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Fluoride; An Updated Review

Document Type : Review Article

Authors

1 Social Determinants on Oral Health Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 Dental School Department of Pediatric Dentistry, Oral & Dental Research Center, Kerman University of Medical Science, Kerman, Iran

Abstract

Background: Fluoride can arrest dental caries and prevent its progression. The most important advantage of fluoride is that there is no need for cavity preparation; in this respect, it eliminates the utilization of air motors. Furthermore, it provides a good choice for younger children without cooperation ability and patients requiring special care. This study aimed to review the literature about fluoride and to advise public health specialists about the types of fluoride and that fluoride is still a right and safe choice in the COVID-19 pandemic.
Methods: Through a search in electronic databases containing Medline, Scopus, Web of Science, and PubMed, a total of one hundred forty-two systematic reviews and original articles in the period of 2008-2021 were selected. The following keywords were used: pediatric dentistry, coronavirus, oral health, tooth remineralization, COVID-19, fluoride, dental fluorosis, and preventive dentistry.
Results: Data from selected papers was extracted and classified to evaluate the importance of fluoride in the prevention of dental caries. Fluoride has been selected as a good choice for the prevention and control of dental caries during the coronavirus pandemic.
Conclusion: The research has focused on increasing the awareness of public health specialists, advising them that any type of fluoride use is expedient and safe during the COVID-19 pandemic.

Highlights

Fatemeh Jahanimoghadam(Google scholar)(Pubmed)

Mahboobeh Shokrizadeh(Google scholar)(Pubmed)

Keywords

References

  1. Sharma A, Jain MB. Pediatric dentistry during coronavirus disease-2019 pandemic: a paradigm shift in treatment options. Int J Clin Pediatr Dent. 2020;13(4):412-5. doi: 10.5005/jp- journals-10005-1809.

  2. Alsaleh MM, Sabbarini JM, Al-Batayneh OB, Khader YS. Changes in behavior management and treatment modalities in pediatric dentistry during COVID-19 pandemic. Int J Clin Pediatr Dent. 2020;13(Suppl 1):S125-S31. doi: 10.5005/jp-

Amount (g) Size

0.25 Pea

journals-10005-1885.
3. Hamdy D, Giraki M, Abd Elaziz A, Badran A, Allam G,

Ruettermann S. Laboratory evaluation of the potential masking of color changes produced by silver diamine fluoride in primary molars. BMC Oral Health. 2021;21(1):337. doi: 10.1186/s12903-021-01697-8.

4. Dawood AE, Manton DJ, Parashos P, Wong RH, Singleton W, Holden JA, et al. Biocompatibility and osteogenic/ calcification potential of casein phosphopeptide-amorphous calcium phosphate fluoride. J Endod. 2018;44(3):452-7. doi: 10.1016/j.joen.2017.11.005.

5. American Dental Association. ADA Fluoridation Policy. Available at: https://www.ada.org/en/public-programs/ advocating-for-the-public/fluoride-and-fluoridation-policy. Accessed November, 2017.

6. Liao Y, Brandt BW, Li J, Crielaard W, Van Loveren C, Deng DM. Fluoride resistance in Streptococcus mutans: a mini review. J Oral Microbiol. 2017;9(1):1344509. doi:10.1080/20002297.2017.1344509.

7. Horri A, Poureslami HR, Jahanimoghadam F, Sharifi A. Preventive methods of dental caries is a problem of most general practitioners yet: a survey of knowledge, attitude and practice. J Oral Health Oral Epidemiol. 2016;5(4):198-204.

8. Darwita RR, Setiawati F, Andiani SG. Association of propolis fluoride with arrested dentinal caries and dental plaque levels. J Int Dent Med Res. 2019;12(2):622-7.

9. Buzalaf MAR, Pessan JP, Honório HM, Ten Cate JM. Mechanisms of action of fluoride for caries control. Monogr Oral Sci. 2011;22:97-114. doi: 10.1159/000325151.

10. Alabbasi D, Alkhtheri B, Alothman S, Altowairgi N, AlAfaliq F, Ingle N. Effect of wide spread use of fluoride on general and oral health: a systematic review. Int J Appl Dent Sci. 2018;4(1):9-11.

