Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Multivariate Multilevel Estimates of Shiraz infants Gross-motor Milestones Achievement Age11033122ENNZareAssistant professorS.M.TAyatolahiProfessorJBehbodianprofessorJournal Article20160920A two-yers longitudinal study waz conducted in 1996.the data are letated to a cohort of 317 healthy neonated(164 girls and 153 boys) randomly selected in june 1996 from the city of shiraz followed from birth to two years of age.Firstly,logistic regression model and HRY (Healy-Rashash-Yang)method were used on ten selected milestones separately.secondly, we use an auto-regressive multivariate multilevel model to account for the serial correlation between milestones.selected centiles were calculated from estimated age of eraching to milestones.Gender,as a predictor,did not show any significant effect.In comparison to Denver children,Shiraz children attained the skills late.Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Effect of New Derivatives of Dihydropyridine on Rat Ileal Smooth Muscle in Vitro111833123ENMRezvanipourAssistant professorHSepehriAssociate professorA.RForomandiAssociate professorGH.RSepehriAssociate professorHNajafi PourInstructorFEsmaeiliOtherJournal Article20160920In this research we evaluated the calcium channel antagonist activity of various diester analohues of nifedipine on rat ileal smooth muscle.in these analogues,the orthophenyl group at position 4 was replaced by 1 methyl 2-meythylsulfonyl or methylthio 5-imidazolyl.wistar rats(180-250g) were killed by a blow to the head.the intestine was removed above the ileucecal junction and longitudinal smooth muscle segments of 2 cm length were maintained at 37c in a 10 ml jacket organ bath containing oxygenated intestinal krebs soluion.the contractions was recorded with a force displacement transducer connected to a physiograp.the contraction was elisited with 80 mmol KCL.test compounds were cumulatively added to produse 50% relaxation of contracted ileal smooth muscle (IC50) THAT WAS DETERMINED FROM THE CINCENTRATION response trace recorded by physiograph.the IC50 of nifedipine was (1.26+-0.37)*10 and of compounds 1,2,3,4,5 and 6 was(2.57+_0.28)*10,(1.03+_0.12)*10,(2.55+_0.50)*10,(1.32+_0.18)*10,(3.16+_0.89)*10, and (1.04+_0.29)*10 mole respectively.the results indicate that replacement of 2_ nitrophenyl at C4 position of nifedipine with methyltion or methyl solfunyl imidazolyl reduces the activity.the comparison of the activites of symetrical esters(compounds No 3&6) indicated that increasing the length of methylen chain in C3 and C5 esters substituend decreases the avtivity.Comparison of the activities of asymetrical esters(compounds No4&5) indicates that,when at C3 there is a small substituent,increasing the length of methylen chain increases activity.comparison of the activites of symetrical esters(compounds 2 and 3) with asymetrical esters(compounds 1,4.5 and 6) indicates that asymetrical esters are not always more potent than symmetrical esters.compound 4 was the most potent new compound in this study.finally we can conclude that nifedipine was significantely more potent than all of these compounds.Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Evaluation of Vascular Injuries Associated with Different Kinds of Traumatic Knee Dislocations192633124ENS.HAyatolahi-mosaviAssistant professorJournal Article20160920In a chart review 31 traumatic knee dislocations were identified in 30 patients during an eight year period (1992-2000).Fifteen dislocations (48.4%) were posterior,seven anterior,eight occult and one medial.out of the five cases of vascular injuries three happened with posterior dislocations and in four patients associated ipsilateral limb injuries were present .the general incidence of simultaneous limb injury was 54.8%(17 cases).two knees with vascular injury required amputation.All vascular compromised limbs had impaired distal pulsation.
Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Evaluation of Correlation between Cases of depressed fracture and Associated Brain lesion273233125ENAEbrahimi NejadAssistant professorHRehani-KermaniAssistant professorJournal Article20160920THis cross-sectional study was performed on 382 patients with depressed skull fracture admitted to the neurosurgery ward of Kerman Bahonar Haspital between 1994 and 1999.329 of the patients(86.1%) had open fractures,while the fracture was of closed type in 53 cases (13.9%).of those with open fracture,42%were associated with dura tearing ,whereas the rate was 34% in closed fractures.the most common causes of depressed fracture were accidents with motor vehicles(59.4%).in most cases (77%) Glasgow coma scale(GCS) on admission was 13-15.there was no associated lesion in 247 patients(64.7%),but 135(35.3%) had one or more lesions,with contusion (34%) and epidural hematoma (23.7%) asb the most common ones.in cases when the fracture was caused by motor vehicle accidents,the occurence of clinical manifestations was more than that of the other causes.of 15 patients who died (3.9%) 14 ases (93.3%) had associated lesions.Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201The Relationship between Chronic Urticaria and Helicobacter pylori Infection333933126ENSFarajzadehAssistant professorSDarvish-moghadamAssistant professorEEsfandyarpourAssistant professorZRahnemaAssistant professorM.JZahediAssistant professorJournal Article20160920Chronic urticaria is a prolonged disease with unknown etiology and management.in order to determine the association of helicobacter pylori(H.pylori) infection with chronic urticaria,a case-control study was carried out in this regard 95 chronic urticaria patients without any underlying etiology and 190 healthy individuals who were matched for age and sex were evaluated by-anti-H.pylori IgG detection.in patients groupe 68(41.6%) were female,27(28.4%)male,and in control group 136 were female and 54 male.the mean age of paatients group was 32.4+_15.7 years and in control group it was 31.9+_14.8 years(p>0.05).the average duration for chronic urticaria was 22.7 months.Among other findings in patients group were asthma (13.7%).allergic rhinitis (16.8%),angioedema(43.2%) and gastrointestinal (GI)complaints (32.1%).anti-H.pylori antibody was detected in 71(74.7%) of patients and in 96(50.5%) of healthy persons with a significant difference (p<0.001).there was a significant difference for H.pylori infection in 20-50 years age class in patients group (p<0.01),but the relation between duration of urticaria,angioedema,and Gl complaints with H.pylori infection wa nonsignificant (p>0.05).according to these results H.pylori infection is more frequent in chronic idiopathic urticaria patients than in healthy subjects.however to clarify its etiopathogenesis it is essential to implement more basic research and therapeutic trials.Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Assessment of corelation between spinal canal shape and spinal cord injury in thoracolumbar spine fractures404533127ENHRehani-KermaniAssistant professorM.ARamezaniOtherJournal Article20160920Traumatic spinal cord injury is one of the important causes of disability.in some of vertebral fractures,spinal canal is deformed and compromised.the relationship between the shape of the cervical canal and spinal cord hnjury has been proved but such a correlation for thoraculombar spine 50 patients with compromised canal(cases) and 50 oatients with intact canal were evaluated in the light of spinal canal shape(using CT scan),neurological defects(using Frankle classification),mechanism of trauma and level of the spinal fracture.of the 100 patients studied ,23 had spinal cord injury and most of injuries were at T12-L2. the most common mechanisms of trauma were road traffic accident and fall.the diference in age,sex and mechanism of trouma between the two grops was not statistically signifacant.No significant difference was found between canal intact group and canal compromised group in necruachment is more important than static canal compromise.Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Toothpaste Eormulation from Miswak powder Extract465233128ENPKHazaeliAssistant professorA.RForomandiAssociate professorM.HMoshafiAssistant professorMAhshamiOtherJournal Article20160920Miswak.is stem of Salvadora perisca,which is particulary used by moslems for tooth brushing.cosidering the useful properties of Miswak and easy use of toothpastes.this research is airned at toothpaste formulation from Miswak extract .toothpaste bases was formulated by use of diferrent ingrediants.some of the formulation were selected for accelerated stability test analysis.by these studies,the best formulation was choosed.this formalation contained calcium carbonate as abrasive,propylen glycol and glycerin as humestant and naCMC as binder.in the next step,methanolic extract of Miswak was prepared by soxelet method,then minimum inhibitory Concentration (MIC) of this extract was determined against streptoccocus sanguis which is one of the most important agents causing dental caries.the MIC was 320 mg/ml, so 0.3%(10 fold of MIC) of extract was used in toothpaste.for evalution of antimicrobial effect,the medical toothpaste were compared against toothpaste base,tetracycline and ampicilin disc in Disc Diffusion method.results showed that there was significant differences between medical toothpaste and toothpaste base,and that medical toothpaste was as effective as ampicilin but less effective than tetracycline.
Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201The prevalence of HSV2 antibodies in blood donors in city of Kerman During the Year 2002535933129ENS.M.AArabzadehAssistant professorA.RFekriAssociate professorS.ASHasodiniprofessorA.RZohorAssistant professorJournal Article20160920Herpes simplex virus infection is almost universal.this virus has two types:HSV1 and HSV2 infect about 500/000 persons annually in the united states,and its prevalence rate has increased during the past decade.Usually HSV1 spreads through kissing or casual contact and HSV2 through sexual intercourses.HSV1 is more frequently associated with oral infection and HSV2 can cause recurrent genital ulcers.Nodata is available about HSV2 prevalence in Iran.this study was conducted to determine the prevalence of HSV2 antibodies in blood donors in city of Kerman During the Year 2002.Data were collected in a cross-sectional study in 966 serum samples.in this study the population were examined for oro-facial and genital herpes.In this servaey age,sex,job,eduction,marrital status,family history of oro-facial and genital herpes of the population were considered.antibody (IgG)of HSV2 was assessed by using ELISA in this study.About 2.7%of the population were seropositive for HSV2 (2.8% were male and 2.6% were female.).None of them have had clinical genital herpes during examination but about 1.1%(11 of 966) of them have had previous history of clinical genital herpes.the population have been examined for HSV1Ab.HBSAb. and HCVAb, and the results were also negative.the prevalence of HSV2 had a significant trend of increasing with increase in age.
Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95109120031201Areport of rare case of parotid Gland Hydatid Cyst606433130ENM.ADamghaniAssistant professorJournal Article20160920Hydatid cyst disease is a zoonotic infection.in human beings it apears as cystic lesions in different organs and the most common form is hydatid cyst of liver.one of the rare sites of the disease is salivary gland,which appears as a neck mass.therefore,when observing a cystic lesion in salivary glands.hydatid cyst should be considered and for confirmation of diagnosis spicial paraclinic techniquse must be used and with suitable therapeuticplan,the disease, should be treated to prevent the possible complications and reccurrence.we present a parotid hydatid cyst in a 15 year old man.