Prevalence of HBe Ag and LFT Survey in HBsAg Positive Blood Donors in Kerman

Document Type: Original Article

Authors

1 Assistant Professor of Internal Medicine

2 Assistant Professor of Internal Medicine,

3 Intern, School of Medicine, Kerman University of Medical Sciences and Health Services, Kerman, Iran

Abstract

The hepatitis-B virus (HBV) is one of the most common chronic pathogens in the world. More than 2 billions of world population have been exposed to this virus and 350 millions of them (5% of world population) are chronic carriers of HBV. One of the most common routes of transmission of this virus is blood products and transfusion . For this reason blood transfusion organization controls all of the blood products for HBsAg . In HBV chronic carriers the state of viral replication should be determined by suitable antigenic markers such as HBeAg. So people who are HBeAg positive and have elevated liver functien test (LFT) be recognized and treated as chronic hepatitis. The aim of this study was to determine people who are HBeAg positive, elevated LFT in HBsAg individuals, and recognition of chronic hepatitis patients in Kerman during the year of 1378. This study was conducted on 300 HBsAg people who were between 17-65 years of age. According to the results 29 persons (9.6%) were HBeAg positive with no significant correlation between the two Measurement of LFT at the same time showed that 12 HBeAg positive persons( 14.4%) had higher serum AST levels (≥47 IU/L) and 13 of them (44.8%) had higher serum ALT levels (>47IU/L) .Overall in 10 HBeAg positive persons both AST and ALT were elevated but only in 19 HBeAg negative persons (7.1%) both ALT and ALT showed elevation. Generally HBeAg positivity is considered a risk factor for elevated aminotransferase levels (P<0.00001). The liver synhetic function tests including PT, serum albumin , total protein and bilirubin did not have any statistically difference in HBeAg positive and negetive patients (P>0.05).The results indicated that in HBsAg blood donors chronic hepatitis is prevalent in a significant number but severe liver disease is absent .

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