TY - JOUR ID - 91888 TI - Beneficial Effects of Dual Frequency Sonodynamic Therapy and Hematoporphyrin Mesoporous Silica Nanoparticles in the Treatment of Mice Breast Adenocarcinoma JO - Journal of Kerman University of Medical Sciences JA - JKMU LA - en SN - 1023-9510 AU - Hoseinzadeh, Monireh AU - Jadidi, Majid AU - Hasanzadeh, Hadi AU - Khani, Tahereh AU - Shahryari, Shoka AU - Saeedi, Shima AD - Department of Medical Physics, Semnan University of Medical Sciences, Semnan, Iran Y1 - 2022 PY - 2022 VL - 29 IS - 2 SP - 112 EP - 122 KW - breast cancer KW - Adenocarcinoma KW - Dual frequency KW - Sonodynamic therapy KW - Hematoporphyrin KW - Mesoporous silica nanoparticle DO - 10.22062/jkmu.2022.91888 N2 - Background: Sonodynamic therapy (SDT) may be a new hopeful non-invasive method for cancer treatment, which incorporates a combination of low-intensity ultrasound and a sonosensitive chemical. The goal of this study was to evaluate the effect of dual-frequency sonication (1 and 3 MHz) and injected Hematoporphyrin encapsulated in mesoporous silica nanoparticles (HP-MSNs) as a sensitizer in the treatment of mice grafted with breast adenocarcinoma.Methods: In this research, one hundred and thirty-two female mice with grafted breast adenocarcinoma were separated into 22 groups including control, sham, 4 groups of sonication 1 or 3 MHz (1 and 2 W/cm2), and 16 groups of SDT with Hematoporphyrin (HP) and HP-MSNs (2.5 and 5 mg/kg). The tumor growth factors and tumor grading were used to assess the treatment management.Results: The results indicate that dual-frequency sonication has a delayed effect on tumor growth. The required time of T5 to the initial volume in all groups of SDT with HP (5 mg/kg) was greater than that in the control group (P<0.05). It was observed that SDT with an injection of HP-MSNs was effective in delaying tumor growth and the time of T2 and T5 was higher than that of other groups (P<0.05). This group had Grade II (intermediate), while others had Grade III (high) malignancy in the histological study of mice breast adenocarcinoma. Conclusion: Our results reveal that dual-frequency SDT therapy with HP-MSN has a delaying tumor growth effect on mice breast adenocarcinoma. Hence, the expansion of minimally invasive methods such as SDT is necessary. UR - https://jkmu.kmu.ac.ir/article_91888.html L1 - https://jkmu.kmu.ac.ir/article_91888_e2b9a60c40adf02fb8b0e854284a4e48.pdf ER -