clin Chem Lab Med 2014; 52(9): 1273-6.
16
ORIGINAL_ARTICLE
The Effect of Regular Swimming Exercise on the Levels of Renal Matrix Mettaloproteinase-2 and Transforming Growth Factor-β1 in Rats with Diabetes
Background & Aims: Numerous studies have reported the renoprotective effects of exercise in both human and animal models of diabetic nephropathy. However, detailed mechanism of action by which exercise has a favorable influence on renal fibrogenic factors is not yet fully understood. Therefore, the aim of this study was to assess the effect of swimming exercise on the activity of renal matrix mettaloproteinase-2 (MMP-2) and transforming growth factor-β1 (TGF- β1) in rats with diabetes. Methods: The study sample consisted of 28 male Wistar rats that were randomly divided into 4 groups (7 rats per group) of control, diabetes, exercise, and diabetes-exercise. Diabetes was induced through an intraperitoneal injection of alloxan (90 mg/kg) in rats. The animals received swimming exercise for 6-30 minutes per day, 5 days a week for 8 weeks. The rats were sacrificed 72 hours after the last treatments and renal MMP-2 activity and TGF- β1 level were evaluated by Zymography and ELIZA (enzyme-linked immunosorbent assay) method. Data were analyzed using one-way analysis of variance. Results: Diabetes induction significantly increased renal TGF-β1 (P < 0.001) and decreased MMP-2 activity (P < 0.001) compared with the control group. Furthermore, 8 weeks of swimming exercise was associated with a significant decrease in renal TGF-β1 level (P = 0.001) and elevated MMP-2 activity (P = 0.001) in rats in the diabetes-exercise group. Conclusion: It seems that the renoprotective effects of regular swimming exercise against diabetes-induced kidney damage may be partly mediated via the up-regulation of renal MMP-2 activity and reduction of TGF-β1 level in diabetic renal tissue.
https://jkmu.kmu.ac.ir/article_16627_3dc8f5a145bf474887ba99fa9afab3ca.pdf
2016-08-01
446
456
Swimming exercise
Diabetes
Transforming growth factor-β1
Matrix mettaloproteinase-2
Masoumeh
Habibian
1
Assistant Professor, Department of Physical Education and Sports Sciences, Faculty of Human Sciences, Qaem Shahr Branch, Islamic Azad University, Qaem Shahr, Iran
LEAD_AUTHOR
Mohammad Reza
Saghafi
2
Department of Exercise Physiology, Faculty of Human Sciences, Sari Branch, Islamic Azad University, Sari, Iran
AUTHOR
Parvin
Farzanegi
3
Associate Professor, Department of Exercise Physiology, Faculty of Human Sciences, Sari Branch, Islamic Azad University, Sari, Iran
AUTHOR
Wang X, Yan L, Chen W, Xu L, Zhang X. The renal protective effects of cilostazol on suppressing pathogenic thrombospondin-1 and transforming growth factor-beta expression in streptozotocin-induced diabetic rats. J Int Med Res 2009; 37(1): 145-53.
1
Ma LJ, Fogo AB. Modulation of glomerulosclerosis. Seminars in Immunopathology 2007; 29(4): 385-95.
2
Mason RM, Wahab NA. Extracellular matrix metabolism in diabetic nephropathy. J Am Soc Nephrol 2003; 14(5): 1358-73.
3
McLennan SV, Kelly DJ, Cox AJ, Cao Z, Lyons JG, Yue DK, et al. Decreased matrix degradation in diabetic nephropathy: effects of ACE inhibition on the expression and activities of matrix metalloproteinases. Diabetologia 2002; 45(2): 268-75.
4
Han SY, Jee YH, Han KH, Kang YS, Kim HK, Han JY, et al. An imbalance between matrix metalloproteinase-2 and tissue inhibitor of matrix metalloproteinase-2 contributes to the development of early diabetic nephropathy. Nephrol Dial Transplant 2006; 21(9): 2406-16.
5
Sun SZ, Wang Y, Li Q, Tian YJ, Liu MH, Yu YH. Effects of benazepril on renal function and kidney expression of matrix metalloproteinase-2 and tissue inhibitor of metalloproteinase-2 in diabetic rats. Chin Med J (Engl) 2006; 119(10): 814-21.
6
Chung AW, Hsiang YN, Matzke LA, McManus BM, van Breemen C, Okon EB. Reduced expression of vascular endothelial growth factor paralleled with the increased angiostatin expression resulting from the upregulated activities of matrix metalloproteinase-2 and -9 in human type 2 diabetic arterial vasculature. Circ Res 2006; 99(2): 140-8.
7
Lewandowski K, Banach E, Bienkiewicz M, Lewinski A. Matrix metalloproteinases in type 2 diabetes and non-diabetic controls: effects of short-term and chronic hyperglycaemia. Arch Med Sci 2011; 7(2): 294-303.
