Document Type : Original Article
Authors
- Simin Saffari 1
- Zahra Mirfeizi 1
- Hanieh Gholamalizadeh 2
- Hasan Mehrad-Majd 3
- Mahmoud Mahmoudi 4
- Kamila Hashemzadeh 5
1 Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.
2 Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3 Clinical Research Development Unit, Ghaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
4 Immunology Research Center, Bu Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
5 Rheumatic Diseases Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract
Background:
Recurrent oral ulcers constitute the most common complaint of patients with Behçet’s disease (BD) and recurrent aphthous stomatitis (RAS). Enhanced innate immune response and neutrophilic activity might be a possible etiopathogenesis of BD. This study aimed to determine the significance of salivary HNP 1-3 in BD and RAS patients and detect their correlation with different clinical presentations, disease activity, and characteristics of oral ulcers.
Methods:
This cross-sectional study included 25 BD patients and 25 RAS patients as well as 25 healthy participants. 5 cc of unstimulated saliva were collected and levels of HNP 1-3 were measured by ELISA. Other data were obtained through interviews, examination, and reviews of medical records. SPSS 25.0 was used to analyze the data.
Results:
Salivary HNP 1-3 levels were not significantly different between the study groups (P=0.282). Duration of oral ulcers did not correlate with HNP 1-3 levels in RAS and BD patients (P>0.05). Also, BD patients with involvements other than oral ulcers were not found to have different levels of HNP 1-3 comparing to those who did not manifest these conditions.
Conclusions:
The validity of HNP 1-3 to be used as a probable biological marker for evaluation, diagnosis, and estimation of disease activity in patients with BD and RAS is still questionable due to our results.
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