Document Type : Review Article

Authors

1 Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran & Department of Traditional Pharmacy, Faculty of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran

2 Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran & Department of Traditional Medicine, Faculty of Traditional Medicine, Kerman University of Medical Sciences, Kerman, Iran

3 Pathology and Stem Cell Research Center, Kerman University of Medical Sciences, Kerman, Iran

4 Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran

5 Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran

6 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran

Abstract

Background: Burn wound is one of the most common injuries worldwide. However, its management still remains a health concern and research is ongoing for more efficient therapies. Persian medicine has described different methods in this regard. Previous reviews have mostly focused on the herbal-based therapies for burn management. Hence, the current study aimed to review both non-herbal and herbal-based therapies used in Persian medicine for their burn healing properties, and to compare them with new evidence.
Method: The most important texts of Persian medicine were reviewed for burn wound classification, managements and treatment approaches. Moreover, herbal, minerals, and animal-based products claimed to possess burn wound healing activity, were extracted. In the next step, digital databases were searched to find new supporting data for the extracted-traditional remedies and their healing mechanisms.
Results: More than one hundred traditional medicinal herbs, minerals, and animal-based products have been recommended to treat burn wound in Persian medicine among them, the healing effect of thirty-five herbs and eight non-herbal treatments (mineral and animal-based compounds) were supported by new evidence. Otherwise, there was not new evidence reporting the healing effect of seventy-three herbs and sixteen non-herbal compounds extracted from Persian Medicine literature.
Conclusion: Although some managements of burn wounds in Persian medicine have been confirmed by new evidence, the efficacy of a plenty of materials needs to be methodically evaluated. Hence, it could introduce new clues for future research.

Keywords

  1. World Health Organization. The global burden of disease. [cited 2020 Oct 25] Available from: https://www.who.int/healthinfo/global_burden_disease/GBD_report_2004update_full.pdf.
  2. Brusselaers N, Monstrey S, Vogelaers D, Hoste E, Blot S. Severe burn injury in Europe: a systematic review of the incidence, etiology, morbidity, and mortality. Crit Care 2010; 14(5):R188. doi: 10.1186/cc9300.
  3. Rowan MP, Cancio LC, Elster EA, Burmeister DM, Rose LF, Natesan S, et al. Burn wound healing and treatment: review and advancements. Crit Care 2015; 19:243. doi: 10.1186/s13054-015-0961-2.
  4. Duke JM, Randall SM, Wood FM, Boyd JH, Fear MW. Burns and long-term infectious disease morbidity: A population-based study. Burns 2017; 43(2):273-81. doi: 10.1016/j.burns.2016.10.020.
  5. Mehdizadeh A, Akbarian A, Samareh PP, Tavajjohi S, MacKay R, Alaghehbandan R, et al. Epidemiology of burn injuries during pregnancy in Tehran, Iran. Ann Burns Fire Disasters 2002; 15(4):163-9.
  6. Rae L, Fidler P, Gibran N. The physiologic basis of burn shock and the need for aggressive fluid resuscitation. Crit CareClin 2016; 32(4):491-505. doi: 10.1016/j.ccc.2016.06.001.
  7. Salas Campos L, Fernándes Mansilla M, Martínez de la Chica AM. Topical chemotherapy for the treatment of burns. Rev Enferm 2005; 28(5):67-70. [In Spanish].
  8. Hassanzadeh G, Hajmanouchehri F, Roi AB, Hassanzadeh N, Shafigh N, Barzroudipour M, et al. Comparing effects of silver sulfadiazine, sucralfate and brassica oleracea extract on burn wound healing. Life Science Journal 2013; 10(SUPPL):104-13.
  9. Aziz Z, Abu SF, Chong NJ. A systematic review of silver-containing dressings and topical silver agents (used with dressings) for burn wounds. Burns 2012; 38(3):307-18. doi: 10.1016/j.burns.2011.09.020.
  10. Oryan A, Alemzadeh E, Moshiri A. Burn wound healing: present concepts, treatment strategies and future directions. J Wound Care 2017; 26(1):5-19. doi: 10.12968/jowc.2017.26.1.5.
  11. Pereira RF, Bartolo PJ. Traditional therapies for skin wound healing. Adv Wound Care (New Rochelle) 2016; 5(5):208-29. doi: 10.1089/wound.2013.0506.
  12. Kopp J, Wang GY, Horch RE, Pallua N, Ge SD. Ancient traditional Chinese medicine in burn treatment: a historical review. Burns 2003; 29(5):473-8. doi: 10.1016/s0305-4179(03)00053-6.
  13. Das U, Behera SS, Pramanik K. Ethno-Herbal-medico in wound repair: an incisive review. Phytother Res 2017; 31(4):579-90. doi: 10.1002/ptr.5786.
  14. Bahramsoltani R, Farzaei MH, Abdolghaffari AH, Rahimi R, Samadi N, Heidari M, et al. Evaluation of phytochemicals, antioxidant and burn wound healing activities of Cucurbita moschata Duchesne fruit peel. Iran J Basic Med Sci 2017; 20(7):798-805. doi: 10.22038/IJBMS.2017.9015.
  15. Mehrabani M, Seyyedkazemi SM, Nematollahi MH, Jafari E, Mehrabani M, Mehdipour M, et al. Accelerated burn wound closure in mice with a new formula based on traditional medicine. Iran Red Crescent Med J 2016; 18(11):e26613. doi: 10.5812/ircmj.26613.
  16. Mehrbani M, Choopani R, Fekri A, Mehrabani M, Mosaddegh M, Mehrabani M. The efficacy of whey associated with dodder seed extract on moderate-to-severe atopic dermatitis in adults: A randomized, double-blind, placebo-controlled clinical trial. J Ethnopharmacol 2015; 172:325-32. doi: 10.1016/j.jep.2015.07.003.
  17. Ebrahimpour N, Mehrabani M, Iranpour M, Kordestani Z, Mehrabani M, Nematollahi MH, et al. The efficacy of a traditional medicine preparation on second-degree burn wounds in rats. J Ethnopharmacol 2020; 252:112570. doi: 10.1016/j.jep.2020.112570.