8
Lee HS. Pathogenic role of TGF- ß in diabetic nephropathy. J Diabetes Metab 2013; S9: 1-7.
9
Ban CR, Twigg SM. Fibrosis in diabetes complications: pathogenic mechanisms and circulating and urinary markers. Vasc Health Risk Manag 2008; 4(3): 575-96.
10
Lane PH, Sun J, Devish K, Langer WJ. Dissociation of renal TGF-beta and hypertrophy in female rats with diabetes mellitus. Am J Physiol Renal Physiol 2004; 287(5): F1011-F1020.
11
Xu J, Lee ES, Baek SH, Ahn SY, Kim S, Na KY, et al. Effect of bilirubin on triglyceride synthesis in streptozotocin-induced diabetic nephropathy. J Korean Med Sci 2014; 29(Suppl 2): S155-S163.
12
Kurdak H, Sandikci S, Ergen N, Dogan A, Kurdak SS. The effects of regular aerobic exercise on renal functions in streptozotocin induced diabetic rats. J Sports Sci Med 2010; 9(2): 294-9.
13
Boor P, Celec P, Behuliak M, Grancic P, Kebis A, Kukan M, et al. Regular moderate exercise reduces advanced glycation and ameliorates early diabetic nephropathy in obese Zucker rats. Metabolism 2009; 58(11): 1669-77.
14
Peng C, Chen KC, Hsieh C, Peng RY. Swimming exercise prevents fibrogenesis in chronic kidney disease by inhibiting the myofibroblast transdifferentiation. PLoS One 2012; 7(6): e37388.
15
Santos Silva KA, de Alcântara Santos R, Arlotti MR, Jorge L, da Silva Luiz R, Rampaso RR, et al. Progressive resistance exercise training attenuated renal damages, but did not improve Muscle Force in STZ-Induced Diabetic Rats. J Diabetes Metab 2014; 5: 461.
16
Tzeng TF, Liou S, Chang C, Liu M. Zerumbone, a tropical ginger sesquiterpene, ameliorates streptozotocin-induced diabetic nephropathy in rats by reducing the hyperglycemia-induced inflammatory response. Nutr Metab (Lond) 2013; 10: 64.
17
Wenbin Z, Guojun G. Resveratrol ameliorates diabetes-induced renal damage through Regulating the expression of TGF-beta1, collagen IV and Th17/Treg-related cytokines in rats. West Indian Med J 2014; 63(1): 20-5.
18
Habibian M, Farzanegi P, Azimi GH. Therapeutic effect of swimming training and arbutin supplement on diabetes-induced renal oxidative stress. Daneshvar Med 2014; 22(114): 13-20. [In Persian].
19
Palladini G, Ferrigno A, Rizzo V, Tarantola E, Bertone V, Freitas I, et al. Lung matrix metalloproteinase activation following partial hepatic ischemia/reperfusion injury in rats. The Scientific World Journal 2014; 2014: 10.
20
Karamessinis PM, Tzinia AK, Kitsiou PV, Stetler-Stevenson WG, Michael AF, Fan WW, et al. Proximal tubular epithelial cell integrins respond to high glucose by altered cell-matrix interactions and differentially regulate matrixin expression. Lab Invest 2002; 82(8): 1081-93.
21
Sharma K, Jin Y, Guo J, Ziyadeh FN. Neutralization of TGF-beta by anti-TGF-beta antibody attenuates kidney hypertrophy and the enhanced extracellular matrix gene expression in STZ-induced diabetic mice. Diabetes 1996; 45(4): 522-30.
22
Hayashi K, Sasamura H, Ishiguro K, Sakamaki Y, Azegami T, Itoh H. Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2. Kidney Int 2010; 78(1): 69-78.
23
Lenz O, Elliot SJ, Stetler-Stevenson WG. Matrix metalloproteinases in renal development and disease. J Am Soc Nephrol 2000; 11(3): 574-81.
24
Ishikawa Y, Gohda T, Tanimoto M, Omote K, Furukawa M, Yamaguchi S, et al. Effect of exercise on kidney function, oxidative stress, and inflammation in type 2 diabetic KK-Ay mice. Experimental Diabetes Research 2012; 2012: 10.
25
Cunha TS, Ronchi F, Sakata MM, Arita DY, Colucci JA, Perez JD, et al. Exercise training reduces kidney angiotensin ii levels and attenuates renal dysfunction in animal diabetic nephropathy [Online]. [cited 2010]; Available from: URL: http://professional.diabetes.org/Abstracts_Display.aspx?TYP=1&CID=79058
26
Peng CC, Chen KC, Lu HY, Peng RY. Treadmill exercise improved adriamycin-induced nephropathy. J Biol Regul Homeost Agents 2012; 26(1): 15-28.
27
Farzanegi P. Impact of the synchronization of portulaca oleracea and aerobic training on levels of MMP2 and MMP9 and TIMP1 in diabetic women type II. Res Mol Med 2014; 2(2): 34-9.
