TY - JOUR ID - 63173 TI - Vascular Endothelial Growth Factor in Serum and Saliva of Oral Lichen Planus and Oral Squamous Cell Carcinoma Patients JO - Journal of Kerman University of Medical Sciences JA - JKMU LA - en SN - 1023-9510 AU - Agha-Hosseini, Farzaneh AU - Mirzaii-Dizgah, Iraj AU - Mohebbian, Mina AU - Sarookani, Mohammad-Reza AD - Dental Research Center, Dental Research Institute, Tehran University of Medical Sciences &amp; Department of Oral and Maxillo facial Medicine, Faculty of Dentistry, The Academy of Medical Sciences, Tehran, Iran. AD - Full Prof. of Department of Physiology, School of Medicine, Aja University of Medical Sciences, Tehran, Iran AD - Assistant Prof. of Oral and Maxillo facial Medicine, Faculty of Dentistry, Zanjan University of Medical Sciences, Zanjan, Iran AD - Full Prof. of Cell and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran Y1 - 2018 PY - 2018 VL - 25 IS - 1 SP - 27 EP - 33 KW - VEGF KW - Oral lichen planus KW - oral squamous cell carcinoma KW - Saliva DO - N2 - Background:Oral lichen planus (OLP) is considered as a potentially malignant disorder and vascular endothelial growth factor (VEGF) may play a key role in cancer development. The aim of this study was to compare serum and saliva VEGF among patients with OLP, oral squamous cell carcinoma (OSCC) and a healthy control group. Methods:A cross sectional study was performed on 27 patients with OLP, 27 patients with OSCC and 27 healthy volunteers. The serum and saliva VEGF were assayed by ELISA method. Statistical analysis of ANOVA was used. Results:The mean saliva flow rate and serum VEGF in OLP and OSCC patients were significantly lower compared to healthy control group (p <0.05), but there was no significant difference between OLP and OSCC patients. There was no significant difference in mean salivary VEGF among groups. Conclusion:It seems that saliva VEGF may not be a good biomarker for OLP and OSCC. UR - https://jkmu.kmu.ac.ir/article_63173.html L1 - https://jkmu.kmu.ac.ir/article_63173_9b42adac3648624cf07f6184e491ffaa.pdf ER -