  18. Rameshk M, Sharififar F, Mehrabani M, Pardakhty A, Farsinejad A, Mehrabani M. Proliferation and in vitro wound healing effects of the microniosomes containing narcissus tazetta L. Bulb Extract on Primary Human Fibroblasts (HDFs). Daru 2018; 26(1):31-42. doi: 10.1007/s40199-018-0211-7.
  19. Choopani R, Mehrbani M, Fekri A, Mehrabani M. Treatment of atopic dermatitis from the perspective of traditional persian medicine: presentation of a novel therapeutic approach. J Evid Based Complementary Altern Med 2017; 22(1):5-11. doi: 10.1177/2156587215598610.
  20. Ibn Sina. Canon of Medicine. Beiruot: Ehya al-Toras al-Arabi Press; 2010. [In Arabic].
  21. Gorgani Z. Zakhireh-e Kharazmshahi. Qom: Rehabilitation Institues Of Natural Medicine; 2012. [In Persian].
  22. al-Razi MZ. Al-Hawi. Tehran: Academy of Medical Sciences; 2005. [In Arabic].
  23. al-Razi MZ. Al-Mansouri fi al-Tibb. Tehran: Tehran Medical University; 1999. [In Arabic].
  24. Aghili Khorasani MH. Makhzan al-Advieh. Tehran: Rah-e Kamal Publications; 2009. [In Persian].
  25. Kermani M. Daghayegh al-Alaj. Kerman: Saadat Press; 1983. [In Persian].
  26. al-Razi MZ. Bar-us-sa'ah. Tehran: Iran University of Medical Sciences; 2005. [In Arabic].
  27. Chashty MA. Romuz-e Azam. Tehran: Iran University of Medical Sciences; 2004. [In Persian].
  28. Kordafshari G, Ardakani MR, Keshavarz M, Esfahani MM, Nazem E, Moghimi M, et al. The role of phlebotomy (fasd) and wet cupping (hijamat) to manage dizziness and vertigo from the viewpoint of persian medicine. J Evid Based Complementary Altern Med 2017; 22(3):369-73. doi: 10.1177/2156587216672757.
  29. Arzani MA. Mofareh al-Gholub. Lahoor: Salim Lahoor; 1915. [In Persian].
  30. Avijgan M, Kamran A, Abedini A. Effectiveness of aloe vera gel in chronic ulcers in comparison with conventional treatments. Iran J Med Sci 2016; 41(3 Suppl):S30.
  31. Goudarzi M, Fazeli M, Azad M, Seyedjavadi SS, Mousavi R. Aloe vera gel: effective therapeutic agent against multidrug-resistant Pseudomonas aeruginosa isolates recovered from burn wound infections. Chemother Res Pract 2015; 2015:639806. doi: 10.1155/2015/639806.
  32. Akhoondinasab MR, Akhoondinasab M, Saberi M. Comparison of healing effect of aloe vera extract and silver sulfadiazine in burn injuries in experimental rat model. World J Plast Surg 2014; 3(1):29-34.
  33. Liu H, Lin S, Xiao D, Zheng X, Gu Y, Guo S. Evaluation of the wound healing potential of resina draconis (dracaena cochinchinensis) in animal models. Evid Based Complement Alternat Med 2013; 2013:709865. doi: 10.1155/2013/709865.
  34. Okuma CH, Andrade TA, Caetano GF, Finci LI, Maciel NR, Topan JF, et al. Development of lamellar gel phase emulsion containing marigold oil (Calendula officinalis) as a potential modern wound dressing. Eur J Pharm Sci 2015; 71:62-72. doi: 10.1016/j.ejps.2015.01.016.
  35. Sengupta R. Combined wound healing activity of Calendula officinalis and Basil leaves. J Pharmacog Phytochem 2017; 6(1):173-76.
  36. Parente LM, Lino Júnior Rde S, Tresvenzol LM, Vinaud MC, de Paula JR, Paulo NM, et al. Wound healing and anti-inflammatory effect in animal models of Calendula officinalis L. growing in Brazil. Evid Based Complement Alternat Med 2012; 2012:375671. doi: 10.1155/2012/375671.
  37. Millán D, Jiménez RA, Nieto LE, Linero I, Laverde M, Fontanilla MR. Preclinical evaluation of collagen type I scaffolds, including gelatin-collagen microparticles and loaded with a hydroglycolic Calendula officinalis extract in a lagomorph model of full-thickness skin wound. Drug Deliv Transl Res 2016; 6(1):57-66. doi: 10.1007/s13346-015-0265-8.
  38. Shafeie N, Tabatabai Naini A, Kargar Jahromi H. Comparison of different concentrations of Calendula officinalis gel on cutaneous wound healing. Biomedical and Pharmacology Journal 2015; 8(2):979-92. doi: 10.13005/bpj/850.
  39. Buzzi M, de Freitas F, de Barros Winter M. Therapeutic effectiveness of a Calendula officinalis extract in venous leg ulcer healing. J Wound Care 2016; 25(12):732-9. doi: 10.12968/jowc.2016.25.12.732.
  40. Parente LM, Andrade MA, Brito LA, Moura VM, Miguel MP, Lino-Junior Rde S, et al. Angiogenic activity of Calendula officinalis flowers L. in rats. Acta Cir Bras 2011; 26(1):19-24. doi: 10.1590/s0102-86502011000100005.
  41. Suntar I, Kupeli Akkol E, Keles H, Yesilada E, Sarker SD, Baykal T. Comparative evaluation of traditional prescriptions from Cichorium intybus L. for wound healing: stepwise isolation of an active component by in vivo bioassay and its mode of activity. J Ethnopharmacol 2012; 143(1):299-309. doi: 10.1016/j.jep.2012.06.036.
  42. Heidari M, Bahramsoltani R, Abdolghaffari AH, Rahimi R, Esfandyari M, Baeeri M, et al. Efficacy of topical application of standardized extract of Tragopogon graminifolius in the healing process of experimental burn wounds. J Tradit Complement Med 2019; 9(1):54-9. doi: 10.1016/j.jtcme.2018.02.002.