28
ORIGINAL_ARTICLE
Prevalence of Different Types of Crown Restorations after Root Canal Treatment of Posterior Teeth in Kerman, Iran
Background & Aims: Crown restoration of teeth after root canal treatment protects their remaining structure against breakage and infection of the root canal, and will replace the missing structure. This study was performed to identify the prevalence of different types of crown restorations after root canal treatment of posterior teeth in Kerman, Iran, in 2013. Methods: This cross-sectional study was carried out on 410 individuals (1047 endodontically treated teeth) in 3 radiology centers in Kerman. To collect data, the existence of an endodontically treated posterior tooth was evaluated through panoramic radiography, and patients’ demographic information (including sex, age, education level, and their dentist’s education level) were obtained. The endodontically treated posterior teeth were not entered into this study if they did not have suitable restorations, had lost the tooth crown due to extensive caries, were not preservable, or were bridge abatements. Crown restorations were recorded based on their types, crown, amalgam, and composite with or without cusp coverage, and being a molar or premolar tooth. Data were analyzed in SPSS software using chi-square test. All P-values of less than 0.05 were considered significant. Results: In the present study, 203 (49.5%) men and 207 (50.5%) women participated. The mean age of subjects was 36.84 ± 9.76 years. Among the 1047 studied teeth, 380 (36.3%) were premolar teeth and 667 (63.7%) were molar teeth, and 316 teeth (30.20%) had a full crown. There was a statistically significant difference between existence of crown treatment, and educational level and age of patients. Amalgam and composite restoration had a statistically significant difference in terms of patients’ sex; amalgam restoration was more common in men, while composite restorations were more common in women. Crown treatment was more common in the specialists group, while amalgam restoration without cusp coverage was more common in the general dentists group. Conclusion: The results showed that amalgam or composite crown restorations without cusp coverage are common, which illustrates the necessity of emphasizing the importance of crown restorations in long term survival of root treated teeth in dentistry colleges.
https://jkmu.kmu.ac.ir/article_16628_c37848b5c2e66a1a606e9e2371fbb7a5.pdf
2016-08-01
457
465
Crown
Root Canal Therapy
Posterior teeth
Amalgam restoration
Composite restoration
Sina
Safari
1
Assistant Professor, Department of Prosthodontics, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Masoud
Parirokh
2
Professor, Department of Endodontic, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Hedayat
Gorjestani
3
Endodontist, Oral and Dental Diseases Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Iman
Ghahraman
4
Dentist, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Molouk
Torabi
5
Associate Professor, Oral and Dental Diseases Research Center, School of Dentistry, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Tang W, Wu Y, Smales RJ. Identifying and reducing risks for potential fractures in endodontically treated teeth. J Endod 2010; 36(4): 609-17.
1
Stavropoulou AF, Koidis PT. A systematic review of single crowns on endodontically treated teeth. J Dent 2007; 35(10): 761-7.
2
Shillingburg HT, Sather DA. Fundamentals of fixed prosthodontics. 4th ed. Berlin, Germany: Quintessence Pub.; 2012. p. 203-28.
3
Berman LH, Hargreaves KM, Cohen SR. Cohen's pathways of the pulp expert consult. 10th ed. Philadelphia, PA: Elsevier Health Sciences; 2010. p. 789-91, 780-805.
4
Salehrabi R, Rotstein I. Endodontic treatment outcomes in a large patient population in the USA: an epidemiological study. J Endod 2004; 30(12): 846-50.
5
Nagasiri R, Chitmongkolsuk S. Long-term survival of endodontically treated molars without crown coverage: a retrospective cohort study. J Prosthet Dent 2005; 93(2): 164-70.
6
Lazarski MP, Walker WA, Flores CM, Schindler WG, Hargreaves KM. Epidemiological evaluation of the outcomes of nonsurgical root canal treatment in a large cohort of insured dental patients. J Endod 2001; 27(12): 791-6.
7
Aquilino SA, Caplan DJ. Relationship between crown placement and the survival of endodontically treated teeth. J Prosthet Dent 2002; 87(3): 256-63.
8
Ray HA, Trope M. Periapical status of endodontically treated teeth in relation to the technical quality of the root filling and the coronal restoration. Int Endod J 1995; 28(1): 12-8.
9
Shelley PQ, Johnson BR, BeGole EA. Use of an Electronic Patient Record system to evaluate restorative treatment following root canal therapy. J Dent Educ 2007; 71(10): 1333-9.
10
Briggs PF, Scott BJ. Evidence-based dentistry: endodontic failure--how should it be managed? Br Dent J 1997; 183(5): 159-64.
11
Sjogren U, Hagglund B, Sundqvist G, Wing K. Factors affecting the long-term results of endodontic treatment. J Endod 1990; 16(10): 498-504.
