Alpha-1- antitrypsin is the most important serine protease inhibitor in serum. This protein has several phenotypes. Some of these phenotypes such as MZ, M, Z, M, S, MS, ZZ,…. Cause a,AT deficiency which leads to damage in many tissues such as liver, lung, kidney. 60 patients and 28 healthy individuals (control group), aged 7-65 years old were studied for a,AT activity and a,AT phenotypes. The control group with HBsAg-negative were selected according to the physician confirmation and liver function tests. The test group who were HbsAG-positive were divided into two groups. The first group without cirrhosis and in the second group hepatic cirrhosis based on the pathological report was confirmed. In the control group the phenotypes of P.MM was 100℅, and in positive-HBs-Ag patients the prevalence of PiMM, PiM2 and PiMS were 80℅, 11℅, and 8.14℅ respectively . There were significant difference s in the phenotypes among the three groups(p<0.05). Based on our results patients with a,AT deficiency infected with HIV are at the higher risk of cirrhosis than those with normal a,AT phenotypes.