  43. Ashkani-Esfahani S, Imanieh MH, Khoshneviszadeh M, Meshksar A, Noorafshan A, Geramizadeh B, et al. The healing effect of arnebia euchroma in second degree burn wounds in rat as an animal model. Iran Red Crescent Med J 2012; 14(2):70-4.
  44. Nasiri E, Hosseinimehr SJ, Azadbakht M, Akbari J, Enayati-Fard R, Azizi S, et al. The healing effect of arnebia euchroma ointment versus silver sulfadiazine on burn wounds in rat. World J Plast Surg 2015; 4(2):134-44.
  45. Mohsenikia M, Khakpour S, Azizian Z, Ashkani-Esfahani S, Razavipour ST, Toghiani P. Wound healing effect of arnebia euchroma gel on excisional wounds in rats. Adv Biomed Res 2017; 6:2. doi: 10.4103/2277-9175.199260.
  46. Aliasl J, Barikbin B, Khoshzaban F, Naseri M, Sedaghat R, Kamalinejad M, et al. Effect of Arnebia euchroma ointment on post-laser wound healing in rats. J Cosmet Laser Ther 2015; 17(1):41-5. doi: 10.3109/14764172.2014.968583.
  47. Ghasemi Pirbalouti A, Yousefi M, Nazari H, Karimi I, Koohpayeh A. Evaluation of burn healing properties of arnebia euchroma and malva sylvestris. Electronic Journal of Biology 2009; 5(3):62-6.
  48. Sarandy MM, Novaes RD, da Matta SL, Mezencio JM, da Silva MB, Zanuncio JC, et al. Ointment of brassica oleracea var. capitata matures the extracellular matrix in skin wounds of wistar rats. Evid Based Complement Alternat Med 2015; 2015:919342. doi: 10.1155/2015/919342.
  49. Rebolla A, Arisawa EA, Barja PR, Posso MB, Carvalho Cda S. Effect of Brassica oleracea in rats skin wound healing. Acta Cir Bras 2013; 28(9):664-9. doi: 10.1590/s0102-86502013000900007.
  50. Goncalves RV, Sarandy MM, da Matta SL, Novaes RD, Pinto MV. Comparative study of the effects of laser photobiomodulation and extract of Brassica oleracea on skin wounds in wistar rats: a histomorphometric study. Pathology - Research and Practice 2013; 209(10):648-53. doi: 10.1016/j.prp.2013.07.006.
  51. Hou Q, He WJ, Chen L, Hao HJ, Liu JJ, Dong L, et al. Effects of the four-herb compound anbp on wound healing promotion in diabetic mice. Int J Low Extrem Wounds 2015; 14(4):335-42. doi: 10.1177/1534734615575244.
  52. Davis SC, Mertz PM. Determining the effect of an oak bark formulation on methicillin-resistant staphylococcus aureus and wound healing in porcine wound models. Ostomy Wound Manage 2008; 54(10):16-8, 20, 22-5.
  53. Ali M, Abdel Motaal A, Ahmed MA, Alsayari A, El-Gazayerly ON. An in vivo study of Hypericum perforatum in a niosomal topical drug delivery system. Drug Deliv. 2018; 25(1):417-25. doi: 10.1080/10717544.2018.1431977.
  54. Farsak M, Özdağli G, Özmüş D, Çömelekoğlu Ü, Yalın S, Bozdoğan Arpacı R, et al. Effects of Hypericum perforatum on an experimentally induced diabetic wound in a rat model. Wounds 2017; 29(2):E10-7.
  55. Yadollah-Damavandi S, Chavoshi-Nejad M, Jangholi E, Nekouyian N, Hosseini S, Seifaee A, et al. Topical hypericum perforatum improves tissue regeneration in full-thickness excisional wounds in diabetic rat model. Evidence-Based Complementary and Alternative Medicine 2015; 2015: doi: 10.1155/2015/245328.
  56. Kýyan S, Uyanikgil Y, Altunci YA, Cavusoglu T, Cetin Uyanikgil EO, Karabey F. Investigation of acute effects of Hypericum perforatum (St. John’s Wort-Kantaron) treatment in experimental thermal burns and comparison with silver sulfadiazine treatment. Ulus Travma Acil Cerrahi Derg 2015; 21(5):323-36. doi: 10.5505/tjtes.2015.
  57. Prisacaru AI, Andritoiu CV, Andriescu C, Havarneanu EC, Popa M, Motoc AG, et al. Evaluation of the wound-healing effect of a novel Hypericum perforatum ointment in skin injury. Rom J Morphol Embryol 2013; 54(4):1053-9.
  58. Mukherjee PK, Verpoorte R, Suresh B. Evaluation of in-vivo wound healing activity of Hypericum patulum (Family: hypericaceae) leaf extract on different wound model in rats. J Ethnopharmacol 2000; 70(3):315-21. doi: 10.1016/s0378-8741(99)00172-5.
  59. Khorasani G, Hosseinimehr SJ, Zamani P, Ghasemi M, Ahmadi A. The effect of saffron (Crocus sativus) extract for healing of second-degree burn wounds in rats. Keio J Med 2008; 57(4):190-5. doi: 10.2302/kjm.57.190.
  60. Solanki R, Mathur V, Purohit SK, Mathur M. Evaluation of wound healing activity of ethanolic extract of Ocimum basilicum and Aegle marmelos leaves in male albino rats. International Journal of Drug Research and Technology 2017; 2(4).
  61. Shetty S, Udupa S, Udupa L. Evaluation of antioxidant and wound healing effects of alcoholic and aqueous extract of ocimum sanctum linn in rats. Evid Based Complement Alternat Med 2008; 5(1):95-101. doi: 10.1093/ecam/nem004.
  62. Osuagwu FC, Oladejo OW, Imosemi IO, Adewoyin BA, Aiku A, Ekpo OE, et al. Wound healing activities of methanolic extracts Ocimum gratissimum leaf in Wistar rats - a preliminary study. Afr J Med Med Sci 2004; 33(1):23-6.