12
Cheung GS. Endodontic failures--changing the approach. Int Dent J 1996; 46(3): 131-8.
13
Weiger R, Axmann-Krcmar D, Lost C. Prognosis of conventional root canal treatment reconsidered. Endod Dent Traumatol 1998; 14(1): 1-9.
14
Linn J, Messer HH. Effect of restorative procedures on the strength of endodontically treated molars. J Endod 1994; 20(10): 479-85.
15
Mondelli RF, Barbosa WF, Mondelli J, Franco EB, Carvalho RM. Fracture strength of weakened human premolars restored with amalgam with and without cusp coverage. Am J Dent 1998; 11(4): 181-4.
16
Hansen EK, Asmussen E, Christiansen NC. In vivo fractures of endodontically treated posterior teeth restored with amalgam. Endod Dent Traumatol 1990; 6(2): 49-55.
17
ORIGINAL_ARTICLE
Optimization of Selenite Removal by Lactobacillus sp. Tra cheese 6 Using Box-Behnken Design
Background & Aims: High concentrations of selenite have carcinogenetic, cytotoxic and genotoxic effects. Therefore, removal of this toxic pullutant from the environment has a particular importance in maintaining public health. In this study, with the aim of optimization of selenite removal process, the design Box-Behnken method was used to estimate the simultaneous effect of variables on removal efficiency and to determine the optimal values of variables on selenite removal with the probiotic bacterium Lactobacillus sp. Tra Cheese 6 Methods: An experimental method using a three-level Box-Behnken method fortesting the effects of four factors including concentrations of selenite ion, cell biomass, NaCl and agitation was investigated. Statistical Data Analysis was performed using Analysis of Variance (ANOVA) method. Regression coefficients of the second-order polynomial model were estimated. Then, by integrating the results and drawing a multivariate quadratic equation, the optimal point was precisely determined. Design-Expert software was used for data analysis. Results: Optimum removal of selenite was obtained at initial concentration of Selenite 49.5 mM, biomass concentration of 56 g/l, NaCl concentration of 4.2 % (w/v) and agitation at 100rpm. Under these conditions, the optimal selenite removal was 77.12 % after a 24-h reaction under the resting cells of Lactobacillus sp. Tra Cheese 6. Conclusion: In the current study, Response Surface Methodology based on Box-Behnken design was successfuly applied for improving selenite removal with the probiotic bacterium Lactobacillus sp. Tra Cheese 6.
https://jkmu.kmu.ac.ir/article_16630_dcbd1d319077d3d09c753c52a37c9032.pdf
2016-08-01
466
482
Selenite removal
Box-Behnken design
Response Surface Methodology
Lactobacillus sp Tra Cheese 6
Morahem
Ashengroph
m.ashengroph@uok.ac.ir
1
Assistant Professor of Microbiology, Department of Biological Sciences, Faculty of Sciences, University of Kurdistan, Sanandaj, Iran
LEAD_AUTHOR
Davoud
Saedi
2
MSc. Student of Molecular Cell Biology, Department of Biological Sciences, Faculty of Sciences, University of Kurdistan, Sananadaj, Iran
AUTHOR
Unrine JM, Jackson BP, Hopkins WA. Selenomethionine biotransformation and incorporation into proteins along a simulated terrestrial food chain. Environ Sci Technol 2007; 41(10): 3601-6.
1
Köhrle J. The trace element selenium and the thyroid gland. Biochimie 1999; 81(5): 527-33.
2
Haug A, Graham RD, Christophersen OA, Lyons GH. How to use the world’s scarce selenium resources efficiently to increase the selenium concentration in food. Microb Ecol Health Dis 2007; 19(4): 209-28.
3
Lavado R, Shi D, Schlenk D. Effects of salinity on the toxicity and biotransformation of L-selenomethionine in Japanese medaka (Oryzias latipes) embryos: mechanisms of oxidative stress. Aquat Toxicol 2012; 108: 18–22.
4
Ikram M, Faisal M. Comparative assessment of selenite (SeIV) detoxification to elemental selenium (Se0) by Bacillus sp. Biotechnol lett 2010; 32(9): 1255-9.
5
Hunter WJ, Kuykendall LD. Reduction of selenite to elemental red selenium by Rhizobium sp. strain B1. Current microbiology 2007; 55(4): 344-9.
6
Jaiswal SK, Prakash R, Acharya R, Nathaniel TN, Reddy AVR, Tejo PN. Bioaccessibility of selenium from Se-rich food grains of the seleniferous region of Punjab, India as analyzed by instrumental neutron activation analysis. CYTA Journal of Food 2012; 10(2): 160–4.
7
MacFarquhar JK, Broussard DL, Melstrom P, Hutchinson e, Wolkin A, Martin C, et al. Acute selenium toxicity ssociated with a dietary supplement. Arch Intern Med 2010; 170(3): 256-61.
