Synthesis of new piperazinyl quinolones and investigation of their in vitro antibacterial activities
A.R
Foromandi
assistant professor
author
P
Haghighat
author
S
Emami
author
M.H
Moshefi
Assistant professor
author
text
article
1997
eng
Quinolone antibacterial agents are currently used for the treatment of various bacterial infections. The nature of functional group at the 7 position of the quinolone ring system is known to have strong influence on the spectrum and extent of in vitro antibacterial activity. Accordingly, a series of N-L2- oxo-2-(2- furyl) and N-[2- oxyimino (2- furyl) ethyl] piperazinyl quinolone derivatives were synthesized and evaluated for in vitro antibacterial activity. Compounds having 2- oxo-2-(-2 furyl) ethyl group attached to the piperazine ring were as potent as norfloxacin and ciprofloxacin. The oximes were more active than corresponding ketones and original quinolone s against gram positive bacteria but less active against gram negative bacteria. The methyl oximes and O- benzyloximes were almost a potent as the corresponding quinolones against gram positive bacteria but less active against gram negative bacteria.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
103
109
https://jkmu.kmu.ac.ir/article_34304_fbc27c95c24b89bab149c47459f926a5.pdf
The effect of topical 5- fluorouracil ointment along with epidermal abrasion in treatment of vitiligo
I
Esfandyarpour
Assistant professor
author
Y
Nikiyan
Assistant professor
author
S
Farajzadeh
author
text
article
1997
eng
Vitiligo is a common idiopathic acquired cutaneous pigmentary disorder resulting in depigmented skin. A wide variety of therapeutic modalities have been employed for its treatment, but none of them are satisfactory, in this study we have tested the effect of 5- fluorouracil 5FU on 54 patients with documented vitiligo in Kerman city. The following treatments were performed on three selected vitiliginous lesions in each patient. A: only 5FU cream: B: epidermal abrasion and C: topical 5FU followed by epidermal abrasion, 5FU was applied once daily for 7-10 days and epidermal abrasion was done on the first day by a strile sand paper. The clinical and medical response was evaluated at the end of the treatment, and two and six weeks latter. The results of this study showed the effect of three methods as follow: dermabrasion plus topical 5FU 81.5℅ topical 5FU 20.4℅, and dermabrasion 7.4℅ . In general the topical application of 5FU followed by epidermal abrasion is capable to regenerate pigmentation in the most patients suffering from vitiligo including segmental lesions ( p<0.001) . The therapeutic response appeared whiting a short time ( less than 2 months) . Therefore this treatment modality is recommended for localized vitiligo and probably for the segmental lesions.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
110
116
https://jkmu.kmu.ac.ir/article_34305_65e3d15f730236262c690fe743cd80da.pdf
The early results of massive osteoarticular allograft in the surgical treatment of lower limb bone tumors
KH.M
Jamshidi
Assistant professor
author
M
Jebal-Ameli
Assistant professor
author
E
Ameri
Assistant professor
author
text
article
1997
eng
This is the early results of 20 cases of massive osteoarticular allograft performed for reconstruction of lower limb s after resection of bone tumors. These cases include 7 distal femur and hemiarticular ,6 proximal tibio and hemiarticular, 3 total knee joints and 4 proximal femur with total hip replacement. Bone allografts were taken at steril condition from early postmortum cadavers and stored at -85. Allograft were fixed by plate and screwss without autogenous bone grafting. Patients were followed up carefully for 6 to 18 months, complications include acute infection in one, chronic infection in 2. Failure of fixation in 1 and skin necrosis on allograft in 1 patient and no sign of severe immunologic reaction was observed. Overall the results was good in 15 patients(75℅).
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
117
122
https://jkmu.kmu.ac.ir/article_34306_d68ea9c679ae8c6c63779ef31c4ab6d6.pdf
Prevalence of varicocele in high school students in Kerman
A.A
Ketabchi
Assistant professor
author
text
article
1997
eng
This cross-sectional study planned to Investigate the prevalence of varicocele among students aged 14 to 17 years in Kerman. Six hundred students were chosen by multi-stage sampling and they were examined for presence of varicocele. The highest rate of prevalence was seen among 17 year old (13.33℅) and the lowest (6.67℅) in 14 year old students. 2.16℅ of the cases suffered from varicocele grade 1.6℅ from grade II and 1.5℅ from grade III. Atrophy of the testis was observed in 41℅ of the patients. Left side involvement was detected in 91.4℅ of the cases, and involvement of both sides was detected in 8.6℅ of cases with significant difference ( p<0.001). There was a positive relationships between age and the prevalence of the disorder. There was no statistically significant relationships between the order of male birth and the probability for developing varicocele.with regard to high prevalence rate of varicocele, and in order to prevent undesirable complications such as infertility ,it is advised to examine the boys annually for varicocele detection before entering high school and up to marriage.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
123
127
https://jkmu.kmu.ac.ir/article_34307_32beb2cf9ce27c83893aab59bd035daf.pdf
Prevalence study of goiter in 6-10 year old girls of Shiraz,1995
E
Setodeh-maram
Assistant professor
author
SH
Ravanshad
Assistant professor
author
sh
solimani
author
H.A
Mostavafi
Assistant professor
author
text
article
1997
eng
