Document Type : Original Article
Authors
1 Assistant Professor, Exercise Physiology Research Center, Life Style Institute, Baqiyatallah University of Medical Sciences, Tehran, Iran
2 Assistant Professor, Department of Sport Sciences, University of Bojnord, Bojnord, Iran
3 Associate Professor, Department of Animal Science, University of Birjand, Birjand, Iran
4 Instructor, Exercise Physiology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
Abstract
Backgrounds: The loss of dopamine-secreting cells and the decrease in the status of antioxidant is associated with incidents of Parkinson's disease. The purpose of the present study was to determine the protective effect of a 12- weeks voluntary wheel running (VWR) along with the injection of eriobotrya japonica flower extract (EJFE, 200 mg/kg body weight, 3 days a week) on cerebral dopamine neurotrophic factor (CDNF), superoxide dismutase (SOD), and malondialdehyde (MDA) in the cerebral cortex of a rat model of Parkinson’s disease (PD).
Method: To do so, the rats were trained for 12 weeks with and without EJFE prior to the induction of Parkinson. In order to obtain the Parkinsonian model, 6-hydroxydopamine (6-OHDA) (5 µL) was injected intracerebrally. Data were statistically analyzed by one-way analysis of variance followed by LSD post-hoc test (P < 0.05).
Results: 6-OHDA injection significantly decreased the CDNF contents, and SOD activity while it increased MDA levels in cerebral cortex of the Parkinsonian control group. The pre-training of PD rats with and without EJFE increased the CDNF content and SOD activity and also decreased MDA levels.
Conclusion: Preconditioning by VWR and EJFE may be effective in reducing the consequences of toxins resulted in Parkinson's disease.
Keywords
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