8
Sun HJ, Rathinasabapathi B, Wu B, Luo J, Pu LP, Ma LQ. Arsenic and selenium toxicity and their interactive effects in humans. Environ Int 2014; 69: 148-58.
9
Bleys J, Navas-Acien A, Guallar E. Selenium and diabetes: more bad news for supplements. Ann Int Med 2007; 147(4):271-2.
10
Vinceti M, Maraldi T, Bergomi M, Malagoli C. Risk of chronic low-dose selenium overexposure in humans: insights from epidemiology and biochemistry. Rev Environ Health 2009; 24(3): 231-48.
11
Stewart MS, Spallholz JE, Neldner KH, Pence BC. Selenium compounds have disparate abilities to impose oxidative stress and induce apoptosis. Free Radic Biol Med 1999; 26(1-2): 42-8.
12
Geoffroy N, Demopoulos GP. The elimination of selenium (IV) from aqueous solution by precipitation with sodium sulfide. J Hazard Mater 2011; 185(1): 148-54.
13
Wang MJ, Xie YL, Chen ZJ, Yao SJ. Optimizing preparation of NaCS-chitosan complex to form a potential material for the colon-specific drug delivery system. Journal of Applied Polymer Science 2010; 117(5): 3001-12.
14
Hurlbut JA, Burkepile RG, Geisler CA, Kijak PJ, Rummel NG. Colorimetric determination of selenium in mineral premixes. J AOAC Int1997; 80(4): 709-16.
15
Ashengroph M, Nahvi I, Zarkesh-Esfahani H, Momenbeik F. Conversion of isoeugenol to vanillin by Psychrobacter sp. strain CSW4. Appl Biochem Biotechnol 2012; 166 (1): 1-12.
16
Box GEP, Behnken DW. Some new three level designs for the study of quantitative variables. Journal of Technometrics 1960; 2(4): 455-75.
17
Khalilian M, Zolfaghari MR, Soleimani M, Zand Monfared MR. Bacillus sp. strain QW90, a bacterial strain with a high potential application in bioremediation of selenite. Report of Health Care 2015; 1(1): 6-10.
18
Mishra RR, Prajapati S, Das J, Dangar TK, Das N, Thatoi H. Reduction of selenite to red elemental selenium by moderately halotolerant Bacillus megaterium strains isolated from Bhitarkanika mangrove soil and characterization of reduced product. Chemosphere 2011; 84 (9): 1231-7.
19
Pieniz S, Okeke BC, Andreazza R, Brandelli A. Evaluation of selenite bioremoval from liquid culture by Enterococcus species. Microbiol Res 2011; 166(3); 176-85.
20
Esmaeili S, Khosravi-Darani K, Pourahmad R, Nazemi L, Komeili R. Production of selenium-enriched yeast using a Plackett-Burman design. Iranian Journal of Nutrition Sciences and Food Technology 2012; 7 (2): 27-36 [In Persian].
21
Sharma SL, Pant A. Biodegradation and conversion of alkanes and crude oil by a marine Rhodococcus. Biodegradation 2000; 11(5):289-94.
22
Rathi P, Saxena RK, Gupta R. A novel alkaline lipase from Burkholderia cepacia
23
for detergent formulation. Process Biochemistry 2001; 37(2): 187-92.
24
Chang YC, Lee CL, Pan TM. Statistical optimization of medium components for the production of Antrodia cinnamomea AC0623 in submerged cultures. Appl Microbiol Biotechnol 2006; 72(4): 654-61.
25
Kiran KR, Manohar B, Karanth NG, Divakar S. Response surface methodological study of esterification of lactic acid with palmitic acid catalysed by immobilized lipases from Mucor miehei and porcine pancreas. Eur Food Res Technol 2000; 211: 130-5.
26
Kumar D, Jain VK, Shanker G, Sirvastava A. Citric acid production by solid state fermentation using sugarcane bagasse. Process Biochemistry 2003; 38(12): 1731-8.
27
Rodrigues RCLB, Felipe MGA, Roberto IC, Vitolo M. Batch xylitol production from sugarcane bagasse hemicellulosic hydrolyzate at controlled pH values. Bioprocess Biosyst Eng 2003; 26(2): 103-107.
28
Mannan S, Fakhru’l-Razi A, Alam MZ. Use of fungi to improve bioconversion of activated sludge. Water Research 2005; 39(13): 2935-43.
29
Soo EL, Salleh AB, Basri M, Rahman RNZA, Kamaruddin, K. Response surface methodological study on lipase-catalyzed synthesis of amino acid surfactants. Process Biochemistry 2004; 39(11): 1511-8.
30
Singh AK, Mehta G, Chhatpar HS. Optimization of medium constituents for improved chitinase production by Paenibacillus sp. D1 using statistical approach. Letters in Applied Microbiology 2009; 49(6): 708-14.
