@article { author = {Bahrami, GH.R and Rahi, H}, title = {The remonal effect of hydrogenated shortening on serum levels of triglycerids,total cholesterol and HDL-cholesterol in normal subjects}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {103-109}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {In Iran,the hydrogenated vegetable oil have content of frans fatty acids and high per capita consumption.this study was aimed to evaliate the effects of substitution of hydrogenated oil by sunflower liquid oil on plasma levels of LDL,HDL, total cholestero and triglycerids in normal subjects.thirty six healthy inmates participated in this research. they were consuming hydrogenated oil before the study,and were maintained on sunflower diet for one month.then they were switched to hydrogenated oil regimen for the next two months.blood samples were collected for meansuring the levels of HDL-cholesterol, LDL-cholesterol ,total cholesterol and triglycerids at the beginning anad 15 days intervals during the study.the results showed that omission of hydrogenated oil from the diet significantly increases the serum HDL-cholesterol (p<0.001) level and reswitching from sunflower oil to shortening regimen reverts such beneficial effects.no significant difference was observed for the other measured parameters between the two lipid regimens.}, keywords = {Trans fatty acids,Cholesterol,shottening,Oil}, url = {https://jkmu.kmu.ac.ir/article_34247.html}, eprint = {https://jkmu.kmu.ac.ir/article_34247_80d49bdbc81a21b31dbb9abe37b7147b.pdf} } @article { author = {Vahidi, A.A and Taheri, A and Niliyan, Y}, title = {Prevalence of hepatitis C among thalassemic patients reffering to Kerman university of medical sciences hospital NO:1 in 1996}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {110-114}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {this prospective case-control study was carried out to evaluate the Prevalence of positive cases of anti-HCV Ab in 107 thalassemic patients  and 107 children without any previous history of blood transfusion as a control group.ELISA GENERATION II was used for serologic investigation and then positive cases were confiemed  by RIBA generation I.the average age of thalassemic patients was 9.2+_4.3 years and those of control group was 8.9+_4.2 years.45.1% of the case group and 39.2% of the control group were female and 54.9% of the case group and 60.8% of the control group were male.Anti-HVC Ab was positive in 22.4% of the thalassemic patients  while there was no positive case in the control group and the difference was statistically significant(p<0.001).the average number of transfusions was 104+_58.2 in anti-HCV Ab positive  thalassemic patients and 85.3+_50.6 in anti-HCV Ab negative patients and the difference was not statistically significant(p=0.126).According to the results of this study,the prevalence of contamination with HCV was zero in normal population of Kernanian children and 22.4% in  thalassemic patients.therefore screening of donated bloods for anti-HCV Ab in order to eliminate the contaminated bloods has a significant bimportant in preventing HCV transmission in highrisk group.  }, keywords = {thalassemic,Hepatitis C,anti-HCV Ab,Blood transfusion}, url = {https://jkmu.kmu.ac.ir/article_34248.html}, eprint = {https://jkmu.kmu.ac.ir/article_34248_a0b289e134265e77e1648f5b9f7e68e4.pdf} } @article { author = {SHaraki, M.R and Zahediasl, S and Sarkaki, A.R}, title = {The effect of Aluminium chloride injection in arcuate nucleus on sperm count and the weight of vas deferens and epididymis in rat}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {115-121}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Aluminium is a blocker of voltage sensitive cakcium channels which intere the body from different soueces.this ion interferes with biological function of Ca++ion.because GnRH synthesis,secretion and spermatogenesis on vas deferens and epididymis sperm count and weight of these organs in male rats.the study was performed on four group of rats(n=49),in whom the arcuate nuleus was bilateraly cannulated by sterotaxic surgery.test group recieved 100 nl ACSF containing 0.15 pmol aluminiym in each side of the arcuate nucleus for 20 days.two groups of animals were recieve the same volume of ACSF with PH=7.2 and 3.4. the sham control group did not recieve any agent after cannulation.at the end of experiment ,animals were anethetised with nesdonal(sodium thiopental) and then vas deferens and epididymis were removed and weighted.these organs were cut and diluted with normal saline.sperms were counted by chmocytometer and calculated per gram of tissuse.results showed that sperm count per gram of tissue in vas deferens and epididymis control group were 107.9+_2.5,76.2+_16.3 million and in test group 45.0+_2.9,67.3+_4.9 million respectively (p<0.05).the weight of these organs in AICI3 group were 103.5+_5.01,462.3+_19.2 mg,and in control group were 117.5+_2.5,515+_16.3 mg respectively.the value of testosterone in control and test groups were 2.11+_0.4,0.8+_0.28 ng/ml (p<0.05).overall the results indicate that injection of aluminium in male rat arcuate nucleus,can decrease sperm count in vas deferens and epididymis.in addition the weight of this organs and serum testosterone were also decreased.