The relation of hypertension and aldosterone-renin ratio with the severity of coronary artery disease in non-diabetic patients

Document Type: Original Article


1 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

2 Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences and Department of Biochemistry, Afzalipur Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran


Background: The aim of this study was to assess the relationship between hypertension and aldosterone-renin ratio (ARR) with the severity of coronary artery disease (CAD).
Methods: This cross-sectional study was performed on non-diabetic patients who were candidate for coronary angiography in Shafa hospital in Kerman in 2017. The levels of active renin and aldosterone were measured by the radioimmunoassay (RIA) method before angiography. All patients underwent coronary angiography to determine the severity of CAD. The CAD severity was described by the Gensini score.
Results: Of the 306 patients, 174 (55.1%) were hypertensive. The overall prevalence of CAD in hypertensive and normotensive groups was not statistically different (39.7% versus 38.9%, p = 0.898). In groups with and without hypertension, normal coronary arteries were found in 60.3% and 60.8%, single-vessel disease in 15.5% and 17.7%, two-vessel disease in 14.4% and 11.5%, and three-vessel disease in 9.8% and 10.0%, respectively. The differences were not significant (p = 0.880). The average Gensini scores in hypertensive and normotensive groups were 29.27 ± 28.42 and 33.74 ± 33.05, respectively with no significant differences (p = 0.370). The mean ARR in those with normal coronaries, one, two, and three-vessel diseases was 3.17 ± 7.63, 2.51 ± 4.21, 1.93 ±1.57, and 1.20 ± 0.68, respectively with no significant difference (p = 0.696). We did not observe any association between the Gensini score and ARR (r = -0.126, p = 0.263). In multivariable linear regression model (Table 3), ARR could not predict the severity of CAD assessed by determining the Gensini score (Beta = -0.463, p = 0.636).
Conclusion: There was no significant relation between hypertension and ARR to the severity of CAD.


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