effect of thyroid hormoned on distension-induced gastrik and pepsin secretion in the stomach of rat

Document Type: Original Article


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2 professor

3 Assistant professor


thyroid hormoned are known to influence acid and pepsin secretion,though exact mechanism(s) are not fully understood.in this study distention-stimulated acid and pepsin secretionof hypo and hyperthyroid rats were compared with controls.each group consisted of 8 N-mari rats from both sexs,weighing  246.6+_9.2g. hypo and hyper thyroid states were induced by administration of methimazole(500mg/l H20) and thyroxine(200mg/l H20) respectively in drinking water.all animals were deprived of food,but not of water 24 hours before the experiments.after anesthesiation with sodium thiopental (50mg/kg body weight,ip),tracheostomy and laparatomy,gastric secretions were collected through a cannula introduced via duodenum.gastric distension was induced by ringer solution in stomach (1.5cm/100gr body weight).acid secretion which were measured by automatic titrator in the hypothyroid,hyperthyroid and control groups were 8+_0.2,14.6+_1.9,10.2+_0.1 mmol/15min,respectively.pepsin secretion were 4.4+_0.5,9.09+_0.4 and 6.1+_0.1 mg/15 min in respective groups.both series show statistically significant differences between control and the other two groups.the results from the measurements of TSH and T4 hormones show that increased or decreased thyroid function can significantly afeect gastric distension-induced acid and pepsin secretion.