ORIGINAL_ARTICLE
Thermostabilized chondroitinase ABC Promotes Neuroprotection after Contusion Spinal Cord Injury
Background: Chondroitinase ABC (cABC), due to its loosening impact on the extracellular matrix scaffold, has been used to enhance regeneration of injured axonal tracts after spinal cord injury (SCI). However, cABC thermal instability at physiological temperature has limited its clinical application. The disaccharide trehalose has been shown to increase the stability of cABC in body temperature. Therefore, the present study was conducted to assess the effect of combined trehalose and cABC on inflammation, lipid peroxidation and histopathological changes following SCI. Methods: Male Wistar rats were randomized into six groups (n=12) including sham, SCI, vehicle, trehalose, cABC and trehalose + cABC. In sham group, only laminectomy was performed. Other groups underwent laminectomy followed by contusion spinal cord injury. Twenty four hours after treatment, the level of IL-1β, Myeloperoxidase (MPO) and Malondialdehyde (MDA) were measured. Histopathological changes were also scored. Results: Spinal cord injury in rats resulted in severe trauma characterized by increase in inflammation, oxidative stress, neutrophils infiltration, hemorrhage, necrosis and edema. The levels of IL-1β, MDA and MPO were 260.3±16.4 nmol/mg protein, 1.2±0.06 mU/mg protein and 18.9±0.7 pg/mg protein, respectively in the vehicle group. However, combined treatment with cABC and trehalose reduced the amount of these factors significantly to 142.4±17 nmol/mg protein, 0.57±0.03 mU/mg protein and 13.8±0.4 pg/mg protein, respectively (p <0.05). In addition, treatment with cABC and trehalose improved histopathological alterations. Conclusions: The present data suggest that coadministration of trehalose and cABC exhibits neuroprotection effect through reducing inflammation and tissue injury events associated with SCI.
https://jkmu.kmu.ac.ir/article_91469_70ac4c381a27583515d71921eb46495a.pdf
2020-09-01
369
379
10.22062/jkmu.2020.91469
Chondroitinase ABC
Trehalose
Spinal cord injury
Neuroprotection
Mahboobe
Akbari
mahboobe.akbari67@gmail.com
1
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Shahriar
Dabiri
2
Professor, Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohammad Mehdi
Moeini-Aghtaei
moini_m@yahoo.com
3
Assistant Professor, Stem Cells Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mahdieh
Nazari-Robati
mnazari@kmu.ac.ir
4
Assistant Professor, Department of Clinical Biochemistry, Faculty of Medicine, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Ahuja CS, Wilson JR, Nori S, Kotter MR, Druschel C, Curt A, et al. Traumatic spinal cord injury. Nat Rev Dis Primers 2017; 3:17018.
1
Putatunda R, Bethea JR, Hu WH. Potential immunotherapies for traumatic brain and spinal cord injury. Chinese Journal of Traumatology 2018; 21(3):125-36.
2
Gensel JC, Zhang B. Macrophage activation and its role in repair and pathology after spinal cord injury. Brain Res 2015; 1619:1-11.
3
Fitch MT, Silver J. CNS injury, glial scars, and inflammation: Inhibitory extracellular matrices and regeneration failure. Exp Neurol 2008; 209(2):294-301.
4
Holmberg E, Zhang SX, Sarmiere PD, Kluge BR, White JT, Doolen S. Statins decrease chondroitin sulfate proteoglycan expression and acute astrocyte activation in central nervous system injury. Exp Neurol 2008; 214(1):78-86.
5
Huang WC, Kuo WC, Cherng JH, Hsu SH, Chen PR, Huang SH, et al. Chondroitinase ABC promotes axonal re-growth and behavior recovery in spinal cord injury. Biochem Bioph Res Co 2006; 349(3):963-8.
6
Kanno H, Pressman Y, Moody A, Berg R, Muir EM, Rogers JH, et al. Combination of engineered Schwann cell grafts to secrete neurotrophin and chondroitinase promotes axonal regeneration and locomotion after spinal cord injury. J Neurosci 2014; 34(5):1838-55.
7
Lee H, McKeon RJ, Bellamkonda RV. Sustained delivery of thermostabilized chABC enhances axonal sprouting and functional recovery after spinal cord injury. Proc Natl Acad Sci USA 2010; 107(8):3340-5.
8
Nazari-Robati M, Khajeh K, Aminian M, Fathi-Roudsari M, Golestani A. Co-solvent mediated thermal stabilization of chondroitinase ABC I form Proteus vulgaris. Int J Biol Macromol 2012; 50(3):487-92.
