1Master of Science in Chemistry, Physiology Research Center & School of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
2Professor of Physiology, Physiology Research Center & Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Background & Aims: Echium amoenum and Citrus aurantifolia are used in traditional medicine for the
treatment of cardiac arrhythmia and regulation of blood pressure. In this study the effects of coadministration
of these herbs on heart rate and blood pressure of rats before and after phynelephrine injection
Methods: Ten groups of rats respectively received 100, 200, 400 and 600 mg/kg Echium Amoenum, 250
mg/kg Citrus Aurantiflia and combination of 250 mg/kg Citrus Aurantiflia with 100, 200, 400 and 600
mg/kg Echium Amoenum for 6 days. Control group received water. Blood pressure and heart rate before
and after phynelephrine injection were measured and compared among groups.
Results: Echium amotnum at 400 and 600 mg/kg dozes significantly increased blood pressure of rats in
comparison to the control group (P<0.05) and this effect was more significant after phynelephrine injection
(P<0.05). Echium amoenum in combination whit citrus aurantiflia decreased heart rate after phynelephrine
injection and also in comparison to the control group. This decreasing effect was more than the effect of
6.688 mg/kg phynelephrine (P<0.05). Conclusion: Since Echium amoentum has an increasing effect on blood pressure especially in higher blood pressures, it is not suggested for those with hypertension. Co-administration of Echium amoentum and Citrus aurantiflia is recommended for decreasing heart rate.