@article { author = {Daneshpajooh, Azar and Mirzaei, Mahboubeh and Farsinejad, Alireza and Naghibzadeh-Tahami, Ahmad and Eslami, Atefe}, title = {The Effect of Periurethral Injection of Pure Platelet-rich Plasma in the Treatment of Urinary Incontinence in Female Patients: a randomized clinical trial}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {330-337}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91713}, abstract = {Background: Stress urinary incontinence is a prevalent condition among a large number of women and has a negative effect on their quality of life. One treatment option is the use of bio-injectable materials to enhance closing pressures. In this study, we aimed to investigate the effects of the periurethral injection of pure platelet-rich plasma on the treatment of stress urinary incontinence. Methods: This study was conducted as a randomized controlled clinical trial on 20 women with stress urinary incontinence. Ten patients received periurethral injections of pure platelet-rich plasma (experimental group), while ten patients received midurethral sling procedure as the standard treatment for stress urinary incontinence ((control group). Follow-up was performed one and three months after the treatment using the international consultation on incontinence questionnaire (ICIQ), incontinence quality of life (I-QOL) questionnaire, urogenital distress inventory (UDI-6), and cough stress test. Results: Out of ten patients in the experimental group, seven cases (70%) relatively recovered after the injection. Out of ten patients in the control group, eight patients completely recovered after the procedure. There was significant difference in the questionnaire results before and after treatments, which indicates the effectiveness of these treatments in both groups. However, the response to the midurethral sling procedure was better than the response to pure platelet-rich plasma injection, and the difference was statistically significant. Conclusion: The periurethral injection of a single dose of pure platelet-rich plasma could relatively eliminate the symptoms of stress urinary incontinence in patients. More definite results can be obtained with repeated doses of pure platelet-rich plasma, even compared with standard treatments.}, keywords = {Stress urinary incontinence,Platelet-rich plasma,Midurethral sling}, url = {https://jkmu.kmu.ac.ir/article_91713.html}, eprint = {https://jkmu.kmu.ac.ir/article_91713_a366b33c660e0f479aa7a1091ba9e8bb.pdf} } @article { author = {Samareh Fekri, Mitra and Gorgich, Amir and Bazrafshani, Maliheh Sadat and Mayel, Masoud}, title = {The Prevalence of Asthma-COPD Overlap Syndrome in Patients with Obstructive Airway Disease in Kerman, Iran}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {338-346}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91714}, abstract = {Background: The coexistence of asthma and chronic obstructive pulmonary disease (COPD) is recognized as asthma–COPD overlap syndrome (ACOS). This study aimed to investigate the prevalence of ACOS and the characteristics of the affected patients in terms of chronic pulmonary airway diseases in the southeastern Iran, Kerman.Methods: This cross-sectional study was conducted in Kerman province, Iran, from March 2017 to March 2018. 295 patients with a history of chronic pulmonary airway diseases including asthma and COPD were enrolled through convenience sampling. Spirometry was performed and forced expiratory volume (FEV1), forced vital capacity (FVC), and FEV1/FVC were calculated. The physician made the final diagnosis according to GOLD/GINA criteria. Chi-square, Fisher’s exact test, t-test, and Mann–Whitney U test were used to compare variables through SPSS version 23.Results: The ACOS prevalence was 36.9% (95% CI: 31.5- 42.7). Asthma patients were younger than ACOS patients (P = 0.001) and they had higher levels of FEV1 (P = 0.02), FEF (P ≤ 0.001), and FEV1/FVC (P ≤ 0.001) before receiving bronchodilator in comparison to ACOS patients. However, COPD patients were older than the ACOS patients (P ≤ 0.001). The lung function in ACOS patients before and after receiving bronchodilators was higher for FEV1 and FVC in COPD patients.Conclusion: The prevalence of ACOS was considerable. The present study showed that gender, age, and BMI could be associated with ACOS. The risk factors underlying ACOS and their impact on the patient’s life quality and treatment costs can be investigated by future studies.