The Effect of Diclofenac Sodium on Nocturia Caused by Benign Prostatic Hyperplasia

Document Type: Original Article

Authors

1 Assistant Professor, Department of Urology, Clinical Research Center, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran

2 Men’s Health and Reproductive Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Department of Stem Cell and Developmental Biology, Royan Institute for Stem Cell Biology and Technology, ACECR, Tehran, Iran

4 Assistant Professor of Medical Informatics, Medical Informatics Research Center, Institute of Futures Studies in Health. Kerman University of Medical Sciences, Kerman, Iran

5 Medical Practitioner, Kerman University of Medical Sciences, Kerman, Iran

6 Associated Professor of Urology, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Background: Nocturia is a common cause of night awakenings which bothers many patients with urinary tract diseases. NSAIDs can improve nocturia by decreasing urine production and modify the altered neural pathways between bladder and CNS. The aim of this study was to evaluate the efficacy of NSAID in the treatment of nocturia secondary to BPH. Seventy-one patients complaining of BPH with LUTS that was prominent with nocturia entered this study.
Methods: Between January 2013 and March 2014, 71 men aged 50-85, complaining of BPH with LUTS that was prominent with nocturia (voiding more than 2 times at night) entered this prospective study. All patients received 100 mg Diclofenac Na suppository for 30 days at night (9pm). The main outcomes included night-time frequency; IPSS, prostate volume and PSA were recorded before and after study. Statistical analysis was performed using the paired t-test, Pearson’s correlation and Wilcoxon rank test.
Results: In our study, 88.7 % of patients had an acceptable response to Diclofenac Na. Prostate size showed a significant reduction after one month treatment with diclofenac Na. There were no serious adverse effects.
Conclusion: In our study Diclofenac Na can improve symptoms of BPH and can be used for the treatment of nocturia secondary to BPH.

Keywords


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