Document Type : Review Article
Authors
- Yaser Mohammadi 1
- Azam Rezaei Farimani 2
- Hossein Beydokhti 3
- Sameep Shetty Shetty 4
- Seyed Mohammad Riahi 5
1 Qaen Faculty of Medical Sciences, Birjand University of Medical Sciences, Birjand, Iran.
2 Department of Clinical Biochemistry, School of Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran
3 Department of General Courses, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
4 Department of Oral and Maxillofacial Surgery, Manipal College of Dental Sciences, Mangalore, Manipal Academy of Higher Education, A Constituent of MAHE, India
5 Department of Community Medicine, Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Abstract
Background. The study aimed to assess the influence of Saffron and its active component on oxidative stress markers in diabetic rats.
Methods. The databases were searched until December 24, 2021. The quality of the included articles was assessed using the SYRCLE’s Risk of Bias tool. To estimate the effects of Saffron and its active component, SMD with 95% confidence intervals were pooled using the random-effects model. Subgroup analysis and meta-regression were used to explore heterogeneity. Publication bias was assessed using Begg and Egger tests. The results were reported under the PRISMA guidelines.
Results. The meta-analysis comprising of 42 articles revealed that prolonged hyperglycemia leads to increased oxidative markers (Malondialdehyde (MDA), Nitric Oxide (NO), Total Oxidant Status (TOS), Xanthine Oxidase (XO), Reactive Oxygen Species (ROS)), and a decrease in antioxidant defense system (Glutathione (GSH), Catalase (CAT), Superoxide Dismutase (SOD), Glutathione Peroxidase (GPX), Total Antioxidant Status (TAS), Thiol groups (SH), Total Antioxidant Capacity (TAC)) Treatment of diabetic rats with saffron, crocin, and safranal decreased oxidant markers and increased the antioxidant markers.
Conclusions. Saffron, Crocin, and Safranal condense the oxidative stress by reinforcement of the antioxidant defense system and plummeting the oxidant markers. Hence, we opine that saffron and its active ingredients can be a favorable option for the management of diabetes and its complications, albeit further human studies are desirable to draw definite conclusions.
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