  63. Orafidiya LO, Agbani EO, Abereoje OA, Awe T, Abudu A, Fakoya FA. An investigation into the wound-healing properties of essential oil of Ocimum gratissimum linn. J Wound Care 2003; 12(9):331-4. doi: 10.12968/jowc.2003.12.9.26537.
  64. Vaghardoost R, Mousavi Majd SG, Tebyanian H, Babavalian H, Malaei L, Niazi M, et al. The healing effect of sesame oil, camphor and honey on second degree burn wounds in rat. World J Plast Surg 2018; 7(1):67-71.
  65. Singh S, Sharma N. Evaluation of wound healing activity of Acacia auriculiformis A. Cunn. Stem bark. Asain J Pharm Clin Res 2014; 7(2):204-7.
  66. Suriyamoorthy S, Subramaniam K, Durai SJ, Wahaab F, Chitraselvi RP. Evaluation of wound healing activity of Acacia caesia in rats. Wound Medicine 2014; 7:1-7. doi: 10.1016/j.wndm.2015.03.001.
  67. Castro B, Palomares T, Azcoitia I, Bastida F, del Olmo M, Soldevilla JJ, et al. Development and preclinical evaluation of a new galactomannan-based dressing with antioxidant properties for wound healing. Histol Histopathol 2015; 30(12):1499-512. doi: 10.14670/HH-11-646.
  68. Sumitra M, Manikandan P, Suguna L, Cehittar G. Study of dermal wound healing activity of Trigonella foenum graceum seeds in rats. J Clin Biochem Nutr 2000; 28(2):59-67.
  69. Ktari N, Trabelsi I, Bardaa S, Triki M, Bkhairia I, Salem RBS-B, et al. Antioxidant and hemolytic activities, and effects in rat cutaneous wound healing of a novel polysaccharide from fenugreek (Trigonella foenum-graecum) seeds. Int J Biol Macromol 2017; 95:625-34. doi: 10.1016/j.ijbiomac.2016.11.091.
  70. Mustafa MR, Mahmood AA, Salmah I. Effects of Trigonella foenum-graecum seed extract in combination with honey on experimental wound healing in rats. International Journal of Molecular Medicine and Advance Science 2005; 1(1):29-33.
  71. Farahpour MR, Aghaei M. Assessment of the effect of co-administration of aloe vera gel and fenugreek seed hydroethanolic extract on the improvement of full-thickness excisional skin wound healing in diabetic mice. Veterinary Clinical Pathology (Veterinary Journal Tabriz) 2016; 9(36):285-95. [In Persian].
  72. Moalla Rekik D, Ben Khedir S, Ksouda Moalla K, Kammoun NG, Rebai T, Sahnoun Z. Evaluation of wound healing properties of grape seed, sesame, and fenugreek oils. Evidence-Based Complementary and Alternative Medicine 2016; 2016: doi: 10.1155/2016/7965689.
  73. Farahpour MR, Aghaei M. Effect fenugreek seeds hydroethanolic extract on a full-thickness wound healing in streptozotocin-induced diabetic mice. Journal of Comparative Pathobiology Iran 2016; 13(54):1979-86.
  74. Muhammed DO, Salih NA. Effect of application of Fenugreek (Trigonella foenum-graecum) on skin wound healing in rabbits. AL-Qadisiyah Journal of Veterinary Medicine Sciences 2012; 11(2):86-93.
  75. Sudheendra AT, Shenoy R, Taranalli AD, MCOPS M. Evaluation of flavonoid fraction of Trigonella foenum-graecum for its wound healing potential. Pharmacologyonline 2009; 1:1154-62.
  76. Selvaraj S, Fathima NN. Fenugreek incorporated silk fibroin nanofibers-a potential antioxidant scaffold for enhanced wound healing. ACS Appl Mater Interfaces 2017; 9(7):5916-26. doi: 10.1021/acsami.6b16306.
  77. Farahpour MR, Taghikhani H, Habibi M, Zandieh MA. Wound healing activity of flaxseed Linum usitatissimum L. in rats. Afr J Pharm Pharmacol 2011; 5(21):2386-9.
  78. de Souza Franco E, de Aquino CM, de Medeiros PL, Evêncio LB, da Silva Góes AJ, de Souza Maia MB. Effect of a semisolid formulation of Linum usitatissimum L.(Linseed) oil on the repair of skin wounds. Evid Based Complement Alternat Med 2012; 2012:270752. doi: 10.1155/2012/270752.
  79. Datta HS, Mitra SK, Patwardhan B. Wound healing activity of topical application forms based on ayurveda. Evid Based Complement Alternat Med 2011; 2011:134378. doi: 10.1093/ecam/nep015.
  80. Jridi M, Sellimi S, Lassoued KB, Beltaief S, Souissi N, Mora L, et al. Wound healing activity of cuttlefish gelatin gels and films enriched by henna (Lawsonia inermis) extract. ColloidsSurf A Physicochem Eng Asp. 2017; 512:71-9.
  81. Shiravi AH, Alebooyeh M, Hojati V, Akbari H. The effect of extract of henna leaves (Lawsonia inermis) on skin wound healing in wistar rats. Journal of Animal Biology 2011; 3(4):45-51. [In Persian].
  82. Nayak BS, Isitor G, Davis EM, Pillai GK. The evidence based wound healing activity of Lawsonia inermis Linn. Phytother Res 2007; 21(9):827-31. doi: 10.1002/ptr.2181.
  83. Afshar M, Ravarian B, Zardast M, Moallem SA, Fard MH, Valavi M. Evaluation of cutaneous wound healing activity of Malva sylvestris aqueous extract in BALB/c mice. Iran J Basic Med Sci 2015; 18(6):616-22.
  84. Pirbalouti AG, Azizi S, Koohpayeh A, Hamedi B. Wound healing activity of Malva sylvestris and Punica granatum in alloxan-induced diabetic rats. Acta Pol Pharm 2010; 67(5):511-6.
