Hymenolepiosis is a common intestinal tapeworm infection among children. To Investigate the relation of the level of blood serum immunoglobulins, with hymenolepiosis a study was undertaken at Mean Reza hospital, Mashhad. The blood specimens of 100 patients infected with Hymenolepis Nana who had no other intestinal parasitic infection and were clinically health as cases and 50 healthy person s whoes stool exams were negative for three times as controls were collected. Immunoglobulins of all cases and control s were measured by SRID and ELISA methods and compared by t- test . The results showed that the level of IgH and IgG of cases were significantly higher than the control group ( p<0.05) but there was no significant difference in IgA and IgM levels. It is concluded that immunological change especially stimulation of humoral immunity may result in partial or complete protection against further infections.