Document Type : Original Article
Authors
- Arian Amirkhosravi 1
- Elham Salari 2
- Seyyed-Mehdi Hashemi-Bajgani 3
- Mitra Samareh Fekri 4
- Mohammad Mehdipour 5
- Ali Mandegary 6
1 Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran
2 Deputy of Research and Technology, Jiroft University of Medical Sciences, Jiroft, Iran
3 Afzalipour Hospital, Kerman University of Medical Sciences, Kerman, Iran
4 Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
5 Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
6 Pharmaceutical Research Center, Department of Toxicology and Pharmacology, Faculty of Pharmacy, Kerman University of Medical Sciences, Kerman, Iran , Department of Toxicology and Pharmacology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Abstract
Background: One of the principal cigarette smokes (CS) mediated diseases is chronic obstructive pulmonary disease (COPD). Methods: In the current case-control study, the relationship between the polymorphisms of interleukin-10 (IL-10), transforming growth factor-β1 (TGF-β1) codon 10, TGF-β1 codon 25, interferon-γ (IFN-γ), and tumor necrosis factor-α (TNF-α) in 213 individuals with COPD and susceptibility to the disease, with 100 healthy age and gender-matched people as a control group, was investigated using PCR-ARMS (polymerase chain reaction-amplification refractory mutation system). Moreover, the combination of the polymorphisms of TGF-β1 codon 10.25 regarding this susceptibility was studied in the same condition.
Results: There was a significant difference between polymorphism of TGF-β1 codon 10 (+869 T/C), codon 25 (G+915C), and susceptibility to the disease (OR=0.50; (95 %CI=0.24-1.07, p=0.05), ORCC=5.31; (95% CI: 1.22-23.2); p=0.02), thus polymorphism of IL-10 and TGF-β1 increased the risk of susceptibility to COPD but the polymorphisms of TNF-α (G-308A) and IFN-γ ( + 847 T/A) did not show any association.
Conclusion: All in all, it is recommended that the patients carrying the above-said genotypes should be paid proper attention, especially those who are exposed to chemicals at their workplaces, pollution, and cigarette smoke.
Highlights
Arian Amirkhosravi(Google scholar)(Pubmed)
Elham Salari(Google scholar)(Pubmed)
Seyyed-Mehdi Hashemi-Bajgani(Google scholar)(Pubmed)
Mitra Samareh Fekri(Google scholar)(Pubmed)
Mohammad Mehdipour(Google scholar)(Pubmed)
Ali Mandegary(Google scholar)(Pubmed)
Keywords
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