11. Iheozor-Ejiofor Z, Worthington HV, Walsh T, O’Malley L, Clarkson JE, Macey R, et al. Water fluoridation for the prevention of dental caries. Cochrane Database Syst Rev. 2015;2015(6):CD010856. doi: 10.1002/14651858. CD010856.pub2.

12. Sicca C, Bobbio E, Quartuccio N, Nicolò G, Cistaro A. Prevention of dental caries: a review of effective treatments. J Clin Exp Dent. 2016;8(5):e604-e10. doi: 10.4317/jced.52890.

13. Maguire A. ADA clinical recommendations on topical fluoride for caries prevention. Evid Based Dent. 2014;15(2):38-9. doi: 10.1038/sj.ebd.6401019.

14. Jahanimoghadam F, Poureslami H, Shamsaddin H, Horri A, Khazaeli P, Mahvi AH. Effect of ER:Yag laser on sodium fluoride varnish uptake by primary tooth enamel: an in-vitro study. Fluoride. 2016;49(4):538-48.

  1. Weyant RJ, Tracy SL, Anselmo TT, Beltrán-Aguilar ED, Donly KJ, Frese WA, et al. Topical fluoride for caries prevention: executive summary of the updated clinical recommendations and supporting systematic review. J Am Dent Assoc. 2013;144(11):1279-91. doi: 10.14219/jada. archive.2013.0057.

  2. Hetrodt F, Lausch J, Meyer-Lueckel H, Conrads G, Apel C. Evaluation of restorative materials containing preventive additives in a secondary caries model in vitro. Caries Res. 2019;53(4):447-56. doi: 10.1159/000496401.

  3. Naik NS, Subba Reddy VV, Shashikiran ND. Comparative evaluation of secondary caries formation around light- cured fluoride-releasing restorative materials. J Indian Soc Pedod Prev Dent. 2017;35(1):75-82. doi: 10.4103/0970- 4388.199235.

  4. Ullah R, Zafar MS, Shahani N. Potential fluoride toxicity from oral medicaments: a review. Iran J Basic Med Sci. 2017;20(8):841-8. doi: 10.22038/ijbms.2017.9104.

  5. Zuo H, Chen L, Kong M, Qiu L, Lü P, Wu P, et al. Toxic effects of fluoride on organisms. Life Sci. 2018;198:18-24. doi: 10.1016/j.lfs.2018.02.001.

  6. Fancher ME, Fournier S, Townsend J, Lallier TE. Cytotoxic effects of silver diamine fluoride. Am J Dent. 2019;32(3):152-6.

  7. Sharma D, Singh A, Verma K, Paliwal S, Sharma S, Dwivedi J. Fluoride: a review of pre-clinical and clinical studies. Environ Toxicol Pharmacol. 2017;56:297-313. doi: 10.1016/j.

    etap.2017.10.008.

  8. Keramati H, Miri A, Baghaei M, Rahimizadeh A, Ghorbani R,

    Fakhri Y, et al. Fluoride in Iranian drinking water resources: a systematic review, meta-analysis and non-carcinogenic risk assessment. Biol Trace Elem Res. 2019;188(2):261-73. doi: 10.1007/s12011-018-1418-7.

  9. Goodarzi F, Mahvi AH, Hosseini M, Nabizadeh Nodehi R, Kharazifard MJ, Parvizishad M. Prevalence of dental caries and fluoride concentration of drinking water: a systematic review. Dent Res J (Isfahan). 2017;14(3):163-8. doi: 10.4103/1735- 3327.208765.

  10. The dynamics of change. In: Pinkham JR CP, Nowak M, eds. Pediatric Dentistry: Infancy Through Adolescence. Philadelphia, PA: Elsevier Saunders; 2019.

  11. Romero V, Norris FJ, Ríos JA, Cortés I, González A, Gaete L, et al. [The impact of tap water fluoridation on human health]. Rev Med Chil. 2017;145(2):240-9. doi: 10.4067/s0034- 98872017000200012. [Spanish].

  12. O’Mullane DM, Baez RJ, Jones S, Lennon MA, Petersen PE, Rugg-Gunn AJ, et al. Fluoride and oral health. Community Dent Health. 2016;33(2):69-99.

