Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
Hematologic status in DMBA-induced mammary gland carcinoma in sprague dawley rats
119
126
EN
N
Razmi
Assistant professor
S
Nazifi
Associate professor
F
Karami- Tehrani
Assistant professor
in this study,14 female sprague-dawley rats 55 days old were randomly divided into two control and experimental groups.2ml of 7,12-dimethylbenz{a} anthracene (DMBA) solution(20 mg of DMBA dissolved in 2 ml of corn oil) and 2 ml corn oil was eaten to each animal of test and control group respectively.tumor development was examined by milk line palpation once every week.during 3-5 months following the DMBA, mammary gland tumor was appeared in all test animals.then complete hematologic tests were done on the tail blood sample of each animal.six inguinal and one chest mammarry gland tumors were observed in experimental group.the DMBA-induced animals showed macrocytic and hypochromic regenerative anemia.there were significant differences between two groups in WBC,RBC and platelet numbers,Hb,PVC, and the percentage of neutrophils,lymphocytes,eosinophils,monocytes,basophils and band neurtophils.the platelet count,in DMBA-induced rats was reduced significantly(p<0.05).in DMBA-induced rats neutrophilia,lymphopenia,monocytosis,eosinopenia and basopenia were seen.moephological abnormalities were observed in neutrophils and erythrocytes of the DMBA-induced animals and giant platelates were observed.
hematologic parameters,mammary gland caricinoma,DMBA,Rat
https://jkmu.kmu.ac.ir/article_34271.html
https://jkmu.kmu.ac.ir/article_34271_7d8e823910718e66d8668649b688eece.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
investigation of the prevalence of toxoplasma antibodies in women during marriage consultation in Kerman city
127
133
EN
Z
Kamyabi
Assistant professor
M
Atapour
based on serological,toxoplasmosis infection is a widespread disease.with regard to this fact and because of the occurence of congenital toxoplasmosis infections due to asymptomatic infections in pregnant women,determination of the rate of toxoplasma antibodise(IgG,IgM) before pregnancy and finding the involved factors in increasing toxoplasmosis prevalence seems to be necessary.in this cross sectional and discriptive study the prevalence of toxoplasma antibodies(IgG,IgM) in Kermanian women was determined by ELISA method.blood samples (n=350) were collected randomly from women reffered for marriage consultation to the central laboratory of Kerman city from Jan.1998 to Dec.1998.the results showed that the generan prevalence of the positive cases based on high titer of IgG was 29.4% and of IgM was 5.1%.there was no relation between positive cases and age,education,place of residence and keeping domestic animals(except cat) at home.but there was a relation between the positive cases of IgG and IgM and keeping cat at home(p<_0.01) and the way of meat consumption(raw or rare) (p<_0.0009).moreover 70.6% of pregnant women in Kerman city were seronegative and they were prone to acute toxoplasmosis during their pregnancy.therefore considering this fact and trying to omit its risk factors especially during pregnancy is very important.
Toxoplasmosis,Pregnancy,TORCH syndrom,IgG,IgM
https://jkmu.kmu.ac.ir/article_34272.html
https://jkmu.kmu.ac.ir/article_34272_e3cefd069f51cdf1c406fc0c6f7c96d8.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
A study on the life cycle of haplorchis taichui(heterophyidae:trematodae) under laboratory conditions
134
140
EN
A
Farahnak
Assistant professor
J
Masood
professor
Haplorchis taichui is parasitic heterophyidae(trematoda) which lives in the intestinal mucosa of its main host and producing heterophyidosis,which is a zonootic diseases.subsequent to the authors, provious studies which were made on parasit,s lift cycle in nature in Khuzestan province,Iran,this experimental study was performed with the aim of establishing the parasite,s lift cycle in laboratory.in this study the heterophyidae eggs were exposed to Milonides tuberculate or Melanopsis spp(fresh-water snails) within an aquarium and then cercariae were obtained.in aquarium,Gambosia affinis(fish) were infected with the above cercariae and then metacercariae were obtained from the latter after one month.domestic cats,rats,hen,s chicken and mus musculus were fed with the ebive infected fishes and then after one month such animals were autopsised,which led to the isolation of H.taichui from rat and cat.this study revaeled that H.taichui as a parasitology research model can be established in susceptible animals such as rat and cat under laboratory conditions.
