Document Type: Original Article
Associate Professor of Pharmacognozy
Assistant Professor of Pharmaceutics, Isfahan University of Medical Sciences, Isfahan, Iran
Anxiety is feeling of danger in a person who is threatening with something. Nowadays, anxiety is increased in different populations and, thus it is became an important problem in many countries. Melissa officinalis (Melissa) and Valeriana officinalis (Valerian) are two medicinal plants. These two plants are traditionally used as sedative herbal drugs and new studies on their pharmacological activity present the same results. Aerial parts of M. officinalis and rhizomes of V. officinalis were extracted with ethanol: water (70:30). The hydroalcoholic extracts were concentrated in vacuum evaporator and then added to an absorbent matrix. Amount of the dried used extracts per one tablet is 180 mg and 60 mg of Melissa and Valerian respectively. After granulation process, other ingredients were added to wet granules and tablets were prepared using a tabletting machine. Tablets tested physically and some modifications were done on the formulation. At last tablets were coated with a film coat by spraying method. As a criterion of active constituents transmission, the amount of trans-caryophillene was determined by GC-MS method. Results of this study indicated that after modification of formulation, tablets with desirable characteristics for film coating had been produced. Physical examinations indicated that the tablets have proper physical characteristics. GC-MS analysis also showed that in spite of long processes of extraction, granulation, and coating, active ingredients transmission was about 38% from plant to film coated tablets.