  13. Bánóczy J, Rugg-Gunn A, Woodward M. Milk fluoridation for the prevention of dental caries. Acta Med Acad. 2013;42(2):156-67. doi: 10.5644/ama2006-124.83.

  14. Vautey S, Ranivoharilanto E, Decroix B, Tubert-Jeannin S. [Salt fluoridation and dental caries: state of the question]. Sante Publique. 2017;29(2):185-90. [French].

  15. Marthaler TM. Salt fluoridation and oral health. Acta Med Acad. 2013;42(2):140-55. doi: 10.5644/ama2006-124.82.

  16. Barker JC, Guerra C, Gonzalez-Vargas MJ, Hoeft KS. Acceptability of salt fluoridation in a rural Latino community in the United States: an ethnographic study. PLoS One. 2016;11(7):e0158540. doi: 10.1371/journal.pone.0158540.

  17. Pollick HF. Salt fluoridation: a review. J Calif Dent Assoc. 2013;41(6):395-7.

  18. Kühnisch J, Thiering E, Heinrich-Weltzien R, Hellwig E, Hickel

R, Heinrich J. Fluoride/vitamin D tablet supplementation in infants-effects on dental health after 10 years. Clin Oral Investig. 2017;21(7):2283-90. doi: 10.1007/s00784-016- 2021-y.

33. Tubert-Jeannin S, Auclair C, Amsallem E, Tramini P, Gerbaud L, Ruffieux C, et al. Fluoride supplements (tablets, drops, lozenges or chewing gums) for preventing dental caries in children. Cochrane Database Syst Rev. 2011;2011(12):CD007592. doi: 10.1002/14651858.CD007592.pub2.

34. Griffin SO, Li CH, Espinoza L, Gooch BF. Filled dietary fluoride supplement prescriptions for Medicaid-enrolled children living in states with high and low water fluoridation coverage. J Am Dent Assoc. 2019;150(10):854-62. doi: 10.1016/j.adaj.2019.05.027.

35. Singhal RK, Rai B. Remineralization potential of three tooth pastes on enamel caries. Open Access Maced J Med Sci. 2017;5(5):664-6. doi: 10.3889/oamjms.2017.090.

36. Cury JA, Tenuta LM. Evidence-based recommendation on toothpaste use. Braz Oral Res. 2014;28 Spec No:1-7. doi: 10.1590/s1806-83242014.50000001.

37. Fernández CE, Tenuta LMA, Del Bel Cury AA, Nóbrega DF, Cury JA. Effect of 5,000 ppm fluoride dentifrice or 1,100 ppm fluoride dentifrice combined with acidulated phosphate fluoride on caries lesion inhibition and repair. Caries Res. 2017;51(3):179-87. doi: 10.1159/000453624.

38. Srinivasan M, Schimmel M, Riesen M, Ilgner A, Wicht MJ, Warncke M, et al. High-fluoride toothpaste: a multicenter randomized controlled trial in adults. Community Dent Oral Epidemiol. 2014;42(4):333-40. doi: 10.1111/cdoe.12090.

39. Chaudhary D, Patthi B, Singla A, Gupta R, Muchhal M, Kumar JK, et al. The anticariogenic efficacy of 5000 ppm fluoridated toothpaste: a systematic review. J Clin Diagn Res. 2018;12(1):ZE4-ZE10. doi: 10.7860/jcdr/2018/26732.11135.

40. Wright JT, Hanson N, Ristic H, Whall CW, Estrich CG, Zentz RR. Fluoride toothpaste efficacy and safety in children younger than 6 years: a systematic review. J Am Dent Assoc. 2014;145(2):182-9. doi: 10.14219/jada.2013.37.

41. Takenaka S, Ohsumi T, Noiri Y. Evidence-based strategy for dental biofilms: current evidence of mouthwashes on dental biofilm and gingivitis. Jpn Dent Sci Rev. 2019;55(1):33-40. doi: 10.1016/j.jdsr.2018.07.001.

42. Doméjean S, Muller-Bolla M, Featherstone JDB. Caries preventive therapy. Clin Dent Rev. 2018;2(1):14. doi: 10.1007/s41894-018-0025-5.

