Various therapeutic methods have been used in treatment of cutaneous leishmaniasis. Each of these methods has its own advantages and disadvantages. One of the old treatment is intra lesional injection of glucantime. Recently , a few cases of treatment by bleomycine have been reported, in the study, the effects of these two drugs were compared. Eighty nine cutaneous leishmaniasis, diagnose by direct smear method, and with previous treatment were treated with either of the two drugs. Forty eight lesions were treated with bleomycine, from which 39℅ showed complete and 23℅ relative recovery , while 38℅ of cases had no recovery. From 41 lesions treated by glucantime, 14.6℅ showed complete, 73.2℅ relative, and 12.2℅ no recovery. It seems that bleomycine was more effective in short term, while glucantime was more effective in long term treatment of leishmaniasis due to its high rate of relative recovery effect found in this study.