Prevalence of GNB3 C825T Gene Polymorphism in Children with Vesicoureteral Reflux in Kerman

Authors

1 Assistant professor of Medical Genetics, Afzalipour School of Medicine and Physiology Research center, Kerman University of Medical Sciences, Kerman, Iran

2 Assistant professor, Department of Pediatrics, Afzalipour School of Medicine and Physiology Research center, Kerman University of Medical Sciences, Kerman, Iran

3 Resident of Pediatrics, Afzalipour school of Medicine, Kerman University of Medical Sciences, Kerman, Iran

4 Researcher, Dr. Bazrafshani Medical Genetic Laboratory, Kerman, Iran

Abstract

Background & Aims: Vesicoureteral Reflux (VUR) is a congenital defect of the urinary tract which has
been reported in approximately 1% of children. Several immunological and genetic factors are listed as
major causes of this problem. The C825T polymorphism of the GNB3 gene is among the genetic factors that
may be involved in the development or progression of the disease. Participatory role of this polymorphism
has been reported in several diseases, but its role in the development or progression of this disease is still not
set correctly.
Methods: This study, based on a Case-Control analysis, was carried out in Kerman province. A total of 80
children with VUR and 80 healthy children were selected and frequency of C825T polymorphism of the
GNB3 gene was examined by using PCR-RLFP.
Results: The overall prevalence of heterozygous CT genotype of GNB3 gene in patients with VUR was
significantly higher compared to the control group (P = 0.012, OR = 1.92).
Conclusion: These results suggest that the C825T polymorphism may be involved in establishing the initial
VUR. However, further studies to determine the role of this gene as a marker for predicting the likelihood of
VUR is required

Keywords