1Resident of Psychiatry, School of Medicine and Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran
2Assistant Professor of Psychiatry, Kerman University of Medical Science, Kerman, Iran
Psychotic disorders have been observed in association with some autoimmune disorders. Moreover, autoimmune mechanisms have been recently considered in evaluation of schizophrenia spectrum disease managements. Vitiligo is one of the autoimmune diseases, but there is no report of vitiligo association with psychosis. We report three patients with vitiligo and schizophrenia spectrum disease that are indicative of the role of autoimmunity in psychosis. Moreover, unusual manifestation and poor response to treatment in the reported cases show that autoimmunity can complicate the prognosis of psychosis.