}, keywords = {Aluminium,arcuate nucleus,deferens,epididymis,sperm count,testosterone}, url = {https://jkmu.kmu.ac.ir/article_34249.html}, eprint = {https://jkmu.kmu.ac.ir/article_34249_29ee0d871471debba9e83e70d0de00fc.pdf} } @article { author = {Eftekhari, N and Mohammad- Alizadeh, S and Hakimi, F}, title = {Comparison of labor induction in normal and preeclamptic women admitted to delivery ward of Shahid Bahonar hospital in Kerman}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {122-128}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {The purpose of this case-control study was to compare successful  labor induction between preeclamptic and non-preeclamptic women admitted to delivery ward of Shahid Bahonar hospital.200 preeclamptic women were selected as case and 200 non-preeclamptic as control group and received labor induction.two groups were similar regarding to age,parity,gravidity,abortion,first and second phase induction,and bishop score of cervix,but there was significant differences based on gestational age (p<0.0001) and membrane ruptuer(p<0.0001).Gestational age and ruptured membrane of preeclamptic women were less than non-preeclamptics.successful induction in preeclamptic and non-preeclamptic  women occured 53.5% and 77% respectively and this difference was significant(p<0.0001).in two groups there was significant differenc in successful induction with bishop score(p<0.01 and p<0.001 respectively),so that the higher bishop score was with higher successful labor.in summary,induction of labor in preeclamptic women may carry a higher risk of failed induction and of cesarean delivery compared to non-preeclamptic women .}, keywords = {Labor induction,Pregnancy,preeclamptic,Bishop score of cervix}, url = {https://jkmu.kmu.ac.ir/article_34250.html}, eprint = {https://jkmu.kmu.ac.ir/article_34250_cd3fda517891cdf7951964367fbb97cd.pdf} } @article { author = {Keshavarz, H and Mamishi, S and Daneshvar, H}, title = {The prevalence of Toxoplasma infection in hospitalized patients in selected hospitals of Kerman.}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {129-136}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Toxoplasmosis is a disease caused by a ubiquitous,obilgate intrace;;ular protozoan"Toxoplasma gondii".the present study was undertaken to determine the prevalence of Toxoplasma infection in Kerman province of Iran.Atotal of 690 bllod samples,collected from patients in Kerman hospitals were serologically tested by indirect fluorescent antibody technique(IFA) for Toxoplasma antibadies.46.9 percent of the samples were found positive with antibody titers of 1:16 and higher.for nall ages the prevalence in males(48.6%) is not significantly different from the prevalence of 44.9% in females.Although there seems be a trend toward increasing seropositivity with increasing age,there was no statistical significance increas in the prevalence of seropositivity with increasing age.the highest prevalence rate (52.5%) was observed in the age group of 10-19 years with GMRT (Geometric Mean of reciprocal titer)77-4.noassociation was found between the seropositivity rate and contact with domestic cats.also,there was no significant correlation between the consumption of improperly cooked meat and seropositivity rates.}, keywords = {Prevalence,Toxoplasma,Human}, url = {https://jkmu.kmu.ac.ir/article_34251.html}, eprint = {https://jkmu.kmu.ac.ir/article_34251_b6dbae7b44a452b0465a1179a7e3d291.pdf} } @article { author = {Mohammadi, M and Alameh, A.A and Nori-Daloii, M.R}, title = {Metabolic activation and DNA adduct formation of Benzo(a) pyrene by adult and newborn rat skin and liver microsomes}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {137-144}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Benzo(a) pyrene is a carcinigen polycyclic aromatic hydrocarbon which diffuses into the environment from combustion of organic meterials.based on various epidemiological evidences it is related to lung,skin and liver cancer.mutagenicity,and immunosuppressivety are among important biological effects of Benzo(a) pyrene.after absorbtion and distribution in the body,it undergoes epoxidation by cytochrome P-450 system in the cells.some of the electrophilic metabolites covalently bind to cellular macromolecules and in particular to DNA. its metabolites are partially detoxified conjunction to cellular glutathione (GSH),glucoronic acid,and sulphate.biological effects of B(a) P and its metabolits depent on various factors such as species,age,sex,tissue,diet,dose,genetic system,etc.the fundemental physiological difference between newborns and adults are variations in susceptibility to chemical carcinogens observed between the two age groups.in this paper we studied the level of binding of B?