  85. Fahimi S, Abdollahi M, Mortazavi SA, Hajimehdipoor H, Abdolghaffari AH, Rezvanfar MA. Wound healing activity of a traditionally used poly herbal product in a burn wound model in rats. Iran Red Crescent Med J 2015; 17(9):e19960. doi: 10.5812/ircmj.19960.
  86. Barua C, Talukdar A, Barua AG, Chakraborty A, Sarma RK, Bora RS. Evaluation of the wound healing activity of methanolic extract of Azadirachta Indica (Neem) and Tinospora cordifolia (Guduchi) in rats. Pharmacologyonline 2010; 1:70-7.
  87. Singh A, Singh AK, Narayan G, Singh TB, Shukla VK. Effect of Neem oil and Haridra on non-healing wounds. Ayu 2014; 35(4):398-403. doi: 10.4103/0974-8520.158998.
  88. Babu KS, Naik VK, Latha J, Prabhakar V. Wound healing activity of ethanolic extract of natural products (Azadirachta indica bark) in albino wister rats. World J Pharm Pharm Sci 2016; 5(6):1624-32.
  89. Shukla R, Kashaw SK, Jain AP, Lodhi S. Fabrication of Apigenin loaded gellan gum–chitosan hydrogels (GGCH-HGs) for effective diabetic wound healing. Int J Biol Macromol 2016; 91:1110-9. doi: 10.1016/j.ijbiomac.2016.06.075.
  90. Amutha K, Selvakumari U. Wound healing activity of methanolic stem extract of Musa paradisiaca Linn. (Banana) in Wistar albino rats. Int Wound J 2016; 13(5):763-7. doi: 10.1111/iwj.12371.
  91. Ozcan O, Ipekci H, Alev B, Ustundag UV, Ak E, Sen A, et al. Protective effect of Myrtle (Myrtus communis) on burn induced skin injury. Burns 2019; 45(8):1856-63. doi: 10.1016/j.burns.2019.07.015.
  92. Raeiszadeh M, Esmaeili-Tarzi M, Bahrampour-Juybari K, Nematollahi-Mahani SN, Pardakhty A, Nematollahi MH, et al. Evaluation the effect of Myrtus communis L. extract on several underlying mechanisms involved in wound healing: An in vitro study. S Afr J Bot 2018; 118:144-50. doi: 10.1016/j.sajb.2018.07.006.
  93. Hashemipour MA, Lotfi S, Torabi M, Sharifi F, Ansari M, Ghassemi A, et al. evaluation of the effects of three plant species (myrtus communis l., camellia sinensis l., zataria multiflora boiss.) on the healing process of intraoral ulcers in rats. J Dent (Shiraz) 2017; 18(2):127-35.
  94. Zahmatkesh M, Manesh MJ, Babashahabi R. Effect of Olea ointment and Acetate Mafenide on burn wounds - A randomized clinical trial. Iran J Nurs Midwifery Res 2015; 20(5):599-603. doi: 10.4103/1735-9066.164507.
  95. Koca U, Süntar I, Akkol EK, Yılmazer D, Alper M. Wound repair potential of Olea europaea L. leaf extracts revealed by in vivo experimental models and comparative evaluation of the extracts' antioxidant activity. J Med Food 2011; 14(1-2):140-6. doi: 10.1089/jmf.2010.0039.
  96. Kazemi-Darabadi S, Akbari G, Jarolmasjed SH, Shahbazfar AA. A histopathologic study of effects of olive oil plus lime water on third-degree burn in mouse model. Iranian Journal of Veterinary Surgery 2017; 12(1):55-63. doi: 22034/ivsa.2017.50916.
  97. Akbari G, Shahbazfar A, Kianifard D, Rezaei H, Shokrollahi S, Mohebi D. Microscopic study of the healing effects of the mixture of olive oil and lime water on the second degree burning in rats. Journal of Ilam University of Medical Sciences 2017; 24(6):169-77. doi: 10.18869/acadpub.sjimu.24.6.169.
  98. Tumen I, Süntar I, Keleş H, Küpeli Akkol E. A therapeutic approach for wound healing by using essential oils of Cupressus and Juniperus species growing in Turkey. Evid Based Complement Alternat Med 2012; 2012:728281.doi: 10.1155/2012/728281.
  99. Shenoy RR, Sudheendra AT, Nayak PG, Paul P, Kutty NG, Rao CM. Normal and delayed wound healing is improved by sesamol, an active constituent of Sesamum indicum (L.) in albino rats. J Ethnopharmacol 2011; 133(2):608-12. doi: 10.1016/j.jep.2010.10.045.
  100. Kiran K, Asad M. Wound healing activity of Sesamum indicum L seed and oil in rats. Indian J Exp Biol 2008; 46(11):777-82.
  101. Sharif M, Alizargar J, Sharif A. Evaluation of the wound healing activity of sesame oil extract in rats. World Journal of Medical Sciences 2013; 9(2):74-8. doi: 10.5829/idosi.wjms.2013.9.2.75195.
  102. Tehrani S, Lotfi P, Tehrani S, Jangholi E, Aryan H, Aidun A. Healing effect of sesame ointment on second-degree burn wound in rats. Galen Medical Journal 2016; 5(2):56-62.
  103. Bazzi P, Akbarzadeh S, Obeidi N, Noohpisheh MK, Daneshi A, Bargahi A. Using toasted barley in sesame oil mixture for non-surgical necrosis debridement of experimental burns in rat. J Med Plant Res 2014; 8(1):81-7. doi: 10.5897/JMPR2013.5183.
  104. Amini M, Kherad M, Mehrabani D, Azarpira N, Panjehshahin MR, Tanideh N. Effect of plantago major on burn wound healing in rat. J Appl Anim Res 2010; 37(1):53-6. doi: 10.1080/09712119.2010.9707093.
  105. Thomé RG, dos Santos HB, dos Santos FV, da Silva Oliveira RJ, de Camargos LF, Pereira MN, et al. Evaluation of healing wound and genotoxicity potentials from extracts hydroalcoholic of Plantago major and Siparuna guianensis. Exp Biol Med (Maywood) 2012; 237(12):1379-86. doi: 10.1258/ebm.2012.012139.