9
Richards AB, Krakowka S, Dexter LB, Schmid H, Wolterbeek AP, Waalkens-Berendsen DH, et al. Trehalose: a review of properties, history of use and human tolerance, and results of multiple safety studies. Food Chem Toxicol 2002; 40(7):871-98.
10
Jain NK, Roy I. Effect of trehalose on protein structure. Protein Sci 2009; 18(1):24-36.
11
Echigo R, Shimohata N, Karatsu K, Yano F, Kayasuga-Kariya Y, Fujisawa A, et al. Trehalose treatment suppresses inflammation, oxidative stress, and vasospasm induced by experimental subarachnoid hemorrhage. J Transl Med 2012; 10:80.
12
Cejka C, Kossl J, Hermankova B, Holan V, Kubinova S, Olmiere C, et al. The healing of oxidative injuries with trehalose in UVB-Irradiated rabbit corneas. Oxid Med Cell Longev 2019; 2019:1-10.
13
Nasouti R, Khaksari M, Mirzaee M, Nazari-Robati M. Trehalose protects against spinal cord injury through regulating heat shock proteins 27 and 70 and caspase-3 genes expression. J Basic Clin Physiol Pharmacol 2019; 31(1):1-8.
14
Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, et al. Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 2006; 26(42):10856-67.
15
Zhang D, Ma G, Hou M, Zhang T, Chen L, Zhao C. The neuroprotective effect of puerarin in acute spinal cord injury rats. Cell Physiol Biochem 2016; 39(3):1152-64.
16
Bradley PP, Priebat DA, Christensen RD, Rothstein G. Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J Inv Dermatol 1982; 78(3):206-9.
17
Esterbauer H, Cheeseman KH. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Method Enzymol 1990; 186:407-21.
18
Kahveci R, Gokce EC, Gurer B, Gokce A, Kisa U, Cemil DB, et al. Neuroprotective effects of rosuvastatin against traumatic spinal cord injury in rats. Eur J Pharmacol 2014; 741:45-54.
19
Ahmed A, Patil AA, Agrawal DK. Immunobiology of spinal cord injuries and potential therapeutic approaches. Mol Cell Biochem 2018; 441(1-2):181-9.
20
Bao F, Chen Y, Dekaban GA, Weaver LC. Early anti-inflammatory treatment reduces lipid peroxidation and protein nitration after spinal cord injury in rats. J Neurochem 2004; 88(6):1335-44.
21
Cheng CH, Lin CT, Lee MJ, Tsai MJ, Huang WH, Huang MC, et al. Local delivery of high-dose chondroitinase abc in the sub-acute stage promotes axonal outgrowth and functional recovery after complete spinal cord transection. PloS one 2015; 10(9):e0138705.
22
Bartus K, James ND, Bosch KD, Bradbury EJ. Chondroitin sulphate proteoglycans: key modulators of spinal cord and brain plasticity. Exp Neurol 2012; 235(1):5-17.
23
Burke SJ, Lu D, Sparer TE, Karlstad MD, Collier JJ. Transcription of the gene encoding TNF-alpha is increased by IL-1beta in rat and human islets and beta-cell lines. Mol Immunol 2014; 62(1):54-62.
24
Boato F, Rosenberger K, Nelissen S, Geboes L, Peters EM, Nitsch R, et al. Absence of IL-1beta positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury. J Neuroinflammation 2013; 10:6.
25
Neirinckx V, Coste C, Franzen R, Gothot A, Rogister B, Wislet S. Neutrophil contribution to spinal cord injury and repair. J Neuroinflammation 2014; 11:150.
26
Lee SM, Rosen S, Weinstein P, van Rooijen N, Noble-Haeusslein LJ. Prevention of both neutrophil and monocyte recruitment promotes recovery after spinal cord injury. J Neurotrauma 2011; 28(9):1893-907.
27
Hall ED, Wang JA, Bosken JM, Singh IN. Lipid peroxidation in brain or spinal cord mitochondria after injury. J Bioenerg Biomembr 2016; 48(2):169-74.
28
Nazari Robati M, Norouzi A, Nasouti R. Effect of Trehalose on the Expression of Heat Shock Protein 70 Gene in PC12 Cells Treated with Hydrogen Peroxide. J Mazandaran Univ Med Sci 2019; 29(172):1-9. [In Persian].
