TY - JOUR ID - 90640 TI - Evaluation of L-arginine Effects on Refractory Seizures in Epileptic Patients JO - Journal of Kerman University of Medical Sciences JA - JKMU LA - en SN - 1023-9510 AU - Ebrahimi meimand, Hossein Ali AU - Iranmanesh, Farhad AU - Ansari, Mahdi AU - Molla Mohammadi, Hasibeh AU - Ebrahimi, Sepideh AD - Professor of Neurology, Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran AD - Professor of Pharmacology, Kerman University of Medical Sciences, Kerman, Iran AD - Medical Student, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran Y1 - 2020 PY - 2020 VL - 27 IS - 3 SP - 213 EP - 221 KW - L KW - arginine Refractory epilepsy Epilepsy Ketogenic diets DO - 10.22062/jkmu.2020.90640 N2 - Background:epilepsy is one of the common neurological disorders and approximately0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy in refractory epileptic patients.Methods: Two groups of epileptic patients (n=21) were selected randomly. Group 1 received lactose as a placebo, and group 2 received L-arginine (twofold of daily need) as a drug for three months. We used a standard questionnaire for evaluating the effect of L-arginine on the quality of life before and after the study.Results: we did not find significant change in the quality of life of patients after using L-arginine, but the epileptic attacks decreased in L-arginine group significantly.Conclusion: L-arginine therapy is safe and can decrease the rate of seizure attacks in refractory epileptic patients, and can be an alternative of ketogenic diets. UR - https://jkmu.kmu.ac.ir/article_90640.html L1 - https://jkmu.kmu.ac.ir/article_90640_6c8c403ebc17b2c86ee48f76b3eefd68.pdf ER -