  106. Patil BS, Mastiholimath VS, Kulkarni AR. Development and evaluation of psyllium seed husk polysaccharide based wound dressing films. Orient Pharm Exp Med 2011; 11:123. doi: 10.1007/s13596-011-0012-8.
  107. Hemmati AA, Kalantari H, Jalali A, Rezai S, Zadeh HH. Healing effect of quince seed mucilage on T-2 toxin-induced dermal toxicity in rabbit. Exp Toxicol Pathol 2012; 64(3):181-6. doi: 10.1016/j.etp.2010.08.004.
  108. Omidian M, Hemmati AA, Farajzade H, Houshmand G, Sattari A, Maryam K. Priority of 5% quince seed cream versus 1% phenytoin cream in the healing of skin ulcers: a randomized controlled trial. Jundishapur J Nat Pharm Prod 2015; 10(2): doi: 10.17795/jjnpp-24590.
  109. Mansouri E, Hardani A, Afzalzadeh MR, Amir Zargar A, Meamar Z. Combined effects of retinoic acid and hydro-alcoholic extract of rosa damascena mill on wound in diabetic rats. Iran J Pharm Res 2016; 15(2):583-9.
  110. d'Alessio PA, Mirshahi M, Bisson JF, Bene MC. Skin repair properties of d-Limonene and perillyl alcohol in murine models. Antiinflamm Antiallergy Agents Med Chem 2014; 13(1):29-35. doi: 10.2174/18715230113126660021.
  111. Yusufoglu HS, Alqasoumi SI. Anti-inflammatory and wound healing activities of herbal gel containing an antioxidant Tamarix aphylla leaf extract. International Journal of Pharmacology 2011; 7(8):829-35. doi: 10.3923/ijp.2011.829.835.
  112. Demling RH, Leslie DeSanti MD. The rate of re-epithelialization across meshed skin grafts is increased with exposure to silver. Burns 2002; 28(3):264-6. doi: 10.1016/s0305-4179(01)00119-x.
  113. Kucan JO, Robson MC, Heggers JP, Ko F. Comparison of silver sulfadiazine, povidone‐iodine and physiologic saline in the treatment of chronic pressure ulcers. J Am Geriatr Soc 1981; 29(5):232-5. doi: 10.1111/j.1532-5415.1981.tb01773.x.
  114. Luo GG, Huang RB, Chen JH, Lin LR, Zheng LS. Diversity of coordination architecture of silver(Ι) complexes with different 2-aminopyrimidyl derivatives: Effect of counter anions and ligands. Polyhedron 2008; 27(13):2791-8. doi: 10.1016/j.poly.2008.06.003.
  115. Chen J, Han CM, Lin XW, Tang ZJ, Su SJ. Effect of silver nanoparticle dressing on second degree burn wound. Zhonghua Wai Ke Za Zhi 2006; 44(1):50-2. [In Chinese].
  116. Lohsiriwat V, Chuangsuwanich A. Comparison of the ionic silver-containing hydrofiber and paraffin gauze dressing on split-thickness skin graft donor sites. Ann Plast Surg 2009; 62(4):421-2. doi: 10.1097/SAP.0b013e31818a65e9.
  117. Otsuka M, Hatakeyama H, Shikamura M, Otsuka K, Ito A. Therapeutic effects of transdermal systems containing zinc-related materials on thermal burn rats. Biomed Mater Eng 2015; 25(2):143-56. doi: 10.3233/BME-151265.
  118. Kaufman KL, Mann FA, Kim DY, Lee S, Yoon HY. Evaluation of the effects of topical zinc gluconate in wound healing. Vet Surg 2014; 43(8):972-82. doi: 10.1111/j.1532-950X.2014.12243.x.
  119. Arslan K, Karahan O, Okuş A, Unlü Y, Eryılmaz MA, Ay S, et al. Comparison of topical zinc oxide and silver sulfadiazine in burn wounds: an experimental study. Ulus Travma Acil Cerrahi Derg 2012; 18(5):376-83. doi: 10.5505/tjtes.2012.45381.
  120. Thompson CB, Wiemken TL, Brown TS. Effect of postoperative dressing on excisions performed on the leg: a comparison between zinc oxide compression dressings versus standard wound care. Dermatol Surg 2017; 43(11):1379-84. doi: 10.1097/DSS.0000000000001209.
  121. Mulder GD, Patt LM, Sanders L, Rosenstock J, Altman MI, Hanley ME, et al. Enhanced healing of ulcers in patients with diabetes by topical treatment with glycyl‐l‐histidyl‐l‐lysine copper. Wound Repair Regen 1994; 2(4):259-69. doi: 10.1046/j.1524-475X.1994.20406.x.
  122. Borkow G, Gabbay J, Dardik R, Eidelman AI, Lavie Y, Grunfeld Y, et al. Molecular mechanisms of enhanced wound healing by copper oxide-impregnated dressings. Wound Repair Regen 2010; 18(2):266-75. doi: 10.1111/j.1524-475X.2010.00573.x.
  123. Malik KI, Malik MA, Aslam A. Honey compared with silver sulphadiazine in the treatment of superficial partial-thickness burns. Int Wound J 2010; 7(5):413-7. doi: 10.1111/j.1742-481X.2010.00717.x.
  124. Lavaf M, Simbar M, Mojab F, Alavi Majd H, Samimi M. Comparison of honey and phenytoin (PHT) cream effects on intensity of pain and episiotomy wound healing in nulliparous women. J Complement Integr Med 2017; 15(1). doi: 10.1515/jcim-2016-0139.
  125. Goharshenasan P, Amini S, Atria A, Abtahi H, Khorasani G. Topical application of honey on surgical wounds: a randomized clinical trial. Forsch Komplementmed 2016; 23(1):12-5. doi: 10.1159/000441994.