29
Taya K, Hirose K, Hamada S. Trehalose inhibits inflammatory cytokine production by protecting IkappaB-alpha reduction in mouse peritoneal macrophages. Arch Oral Biol 2009; 54(8):749-56.
30
ORIGINAL_ARTICLE
Smoking Habits, Stress, and Physical Activity in relation to Diabetes Mellitus: a nationwide study in Indonesia
Background: Diabetes mellitus remains a primary chronic disease all around the world, including Indonesia. A poor lifestyle that includes smoking habits, stress, and lack of physical activities will increase the incidence of diabetes mellitus.This study aimed to explore the relationship of smoking habits, stress, and physical activity with diabetes mellitus incidence in Indonesia. Methods: A total of 12,110 respondents from 13 provinces in Indonesia were interviewed and evaluated in a cross-sectional national-based population study in Indonesia. Multivariate binary logistic regression analysis was used to calculate the adjusted odds ratio value with a 95% confidence interval. Results: Of the 12,110 respondents, 9,154 (75.59%) were ³ 45 years old and 6,704 (55.36%) had low physical activity. Exposure to cigarette smoke (AOR = 0.73, 95% CI = 0.57-0.94, p < 0.05) and high or vigorous physical activity (AOR = 0.81, 95% CI = 0.67-0.9, p <0.05) were significantly related to diabetes mellitus. Conclusion:Smoking habits and physical activity were highly associated with diabetes mellitus but stress was not. Therefore, health promotion measures for improvement of life style and prevention of diabetes mellitus are needed and should be organized by primary health care system.
https://jkmu.kmu.ac.ir/article_91470_975c0552b29d2e172c55e3b2b25bc346.pdf
2020-09-01
380
388
10.22062/jkmu.2020.91470
Diabetes Mellitus
smoking
Stress
physical activity
Indonesia
Nur Aini
Purwaningsih
1
Undergraduate Student, Faculty of Public Health, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
AUTHOR
Solikhah
Solikhah
solikhah@ikm.uad.ac.id
2
Assistant Professor, Faculty of Public Health, Universitas Ahmad Dahlan, Yogyakarta, Indonesia
LEAD_AUTHOR
Zhou B, Lu Y, Hajifathalian K, Bentham J, Cesare MD, Danaei G, et al. Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants. Lancet 2016; 387(10027):1513-30.
1
International Diabetes Federation. IDF Diabetes Atlas: Seventh Edition. Brussels, Belgium: International Diabetes Federation; 2015.
2
Ogurtsova K, da Rocha Fernandes JD, Huang Y, Linnenkamp U, Guariguata L, Cho NH, et al. IDF diabetes atlas: global estimates for the prevalence of diabetes for 2015 and 2040. Diabetes Res Clin Pract 2017; 128:40-50.
3
World Health Organization. Global Report on Diabetes. France: WHO; 2016.
4
Charvat H, Goto A, Goto M, Inoue M, Heianza Y, Arase Y, et al. Impact of population aging on trends in diabetes prevalence: a meta-regression analysis of 160,000 Japanese adults. J Diabetes Investig 2015; 6(5):533-42.
5
Boles A, Kandimalla R, Reddy PH. Dynamics of diabetes and obesity: epidemiological perspective. Biochim Biophys Acta Mol Basis Dis 2017; 1863(5):1026-36.
6
Reddy PH. Can diabetes be controlled by lifestyle activities? Curr Res Diabetes Obes J 2017; 1(4): 555568
7
Pan A, Wang Y, Talaei M, Hu FB. Relation of smoking with total mortality and cardiovascular events among patients with diabetes: a meta-analysis and systematic review. Circulation 2015; 132(19):1795-804.
8
Wang Y, Qu H, Xiong X, Qiu Y, Liao Y, Chen Y, et al. Plasma asprosin concentrations are increased in individuals with glucose dysregulation and correlated with insulin resistance and first-phase insulin secretion. Mediators Inflamm 2018; 2018:9471583.
9
Salunkhe VA, Veluthakal R, Kahn SE, Thurmond DC. Novel approaches to restore beta cell function in prediabetes and type 2 diabetes. Diabetologia 2018; 61(9):1895-901.
10
Akter S, Goto A, Mizoue T. Smoking and the risk of type 2 diabetes in Japan: a systematic review and meta-analysis. J Epidemiol 2017; 27(12):553-61.
11
Cai X, Chen Y, Yang W, Gao X, Han X, Ji L. The association of smoking and risk of diabetic retinopathy in patients with type 1 and type 2 diabetes: a meta-analysis. Endocrine 2018; 62(2):299-306.
