Document Type: Original Article
Physiology Research Center, Institute of Basic and Clinical Physiology & Nutrition Department, School of Health, Kerman University of Medical Sciences. Kerman, Iran
Department of Health and Social Medicine, School of Medicine, Shaheed Beheshti University of Medical Sciences. Tehran, Iran
Human Nutrition & Diet Therapy Department, School of Nutrition and Food Technology, Shaheed Beheshti University of Medical Sciences. Tehran, Iran
Iranian Diabetes Society, Malakotti St., Tehran, Iran
Background: The aim of this study was to find the influence of supplementation with omega-3 plus vitamin E and vitamin C plus zinc on metabolic syndrome components.
Methods: In a double-blind controlled clinical trial, 75 diabetic postmenopausal women were randomly assigned to one of the three therapeutic groups of daily supplementation of 1.8g omega-3 plus 400mg vitamin E (group A), 5mg zinc plus 300mg vitamin C (group B), or placebo (group C) for 12 weeks and the results were evaluated.
Results: One-way repeated measures ANOVA showed that systolic and diastolic blood pressure and waist circumference showed significant difference before and after the intervention (P= 0.0001, 0.001, and 0.045, respectively). Results of Univariate ANOVA showed that the level of plasma fasting blood sugar (FBS) and HDL-cholesterol significantly increased (P=0.01 and P=0.03, respectively) in patients who had been diagnosed as diabetic ≤7 years in group B. The plasma TG concentration significantly decreased (P=0.007) in patients who had been diagnosed as diabetic ≤7 years in group A. Systolic and diastolic BP significantly decreased (P=0.005 and P=0.04, respectively) in patients who had been diagnosed as diabetic ≤7 years in group A. The most effectiveness of nutraceutical supplementation was on patients that had been diagnosed as diabetic ≤7 years. Plasma TG and systolic BP decreased with omega-3 plus vitamin E; however, plasma FBS and HDL- cholesterol increased with zinc plus vitamin C supplementation.
Conclusion: Several factors, such as duration of diabetes, age, gender, pathophysiology status, genetic, and other anthropometric characteristics may influence the effectiveness of supplementation.