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The Incidence Rate of Retinopathy of Prematurity and Related Risk Factors: a Study on premature neonates hospitalized in two hospitals in Sari, Iran, 2014-2015

Authors

1 Assistant Professor, Department of Pediatrics, Booali Hospital, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

2 Assistant Professor, Department of Ophalmology, Booali Hospital, School of Medicine, Booali Clinical Researches Dvelopment Center, Mazandaran University of Medical Sciences, Sari, Iran

3 Resident of Pediatrics, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

4 Assistant Professor, Department of Pediatrics, Infectious Diseases Research Center, Mazandaran University of Medical Sciences, Sari, Iran

5 Associate Professor of Biostatistics, Health Sciences Research Center, School of Health, Mazandaran University of Medical Sciences, Sari, Iran

Abstract

Background & Aims: Retinopathy OF prematurity (ROP) is a developmental disorder of retinal vessels in premature neonates. In recent years, because of advances in the care of neonates hospitalized in equipped Intensive care units, retinopathy of prematurity has become a major cause of blindness in those who are survived. This study assessed the incidence and severity of retinopathy and related risk factors in premature infants in Bo-Alisina and Emam Khomeini Hospitals in Sari. Methods: This was a descriptive cross-sectional study conducted for one year. All neonates hospitalized in NICU and neonatal wards of selected Hospitals with a gestational age less than 30 weeks or gestational age less than 34 weeks with unstable conditions were included for clinical and laboratory studies. Result: The incidence of ROP in 146 studied neonates was 16.4% (24 cases), of which 6 cases were of grade 1, 14 cases of grade 2 and four cases were grade 3. All four cases with grade 3 ROP were recovered with injection of intravitreal avastin or without medical therapy. Sixty six percent of patients with ROP, had a gestational age of less than 30 weeks and all of them had birth weights less than 2000grams. There was statistical correlation between the incidence of ROP and gestational age, birth weight, history of intubation, Intraventricular hemorrhage, PH <7.2, history of high or low blood pressure and fraction of inspired oxygen in newborns. But, no significant relationship was found between duration of oxygen therapy, history of sleep apnea, Resuscitation, sepsis and duration of Phototherapy with ROP. Conclusions: The incidence of retinopathy of prematurity in Bo-Alisina and Emam Khomeini Hospitals in Sari was similar to other studies. The most important risk factors were low gestational age and birth weight. Considering the risk of the disease in premature infants, ROP screening is recommended not only for prematures under 30 weeks of gestational age but also in more mature ones who have any risk factor for ROP.