12
Hilawe EH, Yatsuya H, Li Y, Uemura M, Wang C, Chiang C, et al. Smoking and diabetes: is the association mediated by adiponectin, leptin, or c-reactive protein? J Epidemiol 2015; 25(2):99-109.
13
Derek MI, Rottie J, Kallo V. Hubungan tingkat stres dengan kadar gula darah pada pasien diabetes mellitus tipe II di Rumah Sakit Pancaran Kasih GIMM Manado. J Keperawatan 2017; 5(1).
14
Hackett RA, Steptoe A. Type 2 diabetes mellitus and psychological stress - a modifiable risk factor. Nat Rev Endocrinol 2017; 13(9):547-60.
15
Castaneda C, Layne JE, Munoz-Orians L, Gordon PL, Walsmith J, Foldvari M, et al. A randomized controlled trial of resistance exercise training to improve glycemic control in older adults with type 2 diabetes. Diabetes Care 2002; 25(12):2335-41.
16
Colberg SR, Sigal RJ, Fernhall B, Regensteiner JG, Blissmer BJ, Rubin RR, et al. Exercise and type 2 diabetes: The American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes Care 2010; 33(12): 2692-6.
17
Jadhav RA, Hazari A, Monterio A, Kumar S, Maiya AG. Effect of physical activity intervention in prediabetes: a systematic review with meta-analysis. J Phys Act Health 2017; 14(9):745-55.
18
Grøndahl MF, Bagger JI, Lund A, Faurschou A, Rehfeld JF, Holst JJ, et al. Effects of smoking versus nonsmoking on postprandial glucose metabolism in heavy smokers compared with nonsmokers. Diabetes Care 2018; 41(6):1260-7.
19
Seifu W, Woldemichael K, Tsehaineh T. Prevalence and risk factors for diabetes mellitus and impaired fasting glucose among adults aged 15-64years in gilgel gibe field research center, southwest Ethiopia, 2013: through a who step wise approach. MOJ Public Health 2015; 2(4):136-43.
20
Soelistijo SA, Novida H, Rudijanto A, Soewondo P, Suastika K, Manaf A, et al. Konsensus: pengelolaan dan pencegahan diabetes melitus tipe 2 di Indonesia 2015. Indonesia: PB. PERKENI; 2015.
21
Dolongseda FV, Massie G, Bataha Y. Hubungan pola aktivitas fisik dan pola makan dengan kadar gula darah pada pasien diabetes melitus tipe 2 di poli penyakit dalam rumah sakit Pancaran Kasih Gmim Manado. Jurnal Keperawatan UNSRAT 2017; 5(1).
22
Jonsdottir IH, Rödjer L, Hadzibajramovic E, Börjesson M, Ahlborg G. A prospective study of leisure-time physical activity and mental health in Swedish health care workers and social insurance officers. Prev Med 2010; 51(5):373-7.
23
Zheng Y, Ley SH, Hu FB. Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nat Rev Endocrinol 2018; 14(2):88-98.
24
Kohnert KD, Heinke P, Vogt L, Salzsieder E. Utility of different glycemic control metrics for optimizing management of diabetes. World J Diabetes 2015; 6(1):17-29.
25
White NH, Sun W, Cleary PA, Danis RP, Davis MD, Hainsworth DP, et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus. Arch Ophthalmol 2008; 126(12):1707-15.
26
Chew EY, Lovato JF, Davis MD, Gerstein HC, Danis RP, Ismail-Beigi F, et al. Persistent effects of intensive glycemic control on retinopathy in type 2 diabetes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) Follow-On Study. Diabetes Care 2016; 39(7):1089-100.
27
Śliwińska-Mossoń M, Milnerowicz H. The impact of smoking on the development of diabetes and its complications. Diab Vasc Dis Res 2017; 14(4):265-76.
28
World Health Organization. WHO Diabetes Country Profile. WHO; 2016.
29
Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S. Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol 2010; 47(1):15-22.
30
Mann S, Beedie C, Balducci S, Zanuso S, Allgrove J, Bertiato F, et al. Changes in insulin sensitivity in response to different modalities of exercise: a review of the evidence. Diabetes Metab Res Rev 2014; 30(4):257-68.
31
Chudyk A, Petrella RJ. Effects of exercise on cardiovascular risk factors in type 2 diabetes: a meta-analysis. Diabetes Care 2011; 34(5):1228-37.