  126. Takzaree N, Hassanzadeh G, Rouini MR, Manayi A, Hadjiakhondi A, Majidi Zolbin M. Evaluation of the effects of local application of thyme honey in open cutaneous wound healing. Iran J Public Health 2017; 46(4):545-51.
  127. Mphande AN, Killowe C, Phalira S, Jones HW, Harrison WJ. Effects of honey and sugar dressings on wound healing. J Wound Care. 2007; 16(7):317-9. doi: 10.12968/jowc.2007.16.7.27053.
  128. Paydar S, Akrami M, Dehghanian A, Alavi Moghadam R, Heidarpour M, Bahari Khoob A, et al. A comparison of the effects of alpha and medical-grade honey ointments on cutaneous wound healing in rats. J Pharm (Cairo) 2016; 2016:9613908. doi: 10.1155/2016/9613908.
  129. Alizadeh AM, Sohanaki H, Khaniki M, Mohaghgheghi MA, Ghmami G, Mosavi M. The effect of teucrium polium honey on the wound healing and tensile strength in rat. Iran J Basic Med Sci 2011; 14(6):499-505.
  130. Chamani G, Zarei MR, Mehrabani M, Mehdavinezhad A, Vahabian M, Ahmadi-Motamayel F. Evaluation of Honey as a Topical Therapy for Intraoral Wound Healing in Rats. Wounds 2017; 29(3):80-6.
  131. Ghaderi R, Afshar M. Topical application of honey for treatment of skin wound in mice. Iran J Med Sci 2004; 29(4):185-8.
  132. Iftikhar F, Arshad M, Rasheed F, Amraiz D, Anwar P, Gulfraz M. Effects of acacia honey on wound healing in various rat models. Phytother Res 2010; 24(4):583-6. doi: 10.1002/ptr.2990.
  133. Baghel PS, Shukla S, Mathur RK, Randa R. A comparative study to evaluate the effect of honey dressing and silver sulfadiazene dressing on wound healing in burn patients. Indian J Plast Surg 2009; 42(2):176-81. doi: 10.4103/0970-0358.59276.
  134. Sirousazar M, Jahani-Javanmardi A, Kheiri F, Hassan ZM. In vitro and in vivo assays on egg white/polyvinyl alcohol/clay nanocomposite hydrogel wound dressings. J Biomater Sci Polym Ed 2016; 27(16):1569-83. doi: 10.1080/09205063.2016.1218210.
  135. Fu H, Wang XJ, Lu HF, Xu QW. Experimental study on beeswax ointment in diabetic rabbit's model of wound healing. Journal of Dalian Medical University 2007; 4.
  136. Kumari P, Chahar MK, Veerapur VP, Spandana G, Thippeswamy BS, Badami S. Spider web ointment: A traditional based approach in Cutaneous wound healing. Indian Journal of Traditional Knowledge 2013; 12(4):657-63.
  137. Bhat ZA. Traditional medicines in drug discovery. J Pharm Res 2012; 5(5):2457-9.
  138. Campelo AP, Campelo MW, Britto GA, Ayala AP, Guimarães SB, Vasconcelos PR. An optimized animal model for partial and total skin thickness burns studies. Acta Cir Bras 2011; 26(Suppl 1):38-42. doi: 10.1590/s0102-86502011000700008.
  139. Carvalho AR Jr, Diniz RM, Suarez MA, Figueiredo CS, Zagmignan A, Grisotto MA, et al. Use of some asteraceae plants for the treatment of wounds: from ethnopharmacological studies to scientific evidences. Front Pharmacol 2018; 9:784. doi: 10.3389/fphar.2018.00784.
  140. Denisow-Pietrzyk M, Pietrzyk Ł, Denisow B. Asteraceae species as potential environmental factors of allergy. Environ Sci Pollut Res Int 2019; 26(7):6290-300. doi: 10.1007/s11356-019-04146-w.
  141. Salekzamani S, Ebrahimi-Mameghani M, Rezazadeh K. The antioxidant activity of artichoke (Cynara scolymus): A systematic review and meta-analysis of animal studies. Phytother Res 2019; 33(1):55-71. doi: 10.1002/ptr.6213.
  142. Ben Salem M, Affes H, Dhouibi R, Charfi S, Turki M, Hammami S, et al. Effect of Artichoke (cynara scolymus) on cardiac markers, lipid profile and antioxidants levels in tissue of HFD-induced obesity. Arch Physiol Biochem 2019; 1-11. doi: 10.1080/13813455.2019.1670213.
  143. Biel W, Witkowicz R, Piątkowska E, Podsiadło C. Proximate composition, minerals and antioxidant activity of artichoke leaf extracts. Biol Trace Elem Res 2020; 194(2):589-95. doi: 10.1007/s12011-019-01806-3.
  144. Pareek A, Suthar M, Rathore GS, Bansal V. Feverfew (Tanacetum parthenium L.): A systematic review. Pharmacogn Rev 2011; 5(9):103-10. doi: 10.4103/0973-7847.79105.
  145. Bouziri A, Hamdi A, Menif K, Ben Jaballah N. Hepatorenal injury induced by cutaneous application of Atractylis gummifera L. Clin Toxicol (Phila) 2010; 48(7):752-4. doi: 10.3109/15563650.2010.498379.
  146. Doulah A, Neisi N, Zekavati R, Farjam M. Antibacterial, antifungal and antioxidant activity of four species from Arnebia genus growing wild in Iran. Iranian Journal of Science & Technology 2014; 38(2):159-64.
  147. Tasset-Cuevas I, Fernández-Bedmar Z, Lozano-Baena MD, Campos-Sánchez J, de Haro-Bailón A, Muñoz-Serrano A, et al. Protective effect of borage seed oil and gamma linolenic acid on DNA: in vivo and in vitro studies. PLoS One 2013; 8(2):e56986. doi: 10.1371/journal.pone.0056986.
  148. Silva JR, Burger B, Kuhl CM, Candreva T, Dos Anjos MB, Rodrigues HG. Wound healing and omega-6 fatty acids: from inflammation to repair. Mediators Inflamm 2018; 2018:2503950. doi: 10.1155/2018/2503950.