43. Weyant RJ, Tracy SL, Anselmo TT, Beltrán-Aguilar ED, Donly KJ, Frese WA, et al. Topical fluoride for caries prevention: executive summary of the updated clinical recommendations and supporting systematic review. J Am Dent Assoc. 2013;144(11):1279-91. doi: 10.14219/jada. archive.2013.0057.

44. Karabekiroğlu S, Kahraman FB, Ünlü N. Effectiveness of different preventive agents on initial occlusal and proximal caries lesions: a follow-up study. J Dent Sci. 2018;13(2):109- 15. doi: 10.1016/j.jds.2017.05.005.

45. Aoun A, Darwiche F, Al Hayek S, Doumit J. The fluoride debate: the pros and cons of fluoridation. Prev Nutr Food Sci. 2018;23(3):171-80. doi: 10.3746/pnf.2018.23.3.171.

46. Sardana D, Manchanda S, Ekambaram M, Yang Y, McGrath CP, Yiu CKY. Effectiveness of self-applied topical fluorides against enamel white spot lesions from multi-bracketed fixed orthodontic treatment: a systematic review. Eur J Orthod. 2019;41(6):661-8. doi: 10.1093/ejo/cjz015.

47. Twetman S, Keller MK. Fluoride rinses, gels and foams: an update of controlled clinical trials. Caries Res. 2016;50 Suppl 1:38-44. doi: 10.1159/000439180.

48. Milgrom P, Tut O, Rothen M, Mancl L, Gallen M, Tanzer protocol for a phase II randomised controlled trial. BMJ Open. 2017;7(6):e017866. doi: 10.1136/bmjopen-2017-017866.

  1. Bonetti D, Clarkson JE. Fluoride varnish for caries prevention: efficacy and implementation. Caries Res. 2016;50 Suppl 1:45-9. doi: 10.1159/000444268.

  2. Gao SS, Zhang S, Mei ML, Lo EC, Chu CH. Caries remineralisation and arresting effect in children by professionally applied fluoride treatment - a systematic review. BMC Oral Health. 2016;16:12. doi: 10.1186/s12903- 016-0171-6.

  3. Shamsaddin H, Jahanimoghadam F, Poureslami H, Haghdoost AA. The association between growth factors and blood factors with early childhood caries. J Oral Health Oral Epidemiol. 2017;6(4):196-202.

  4. Jahanimoghadam F, Bazrafshani M, Hali H, Hosseini F. Effect of fluoride on cariogenic Streptococcus mutans and Lactobacillus counts in children as determined by quantitative real time-PCR. Online J Vet Res. 2015;19(8):491-6.

  5. Rahimi F, Sadeghi M, Mozaffari HR. Efficacy of fluoride varnish for prevention of white spot lesions during orthodontic treatment with fixed appliances: a systematic review study. Biomed Res Ther. 2017;4(8):1513-26.

  6. Satyanegara A, Darwita RR, Setiawati F, Adiatman M, Muhammad R. An invitro study of caries arresting effect of propolis fluoride and silver diamine fluoride on dentine carious lesions. J Int Dent Med Res. 2017;10:751-6.

  7. Mei ML, Ito L, Cao Y, Lo EC, Li QL, Chu CH. An ex vivo study of arrested primary teeth caries with silver diamine fluoride therapy. J Dent. 2014;42(4):395-402. doi: 10.1016/j. jdent.2013.12.007.

  8. Milgrom P, Horst JA, Ludwig S, Rothen M, Chaffee BW, Lyalina S, et al. Topical silver diamine fluoride for dental caries arrest in preschool children: a randomized controlled trial and microbiological analysis of caries associated microbes and resistance gene expression. J Dent. 2018;68:72-8. doi: 10.1016/j.jdent.2017.08.015.

  9. Anggraini R, Darwita RR, Adiatman M. The effectiveness of silver diamine fluoride and propolis fluoride in arresting caries on primary teeth: a study on kindergarten students in West Jakarta, Indonesia. J Int Dent Med Res. 2017;10:668-72.

  10. Horst JA. Silver fluoride as a treatment for dental caries. Adv Dent Res. 2018;29(1):135-40. doi: 10.1177/0022034517743750.