In this cross-sectional study, 1975 school girls age 6-10 were selected randomly by proportionate multi-stage cluster sampling method. Subjects underwent clinical examination for presence of Goiter. Clinical examination and classification of Goiter were made according to world health organization standard. Prevalence rate of Goiter in girls was 64.3 percent. Age specific prevalence rate of Goiter ( all grades) was highest (96℅) among 7 and 9 years old and lowest (53℅) among 8. Age specific prevalence rate of Goiter grades (1b and 2) was highest (℅54.6) ,at 9 years of age and lowest (38℅) at 8. Prevalence rates specific for different districts were compared, which was higher in districts with lower economic status. Girls whose fathers were illiterate had a significantly higher prevalence rate of Goiter (60.7℅), in comparison with girls whose fathers had university educations 34.3℅ ( p<0.001). A similar situation was observed with mother,s education. Girls whose mothers were illiterate had a prevalence rate of 71℅ while in girls whose mothers had university education was 55℅ . To measure inter observer reliability a random sample of subjects were reexamined by an endocrinologist, which showed 93.75℅ agreement between the two examiner.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
128
133
https://jkmu.kmu.ac.ir/article_34308_ac4f51851f5bacdad1ed92a6806afacd.pdf
The relationship between the tooth size, arch dimensions and dental crowding
B.A
Ramezanzadeh
Assistant professor
author
N
Shirvani
author
text
article
1997
eng
In this study two groups of dental study models were selected to evaluate the relationship between the tooth size, arch dimensions , and dental crowding. The first group consisting of 56 pairs of dental study models (28 males and 28 females) with normal occlusion ( without dental crowding) ranging in age from 16 to 20 years, were selected among 4445 students from Kerman by multi stage random sampling method. The second group consisting of 65 pairs of dental study models (12 males and 53 females) with class 1 malocclusion between the age of 16 to 26 years, were selected among the patients of three private orthodontic clinics and the orthodontic department of school of dentistry in Kerman. Mesiodistal tooth diameters, buccal and lingual dental arch widths, dental arch perimeter s and dental arch length measured in two groups. The student "t" test was used for statistical analysis of the relevant data.the tooth size in crowded group was generally larger than the noncrowded group, and the dental arch width was smaller in the crowded group. No significant differences were found in dental arch perimeters and dental arch length between the two groups. Therefore it seems that in the crowded group, dental crowding is caused by both excessively large teeth and excessively small dental arch widths especially in maxilla.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
134
141
https://jkmu.kmu.ac.ir/article_34309_9d926ebfa1569a9e68d260203d829853.pdf
Prevalence study of Goiter in 6-10 year old children of Khorramabad ,1995
E
Setodeh maram
Assistant professor
author
O.A
Paei
Tnstrutor
author
SH
Ravanshad
Assistant professor
author
A
Sadegh -Hasanabadi
Associate professor
author
text
article
1997
eng
In this cross-sectional study, 932 school boys and 927 school girls,6-10 years old of Khorramabad, Lorestan were selected randomly by proportionate multi-stage cluster sampling method. All students underwent clinical examination for presence of Goiter with the method and criteria recommended by world health organization ( WHO). Age specific prevalence rates of Goiter in boys 6 through 10 years, were 49.5-62.6-64-65.5 and 63.5 percent, and in girls were 70.6 -74 – 65.2- 70.4 and 80 percent respectively. Khorramabad is considered as a hyperenbemic area for Goiter. Comparison of prevalence rates in both sexes revealed that the rates were significantly higher in girls at all ages ( p<0.001). Also , total prevalence rates of Goiter in girls (72℅) and boys (61℅) were significantly different ( p<0.001). In different regions of the city the prevalence rates were more than 50℅ . Age specific prevalence rates in girls in groups of 6-8 years and 9-10 years and in boys in previous group were significantly different. Girl to boy sex ratio as an index of severity of endemia was 1.24 at age of 6 and 1.27 at age of 10. The results showed that the prevalence rates of Goiter in this area is significantly lower than the rate reported in 1989.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
142
147
https://jkmu.kmu.ac.ir/article_34310_ae4370ae2ccd9990b11983e00fcb90b6.pdf
Bipolar mood disorder ( manic phase) in a patient with neurofibromatosis type 1 with cerebral involvement
A.R
Gafari nejhad
Assistant professor
author
text
article
1997
eng
Even though neurofibromatosis ( NF) is not a rare neurological disorder, but there is few studies regarding the relationship between NF and psychological disorders. A 14 year old girl with NF type 1 associated with multiple cerebral lesions was admitted in psychiatric ward due to restlessness , hypertalktiveness aggressive behavior, and flight of idea. Psychiatric diagnosis, based on DSM IV was bipolar mood disorder ( Manic phase). Coincidental occurrence of mania and NF type I with cerebral involvement in a patient is spares and despite of absence of reports about classical mania in patients with NF type I, the possibility of secondary mood disorder followed by primary neurological disorder is discussed.
Journal of Kerman University of Medical Sciences
Kerman University of Medical Sciences
1023-9510
5
v.
3
no.
1997
148
152
https://jkmu.kmu.ac.ir/article_34311_d41e38336761250d21150e09f95ec220.pdf