Document Type : Original Article
Authors
1 Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
2 School of Dentistry, North Khorasan University of Medical Sciences, Bojnurd, Iran
3 Department of Epidemiology and Biostatistics, School of Health, North Khorasan University of Medical Sciences, Bojnurd, Iran
Abstract
Objective: The primary aim was to diminish the gag reflex, quantified by the Gagging Severity Index (GSI), during orthodontic impression procedures. The goal was to enhance patient compliance by incorporating Punica granatum peel aqueous extract (P. granatum PAE) into a mouthwash solution used during the process.
Methodology: This double-blind, longitudinal, controlled clinical trial was conducted with patients at a dental clinic. A total of 40 patients—21 females and 19 males, averaging 29.3 ± 6.0 years old—with GSI scores of 2 and 3 were selected. The P. granatum PAE was prepared via freeze-drying and enriched with ascorbic acid, potassium sorbate, glycerin, and food coloring. A placebo mouthwash, devoid of P. granatum PAE, was also created. These mouthwashes, labeled ‘A’ and ‘B’, were administered randomly across two sessions, ensuring each patient received both types. The GSI was assessed before and after administration during the impression procedure.
Results: Statistical analysis using the chi-squared test revealed that both mouthwash variants generally decreased GSI scores. However, the P. granatum PAE was notably more effective in reducing these scores (p < 0.005).
Conclusion: The study confirms that P. granatum PAE is a powerful antiemetic. Its inclusion in mouthwash formulations can significantly lower GSI scores, thereby improving patient compliance with orthodontic procedures.
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