(A)p to calf thymus DNA and formation of DNA adduct in the incubation systems which contained adilt and newborn rat liver and skin microsomes.results indicate that in both age groups liver microsomes in comparison to skin microsomes cause a higher increase in the level of DNA addult and the ratio of DNA aduct in the liver of adults compared to animal skin was 4.2 to 1.the quatity of adduct in the incubation systems containing liver microsomes of newborn was 1-51 higher than that of skin microsomes.Moreover phenobarbiton failed to induce cytochrome p-450 and any increase in DNA adduct level of B(a)P in the newborns rat.the level of Cytochrome P-450 in adult liver was 2.86 times higher than that in newborns, liver.}, keywords = {Benzo(a) pyrene,DNA,Newborn,adult,Phenobarbiton}, url = {https://jkmu.kmu.ac.ir/article_34252.html}, eprint = {https://jkmu.kmu.ac.ir/article_34252_43995aa17a3e8ff32f99ca9df079059e.pdf} } @article { author = {Moghadam nia, A.A and Kavosi, A and Daliri hampa, A}, title = {Formulation of oral mucoadhesive form of alum and its clinical assessment}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {145-151}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Alum had been used in traditional medicine for treatment of oral lesions in Iran.the main aim of this study was to find out a suitable formulation for the mucoadhesive fprm of alum.in this study some materials such as alum,carboxymethyl cellulose  (CMC) and Arabic Gum were used.different bases of gum and CMC were made and titration of alum was performed with suitable vbuffer and the rate of water absorption from gingive was used as an index of active ingredient release.the mean weight of released alum with CMC  base(10% alum) at minute 60 compared to minutes 15,30,90,120 and alum 10% with Gum base in minutes 15,30,60.90 each compared to minute of 120 showed significant differences (P<0.01).also the mean weight of released alum with CMC base(10% alum) in minute 60 compared to alum with Gum base in minute 15,30,60,90,120 showed significant differences (p<0.01)the volume increasing of patches after 60 minutes in Gum was 1.5 times more compared to those of CMC.threr were significant differnces between mean weight avrieations at minutes 20,40,60,(p<0.05).on the basis of these findings,the best for formulation of alum is Gum base with alum 2% using up to 30 minutes and CMC base with alum 10% using up to 15 MINUTES.}, keywords = {Formulation,mucoadhesive,Alum,release,carboxymethyl cellulose,Gum}, url = {https://jkmu.kmu.ac.ir/article_34253.html}, eprint = {https://jkmu.kmu.ac.ir/article_34253_6633e00b4e06b02b0526988e7cac5bda.pdf} } @article { author = {Zahedi, M.J and Darvish-Moghadam, S and Abdirad, A}, title = {Acase report of primary amyloidosis with prominent hepatic involvement}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {152-157}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {primary amyloidosis is a rare disrder wihich is diagnosed by extracellular deposition of proteinaceous material in different organs.in this report,a case of this disease with prominent hepatic involvement is presented.the case is a 63 years old male refered with abdominal enlargement,weight loss,generalized pruritus,anorexia and vague abdominal pain started from six months ago.on physical examination excoriation mark and hepatomegaly with liver span about 20cm were noted.jaundice,splenomegaly,ascitis,edema and skin lesions were absent.based on labaratory report there were an increase in alkaline phosphatase 3 times above the norman range and mild elevation in aminotranferases.proteinuria was 2.7 grams in 24hr uring collection.liver biopsy revealed homogenous and amorphous deposition of extracellular material with green birefregence in congo red staining.therefore the diagnosis of primary amyloidosis after exclusion of other causes was comfirmed.}, keywords = {primary amyloidosis}, url = {https://jkmu.kmu.ac.ir/article_34254.html}, eprint = {https://jkmu.kmu.ac.ir/article_34254_6ae3ce7aa555315a13df38b3c8a6959a.pdf} } @article { author = {Yarmohammadi, A.A}, title = {Fournier,s gangrene in children:report of two cases}, journal = {Journal of Kerman University of Medical Sciences}, volume = {7}, number = {3}, pages = {157-160}, year = {2000}, publisher = {Kerman University of Medical Sciences}, issn = {1023-9510}, eissn = {2008-2843}, doi = {}, abstract = {Fournier,s gangrene as an infectious necrotizing fascitis of the genitalia is A RARE UROLOGIC EMERGENCY.pediatric cases have been successfully managed with a more conservative surgical approach and have had a significant lower mortality rate compared to adults.in spite of this fact we report two cases in two 6 and 7 year old boys following circumcision which ended up in death.failure in treatment was due to late reffering and diabetes in one of them}, keywords = {Gangrene,circumcision,children}, url = {https://jkmu.kmu.ac.ir/article_34255.html}, eprint = {https://jkmu.kmu.ac.ir/article_34255_8800c0644e4da4a6142d237a88c4f4a6.pdf} }