Authors
1 M.Sc. of Exercise Physiology, Azad University of Kerman, Kerman. Iran
2 Department of exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran & Cardiovascular Research Center,
3 Professor of Clinical Biochemistry, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Abstract
Background & Aims: The main long-term problems of chronic diabetes are cardiovascular complications classified as micro/macro-vascular complications. The consequences for patients include cardiovascular diseases, nephropathy, retinopathy, and so on. Due to the effect of exercise on tissue blood flow distribution and the different nature of the two types of resistance and aerobic exercises, this study aimed to compare the effect of aerobic and resistance trainings on angiostatinlevel of men with type 2 diabetes. Methods: A total of 26 men with type 2 diabetes (mean age: 64.56±11.3 years, mean weight: 68.50±5.42 kg, mean height: 150±43.162 cm and 10- year history of diabetes) referred to Kerman Diabetes Center were purposefully selected and randomly divided into two groups of aerobic and resistance trainings. After being familiarized with the research protocol, subjects did resistance exercises based on a percentage of the maximal strength (1 RM) and the endurance exercise with the intensity of percentage of maximum consumed oxygen three sessions in week (40-60 minutes each session) and for 12 weeks. Blood samples before and 24 hours after the last training session were collected. For comparison within the groups, independent t- test and for comparison between groups, repeated measure two-way ANOVA were used. Results: Serum anigiostatin level and VEGFR showed no significant difference between the two groups (P=0.116, P=0.218 respectively), but groups showed significant increase in serum angiostatinlevel and VEGFR after the intervention (P<0.05). Conclusion: The results showed that twelve weeks of resistance and aerobic exercises can improve of men with type 2 diabetes and increases their anigiostatin level but non significantly.
Keywords
- Schneider BP, Miller KD. Angiogenesis of breast cancer. J ClinOncol 2005; 23(8): 1782-90.
- Milkiewicz M, Ispanovic E, Doyle JL, Haas TL. Regulators of angiogenesis and strategies for their therapeutic manipulation. IntJBiochem Cell Biol2006; 38(3): 333-57.
- Calle MC, Fernandez ML. Effects of resistance training on the inflammatory response. Nutr Res Pract 2010; 4(4): 259-69.
- Ruas JL., White JP, Rao RR, Kleiner S, Brannan KT, Harrison B.C, et al. A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. Cell 2012; 151(6): 1319-31.
- Cheema BS, Gaul CA. Full-body exercise training improves fitness and quality of life in survivors of breast cancer. J Strength Cond Res 2006; 20 (1): 14-21.
- Agha-Alinejad H, Toufighi A, Mohammad HZ, Mahdavi M, Shahrokhi S. The effect of continuous aerobic exercise on the rate of hsp70 in mice with breast cancer tumor. Olympic 2008; 42: 75-86.
- Gensch C, Clever Y, Werner C, Hanhoun M, Bohm M, Laufs U. Regulation of endothelial progenitor cells by prostaglandin E1 via inhibition of apoptosis. J Mol Cell Cardiol 2007; 42(3): 670-7.
- Dominguez, MG, Hughes VC, Pan L, Simmons M, Daly C, Anderson K, et al. Vascular endothelial tyrosine phosphatase (VE-PTP)-null mice undergo vasculogenesis but die embryonically because of defects in angiogenesis. ProcNatl AcadSci USA 2007; 104 (9): 3243-48.
- Liekens S, De Clercq E, Neyts J. Angiogenesis: regulators and clinical applications. BiochemPharmacol 2001; 61(3): 253-70.
- Thompson HJ, Ronan AM, Ritacco KA, Tagliaferro AR, Meeker LD. Effect of exercise on the induction of mammary carcinogenesis. Cancer Res 1988; 48(10): 2720-3.
- Dass C, Tran TM, Choong PF. Angiogenesis inhibitors and the need for anti-angiogenic therapeutics. J Dent Res 2007; 86(10):927-36.
- Lee J, Ku T, Yu H, Chong K, Ryu SW, Choi K, Choi C. Blockade of VEGF-Asuppresses tumor growth via inhibition of autocrine signaling through FAK and AKT. Cancer Lett 2012; 318(2): 221-5.
- Yoon SS, Eto H, Lin CM, Nakamura H, Pawlik TM, Song SU, et al. Mouse endostatin inhibits the formation of lung and liver metastases. Cancer Res1999; 59(24): 6251-6.
- Tudor-Locke C, Brashear MM, Johnson WD, Katzmarzyk PT. Accelerometer profiles of physical activity and inactivity in normal weight, overweight, and obese US men and women. Int J BehavNutrPhys Act 2010; 7(1): 60.
- Guimarães GV,Ciolac EG, Carvalho VO, D,Avila VM, Bortolotto LA, Bocchi EA. Effects of continuous vs. interval exercise training on blood pressure and arterial stiffness in treated hypertension. Hypertens Res 2010; 33(6): 627-32.
- Jager S, Handschin C, St-Pierre J, Spiegelman BM. AMP-activatedprotein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. ProcNatlAcadSci USA 2007; 104(29): 12017–22.
- Ojuka EO. Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle. ProcNutrSoc 2004; 63(2): 275-8.
- Chung JH, Eun HC. Angiogenesis in skin aging and photoaging. J Dermatol 2007; 34(9): 593-600.
- Zielinski MR, Muenchow M, Wallig MA, Horn PL, Woods JA. Exercise delays allogeneic tumor growth and reduces intratumoral inflammation and vascularization. J ApplPhysiol 2004; 96(6): 2249-56.
- Pratheeshkumar P, Kuttan G. Nomilin inhibits tumor-specific angiogenesis by down regulating VEGF, NO and pro inflammatory cytokine profile and also by inhibiting the activation of MMP-2 and MMP-9. Eur J Pharmacol 2011; 668(3):450-8.
- LähteenvuoA, Rosenzweig A. Effects of aging on angiogenesis. Circ Res 2012; 110(9): 1252-64.
- Shen, M, Gao J, Li J, Su J. Effect of ischaemic exercise training of a normal limb on angiogenesis of a pathological ischaemic limb in rabbits. ClinSci 2009; 117(5): 201-8.
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