32
Alanazi FK, Alotaibi JS, Paliadelis P, Alqarawi N, Alsharari A, Albagawi B. Knowledge and awareness of diabetes mellitus and its risk factors in Saudi Arabia. Saudi Med J 2018; 39(10):981-9.
33
Alsous M, Jalil MA, Odeh M, Kurdi RA, Alnan M. Public knowledge, attitudes and practices toward diabetes mellitus: A cross-sectional study from Jordan. PLoS One 2019; 14(3):e0214479.
34
ORIGINAL_ARTICLE
Is there any Correlation between Cerebrospinal Fluid and Serum C-reactive Protein in Neonates Suspected to Meningitis?
Background: Meningitis is a common life threatening infection in neonatal period. Diagnostic value of CSF-CRP level in bacterial meningitis in children and adults has been studied worldwide, but there are limited studies on CSF-CRP in neonatal meningitis. This study conducted to assess any relation between CSF-CRP and plasma CRP levels and abnormal CSF findings in neonates suspected to meningitis. Methods: Seventy five hospitalized neonates suspected to meningitis were enrolled in this cross sectional study. All infants were gone through a complete sepsis workup including blood and CSF CRP. Results: CSF-CRP level had statistically significant correlation with serum WBC (p= 0.048) and also poor correlation with CSF protein level (p= 0.054). Serum CRP level had statistically significant correlation with CSF WBC (p= 0.008). Conclusion: No correlation found between CSF and serum CRP levels of patients in this study. Although, CSF-CRP is a rapid and easy to interpret test, it can be performed alongside CSF cytology and biochemical analysis, smear and culture as a confirmatory test for definite diagnosis of neonatal meningitis.
https://jkmu.kmu.ac.ir/article_91471_d5aa768953aae7c8db10cbb1bb6370ce.pdf
2020-09-01
389
393
10.22062/jkmu.2020.91471
Newborn Meningitis Cerebrospinal fluid C
reactive protein Sepsis
Mandana
Kashaki
kashakimd@gmail.com
1
Assistant Professor of Neonatal-Perinatal Medicine, Shahid Akbarabadi Clinical Research Development Unit (ShACRDU), Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Elahe
Norouzi
elahenorouzimd@gmail.com
2
Assistant Professor of Pediatrics, Neonatologist, Department of Pediatrics, Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran, Iran
LEAD_AUTHOR
Saeideh
Heidarali
eheydarali@gmail.com
3
Pediatrician, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Parisa
Mohagheghi
pmohagh@yahoo.com
4
Associate Professor of Pediatrics, Neonatologist, Department of Pediatrics, Pediatric Growth and Development Research Center, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Mahmoud
Soltani
doctorsoltani@yahoo.com
5
Assistant Professor of Neonatal-Perinatal Medicine, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Hamid Karbalaei Hasani
Karbalaei Hasani
6
Pediatrics Resident, Iran University of Medical Sciences, Tehran, Iran
AUTHOR
Ku LC, Boggess KA, Cohen-Wolkowiez M. Bacterial meningitis in infants. Clin Perinatol 2015; 42(1):29-45.
1
Gaschignard J, Levy C, Romain O, Cohen R, Bingen E, Aujard Y, et al. Neonatal bacterial meningitis: 444 cases in 7 years. Pediatr Infect Dis J 2011; 30(3):212-7.
2
Polin RA, Harris MC. Neonatal bacterial meningitis. Semin Neonatol 2001; 6(2):157-72.
3
Franco SM, Cornelius VE, Andrews BF. Long-term outcome of neonatal meningitis. Am J Dis Child 1992; 146(5):567-71.
4
Niknafs P; Norouzi E; Bahman Bijari B; Baneshi MR. Can we Replace Arterial Blood Gas Analysis by Pulse Oximetry in Neonates with Respiratory Distress Syndrome, who are Treated According to INSURE Protocol? IJMS 2015; 40(3): 264-7.
5
Corrall CJ, Pepple JM, Moxon R, Hughes WT. C-Reactive protein in spinal fluid of children with meningitis. Journal of Pediatrics 1981; 99(3):365-9.
6
Pepys MB. C-reactive protein-fifty years on. Lancet 1981; 1(8221):653-7.
7
Gabay C, Kushner I. Acute-phase proteins and other systemic responses to inflammation. N Engl J Med 1999; 340(6):448-54.
8
Hofer N, Zacharias E, Muller W, Resch B. An update on the use of C-reactive protein in early-onset neonatal sepsis: current insights and new tasks. Neonatology 2012; 102(1):25-36.
