Treatment of Ifosfamide -induced Encephalopathy with Methylene Blue in an Adolescent with Relapsed Acute Lymphoblastic Leukemia: a case report


1 Associate Professor of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran.

2 Fellow of Pediatric Hematology-Oncology, Tehran University of Medical Sciences, Tehran, Iran


Ifosfamide is one of the most important chemotherapeutic agents used for the treatment of numerous types of malignancies. Neurotoxicity is one of its life-threatening complications and is potentially fatal. In this paper we present a case of severe ifosfamide- induced encephalopathy in an adolescent with acute lymphoblastic leukemia in whom treatment with methylene blue led to complete improvement of neurologic symptoms.