Keywords

References
  1. Pediatrics AAO. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 2006; 117(2): 572-6.
  2. Augsburger JJ, Bornfeld N, Ophtalmology In: Yanoff M, Duker JS, (editors), St. Louis, MO: Mosby 2004; PP. 1097-102.
  3. Patz A. Oxygen administration to the premature infant. Am j Ophthalmol 1967; 63(2): 351-3.
  4. Fierson WM, Saunders RA, Good W, Palmer EA, Phelps D, Reynolds J, et al. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 2013; 131(1): 189-95.
  5. Shah PS, Sankaran K, Aziz K, Allen AC, Seshia M, Ohlsson A, et al. Outcomes of preterm infants< 29 weeks gestation over 10-year period in Canada: a cause for concern?. J Perinatol 2012; 32(2): 132-8.
  6. Tavosnanska J, Carreras IM, Fariña D, Luchtenberg G, Celadilla ML, Celotto M, et al. Morbimortalidad de recién nacidos con menos de 1500 gramos asistidos en hospitales públicos de la ciudad de Buenos Aires. Archivos argentinos de pediatría. 2012;110(5):394-403 [In Spaniol].
  7. Gunn DJ, Cartwright DW, Gole GA. Incidence of retinopathy of prematurity in extremely premature infants over an 18‐year period. Clin experiment ophthalmol 2012; 40(1): 93-9.
  8. Schwarz EC, Grauel EL, Wauer RR. No increase incidence of retinopathy of prematunity and improvement of its outcome in a university perinatal. Klin Monatsbl Augenheilkd 2011; 228(3): 208-19 [In German].
  9. Horbar JD, Carpenter JH, Badger GJ, Kenny MJ, Soll RF, Morrow KA, et al. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics 2012;129(6):1019-26.
  10. Akkoyun I, Oto S, Yilmaz G, Gurakan B, Tarcan A, Anuk D, et al. Risk factors in the development of mild and severe retinopathy of prematurity. J AAPOS 2006; 10(5): 449-53.
  11. Shah VA, Yeo CL, Ling YL, Ho LY. Incidence, risk factors of retinopathy of prematurity among very low birth weight infants in Singapore. Ann Acad Med Singapore 2005; 34(2): 169-78.
  12. Hungi B, Vinekar A, Datti N, Kariyappa P, Braganza S, Chinnaiah S, et al. Retinopathy of prematurity in a rural neonatal intensive care unit in South India—a prospective study. Indian J Pediatri 2012; 79(7): 911-5.
  13. Wani VB, Kumar N, Sabti K, Raizada S, Rashwan N, Shukkur MM, et al. Results of screening for retinopathy of prematurity in a large nursery in Kuwait: Incidence and risk factors. Indian JOphthalmol 2010; 58(3): 204-8.
  14. Saeidi R, Hashemzadeh A, Ahmadi S, Rahmani S. Prevalence and predisposing factors of retinopathy of prematurity in very low-birth-weight infants discharged from NICU. Iranian journal of pediatrics 2009; 19(1): 59-63.
  15. Amer M, Jafri WH, Nizami AM, Shomrani AI, Al-Dabaan AA, Rashid K. Retinopathy of prematurity: are we missing any infant with retinopathy of prematurity? Br J Ophthalmol 2012; 96(8): 1052-5.
  16. Austeng D, Källen KB, Ewald UW, Jakobsson PG, Holmström GE. Incidence of retinopathy of prematurity in infants born before 27 weeks' gestation in Sweden. Arch Ophthalmol 2009; 127(10): 1315-9.
  17. Zin AA, Moreira ME, Bunce C, Darlow BA, Gilbert CE. Retinopathy of prematurity in 7 neonatal units in Rio de Janeiro: screening criteria and workload implications. Pediatrics 2010; 126(2): e410-e7.
  18. Li QP, Wang ZH, Li YY, Huang QM, Huang JJ, Chen Y, et al. Retinopathy of prematurity screening in 2185 premature infants. Zhonghua yan ke za zhi 2012; 48(10): 903-7.
  19. Taqui AM, Syed R, Chaudhry TA, Ahmad K, Salat MS. Retinopathy of prematurity: frequency and risk factors in a tertiary care hospital in Karachi, Pakistan. J Pak Med Assoc 2008; 58(4): 186-90.
  20. Ahmed AS, Muslima H, Anwar KS, Khan NZ, Chowdhury MA, Saha SK, et al. Retinopathy of prematurity in Bangladeshi neonates. J Trop Pediatric 2008; 54(5): 333-9.
  21. Karkhaneh R, Mousavi SZ, Riazi-Esfahani M, Ebrahimzadeh SA, Roohipoor R, Kadivar M, et al. Incidence and risk factors of retinopathy of prematurity in a tertiary eye hospital in Tehran. Br J Ophthalmol 2008; 92(11): 1446-9.
  22. Zarshenas MM. Prevalenceand risk factors of retinopathy of prematurity among preterm infants in Shiraz. First congress of Pediatrics intensive care Mashhad, Iran, 2012.
  23. Ebrahim M, Ahmad RS, Mohammad M. Incidence and risk factors of retinopathy of prematurity in Babol, North of Iran. Ophthalmic Epidemiol 2010; 17(3): 166-70.
  24. Nakshab M, Bayani G, Ahmadzadeh amiri A, Eshaghi M. Prevalence of retinopathy in premature neonates in neonatal intensive care unit of Boali sina hospital in 2001. J Mazandaran Univ Med Sci 2003; 13(39): 63-70.
  25. Abrishami M, Maemori GA, Boskabadi H, Yaeghobi Z, Mafi-Nejad S, Abrishami M. Incidence and Risk Factors of Retinopathy of Prematurity in Mashhad, Northeast Iran. Iran Red Crescent MedJ 2013; 15(3):229-33.
  26. Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Quintos M, et al. The incidence and course of retinopathy of prematurity: findings from the Early Treatment for Retinopathy of Prematurity Study. Pediatrics 2005; 116(1): 15-23.
  27. Darlow BA, Hutchinson JL, Henderson-Smart DJ, Donoghue DA, Simpson JM, Evans NJ. Prenatal risk factors for severe retinopathy of prematurity among very preterm infants of the Australian and New Zealand Neonatal Network. Pediatrics 2005; 115(4): 990-6.
  28. Conrath JG, Hadjadj EJ, Forzano O, Denis D, Millet V, Lacroze V, et al. Screening for retinopathy of prematurity: results of a retrospective 3-year study of 502 infants. JPediat Ophthalmol Strabismus 2004; 41(1): 31-4.
  29. Mathew MR, Fern AL, Hill R. Retinopathy of prematurity: are we screening too many babies? Eye 2002; 16(5): 538-42.
  30. Subhani M, Combs A, Weber P, Gerontis C, DeCristofaro J. Screening guidelines for retinopathy of prematurity (ROP): The need for revision in extremely low birth weight (ELBW) infants. Pediatrics 2001; 107(4): 656-9.
  31. No authors. Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Pediatrics 1988; 81(5): 697-706.
  32. Lichtenstein S, Buckley E, Ellis G, Kivlin J, Lueder G, Ruben J, et al. Screening examination of premature infants for retinopathy of prematurity. Pediatrics 2006; 118(3): 1324.
  33. Chiang MF, Arons RR, Flynn JT, Starren JB. Incidence of retinopathy of prematurity from 1996 to 2000: analysis of a comprehensive New York state patient database. Ophthalmology 2004;111(7):1317-25.
Journal of Kerman University of Medical Sciences
Volume 23, Issue 3
July and August 2016
Pages 296-307
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