Evaluation of rs37464444 Polymorphism of miR-499 Gene in Patients with Colon Cancer Compared with Healthy Subjects

Document Type : Original Article


1 Assistant Professor, Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

2 Assistant Professor, Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran

3 Assistant Professor, Department of Internal Medicine, Rafsanjan University of Medical Scienses, Rafsanjan, Iran

4 Professor, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

5 Professor, Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran

6 Professor, Gastroenterology and Hepatology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran


Background: Single nucleotide polymorphisms (SNPs) have been introduced as a new genomic source for cancer. Therefore, it was decided to conduct a study to evaluate the rs3746444 polymorphism of miR-499 in patients with colon cancer in comparison with healthy subjects.
Methods: This case-control study was conducted to investigate rs3746444 polymorphism of miR-499 in blood samples of case and control groups. Patients with a confirmed diagnosis of cancer based on pathologic report were enrolled in the study as the case group and compared with healthy subjects. The level of significance was considered at p< 0.05.
Result: The mean of DNA count in samples was 63.17± 23.51 that was significantly higher in the case group. The rs3746444 polymorphism of miR-499 was significantly higher in patients with cancer compared to the healthy subjects (P < 0.05).
Conclusion: In this study, rs3746444 polymorphism of miR-499 was significantly higher in patients with colon cancer, which indicated that people with this polymorphism had a higher risk for malignancy.


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