}, keywords = {Asthma,COPD,Iran,Asthma-COPD overlap syndrome}, url = {https://jkmu.kmu.ac.ir/article_91714.html}, eprint = {https://jkmu.kmu.ac.ir/article_91714_a976e5896901b7a2f0c8b92a64f36b1b.pdf} } @article { author = {Rami, Mohammad and Fathi, Mohammad and Rahmati, Masoud and Tabandeh, Mohammad Reza}, title = {Effect of 6-week Endurance Training on the Hippocampal Tissue in the Streptozotocin-Induced Diabetic Rats: A Histological Study}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {347-357}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91715}, abstract = {Background: Glial cells perform several critical functions and exercise can moderate many of these interventions, so a comprehensive study is needed to elucidate the mechanisms that influence brain function following diabetes and exercise. In this study, the quantitative histological changes of glial in the hippocampus of Streptozotocin (STZ)-induced diabetic rats following endurance training were investigated.Methods: Twenty-four adult male Wistar Rats (aged 10 weeks with an average weight of 256 ± 11.8 g), were classified into four groups: Diabetic, diabetic trained, untreated control, and trained groups. Diabetes was induced by a single dose intraperitoneal injection of Streptozotocin (45 mg/kg). Then, moderate exercise was performed for 6 weeks (5 sessions in a week). Rats were anesthetized 48 hours after the last training session. Then, they were sacrificed and the hippocampal tissue was removed. Sections (5-6 µ) were prepared and stained with Hematoxylin and Eosin (H & E) staining method.Results: Histological evaluations showed that the number of astrocyte and oligodendrocyte cells in different hippocampal regions in diabetic rats significantly decreased compared to the untreated control and trained rats. However, the number of microglia cells in diabetic rats was significantly higher than that in the untreated control and trained rats (P ˂ 0.05). In addition, the number of astrocytes and oligodendrocytes significantly increased in the dentate gyrus, Cornu Ammonis, and subiculum of the hippocampal tissue after endurance training compared to the control group, while the number of microglial cells significantly decreased (P < 0.05).Conclusion: The findings of the present study confirmed the potential effects of moderate exercise on diabetes. Therefore, it seems that physical activity plays an essential role in improving the nervous complications in patients with diabetes.}, keywords = {Endurance Training,Glial cells,Histological,Hippocampus,Diabetes}, url = {https://jkmu.kmu.ac.ir/article_91715.html}, eprint = {https://jkmu.kmu.ac.ir/article_91715_591a9b88af60f4a4706f7b15752a02bb.pdf} } @article { author = {Najafipour, Hamid and Sadeghi, Mohammad and Kordestani, Zeinab and Naghibzadeh-Tahami, Ahmad and Ghavipisheh, Marjan and Shadkam Farokhi, Mitra}, title = {The Prevalence of Musculoskeletal Pain Syndrome in 15-80 years old Population of Kerman: The Role of Smart Phone Use and its Related Factors}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {358-366}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91716}, abstract = {Background: Musculoskeletal pain syndromes (MSPS) are among the most common disorders of societies today. Excessive use and inappropriate posture when using mobile phones seem to play a role in MSPS. In this study, the relationship between mobile phones use and MSPS and its predictive factors in southeastern Iran, Kerman, was investigated.Method: This cross-sectional community-based study was performed on 1,135 people aged 15-80 years. A questionnaire containing demographic information, risk factors, musculoskeletal pain (types and symptoms), cell phone models, and the duration and how to use mobile phone in the preceding year, was completed.Results: 51.1% of the participants were male. The overall prevalence of MSP was 71.30%, which was higher in female subjects (86.5%) than male subjects (56.7%). The risk of MSPS in people who used a smartphone was 45% higher than those who did not use a smartphone (Adjusted Odds Ratio (AOR) = 1.45, 95% CI: 0.98-3.1). The AOR was 2.02 (1.36-3.01) in female subjects relative to male subjects and reached 2.38 (1.50-3.76) in the age group over 55 years. The AOR was 1.98 (95% CI: 1.05-3.73) in diabetic and depressed individuals, 1.65 (1.22-2.23) in obese people, 1.63 (1.12-2.36) in hypertensive individuals, 1.55 (1.23-1.96) in anxious individuals, 1.94 (1.1-3.35) in employed people, 3.08 (1.53-6.22) in housewives, and 0.68 (0.47-0.98) in people with high physical activity.Conclusion: 71% of the sample population of Kerman suffered from MSPS. The use of smartphones has contributed to this syndrome, and female gender, age, obesity, diabetes, hypertension, anxiety, depression, low physical activity, and being employed have exacerbated the disease. Taking educational measures regarding the rate of use and body position when using mobile phones is necessary.}, keywords = {musculoskeletal pain,Prevalence,Smartphone,Related factors,Kerman}, url = {https://jkmu.kmu.ac.ir/article_91716.html}, eprint = {https://jkmu.kmu.ac.ir/article_91716_ee0c45c40884b62f2117c91138c0e0a2.pdf} } @article { author = {Karimi-Afshar, Marzieh and Torabi, Molok and Abdollahi, Sara and Safarian, Mohammad Sadegh and Farsinejad, Alireza}, title = {A Comparative Study on the IL-8 Expression in Gingival Crevicular Fluid during Early Alignment Stage of Orthodontic Treatment in Adults and Adolescents}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {367-373}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91717}, abstract = {Bakground: Orthodontic tooth movement causes the release of various biomolecules such as interleukins. The aim of this study was to compare IL-8 expression in gingival crevicular fluid during early alignment stage of orthodontic treatment in adults and adolescents.Methods: The present study was done on 20 orthodontic patients, including 10 adolescents and 10 adults. Before bonding, gingival crevicular fluid (GCF) was collected with a paper strip in gingival sulcus of maxillary right central incisor on the distolabial aspect for 60 seconds, followed by bonding and insertion of initial 14 NiTi arch wire. GCF collection was repeated 24 hours, 7 days, and 28 days after bonding. The IL-8 levels was measured by the enzyme-linked immunosorbent assay (ELISA). Data were analyzed by SPSS version 21 using repeated measurement test. Statistically significant level was considered at P = 0.05.Results: In the present study, 14 patients (70%) were female and the rest were male. The mean age of the patients was 19.11 ± 6.23 years. The level of IL-8 at the baseline was higher than the other time periods, and on the first day after treatment, significantly decreased compared to the baseline. There was no statistically significant difference between age groups Conclusion: Theresults of the present study revealed that the level of IL-8 significantly decreased on the first day of orthodontic treatment, and then, increased. There was no statistically significant difference between gender and age and IL-8 levels during treatment. Further studies with larger sample sizes and different treatment methods are recommended.}, keywords = {cytokine,IL-8,Tooth movement,Orthodontic treatment,Gingival crevicular fluid}, url = {https://jkmu.kmu.ac.ir/article_91717.html}, eprint = {https://jkmu.kmu.ac.ir/article_91717_05bda164c7b60e2d07b2c6e01e954973.pdf} } @article { author = {Shahedi, Abbas and Anvari, Morteza and Mirjalili, Aghdas and Pourentezari, Majid}, title = {Attenuation of Detrimental Effects of Formaldehyde on Sperm Chromatin Quality and Rate of Apoptosis in Mice by Curcumin}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {374-381}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91718}, abstract = {Background: The present study aimed to evaluate the sperm chromatin quality and rate of apoptosis in formaldehyde (FA)-exposed mice and the possible protective effects of curcumin (Cur) on the fertility potential of spermatozoa.Methods: Twenty-four adult male NMRI mice were randomly divided into three groups: Group Ι (control), group ΙΙ (Sham) received Cur solvent (2 ml/day, intraperitoneal), group ΙΙΙ received FA (10 mg/kg, intraperitoneal), and group ΙV received FA+Cur (100 mg/kg, intraperitoneal). After 35 days, the spermatozoa from right cauda epididymis were analyzed using Chromomycin A3 (CMA3) and TUNEL staining.Result: Regarding CMA3 and TUNEL tests, the data revealed a significant increase (p <0.05) in control and sham groups compared to the FA and FA+Cur groups. There was also a significant decrease in CMA3 tests and apoptosis in FA+Cur group compared to FA group (p <0.05).Conclusion: Cur, as a potent antioxidant, can attenuate detrimental effects of FA on the chromatin quality and apoptosis in an experimental animal model.