31
Singh KP, Singh AK, Gupta S, Sinha, S. Optimization of Cr (VI) reduction by zero-valent bimetallic nanoparticles using the response surface modeling approach. Desalination 2011; 270(1-3): 275-84.
32
Ashengroph M, Nahvi I, Amini J. Application of Taguchi Design and Response Surface Methodology for Improving Conversion of Isoeugenol into Vanillin by Resting Cells of Psychrobacter sp. CSW4. Iranian Journal of Pharmaceutical Research 2013; 12(3): 411-21.
33
Bosque-Sendra JM, Pescarolo S, Cuadros-Rodríguez L, García-Campaña AM, Almansa-López EM. Optimizing analytical methods using sequential response surface methodology: Applicationto the pararosaniline determination of formaldehyde. Fresenius' J Anal Chem 2001; 369(7-8): 715-18.
34
ORIGINAL_ARTICLE
The Role of Behavioral Activation-Inhibition, Impulsivity and Alexithymia in Discriminating Students with Symptoms of Obsessive-Compulsive and Paranoid Personality Disorders from Normal Controls
Background and Aims: The purpose of the study was to examine the role of behavioral activation-inhibition, impulsivityand alexithymia in discriminating students with symptoms of obsessive-compulsive and paranoid personality disorders from normal controls. Methods: The studied sample includes all the students in University of Mohaghegh Ardabili, Iran, in 2011 (n = 8344). At the first stage, to identify the students with obsessive-compulsive and paranoid personality disorders, 368 students were selected through simple random sampling method and the Millon Clinical Multiaxial Inventory-III was completed for them. In the second stage, 25 students were selected for each group and the Gray-Wilson Personality Questionnaire, Barratt Impulsiveness Scale and the Toronto Alexithymia Scale were completed by them. Data were analyzed using descriptive statistics and discriminant analysis. Results: Behavioral activation-inhibition, impulsivity and alexithymia played significant role in discriminating students with symptoms of obsessive-compulsive and paranoid personality disorders and had the potential to predict the changes concerned with obsessive-compulsive and paranoid personality disorders. Conclusion: It seems that attention to and evaluation of the roles of behavioral activation-inhibition, impulsivity and alexithymia as effective factors in obsessive-compulsive and paranoid personality disorders is necessary.
https://jkmu.kmu.ac.ir/article_16631_a76b13a835d3c1ccabd8b0713febabaf.pdf
2016-08-01
483
496
Obsessive-compulsive personality disorder
Paranoid personality disorder
Behavioral activation
Behavioral inhibition
Impulsivity
alexithymia
Mohammad
Narimani
narimani@uma.ac.ir
1
Professor, Department of Psychology, School of Educational and psychology, University of Mohaghegh Ardabili, Ardabil, Iran
LEAD_AUTHOR
Zohreh
Vahidi
2
Department of General Psychology, School of Educational and psychology, University of Mohaghegh Ardabili, Ardabil, Iran
AUTHOR
Abbas
Abolghasemi
3
Associate Professor, Department of Psychology, School of Educational and psychology, University of Mohaghegh Ardabili, Ardabil, Iran
AUTHOR
Jazayeri AR, Jafarizadeh Z, Pourshahbaz A. Study and comparison between personality traits and coping strategies among opium addicts (within the age of 30-36). Research on Addiction 2003; 1(2): 3-18. [In Persian].
1
Azad H. Psychopathology. Tehran, Iran: Besat Publication; 2010. [In Persian].
2
Sadock B, Kaplan H, Sadock VA. Kaplan & Sadock's synopsis of psychiatry: behavioral sciences/clinical psychiatry. Philadelphia, PA: Lippincott Williams & Wilkins; 2007.
3
American Psychiatry Association. The revised passage of the statistical and recognition guide of mental disorders. Trans. Nikkhoo MR. Tehran, Iran: Sokhan Publication; 2010. [In Persian].
4
Majlesi N, Behzadi S, Ganji H. Comparison between net reaction time span, short term spatial memory and cognitive inhibition in those suffering from compulsion and obsession. Thought and Behavior in Clinical Psychology 2008; 3(10): 83-98. [In Persian].
5
Fontenelle LF, Mendlowicz MV, Versiani M. Impulse control disorders in patients with obsessive-compulsive disorder. Psychiatry Clin Neurosci 2005; 59(1): 30-7.
6
Grant JE, Mancebo MC, Pinto A, Eisen JL, Rasmussen SA. Impulse control disorders in adults with obsessive compulsive disorder. J Psychiatr Res 2006; 40(6): 494-501.
7
Lumley MA, Stettner L, Wehmer F. How are alexithymia and physical illness linked? A review and critique of pathways. J Psychosom Res 1996; 41(6): 505-18.
8
Gray J. Framework for taxonomy of psychiatric disorders. In: van Goozen S, van de Poll N, Sergeant JA, Editors. Emotions: Essays on Emotion Theory. New York, NY: Psychology Press, 1994.