9
Javadinia S, Tabasi M, Naghdalipour M, Atefi N, Asgarian R, Khezerloo JK, et al. C-reactive protein of cerebrospinal fluid, as a sensitive approach for diagnosis of neonatal meningitis. Afri Health Sci 2019; 19(3):2372-7.
10
Natani BS, Goyal P, Agarwal A, Bhatia S, Kumar M. Study of CSF C-reactive protein in meningitis to differentiate bacterial meningitis from aseptic meningitis in children between 1 month and 12 years of age. Int J Contemp Pediatr 2017; 4(3):943-6.
11
Singh N, Arora S, Kahlon PS. Cerebrospinal fluid C- reactive protein in meningitis. Indian Pediatr 1995; 32:687-8.
12
Prasad PL, Nair MN, Kalghatg AT. Childhood bacterial meningitis and usefulness of C-reactive protein. Med J Armed Forces India 2005; 61(1):13-15.
13
Chandel R, Goyal S, Poswal L, Asif M. Diagnostic value of CSF C-reactive protein in meningitis: A prospective study. International Journal of Biomedical Research 2016; 7(6):387-390.
14
Malla KK, Malla T, Rao KS, Basnet S, Shah R. Is cerebrospinal fluid C-reactive protein a better tool than blood C-reactive protein in laboratory diagnosis of meningitis in children? Sultan Qaboos Univ Med J 2013; 13(1):93-9.
15
Jain S, Nayak R, Sharma A. Role of C- reactive proteins in cerebro-spinal fluid in differentiating pyogenic from nonpyogenic meningitis. International Journal of Research in Medical Sciences 2016; 4(7): 2839-42.
16
Belagavi AC, Shalini M. Cerebrospinal fluid C reactive protein and adenosine deaminase in meningitis in adults. J Assoc Physicians India 2011; 59:557-60.
17
Gedam DS. CRP, an acute phase reactant: role in Differentiating Bacterial and Non-Bacterial CNS Infections. Int J Med Res Rev 2013; 1(2):45-46.
18
Komorowski RA, Farmer SG, Knox KK. Comparison of cerebrospinal fluid C-reactive protein and lactate for diagnosis of meningitis. J Clin Microbiol 1986; 24(6):982-5.
19
ORIGINAL_ARTICLE
Antibacterial and Antifungal Activity of Synthesized Potassium Dithiocarbazinates: A Preliminary In Vitro Study
Background:The spread of drug-resistant microbial strains has led many studies for identifying, designing, and synthesizing new antimicrobial agents.The aim of this study was to evaluate antimicrobial effects of some synthesized potassium dithiocarbazinate derivatives against 6 Gram-negative and 4 Gram-positive bacteria as well as 2 molds and 1 yeast. Potassium salts of dithiocarbazinic acids were prepared in good yields from the reaction of various hydrazides with carbon disulfide. Potassium hydroxide and diethyl ether were used as base and solvent, respectively. Methods:Broth microdilution and streak plate methodswere applied according to the Clinical and Laboratory Standards Institute (CLSI) guidelines to determine the minimum inhibitory concentration (MIC), the minimum bactericidal concentration (MBC), and the minimum fungicidal concentration (MFC) values. Results:Good to excellent inhibitory effects especially on fungi were observed with the tested compounds. Dithiocarbazinates 3b and 3f containing 4-nitrophenyl and 3-hydroxy-2-naphthyl substituents could effectively inhibit the growth of all tested bacterial strains. In addition, all synthesized derivatives were effective against fungal pathogens. Conclusion:Based on the data obtained from antimicrobial susceptibility testing,designed derivatives are especially potent antifungal agents. Potassium 2-(3-hydroxy-2-naphthoyl) hydrazine-1-carbodithioate was introduced as a new wide-spectrum antimicrobial agent. Other biological activities of these water-soluble derivatives can be studied in living organisms.
https://jkmu.kmu.ac.ir/article_91472_17f59623aa089ec48fde9b1ef336ff67.pdf
2020-09-01
394
403
10.22062/jkmu.2020.91472
Antibacterial study
Antifungal evaluation
Broth microdilution technique
Potassium dithiocarbazinate
Streak plate method
Hamid
Beyzaei
hbeyzaei@uoz.ac.ir
1
Associate Professor, Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
LEAD_AUTHOR
Sedigheh
Esmaeilzadeh Bahabadi
esmaeilzadeh@uoz.ac.ir
2
Associate Professor, Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran
AUTHOR
Ali
Shahryari
hamidchem@yahoo.com
3
M.Sc. Student, Department of Biology, Faculty of Science, University of Zabol, Zabol, Iran
AUTHOR
Li L, Ding H, Wang B, Yu S, Zou Y, Chai X, et al. Synthesis and evaluation of novel azoles as potent antifungal agents. Bioorg Med Chem Lett 2014; 24(1):192-4.
