Document Type : Original Article
Authors
1 Associate professor, Radiologist, Radiology department in Afzalipour hospital, Kerman University of Medical Science, Kerman, Iran
2 Assistant professor of internal medicine, gastroenterology department, kerman university of medical sciences, kermam, iran
3 Resident of radiology,kerman university of medical sciences,kerman,iran
4 Endocrinology and Metabolism Research Center, Kerman University of Medical Sciences Kerman, Iran
5 Ph. D. Student of Anatomical Sciences, Anatomy Department, School of Medicine, kerman University of Medical Sciences, Kerman, Iran and Faculty member of Anatomy Department, school of Medicine, Bam University of Medical Sciences, Bam, Iran
Abstract
Background: By examining flow-mediated dilation (FMD) as an index for indirect assessment of arterial endothelial function, this study aimed to investigate the relationship between inflammatory bowel disease (IBD) and early atherosclerosis.
Methods: This study was performed on 75 patients with ulcerative colitis, 15 patients with Crohn's disease, and 75 healthy individuals as the control group. Vascular endothelial function was assessed by flow-mediated dilation (FMD) and Doppler ultrasonography of the right brachial artery.
Results: The mean FMD in the IBD patients (12.04±3.8) was lower than that of the persons in the control group (16.68±2.2). Besides, the mean FMD in Crohn's patients was 12.02±3.5 and the corresponding value in the patients with ulcerative colitis was 12.07±4.2, showing no significant difference (p = 0.78). There was a significant relationship between age and FMD in the control group so that with increasing age, FMD decreased (r = 0.6, p = 0.01). However, there was no association between age and FMD among IBD patients.
Conclusion: Given that this study focused on people without known risk factors for atherosclerosis, the results pointed to endothelial dysfunction in IBD patients, and IBD can be considered as an independent factor in the development of atherosclerosis.
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