TY - JOUR ID - 91569 TI - Antidiabetic and Antioxidant Properties of Sea Urchin Echinometra mathaei from the Persian Gulf JO - Journal of Kerman University of Medical Sciences JA - JKMU LA - en SN - 1023-9510 AU - Soleimani, Soolmaz AU - Pirmoradloo, Elham AU - Farmani, Fatemeh AU - Moein, Soheila AU - Yousefzadi, Morteza AD - Professor of Department of Marine Biology, Faculty of Marine Science and Technology, University of Hormozgan, Bandar Abbas, Iran AD - Department of Biochemistry, Fars Sciences and Research Branch, Islamic Azad University, Shiraz, Iran AD - Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran AD - Professor of Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran Y1 - 2021 PY - 2021 VL - 28 IS - 1 SP - 104 EP - 115 KW - Antidiabetic KW - Antioxidant Properties Echinometra mathaei The Persian Gulf DO - 10.22062/jkmu.2021.91569 N2 - Background: The aim of the present study was to evaluate the inhibition of α-glucosidase and antioxidant properties of different tissues of sea urchin Echinometra mathaei. Methods: α-glucosidase inhibition was determined using p-Nitrophenyl-a-D-glucopyranoside as a substrate, and the antioxidant properties were evaluated by 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS),1,1-diphenyl-2-picrylhydrazyl (DPPH), and nitric oxide radicals scavenging. Also, antioxidant potential was evaluated by the ferric reducing antioxidant power (FRAP) method. Results: Among the studied tissues, the highest α-glucosidase inhibition was revealed by the ethyl acetate extract of the shell and Aristotle’s lantern (IC50 = 3.7 and 4 mg/mL, respectively). Shell had the highest ABTS (IC50 = 183) and DPPH (IC50 = 208 μg/mL) radicals scavenging, respectively. And, gonad had the highest antioxidant potential by the FRAP method (1140 μg ASA/mg) and NO radical scavenging (70.68%), respectively. Conclusion: Antidiabetic potentials of the ethyl acetate extracts of sea urchin tissues suggest that these extracts can be used as antidiabetic drugs. UR - https://jkmu.kmu.ac.ir/article_91569.html L1 - https://jkmu.kmu.ac.ir/article_91569_e7512c883b8f508282e5d75d0cddb487.pdf ER -