Document Type: Original Article
Professor of Neurology, Neurology Research Center, Kerman University of Medical Sciences, Kerman, Iran
Professor of Pharmacology, Kerman University of Medical Sciences, Kerman, Iran
Medical Student, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
Background:epilepsy is one of the common neurological disorders and approximately
0.5-1% of populations suffers from it. Unfortunately, despite of treatment by antiepileptic drugs, between 20-30% of patients cannot be controlled completely. There are a lot of supplementary therapies for this group of patients and in this study, L-arginine was used as an additional therapy in refractory epileptic patients.
Methods: Two groups of epileptic patients (n=21) were selected randomly. Group 1 received lactose as a placebo, and group 2 received L-arginine (twofold of daily need) as a drug for three months. We used a standard questionnaire for evaluating the effect of L-arginine on the quality of life before and after the study.
Results: we did not find significant change in the quality of life of patients after using L-arginine, but the epileptic attacks decreased in L-arginine group significantly.
Conclusion: L-arginine therapy is safe and can decrease the rate of seizure attacks in refractory epileptic patients, and can be an alternative of ketogenic diets.