9
Azad Falah P, Dadsetan P. Brain- Behavioral systems: Bio functions of personality. Modarres Human Sciences 2000; 4(1): 63-82. [In Persian].
10
Gray J, McNaughton N. The neuropsychology of anxiety: Reprise. In: Hope DA, Izard CE, Editors. Perspectives on anxiety, panic, and fear. Omaha, NE: University of Nebraska Press, 1996. p. 61-134.
11
Corr PJ, Perkins AM. The role of theory in the psychophysiology of personality: from Ivan Pavlov to Jeffrey Gray. Int J Psychophysiol 2006; 62(3): 367-76.
12
Erdle S, Rushton JP. The general factor of personality, BIS–BAS, expectancies of reward and punishment, self-esteem, and positive and negative affect. Personality and Individual Differences 2010; 48(6): 762-6.
13
Corr PJ, Pickering AD, Gray JA. Personality and reinforcement in associative and instrumental learning. Personality and Individual Differences 1995; 19(1): 47-71.
14
Corr PJ. Reinforcement sensitivity theory and personality. Neurosci Biobehav Rev 2004; 28: 317-32.
15
Purkord M, Abolghasemi A, Narimani M, Rezaee H. Direct and indirect impact of self-efficacy, impulsivity, behavioral activation-inhibition and social skills on substance abuse in students. Journal of Research and Education Office 2013; 7(26): 11-28. [In Persian].
16
Dawe S, Loxton NJ. The role of impulsivity in the development of substance use and eating disorders. Neurosci Biobehav Rev 2004; 28(3): 343-51.
17
Arce E, Santisteban C. Impulsivity: a review. Psicothema 2006; 18(2): 213-20.
18
Ekhteyari H, Behzadi A. Frontal paddle shell, Making-decision disorders and the evaluating tests. Recog Sci 2001; 3: 64-86. [In Persian].
19
Dickman SJ, Meyer DE. Impulsivity and speed-accuracy tradeoffs in information processing. J Pers Soc Psychol 1988; 54(2): 274-90.
20
Zuckerman M. P-impulsive sensation seeking and it’s behavioral, psychophysiological and biochemical correlates. Neuropsychobiology 1993; 28(1-2): 30-6.
21
Sifneos P. Clinical observations on some patients suffering from a variety of psychosomatic diseases. Acta Medicina Psychosomatic, 1967; 7: 1-10.
22
Madadi A, Ghaeli P. Effect of fluoxetine on alexithymia in patient with major depression disorder [Online]. [cited 2002]; Available from: URL: http://www.iranpa.org/second [In Persian].
23
Besharat MA. Relation of alexithymia with ego defense styles. J Fundam Ment Health 2008; 10(3): 181-90.
24
Bankier B, Aigner M, Bach M. Alexithymia in DSM-IV disorder: comparative evaluation of somatoform disorder, panic disorder, obsessive-compulsive disorder, and depression. Psychosomatics 2001; 42(3): 235-40.
25
Richards HL, Fortune DG, Griffiths CE, Main CJ. Alexithymia in patients with psoriasis: clinical correlates and psychometric properties of the Toronto Alexithymia Scale-20. J Psychosom Res 2005; 58(1): 89-96.
26
Haviland MG, Shaw DG, Cummings MA, MacMurray JP. Alexithymia: subscales and relationship to depression. Psychother Psychosom 1988; 50(3): 164-70.
27
Millon T, Millon C, Davis R, Grossman S. MCMI-III, Millon clinical multiaxial inventory-III: manual. Piscataway, NJ: National Computer Systems; 1994.
28
Sharifi AA. MCMI-III guide. Tehran, Iran: Ravansanji Publication; 2007. [In Persian].
29
Sepah Mansour M. Relationship between Behavioral Activation System (BAS) and Behavioral Inhibition System (BIS) with students' capabilities and behavioral disorder. Thought and Behavior in Clinical Psychology 2010; 5(17): 57-64. [In Persian].
30
Barratt E. Impulsivity: Integrating cognitive, behavioral, biological, and environmental data. Washington, DC: American Psychological Association; 1993. p. 446.
31
Patton JH, Stanford MS, Barratt ES. Factor structure of the Barratt impulsiveness scale. J Clin Psychol 1995; 51(6): 768-74.
32
Bagby RM, Taylor GJ, Parker JD. The Twenty-item Toronto Alexithymia Scale--II. Convergent, discriminant, and concurrent validity. J Psychosom Res 1994; 38(1): 33-40.
33
Müller J, Alpers GW, Reim N. Abnormal attentional bias in alexithymia. Journal of Psychosomatic Research 2004; 56(6): 617.
34
Carver C, White TL. Behavioral inhibition, behavioral activation, and affective responses to impending reward and punishment: The BIS/BAS Scales. J Pers Soc Psychol 1994; 67(2): 319-33.