}, keywords = {Formaldehyde,curcumin,Chromatin quality,Apoptosis,Sperm,Mice}, url = {https://jkmu.kmu.ac.ir/article_91718.html}, eprint = {https://jkmu.kmu.ac.ir/article_91718_6a9b2752c19e481a23e7ddc66ddbc602.pdf} } @article { author = {Ghorbani, Soolmaz and Mollaei, Hamidreza and Mirshekari, Tourajreza and Ahmadipour, Habibeh and Arabi mianroodi, Ali asghar and Iranmanesh, Kimia and Khanjani, Narges}, title = {Frequency of Human Papillomavirus Genotypes in Head and Neck Epithelial Cancers in the Ear, Throat, and Nose Department of Shafa Hospital, Kerman, Iran in 2017}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {382-390}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91719}, abstract = {Background: Human papillomavirus virus (HPV) plays an important role in some human malignancies, including head and neck squamous cell carcinoma (SCC). However, it is necessary to evaluate the role of carcinogenic agents in local settings as well. Therefore, this study aimed to evaluate the frequency of HPV genotypes in head and neck epithelial cancers.Methods: In this case-control study, 202 patients with suspected carcinoma referred to Shafa Hospital (Kerman, Iran, 2017) for pathological evaluation were enrolled. A definitive diagnosis of carcinoma was reported for 101 patients (case group) and in the other 101 subjects, carcinoma was not diagnosed. In order to determine the presence and type of HPV in tissue samples, the PCR method was used. Data analysis was performed using Fisher’s exact test, independent t-test, and logistic regression. Results: In total, 27 head and neck SCC samples (26.7%) were positive for HPV DNA. In addition, the virus species were HPV-11 in 15 cases (14.9%), HPV-16 and HPV-18 in 12 cases (11.9%), and HPV-6 in 10 cases (9.9%). According to the results, the presence of HPV was significantly higher in patients with SCC (P < 0.001). Moreover, smoking (P = 0.03) and opioid use (P < 0.001) were also significantly associated with SCC.Conclusion: The results of the present study demonstrated the presence of HPV in tissue samples of head and neck SCC patients in Kerman, Iran. Further studies are needed to investigate the preventive role of HPV vaccination in head and neck SCC.}, keywords = {HPV,Head and neck cancers,Kerman}, url = {https://jkmu.kmu.ac.ir/article_91719.html}, eprint = {https://jkmu.kmu.ac.ir/article_91719_5aa3592d7d4ab351b84f0df3151877ad.pdf} } @article { author = {Mirahmadi, Hadi and Mehravaran, Ahmad and sani Haidari, Masoumeh and Rahmati-Balaghaleh, Mansour and Raissi, Vahid and shafiei, Reza}, title = {Serological and Molecular Survey of Toxoplasma gondii Infection in Hemodialysis Patients with Chronic Renal Disease in Zahedan, Iran}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {391-398}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91720}, abstract = {Background: Toxoplasma gondii is one of the most prevalent zoonotic opportunistic parasitic infections in the world. The aim of this study was to examine chronic and acute toxoplasmosis molecularly and serologically in Hemodialysis patients.Methods: A total of 238 serum samples of hemodialysis patients with chronic renal disease (119 samples) as case group and healthy individuals (119 samples) as control group were enrolled in Zahedan City, southeastern Iran. The molecular and serological detection of toxoplasmosis were conducted on all samples using nested-PCR and ELISA.Results: The prevalence rates of anti-T. gondii IgM and IgG and T. gondii DNA in the case group were respectively 0%, 44.5% and 29.4% and the corresponding values in the control group were 0.8%,23.5% and 2.52 % respectively (p≥0.05).Conclusion: In conclusion, preliminary Toxoplasma gondii infection screening is required using serological techniques, particularly in hemodialysis patients who are frequently exposed to hemodialysis so as to stop infection dissemination.