1
Liu XJ, Wang L, Yin L, Cheng FC, Sun HM, Liu WW, et al. Synthesis and biological evaluation of novel glycosyl-containing 1,2,4-triazolo[3,4-b][1,3,4]thiadiazole derivatives as acetylcholinesterase inhibitors. J Chem Res 2017; 41(10):571-5.
2
Li Z, Liu Y, Bai X, Deng Q, Wang J, Zhang G, et al. SAR studies on 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles as inhibitors of Mtb shikimate dehydrogenase for the development of novel antitubercular agents. RSC Adv 2015; 5(118):97089-101.
3
Seelolla G, Ponneri V. Synthesis, antimicrobial, and antioxidant activities of some fused heterocyclic [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazole derivatives. J Heterocycl Chem 2016; 53(3):929-36.
4
Gupta JK, Mishra P. Pharmacological screening of some newly synthesized triazoles for H1 receptor antagonist activity. Med Chem Res 2017; 26(10):2260-71.
5
Wang XF, Zhang S, Li BL, Zhao JJ, Liu YM, Zhang RL, et al. Synthesis and biological evaluation of disulfides bearing 1,2,4-triazole moiety as antiproliferative agents. Med Chem Res 2017; 26(12):3367-74.
6
Xie W, Zhang J, Ma X, Yang W, Zhou Y, Tang X, et al. Synthesis and biological evaluation of kojic acid derivatives containing 1,2,4‐triazole as potent tyrosinase inhibitors. Chem Biol Drug Des 2015; 86(5):1087-92.
7
Panda S, Nayak S. Antibacterial, antioxidant and anthelmintic studies of inclusion complexes of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols. Supramol Chem 2015; 27(10):679-89.
8
Udupi RH, Suresh GV, Ramachandra Setty S, Bhat AR. Synthesis and biological evaluation of 3-substituted-4-[2'-(4''-isobutylphenyl)propionamido]-5-mercapto-1,2,4-triazoles and their derivatives. Journal of the Indian Chemical Society 2000; 77(6):302-4.
9
Panda S, Nayak S. Studies on absorption and emission characteristics of inclusion complexes of some 4-arylidenamino-5-phenyl-4H-1,2,4-triazole-3-thiols. Journal of Fluorescence 2016; 26(2):413-25.
10
Wang X, Wang H, Chen P, Pang Y, Zhao Z, Wu G. Synthesis and biological activities of some novel (E)-alpha-(methoxyimino)benzeneacetate derivatives with modified 1,2,4-triazole moiety. Journal of Chemistry 2014; 2014:681364.
11
Bhasin G, Srivastava R, Singh R. Synthesis of triazole based novel ionic liquids and salts. Org Prep Proced Int 2017; 49(4):370-6.
12
Mohamed FK. Synthesis, reactions and antimicrobial activity on some novel phthalazinones derivatives. Der Chemica Sinica 2010; 1(1):20-31.
13
Aouad MR, Mayaba MM, Naqvi A, Bardaweel SK, Al-blewi FF, Messali M, et al. Design, synthesis, in silico and in vitro antimicrobial screenings of novel 1,2,4-triazoles carrying 1,2,3-triazole scaffold with lipophilic side chain tether. Chem Cent J 2017; 11:117.
14
Yarmohammadi E, Beyzaei H, Aryan R, Moradi A. Ultrasound-assisted, low-solvent and acid/base-free synthesis of 5-substituted 1,3,4-oxadiazole-2-thiols as potent antimicrobial and antioxidant agents. Mol Divers 2020.
15
Liu XJ, Liu HY, Wang HX, Shi YP, Tang R, Zhang S, et al. Synthesis and antitumor evaluation of novel fused heterocyclic1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole derivatives. Med Chem Res 2019; 28(10):1718-25.
16
Thakkar SS, Thakor P, Doshi H, Ray A. 1,2,4-Triazole and 1,3,4-oxadiazole analogues: Synthesis, MO studies, in silico molecular docking studies, antimalarial as DHFR inhibitor and antimicrobial activities. Bioorg Med Chem 2017; 25(15):4064-75.