  149. Nogueira AO, Oliveira YI, Adjafre BL, de Moraes ME, Aragao GF. Pharmacological effects of the isomeric mixture of alpha and beta amyrin from Protium heptaphyllum: a literature review. Fundam Clin Pharmacol 2019; 33(1):4-12. doi: 10.1111/fcp.12402.
  150. Zarshenas MM, Arabzadeh A, Ajdari Tafti M, Kordafshari G, Zargaran A, Mohagheghzadeh A. Application of herbal exudates in traditional Persian medicine. Galen Medical Journal 2012; 1(2):78-83.
  151. Amen YM, Marzouk AM, Zaghloul MG, Afifi MS. The genus Machaerium (Fabaceae): taxonomy, phytochemistry, traditional uses and biological activities. Nat Prod Res 2015; 29(15):1388-405. doi: 10.1080/14786419.2014.1003062.
  152. Wong VW, Martindale RG, Longaker MT, Gurtner GC. From germ theory to germ therapy: skin microbiota, chronic wounds, and probiotics. Plast Reconstr Surg 2013; 132(5):854e-61e. doi: 10.1097/PRS.0b013e3182a3c11e.
  153. Baquerizo Nole KL, Yim E, Keri JE. Probiotics and prebiotics in dermatology. J Am Acad Dermatol 2014; 71(4):814-21. doi: 10.1016/j.jaad.2014.04.050.
  154. Peral MC, Huaman Martinez MA, Valdez JC. Bacteriotherapy with Lactobacillus plantarum in burns. Int Wound J 2009; 6(1):73-81. doi: 10.1111/j.1742-481X.2008.00577.x.
  155. Valdez JC, Peral MC, Rachid M, Santana M, Perdigon G. Interference of Lactobacillus plantarum with Pseudomonas aeruginosa in vitro and in infected burns: the potential use of probiotics in wound treatment. Clin Microbiol Infect 2005; 11(6):472-9. doi: 10.1111/j.1469-0691.2005.01142.x.
  156. Jebur MS. Therapeutic efficacy of Lactobacillus acidophilus against bacterial isolates from burn wounds. N Am J Med Sci 2010; 2(12):586-91. doi: 10.4297/najms.2010.2586.
  157. Chatterjee D. A controlled comparative study of the use of porcine xenograft in the treatment of partial thickness skin loss in an occupational health centre. Curr Med Res Opin 1978; 5(9):726-33. doi: 10.1185/03007997809110213.
  158. Voineskos SH, Ayeni OA, McKnight L, Thoma A. Systematic review of skin graft donor-site dressings. Plast Reconstr Surg 2009; 124(1):298-306. doi: 10.1097/PRS.0b013e3181a8072f.
  159. Ruszczak Z. Effect of collagen matrices on dermal wound healing. Adv Drug Deliv Rev 2003; 55(12):1595-611. doi: 10.1016/j.addr.2003.08.003.
  160. Shevchenko RV, Sibbons PD, Sharpe JR, James SE. Use of a novel porcine collagen paste as a dermal substitute in full-thickness wounds. Wound Repair Regen 2008; 16(2):198-207. doi: 10.1111/j.1524-475X.2008.00360.x.
  161. Chashty MA. Great Elixir. Tehran: Iran University of Medical Sciences (Republished by Institute of Medical History, Islamic and Complementary Medicine); 2005. [in Persian].
  162. Heyneman A, Hoeksema H, Vandekerckhove D, Pirayesh A, Monstrey S. The role of silver sulphadiazine in the conservative treatment of partial thickness burn wounds: A systematic review. Burns 2016; 42(7):1377-86. doi: 10.1016/j.burns.2016.03.029.
  163. You C, Li Q, Wang X, Wu P, Ho JK, Jin R, et al. Silver nanoparticle loaded collagen/chitosan scaffolds promote wound healing via regulating fibroblast migration and macrophage activation. Sci Rep 2017; 7(1):10489. doi: 10.1038/s41598-017-10481-0.
  164. Pati R, Mehta RK, Mohanty S, Padhi A, Sengupta M, Vaseeharan B, et al. Topical application of zinc oxide nanoparticles reduces bacterial skin infection in mice and exhibits antibacterial activity by inducing oxidative stress response and cell membrane disintegration in macrophages. Nanomedicine 2014; 10(6):1195-208. doi: 10.1016/j.nano.2014.02.012.
  165. Lansdown AB, Mirastschijski U, Stubbs N, Scanlon E, Ågren MS. Zinc in wound healing: Theoretical, experimental, and clinical aspects. Wound Repair Regen 2007; 15(1):2-16. doi: 10.1111/j.1524-475X.2006.00179.x.
  166. Zamboni P, Scapoli G, Lanzara V, Izzo M, Fortini P, Legnaro R, et al. Serum iron and matrix metalloproteinase‐9 variations in limbs affected by chronic venous disease and venous leg ulcers. Dermatol Surg 2005; 31(6):644-9. doi: 10.1111/j.1524-4725.2005.31611.
  167. Zamboni P. The big idea: iron-dependent inflammation in venous disease and proposed parallels in multiple sclerosis. J R Soc Med 2006; 99(11):589-93. doi: 10.1258/jrsm.99.11.589.
  168. Koh TJ, DiPietro LA. Inflammation and wound healing: the role of the macrophage. Expert Rev Mol Med 2011; 13:e23. doi: 10.1017/S1462399411001943.
  169. Mohammadpour M, Behjati M, Sadeghi A, Fassihi A. Wound healing by topical application of antioxidant iron chelators: kojic acid and deferiprone. Int Wound J 2013; 10(3):260-4. doi: 10.1111/j.1742-481X.2012.00971.x.
  170. Mehrabani M, Najafi M, Kamarul T, Mansouri K, Iranpour M, Nematollahi MH, et al. Deferoxamine preconditioning to restore impaired HIF-1alpha-mediated angiogenic mechanisms in adipose-derived stem cells from STZ-induced type 1 diabetic rats. Cell Prolif 2015; 48(5):532-49. doi: 10.1111/cpr.12209.