}, keywords = {Toxoplasma,Hemodialysis patients,Nested-PCR,Zahedan}, url = {https://jkmu.kmu.ac.ir/article_91720.html}, eprint = {https://jkmu.kmu.ac.ir/article_91720_db4d042386f66e24fe61a34f0a2e931e.pdf} } @article { author = {Sarabadani, Javad and Samiee, Negin}, title = {Suppressing Gag Reflex with Low-Level Laser Therapy on Acupoint PC6: A Case Report}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {399-403}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91721}, abstract = {Background: Gag reflex is a common problem in dental procedures such as pediatric patients, third molar extraction, periodontal surgery, taking radiography, oral examination, and alginate impression. Among different anti-gagging methods, laser acupuncture that use low-level laser therapy (LLLT) or photobiomodulation seems to be the newest and most practical method. Case report: Here, we report pericard 6 (PC6) point laser acupuncture as a practical chairside method to suppress gagging in our patient just before scaling and root planning (SRP). Results: Our case was a 33-year-old man who had sever gag reflex, and therefore, could not receive dental care in his whole life. His dentist scheduled to do scaling and surgically extract his third molar. We controlled the gag reflex successfully by stimulating PC6 point on his wrist with Diode LASER. SRP and extraction of third molar were done at the same session. Conclusion: LLLT acupuncture is a preferred method due to less chair time, low invasiveness, and high safety compared to other methods. The acupoint P6 seems to be more practical than other anti-gaging points in dentistry as it is accessible when patient is on dental unit.}, keywords = {Low-level laser therapy,Gagging,Acupuncture,Dentistry}, url = {https://jkmu.kmu.ac.ir/article_91721.html}, eprint = {https://jkmu.kmu.ac.ir/article_91721_1ea2c9a259a8e1f93bf015c42ac7b6fa.pdf} } @article { author = {Tavasoli, Azita and Hakim Shooshtari, Mitra and Parvini, Behnaz}, title = {Autoimmune Encephalitis: Report of Two Pediatric Cases}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {404-408}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91722}, abstract = {Background: Autoimmune encephalitis (AIE) with neural cell autoantibodies is a treatable category of non-viral encephalitis in children and adolescents which presents with neuropsychiatric manifestations. Anti-N-methyl- D-aspartate receptor encephalitis, the most common identified type of AIE, is more frequent than individual viral encephalitis in young patients. Early diagnosis and treatment of the disease have been associated with improvement in the majority of patients.Case Report: we report two pediatric cases with acute neuropsychiatric presentations in whom the diagnosis of AIE was proved based on the cerebrospinal fluid (CSF) antineuronal antibodies in one and on clinical and paraclinical grounds in another seronegative patient. Immunotherapy in both patients resulted in improvement. No underlying tumor was found in patients.Pediatricians should be aware of manifestations, investigations, and treatment of AIE and consider it as the differential diagnosis of encephalitis.}, keywords = {Autoimmune encephalitis,Anti-N-Methyl-D-Aspartate Receptor Encephalitis,Pediatrics,Encephalitis,Immune-mediated encephalitis}, url = {https://jkmu.kmu.ac.ir/article_91722.html}, eprint = {https://jkmu.kmu.ac.ir/article_91722_db4e3c438ee019861c61efa6b025a74c.pdf} } @article { author = {Parvaresh, Saeedeh and Nikpour, Hossein and Hosseininasab, Ali and Sinaei, Reza and Jafari, Maedeh}, title = {A Case Report of Tuberculosis with Ascites}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {409-411}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91723}, abstract = {Background: Tuberculosis is a highly contagious infectious disease caused by mycobacterium tuberculosis. This disease is mostly recognized as a pulmonary disorder but it can be transmitted to other parts of the body by blood. The most common extra pulmonary sites, including lymph nodes, abdomen, pleura, and abdominal tuberculosis, are less common than pulmonary tuberculosis. Given the importance of tuberculosis, a rare case of tuberculosis was reported.Case Report: A 13-year-old girl was admitted to Afzalipour hospital, Kerman, because of fever and abdominal pain. Her fever started from two weeks ago and generalized abdominal pain started a week ago. Ultrasound and abdominal CT scan showed fluid accumulation in the abdominal cavity. The result of chronic granuloma pathology was reported in favor of mycobacterium tuberculosis, and PCR test of pleural tuberculosis was positive. She was treated empirically with Isoniazid, Rifampin, Ethambutol, and Pyrazinamide. She was visited a month later. Her general condition was good and the clinical symptoms disappeared.