  11. Seifo N, Cassie H, Radford JR, Innes NPT. Silver diamine fluoride for managing carious lesions: an umbrella review. BMC Oral Health. 2019;19(1):145. doi: 10.1186/s12903- 019-0830-5.

  12. Crystal YO, Niederman R. Evidence-based dentistry update on silver diamine fluoride. Dent Clin North Am. 2019;63(1):45- 68. doi: 10.1016/j.cden.2018.08.011.

  13. Galui S, Pal S, Pabale SL, Saha S, Sarkar S. Stretching new boundaries of caries prevention with silver diamine fluoride: a review of literature. Int J Pedod Rehabil. 2018 ;3(1):1-4. doi: 10.4103/ijpr.ijpr_32_17.

  14. Sari DL, Bahar A, Gunawan HA, Adiatman M, Rahardjo A, Maharani DA, et al. Fluoride concentration in urine after silver diamine fluoride application on tooth enamel. J Phys Conf Ser. 2017;884(1):012054. doi: 10.1088/1742- 6596/884/1/012054.

  15. Nazzal H, Duggal MS, Kowash MB, Kang J, Toumba KJ. Comparison of residual salivary fluoride retention using amine fluoride toothpastes in caries-free and caries-prone children. Eur Arch Paediatr Dent. 2016;17(3):165-9. doi: 10.1007/s40368-015-0220-x.

  16. Horst JA, Ellenikiotis H, Milgrom PL. UCSF protocol for caries arrest using silver diamine fluoride: rationale, indications and

consent. J Calif Dent Assoc. 2016;44(1):16-28.
65. Crystal YO, Niederman R. Silver diamine fluoride treatment considerations in children’s caries management. Pediatr Dent.

2016;38(7):466-71.
66. Widianti TA, Bahar A, Maharani DA, Tumen EC, Yavuz I.

Effect of silver diamine fluoride application on fluoride concentration in saliva. J Phys Conf Ser. 2018;1073(5):052001. doi: 10.1088/1742-6596/1073/5/052001.

67. Chen KJ, Gao SS, Duangthip D, Lo ECM, Chu CH. Managing early childhood caries for young children in China. Healthcare (Basel). 2018;6(1):11. doi: 10.3390/healthcare6010011.

68. Subbiah GK, Gopinathan NM. Is silver diamine fluoride effective in preventing and arresting caries in elderly adults? A systematic review. J Int Soc Prev Community Dent. 2018;8(3):191-9. doi: 10.4103/jispcd.JISPCD_99_18.

69. Tao S, Zhu Y, Yuan H, Tao S, Cheng Y, Li J, et al. Efficacy of fluorides and CPP-ACP vs fluorides monotherapy on early caries lesions: a systematic review and meta-analysis. PLoS One. 2018;13(4):e0196660. doi: 10.1371/journal. pone.0196660.

70. Wang Y, Li J, Sun W, Li H, Cannon RD, Mei L. Effect of non-fluoride agents on the prevention of dental caries in primary dentition: a systematic review. PLoS One. 2017;12(8):e0182221. doi: 10.1371/journal.pone.0182221.

71. Bijle MNA, Yiu CKY, Ekambaram M. Calcium-based caries preventive agents: a meta-evaluation of systematic reviews and meta-analysis. J Evid Based Dent Pract. 2018;18(3):203- 17.e4. doi: 10.1016/j.jebdp.2017.09.003.

72. Bayrak S, Tuloglu N, Bicer H, Sen Tunc E. Effect of fluoride varnish containing CPP-ACP on preventing enamel erosion. Scanning. 2017;2017:1897825. doi: 10.1155/2017/1897825.

73. Haghgou EH, Haghgoo R, Roholahi MR, Ghorbani Z. Effect of casein phosphopeptide-amorphous calcium phosphate and three calcium phosphate on enamel microhardness. J Contemp Dent Pract. 2017;18(7):583-6. doi: 10.5005/jp- journals-10024-2088.

74. Khamverdi Z, Kordestani M, Soltanian AR. Effect of proanthocyanidin, fluoride and casein phosphopeptide amorphous calcium phosphate remineralizing agents on microhardness of demineralized dentin. J Dent (Tehran). 2017;14(2):76-83.