35
Pickering A, Gray J. The neuroscience of personality. In: Pervin JL, Editor. Handbook of personality. New York, NY: Guilford Press; 1999. p. 227-99.
36
Muris P, Meesters C, de Kanter E, Timmerman PE. Behavioural inhibition and behavioural activation system scales for children: relationships with Eysenck's personality traits and psychopathological symptoms. Pers Individ Dif 2005; 38(4): 831-41.
37
Ghafari M, Mehrabizadeh M, Khajedin N, Mousavi N. The comparison of impulsivity between responsive and non-responsive obsessive-compulsive patients to selective serotonin reuptake inhibitors. Sci Med J 2011; 10(2): 221-8. [In Persian].
38
Carpiniello B, Lai L, Pirarba S, Sardu C, Pinna F. Impulsivity and aggressiveness in bipolar disorder with co-morbid borderline personality disorder. Psychiatry Res 2011; 188(1): 40-4.
39
Motan I, Gencoz T. [The relationship between the dimensions of alexithymia and the intensity of depression and anxiety]. Turk Psikiyatri Derg 2007; 18(4): 333-43.
40
Sifneos PE. Alexithymia, clinical issues, politics and crime. Psychother Psychosom 2000; 69(3): 113-6.
41
ORIGINAL_ARTICLE
The Effect of a Training Program Based on the Theory of Planned Behaviour (TPB) on Sexual High-Risk Behavioural Intentions in Female Prisonors, Vakil Abad Prison, Mashhad, Iran, 2013
Background and Aims: High-risk sexual behaviors are of the most important risky behaviours in the area of sexual and reproductive health. It seems that educational programs based on health behavioural change theories are of the most basic measures in prevention of social damages. Therefore, the present study was carried out to determine the effect of a training program based on the theory of planned behaviour (TPB) on sexual high-risk behavioural intentions in female prisonors in Vakil Abad Prison, Mashhad, Iran, in 2013. Methods: This was a pre-experimental one group designed study on 40 women gotten prisoned due to doing high-risk sexual behaviours. Data were collected using self-structured questionnaires including demographics information, data related to sexual activity and constructs of the theory of planned behaviour. The training program was designed based on the constructs of this theory and was then implemented as seven 70-minute sessions. The questionnaires were completed before, immediately after, and four weeks after completing the training program. Data were analyzed using descriptive and inferential statistics tests via SPSS software. Results: There were significant differences between the mean scores of attitude, subjective norms, perceived behavioral control and behavioral intention for abstinence from high-risk sexual behaviors in female prisoners before, immediately after and four weeks after implementation of the training program (P < 0.001 for all). Conclusion: Developed health educational program on the basis of theory of planned behavior was an effective strategy for abstinence from high-risk sexual behavioral intention in jailed women.
https://jkmu.kmu.ac.ir/article_16633_cc687f0195cc7c823c44438ca8b73a67.pdf
2016-08-01
497
514
Education
Theory of planned behaviour
Behavioral Intention
High-risk sexual behaviour
Female prisoners
Mona
Larki
1
Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mahin
Taffazoli
tafazolim@mums.ac.ir
2
Lecturer, Department of Midwifery, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
Robab
Latifnejad-Roudsari
3
Associate Professor, Department of Midwifery AND Evidence-Based Care Research Center, School of Nursing and Midwifery, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Mohammad Taghi
Shakeri
4
Professor, Department of Biostatistics, School of Public Health, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Ali
Babaee
5
General Practitioner, Applied Science Education Center, District 6 Prison Organization, Mashhad, Iran
AUTHOR
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45
ORIGINAL_ARTICLE
A Glance into Cancer Stem Cells
The presence of stem cells in leukemia and solid tumors has been demonstrated in recent decades. Cancer stem cells have the potency of tumorigenesis; furthermore, they have the ability of self-renewing and differentiation like other stem cells. They also play important role in the process of tumor invasion and metastasis. Several studies have been performed to discover the specific markers and different phenotypes of these cells that can be very important in their identification. It seems that the characteristic of cancer stem cells, like tumor genesis, is greatly related to the specific signaling pathways such as Wnt, β catenin and hedgehog. In addition, the tumor microenvironment and its controlling agents are the important factors involving in the regulation of cancer stem cell function. The present review aimed to investigate the biology of cancer stem cells, specific signaling pathways, factors controlling the microenvironment as well as the role of microRNAs in controlling the function of these cells to provide new therapeutic methods.
https://jkmu.kmu.ac.ir/article_16638_1f76daa463d309288d3c0f057c17da1f.pdf
2016-08-01
515
542
Stem Cell
cancer
Review study
Hamid
Khodayari
1
Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Reyhaneh
Chamani
2
Ph.D. in Biochemistry, Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Saeed
Khodayari
3
Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
AUTHOR
Ali Mohammad
Alizadeh
alizadehtums92@sina.tums.ac.ir
4
Assistant Professor of Medical Physiology, Cancer Research Center, Tehran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
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