}, keywords = {Mycobacterium tuberculosis,Fever,Ascites}, url = {https://jkmu.kmu.ac.ir/article_91723.html}, eprint = {https://jkmu.kmu.ac.ir/article_91723_37f0e1c8342baf5491da07b003b59c14.pdf} } @article { author = {Masoori, Leila and Molazadeh, Morteza and Rezaei, Nahid and Alizadeh, Somaye and Hassanpour, Hamid and Badirzadeh, Alireza}, title = {Development of Rheumatoid Arthritis by Toxoplasmosis in Iranian Patients}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {412-419}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91724}, abstract = {Background: Toxoplasma gondii (T. gondii) is an intracellular protozoan parasite capable of infecting approximately one-third of the world human population. In this study, the seroprevalence of Toxoplasma gondii (T. gondii) antibodies in Iranian patients with rheumatoid arthritis was investigated, given the lack of information on the magnitude of toxoplasmosis in these patients.Methods: The serum was collected from patients with rheumatoid arthritis (n = 93) and a healthy control group (n = 93) from central parts of Iran to investigate the prevalence of anti-T. gondii IgG and IgM antibodies.Results: Anti-T. gondii IgG was detected among 76 of 93 patients with rheumatoid arthritis (81.72%) versus 37 of 93 healthy control group (39.80%), and it was higher among patients with rheumatoid arthritis than controls. The seroprevalence of anti-T. gondii IgM was significantly higher in patients with rheumatoid arthritis (36 of 93; 38.70%) compared to the healthy control group (2 of 93; 2.1%). Demographic variables (age and sex) did not have significant correlations in patients with rheumatoid arthritis who were positive for T. gondii infection.Conclusion: The findings of the present study provide efficient evidence that confirm the association between toxoplasmosis and development of rheumatoid arthritis, suggesting that Toxoplasma may contribute to the rheumatoid arthritis pathogenesis.}, keywords = {Toxoplasma gondii,Autoimmunity,Rheumatoid Arthritis,Iran,Immune system}, url = {https://jkmu.kmu.ac.ir/article_91724.html}, eprint = {https://jkmu.kmu.ac.ir/article_91724_e83681d953c7eee380dfb42095bac07d.pdf} } @article { author = {Barati, Mahmood and Gholipourmalekabadi, Mazaher and Ranjbari, Javad and Shakib, Pegah and Bahar, Mohammad Ali and Samadikuchaksaraei, Ali}, title = {Antibiotic Resistance Pattern and Molecular Typing by PCR-RAPD Analysis in Clinical Isolates of Pseudomonas aeruginosa from Motahari Hospital, Tehran, Iran}, journal = {Journal of Kerman University of Medical Sciences}, volume = {28}, number = {4}, pages = {420-426}, year = {2021}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {10.22062/jkmu.2021.91725}, abstract = {Background: Pseudomonas aeruginosa infection is one of the major challenges in burn patients. This organism is resistant to a wide range of antibiotics. The aim of this study was to investigate the antibiotic susceptibility and genetic relatedness in Pseudomonas aeruginosa isolated from patients admitted to Motahari Burn Center, Tehran, Iran.Methods: This study was conducted on 186 burn patients with Pseudomonas aeruginosa colonization following admission in Motahari Burn Center during one year. Antibiotic resistance test was performed by disc diffusion method and genetic relatedness was evaluated by PCR-RAPD analysis.Results: The highest and lowest percentage of resistance was observed against ceftizoxime and ciprofloxacin. The genotyping study by RAPD PCR technique revealed 57 different genotypes, among which RAPD 5, RAPD 8, and RAPD 9 were the most prevalent patterns and produced by 14%, 9%, and 7% of the isolates, respectively.Conclusion: In total, no association was found between RAPD genotypes and antibiotic resistance patterns, and death rate.}, keywords = {RAPD PCR,Pseudomonas aeruginosa,Antibiotic Resistance,Genotypes}, url = {https://jkmu.kmu.ac.ir/article_91725.html}, eprint = {https://jkmu.kmu.ac.ir/article_91725_2e3fc8db78b1bf8ebaa74640dba1b5d8.pdf} }