75. Janakiram C, Deepan Kumar CV, Joseph J. Xylitol in preventing dental caries: a systematic review and meta-analyses. J Nat Sci Biol Med. 2017;8(1):16-21. doi: 10.4103/0976-9668.198344.

76. Cocco F, Carta G, Cagetti MG, Strohmenger L, Lingström P, Campus G. The caries preventive effect of 1-year use of low- dose xylitol chewing gum. A randomized placebo-controlled clinical trial in high-caries-risk adults. Clin Oral Investig. 2017;21(9):2733-40. doi: 10.1007/s00784-017-2075-5.

77. Harris N, Garsia-Godoy F, Nathe C. Primary Preventive Dentistry. 8th ed. London, UK: Pearson; 2014.

78. Nayak PA, Nayak UA, Khandelwal V. The effect of xylitol on dental caries and oral flora. Clin Cosmet Investig Dent. 2014;6:89-94. doi: 10.2147/ccide.s55761.

79. Salli K, Lehtinen MJ, Tiihonen K, Ouwehand AC. Xylitol’s health benefits beyond dental health: a comprehensive review. Nutrients. 2019;11(8):1813. doi: 10.3390/nu11081813.

80. Xiao J, Alkhers N, Kopycka-Kedzierawski DT, Billings RJ, Wu TT, Castillo DA, et al. Prenatal oral health care and early childhood caries prevention: a systematic review and meta-analysis. Caries Res. 2019;53(4):411-21. doi: 10.1159/000495187.

81. Poosti M, Ahrari F, Moosavi H, Najjaran H. The effect of fractional CO2 laser irradiation on remineralization of enamel white spot lesions. Lasers Med Sci. 2014;29(4):1349-55. doi: 10.1007/s10103-013-1290-9.

 

  1. Ana PA, Tabchoury CP, Cury JA, Zezell DM. Effect of Er,Cr:YSGG laser and professional fluoride application on enamel demineralization and on fluoride retention. Caries Res. 2012;46(5):441-51. doi: 10.1159/000333603.

  2. Chand BR, Kulkarni S, Mishra P. Inhibition of enamel demineralisation using “Nd-YAG and diode laser assisted fluoride therapy”. Eur Arch Paediatr Dent. 2016;17(1):59-64. doi: 10.1007/s40368-015-0206-8.

  3. Mohan AG, Ebenezar AVR, Ghani MF, Martina L, Narayanan A, Mony B. Surface and mineral changes of enamel with different remineralizing agents in conjunction with carbon-dioxide laser. Eur J Dent. 2014;8(1):118-23. doi: 10.4103/1305-7456.126264.

  4. Azevedo DT, Faraoni-Romano JJ, Derceli Jdos R, Palma- Dibb RG. Effect of Nd:YAG laser combined with fluoride on the prevention of primary tooth enamel demineralization. Braz Dent J. 2012;23(2):104-9. doi: 10.1590/s0103- 64402012000200003.

86. Al-Maliky MA, Frentzen M, Meister J. Laser-assisted prevention of enamel caries: a 10-year review of the literature. Lasers Med Sci. 2020;35(1):13-30. doi: 10.1007/s10103-019-02859-5.

87. Yeung CA. A systematic review of the efficacy and safety of fluoridation. Evid Based Dent. 2008;9(2):39-43. doi: 10.1038/ sj.ebd.6400578.

88. Nasiri P, Malekzadeh Shafaroudi A, Elyassi Gorgi N, Arab- Nozari M, Nahvi A. Efficacy and safety of fluoride in children: a narrative review. J Pediatr Rev. 2021;9(1):37-46. doi: 10.32598/jpr.9.1.870.1.

89. European Academy of Paediatric Dentistry. Guidelines on the use of fluoride in children: an EAPD policy document. Eur Arch Paediatr Dent. 2009;10(3):129-35. doi: 10.1007/ bf03262673.

90. Kanduti D, Sterbenk P, Artnik B. Fluoride: a review of use and effects on health. Mater Sociomed. 2016;28(2):133-7. doi: 10.5455/msm.2016.28.133-137.

Journal of Kerman University of Medical Sciences
Volume 30, Issue 3
May and June 2023
Pages 189-198
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