Haplorchis taichui,heterophyidae,life cycle,experimental study
https://jkmu.kmu.ac.ir/article_34273.html
https://jkmu.kmu.ac.ir/article_34273_0296b6dfa954523372369cba7adaefbf.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
Estimating prevalence rates of migraine and tension-type headache among the students of Shiraz university of medical sciences
141
148
EN
S.M.T
Ayatolahi
Associate professor
T
Darabzand
F
Bozorgi
F
Shibani-Monfared
this study investigated the prevalence rates of migrine and tension-type headaches among the students of Shiraz university of medical sciences during the academic year 1996-1997.the study was carried out cross-sectionally on a representative random sample of 310 students selected systematically.A semi structured questionnaire was used to screen headache among the students,applying the international Headache society Classification.A total of 123(39.7%) students were screened for headache and examined clinically for a proper diagnosis.as a result 80(25.8%) students were diagnosed to have migraine,tension-type headache or coexiting migraine and tension-headache.prevalence rates for tension-headache,migraine,coexisting tension-headache and migraine were 15.5%,7.4% and 2.6% respectively.odds ratio of tension-headache in boys was 3.4 times higher than that of girls,(p<0.01),but it was not statistically different for migraine and coexisting migraine and tension-headache.the relationship between the headaches and sevral factors were examined and significant associations were found between migraine and coexisting migraine and tension-type headache with sleeping pattern of students(p<0.05).the odds ratio of migraine in students who had abnormal sleeping pattern was 2.5 times higher than those with normal sleeping pattern,but for coexisting migraine and tension-headache with regard to sleeping pattern it was estimated to be 7.8 times higher than normal.both odds ration were statistically significant(p<0.05).in general,headaches including migraine.tension-type,etc were significantly associated with family history of headache (p<0.001)
Epidemiology,Prevalence,Headache,migraine,tension-type headache,Student
https://jkmu.kmu.ac.ir/article_34274.html
https://jkmu.kmu.ac.ir/article_34274_0bfd1b65a0d978a5a5e0c19f76b66020.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
Determination of the point prevalance of psychotic disorders among students of Kerman university of madical sciences
149
156
EN
S.H
Moetamedi
Assistant professor
Y
Nikiyan
Assistant professor
H
Tazari
MD Student
world health organization(WHO) defines health,as a complete physical,mental,and social well being. According to the reports of this organization 25 million people in the wprld in different age groups are suffering from severe and 150 million from mild psychotic disorders.based on the studies,these statistics are not lower in Iran than the other countries.the aim of this study was to determine the prevalence of psychotic disorders among the students of Kerman university of medical sciences with the hope of finding the ways to decrease the promlems of this intellectual class which play an important role in the future of the country.this study was performed by census sampling from all students who started their studies in september and january 1996 using standardized questionarise SCL-90-R.reliability and validity of the questionarie was previously satisfied by Mirzaie(1359) and Bagheri Yazdi(1373). A total of 387 questionarie were completed in Autum 1996 and spring 1997.the point prevalence of the diseases was 28.2%.the highest rate of prevalence was paranoia,and the lowest was phobia.the average rate of disorders was higher in male than female students.the results of this study showed that mental disorders were lower in students than in general population.
Prevalence,mental disorders,college students,Kerman
https://jkmu.kmu.ac.ir/article_34275.html
https://jkmu.kmu.ac.ir/article_34275_feb6fd19e32cd08b5a9d47f278a5c652.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
the effect of isoproterenol on protein electrophoretic pattern of rabbit salivary Glands
157
164
EN
M
Saeb
Associate professor
S
Shafia
Instructor
J
Sajedian fard
Instructor
Isoproterenol is a potent B-adrenergic agonist which its effect on rabbit salivary Glands has been studied in this research.two groups of male albino rabbits(five in each group with the mean weight of 1000+_300 gr) were injected with 20 mg/kg of isoproterenol intrapritoneally each day for fifteen days and one similar group(n=5) was chosen as control group.in one of the test groups in addition to normal diet (day food) animals were fed by liquid diet.increase in the weight of parotid salivary Glands was five folds in test groups as compared to control group(p<0.01).also,twelve folds increase in total protein content of the gland was observed in test groups as compared to control group(p<0.01).the increase in submandibular gland weight was significant but not as much as that in parotid gland(p<0.01).the total protein of submandibular glands of those experimental animals which were fed with solid diet was 2.5 folds as compared to control group(p<0.01).the total protein of the other test group fed with liquid diet showed a non-significant increase in comparison to control group.the increase in submandibular gland weight was significant in this group compared to control group(p<0.01).regarding sublingual gland, there was just significant increase in weight of gland in the solid diet group(p<0.01).however the increase in total protein content of sublingual glands of experimental groups was not significant compared to control group.sodium didecyl sulfate polyacrylamide gel electrophoresis of parotid gland revealed protein bands with molecular weight of about 14,44,58,96,and 98 KD in experimental groups compared to control group.electrophoretic pattern of submandibular gland of test groups showed protein bands with 20.KD which probably is a kind of proteins.since isoproterenol was not effective on sublingual gland,significant differnce in its electrophoretic pattern was not observed.
