1Associate Professor of Pharmacology and Toxicology, School of Pharmacy , Babol University of Medical Sciences and Health Services, Babol, Iran.
Caffeine, dose dependently can reinforce or deteriorate learning. In previous studies, the effect of glucose on decreasing of amnesia was investigated. In this study, the effect of caffeine on three phases of learning and also probable interference of glucose in mice were examined by using of passive avoidance learning .Male albino mice were examined as follows: 1. test group: a) this group received electric shock and caffeine (25,50, 100mg/kg) without dextrose regimen, b) this group received electric shock and caffeine with dextrose regimen, 2. Control group (saline). In all groups, the latency period of moving from a cubic platform to the wire floor of aparatus in three steps was studied. Data were analysed by non- parametric Mann – Whitney U and Kruskall – Wallis H-tests. Differences between points of data were statistically considered significant at p<0.05. Caffeine in low dose (25 mg/kg) increased retention time in consolidation phase but in high dose (100mg/kg) compared to other doses, it decreased the retention time in phases of learning. According to the results, the negative effect of caffeine in high dose on all phases of memory can be reversed with long-term dextrose regimen.