TY - JOUR ID - 17289 TI - The Association of Vitamin D Receptor Gene BsmI Polymorphism with Multiple Sclerosis in Iranian Patients JO - Journal of Kerman University of Medical Sciences JA - JKMU LA - en SN - 1023-9510 AU - Nik seresht, A.R AU - Dadkhah, B AU - Kamali sarvestani, E AD - Associate Professor of Neurology, School of Medicine and Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Resident of Neurology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran. AD - Professor of Immunology, School of Medicine and Autoimmune Diseases Research Center, Shiraz University of Medical Sciences, Shiraz, Iran. Y1 - 2009 PY - 2009 VL - 16 IS - 4 SP - 116 EP - 123 KW - Multiple Sclerosis KW - Vitamin D KW - Polymorphism KW - Iran DO - N2 - Background & Aims: 1,25-dihydroxyvitamin D3 (1,25 (OH)2 D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of BsmI polymorphism in vitamin D receptor gene (VDR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients with MS and 292 ethnically and sex matched controls were included in this study. BsmI polymorphism in VDR gene was assessed by PCR-RFLP method. Results: No differences in the allelic distribution were observed in the patients as compared to the controls. Also no difference in genotype distribution of VDR-BsmI polymorphism was observed between patients and controls (p=0.43). Conclusion: Considering the significance of vitamin D3 as an immune system regulator and its inhibitory effects on MS, investigation on other VDR gene polymorphisms is recommended. UR - https://jkmu.kmu.ac.ir/article_17289.html L1 - https://jkmu.kmu.ac.ir/article_17289_95de4840983e4d83d1f7f214c192d8a1.pdf ER -