The usual outcome of pemphigus whitout treatment is death. The introduction of corticosteroids has greatly reduced the mortality of this condition, though a significant morbidity remains. The patients who are receiving high- dose steroids together with other immunosuppressive agents are at risk and may cause death through drug side effects and opportunitic infections. The descriptive study has been done on 75 cases of hospitalised or outpatients suffering from pemphigus, data collection was retrospective. Fifty six cases were pemphigus vulgaris and 7 cases were foliaceous type. The high peak frequency of pemphigus was in the age range of 30-40. Females were 3 times more affected to pemphigus vulgaris than men. Epidemiological varieties and therapeutic side effects such as pulmonary tuberculosis, Hyperglycemia, ophthalmic herpes, diarrhea, eczema hypericum growth retardation, malignancy, corticosteroidal depression and suicide in a case have been evacuated in the study.