Document Type: Original Article
Internist, Tehran University of Medical Sciences, Tehran, Iran
Assistant Professor of gastroenterology, Tehran University of Medical Sciences, Tehran, Iran
Associate Professor of gastroenterology, Tehran University of Medical Sciences, Tehran, Iran
Professor of colorectal cancer surgery, Department of Surgery, Tehran University of Medical Sciences, Tehran, Iran
Ph.D. Candidate of Cognitive Neuroscience linguistics, Institute for Cognitive Science Studies (ICSS), Tehran, Iran
Background: Colorectal cancer is a common cancer and has a high rate of mortality and morbidity. This can be reduced by screening tests. Some of the studies have recently referred to Red Cell Distribution Width (RDW) as a marker for early detection of various cancers. The aim of this study was to investigate the RDW and early detection of colorectal cancer and polyp.
Methods:A total of 90 patients were divided into three groups. One group included patients with colon cancer, another group with colon polyps, and the third group with normal colonoscopy as a control group. Blood samples were taken from patients and mean corpuscular volume (MCV), hemoglobin (HB), platelet (PLT), red blood cell distribution width (RDW), ferritin, serum iron, and total iron-binding capacity (TIBC) values were recorded. Transferrin saturation (Tsat) was also calculated. Statistical analysis was performed to remove the anemia effect of patients who had Tsat less than 20%, which was compared to patients who had Tsat over 20%. For the relationship between RDW and colon cancer, a receiver operating characteristic (ROC) curve was used.
Results: The area under the receiver-operating characteristic curve (AUC) of the RDW for predicting colon cancer was 0.698, with cut off >14 which had 80% sensitivity and 60% specificity.
Conclusions: RDW can be considered as a parameter for predicting colorectal cancer.