Document Type : Original Article
Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
Department of Urology, Shahid Bahonar Hospital, Kerman University of Medical Sciences, Kerman, Iran
Cell Therapy and Regenerative Medicine Center, Kerman University of Medical Sciences, Kerman, Iran
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, and Department of Physiology and Pharmacology, Afzalipour Mediacl Faculty, Kerman University of Medical Sciences, Kerman, Iran
Urology-Nephrology Research Center, Shaheed Labbafinejad Medical Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Background: Stress urinary incontinence is a prevalent condition among a large number of women and has a negative effect on their quality of life. One treatment option is the use of bio-injectable materials to enhance closing pressures. In this study, we aimed to investigate the effects of the periurethral injection of pure platelet-rich plasma on the treatment of stress urinary incontinence.
Methods: This study was conducted as a randomized controlled clinical trial on 20 women with stress urinary incontinence. Ten patients received periurethral injections of pure platelet-rich plasma (experimental group), while ten patients received midurethral sling procedure as the standard treatment for stress urinary incontinence ((control group). Follow-up was performed one and three months after the treatment using the international consultation on incontinence questionnaire (ICIQ), incontinence quality of life (I-QOL) questionnaire, urogenital distress inventory (UDI-6), and cough stress test.
Results: Out of ten patients in the experimental group, seven cases (70%) relatively recovered after the injection. Out of ten patients in the control group, eight patients completely recovered after the procedure. There was significant difference in the questionnaire results before and after treatments, which indicates the effectiveness of these treatments in both groups. However, the response to the midurethral sling procedure was better than the response to pure platelet-rich plasma injection, and the difference was statistically significant.
Conclusion: The periurethral injection of a single dose of pure platelet-rich plasma could relatively eliminate the symptoms of stress urinary incontinence in patients. More definite results can be obtained with repeated doses of pure platelet-rich plasma, even compared with standard treatments.