Isoproterenol,Salivary Gland,proline-rich protein,Rabbit
https://jkmu.kmu.ac.ir/article_34277.html
https://jkmu.kmu.ac.ir/article_34277_5a91b23ce3e3feebe709056a14650a2c.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
patients satisfaction from their consultant physicians in Shiraz
165
173
EN
S.M.T
Ayatolahi
Associate professor
Z
Heidari
H
Hagh-Shenas
Assistant professor
S.A.R
Ayatolahi
Instructor
the present study was designed to investigate a quantitative method for evaluation of patients satisfaction from their consultant physicians.seventy eight physicians were selected randomly by systematic sampling method from a total of 421 consultant physicians practicing in Shiraz.ten patients were selected randomly for each consultant physician that results in a sample of 780 patients.a questionnaire which covered 5 areas of demographical variables patient-physician relationship,physician area of speciality and other relevent variables was prepared.a persian version of general health questionnaire(GHQ) and the other mentioned questionnaire were completed by the second author,the physician,s secretary and the physician himself.the results reveled that the patients were more satisfied with male physicians prectice.elder patients had higher level of satisfaction than youngers.higher education showd negative correlation with the degree of satisfaction.the highest degree of satisfaction showed for pediatricians and the lowest for dermatologists.the score of GHQ factors showed positive correlation with the degree of satisfaction,i.e., less healthire were less satisfied.in the fitting logistic regression on some variables,appropriate model was obtained where the correct prediction in two groups satisfied and not satisfied patients,was 99.7% and 97.3% respectively.in the principal component analysis,the first component explained 51.4% of the total variation of variables related to the patients satisfaction.this model could be applied as a guide for measuring patients bsatisfaction.
patients,Satisfaction,quantitative method,consultant physician,risk factors
https://jkmu.kmu.ac.ir/article_34278.html
https://jkmu.kmu.ac.ir/article_34278_46fcfc0e355ee3c30f62841a4c1458f5.pdf
Kerman University of Medical Sciences
Journal of Kerman University of Medical Sciences
1023-9510
2008-2843
6
3
1999
07
01
The significance of determining the therapeutic dose of cyclosporine-A in patients undergoing organ transplantation
173
183
EN
H
Kharazi
Associate professor
GH.A
Khosh-Sarvar
Assistant professor
Immunosuppressive drugs are now unavoidibly used after the transpantation of liver,heart and bone marrow, as well as in certain autoimmune diseases.among these agents,cyclosporine-A (CYA) is one of the most effective Immunosuppressants which is widely used.but as any Immunosuppressive agent,the use of CYA is not without harmful side effects.neurotoxin,nephrotoxic and hepatotoxic complications,may be seen in patients treated with CYA. for the first time borel from sandoz research center (Switzerland) showed that the metabolite of a fungus named tolypcladium inflatum gams,has a suppressive effect on immune system.thirty intermediate products of CYA metabolic pathway have been known so far and some studies have demonstrated the properties of a limited number of these products (M1,M8,M17,M21).pharmacodynamic studies on CYA have revaled that the Immunosuppressive effect of this drug is mainly achievable by its activity on T-lymphocyte.in fact.CYA inhibits the gene transcription in T-lymphocytes which results in lesser or no production of antigen-antibody complex.since the administred therapeutic dose of drug is a variable of many factors such as the type of transplanted organ,physiologic state of the patient,bioavailability and the treatment protocol and on the other hand,CYA has some destructive side effects on the other body organs,therefore determinations of the effective therapeutic dose of CYA ,and freauent measurement of CYA and its metabolites concentrations in blood is a necessity.
cyclosporine-A,Immunosuppressive drug,organ transplantion
https://jkmu.kmu.ac.ir/article_34279.html
https://jkmu.kmu.ac.ir/article_34279_33350e915608180b46f4aded0fc95455.pdf