The Prevalence of Coronary Artery Diseases Risk Factors in Four Regions of Kerman City

Document Type: Original Article


1 Professor of Physiology, Physiology Research Center and Department of Physiology, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

2 PhD Candidate of Physiology, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

3 PhD Candidate of Epidemiology, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

4 Gasteroentrology and Hepatology Research Center, Kerman University of Medical Sciences, Kerman, Iran


Abstract Background and Aims: Cardiovascular diseases (CADs) are the most important causes of mortality and morbidity in the world and in Iran. These diseases are not completely curable but factors affecting them are preventable. The aim of this study was investigation of CAD risk factors in four municipal regions of Kerman city.
Methods: From the city postal codes, 250 postal codes (as clusters) were selected randomly. Research coordinator team attended households in clusters and all the eligible members were recruited to the study. The recruitment was continued to reach 24 subjects in each cluster. The sample size was 5900 individuals aged from 15 to 75 years old. The prevalence of CAD risk factors including diabetes, hypertension, overweight and obesity, low physical activity, hyperlipidaemia, cigarette and opium smoking, depression and anxiety, oral and dental hygiene were assessed.
Results: Overweight with overall prevalence of 30.5% in the city, showed significant different prevalence rates in four regions (region 1: 29.9%, region 2: 33.8%, region 3: 29.7% and region 4: 30.5%, P<0.001). Overall, diabetes and hypertension had prevalence rates of 8.1% and 11.3%, both with similar distribution in the four regions. However, in diabetic patients, the prevalence of abnormal HbA1C was 67.3%, 50.2%, 70.4% and 45.1% in regions one to four respectively (P<0.0005). The region four with 15.4% opium consumption had the highest rank among the four regions. Depression and anxiety had the highest prevalence in region 4 and the lowest in region 2 (P<0.01). The gingival score index was 72.6% in men and 68.1% in women with region four having the maximum prevalence of 80.1%.
Conclusion: Overall, the prevalence of CADs in Kerman is relatively high and differs based on the region. Therefore, it is recommended that in designing educational programs for improving health behaviours, those differences are considered. It is suggested that these educations persist on reduction of obesity, opium consumption and improvement of mental health in region 4, on weight and LDL reduction in region 2, on diabetes control in regions 1 and on mental health improvement in region 3.


  1. Murray CJ, Lopez AD. Global mortality, disability, and the contribution of risk factors: Global Burden of Disease Study. Lancet 1997;349(9063):1436-42.
  2. Azizi F, Esmaeilzadeh A, Mirmiran P. Obesity and cardiovascular risk factors: An epidemiological study in Tehran. Iranian Journal of Endocvinology and Metabolism 2004; 5(4): 389-97.
  3. Hadaegh F, Harati H, Ghanbarian A, Azizi F. Prevalence of coronary heart disease among Tehran adults: Tehran Lipid and Glucose Study. East Mediterr Health J 2009; 15(1): 157-66.
  4. Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American heart association. Circulation 2011; 123(8):933-44.
  5. Kuulasmaa K, Tunstall-Pedoe H, Dobson A, Fortmann S, Sans S, Tolonen H, et al. Estimation of contribution of changes in classic risk factors to trends in coronary-event rates across the WHO MONICA Project populations. lancet 2000; 355(9205): 675-87.
  6. Navaii L, Mehrabi Y, Azizi F. An epidemiologic study of hyperlipidemia, obesity, and hypertension in Tehran villages. Iranian Journal of endocrinology and Metabolism 2000; 2(4): 253-62.
  7. Pletcher MJ, Lazar L, Bibbins-Domingo K, Moran A, Rodondi N, Coxson P, et al. Comparing impact and cost-effectiveness of primary prevention strategies for lipid-lowering. Ann Internal Med 2009;150(4):243-54.
  8. Sadeghi R, Adnani N, Erfanifar A, Gachkar L, Maghsoomi Z. Premature coronary heart disease and traditional risk factors-can we do better? Int Cardiovasc J Res 2013; 7(2):46.
  9. Reis JP, Loria CM, Lewis CE, Powell-Wiley TM, Wei GS, Carr JJ, et al. Association between duration of overall and abdominal obesity beginning in young adulthood and coronary artery calcification in middle age. Jama 2013; 310(3): 280-8.
  10. Boreham C, Twisk J, Murray L, Savage M, Strain JJ, Cran G. Fitness, fatness, and coronary heart disease risk in adolescents: the Northern Ireland Young Hearts Project. Med Sci Sports Exerc 2001;33(2):270-4.
  11. Sacheck JM, Kuder JF, Economos CD. Physical fitness, adiposity, and metabolic risk factors in young college students. Med Sci Sports exerc 2010;42(6): 1039-44.
  12. Morrell JS, Lofgren IE, Burke JD, Reilly RA. Metabolic syndrome, obesity, and related risk factors among college men and women. J Am Coll Health 2012; 60(1): 82-9.
  13. Barzigar A, Tehrani HS. Prevalence of atherosclerosis risk factors in Sowme Sara district of Gilan in 1996. Journal of Kerman University of Medical Sciences 1997; 4(4): 182-9.
  14. Rashidy-Pour A, Malek M, Eskandarian R and Ghorbani R .Obesity in the Iranian population. Obes Rev 2009;10(1):2-6.
  15. Mahmoudi MJ, Nematipour E, Moradmand S, Gharouni M, Mahmoudi M, Rezaei N, et al. Assessment of cardiac risk factors in medical students of Tehran university. Acta Medica Iranica 2004; 42(6): 402-10.
  16. Asgari F, Mirzazadeh A, Heidaria H. Iran Non-Communicable Diseases Risk Factors Surveillance, Data-Book For 2007. Tehran, Chakameh Ava Group, 2009.
  17. Ghazanfari Z, Mohammad Alizadeh S, Azizzadeh Furozi M, Bahadini N. Prevalence of coronary artery diseases risk factors in Kerman. Iranian Journal of Critical Care Nursing 2010, 3(1): 29-32.
  18. Najafipour H, Mirzazadeh A, Haghdoost A, Shadkam M, Afshari M, Moazenzadeh M, et al. Coronary artery disease risk factors in an urban and peri-urban setting, Kerman, Southeastern Iran (KERCADR study): methodology and preliminary report. Iran J Public Health 2012; 41(9): 86-92.
  19. Najafipour H, Masoomi M, Shahesmaeili A, Haghdoost AA, Afshari M, Nasri HR, et al. Effects of opium consumption on coronary artery disease risk factors and oral health: Results of Kerman Coronary Artery Disease Risk factors Study a population-based survey on 5900 subjects aged 15-75 years. Int J Prev Med 2015;6(1):42.
  20. Grund A, Krause H, Siewers M, Rieckert H, Müller M. Is TV viewing an index of physical activity and fitness in overweight and normal weight children? Public Health Nutr 2001;4(6):1245-51.
  21. Falkner B, Michel S. Obesity and other risk factors in children. Ethn Dis 1999; 9(2): 284-9.
  22. Ramachandran A, Snehalatha C, Vinitha R, Thayyil M, Kumar CK, Sheeba L, et al. Prevalence of overweight in urban Indian adolescent school children. Diabetes Res Clin Pract 2002;57(3):185-90.
  23. Cecil J, Watt P, Murrie I, Wrieden W, Wallis DJ, Hetherington MM, et al. Childhood obesity and socioeconomic status: a novel role for height growth limitation. Int J Obes 2005; 29(10): 1199-203.
  24. Agardh E, Allebeck P, Hallqvist J, Moradi T, Sidorchuk A. Type 2 diabetes incidence and socio-economic position: a systematic review and meta-analysis. Int J Epidemiol 2011; 40(3): 804-18
  25. Björntorp P, Holm G, Rosmond R. Hypothalamic arousal, insulin resistance and type 2 diabetes mellitus. Diabet Med 1999;16(5):373-83.
  26. Rosmond R, Björntorp P. The hypothalamic–pituitary–adrenal axis activity as a predictor of cardiovascular disease, type 2 diabetes and stroke. J Int Med 2000;247(2):188-97.
  27. Najafipour H, Nasri HR, Afshari M, Moazenzadeh M, Shokoohi M, Foroud A, et al. Hypertension: diagnosis, control status and its predictors in general population aged between 15 and 75 years: a community-based study in southeastern Iran. Int J Public Health 2014; 59(6): 999-1009.
  28. Najafipour H, Sanjari M, Shokoohi M, Haghdoost AA, Afshari M, Shadkam M, et al. Epidemiology of diabetes mellitus, pre‐diabetes, undiagnosed and uncontrolled diabetes and its predictors in general population aged 15 to 75 years: A community‐based study (KERCADRS) in southeastern Iran. J Diabetes 2015; 7(5): 613-21
  29. Najafipour H, Moazenzadeh M, Afshari M, Nasri HR, Khaksari Hadad M, Forood A, Mirzazadeh A. Epidemic of low physical activity in an urban population and its relationship with other cardiovascular risk factors: Findings of a community-based study (KERCADRS) in South East of Iran. ARYA Atherosclerosis, 2016 [in press].
  30. Najafipour H, Yousefzadeh G , Forood A, Karamozian M, Shadkam farokhi M, Mirzazadeh A. Overweight and Obesity Prevalence and its Predictors in a General Population Aged 15 to 75 Years: A Community-based Study in Southeastern Iran (KERCADR Study). ARYA Atherosclerosis 2016; 12(1): 18-27
  31. Najafipour H, Banivaheb G, Sabahi A, Naderi N, Nasirian M, Mirzazadeh A. Prevalence of anxiety and depression symptoms and their relationship with other coronary artery disease risk factors: A population-based study on 5900 residents in Southeast Iran. Asian J Psychiatr 2016; 20: 55-60
  32. Joukar S, Najafipour H, Malekpour-Afshar R, Mirzaeipour F, Nasri HR. The effect of passive opium smoking on cardiovascular indices of rabbits with normal and ischemic hearts. Open Cardiovasc Med J 2010; 4:1-6