17
Adak AK, Leonov AP, Ding N, Thundimadathil J, Kularatne S, Low PS, et al. Bishydrazide glycoconjugates for lectin recognition and capture of bacterial pathogens. Bioconjug Chem 2010; 21(11):2065-75.
18
Beyzaei H, Kamali Deljoo M, Aryan R, Ghasemi B, Zahedi MM, Moghaddam-Manesh M. Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles. Chem Cent J 2018; 12(1):114.
19
Hoggarth E. 2-Benzoyldithiocarbazinic acid and related compounds. J Chem Soc 1952; 1952(0):4811-7.
20
Centore R, Fusco S, Peluso A, Capobianco A, Stolte M, Archetti G, et al. Push–pull azo‐chromophores containing two fused pentatomic heterocycles and their nonlinear optical properties. Eur J Org Chem 2009; 2009(21):3535-43.
21
Sonawane AD, Rode ND, Nawale L, Joshi RR, Joshi RA, Likhite AP, et al. Synthesis and biological evaluation of 1,2,4‐triazole‐3‐thione and 1,3,4‐oxadiazole‐2‐thione as antimycobacterial agents. Chem Biol Drug Des 2017; 90(2):200-9.
22
Saha A, Kumar R, Kumar R, Devakumar C. Green synthesis of 5‐substituted‐1,3,4‐thiadiazole‐2‐thiols as new potent nitrification inhibitors. J Heterocycl Chem 2010; 47(4):838-45.
23
Baeeri M, Foroumadi A, Motamedi M, Yahya‐Meymandi A, Firoozpour L, Ostad SN, et al. Safety and efficacy of new 3,6‐diaryl‐7H‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazine analogs as potential phosphodiesterase‐4 inhibitors in NIH‐3T3 mouse fibroblastic cells. Chem Biol Drug Des 2011; 78(3):438-44.
24
Singh NK, Bharty MK, Kushawaha SK, Butcher RJ. Nickel (II) complexes of 5-phenyl and 5-furan-1,3,4-oxadiazole-2-thiones containing ethylenediamine: synthesis, spectral and X-ray characterization. Transition Met Chem 2010; 35(2):205-11.
25
Singh NK, Bharty MK, Kushawaha SK, Singh UP, Tyagi P. Synthesis, spectral and structural studies of a Mn(II) complex of [N′-(pyridine-4-carbonyl)-hydrazine]-carbodithioic acid ethyl ester and Mn(II) and Ni(II) complexes of [N′-(pyridine-4-carbonyl)-hydrazine]-carbodithioic acid methyl ester. Polyhedron 2010; 29(8):1902-9.
26
Tiperciuc B, Zaharia V, Colosi I, Moldovan C, Crişan O, Pîrnau A, et al. Synthesis and evaluation of antimicrobial activity of some new hetaryl-azoles derivatives obtained from 2-aryl-4-methylthiazol-5-carbohydrazides and isonicotinic acid hydrazide. J Heterocycl Chem 2012; 49(6):1407-14.
27
Pandeya SN, Chattree A, Fatima I. Synthesis, antimicrobial activities and structure activity relationship of some dithiocarbazinate, 1,2,4-triazoles and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles. Der Pharma Chem 2012; 4(4):1667-73.
28
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Wu Y, Bai J, Zhong K, Huang Y, Qi H, Jiang Y, et al. Antibacterial activity and membrane-disruptive mechanism of 3-p-trans-coumaroyl-2-hydroxyquinic acid, a novel phenolic compound from pine needles of Cedrus deodara, against Staphylococcus aureus. Molecules 2016; 21(8):1084.
30
ORIGINAL_ARTICLE
The Relationship between Abnormal Ankle-brachial Index and Micro-vascular Complications of Diabetes Type II
Background:The prevalence of diabetes mellitus is increasing worldwide and the relationship between peripheral vascular involvement and the complications of diabetes disease, such as retinopathy, has been reported in some studies but has not yet been fully proven. The aim of this study was to investigate the relationship between diabetes complications and peripheral and central vascular involvement. Method:A number of 150 patients with diabetes type II aged 30 to 70 years old were entered into this cross- sectional study. Ankle-brachial index (ABI), carotid intima media thickness and diabetes complications were investigated in them. Results:Abnormal ABI was more prevalent (79%) in Female patients. Furthermore, diabetes disease duration (P=0.005), systolic blood pressure (P=0.005) and retinopathy (P=0.003) were higher in females. Based on regression model, the highest relation of abnormal ABI incidence was observed with female gender (OR=2.4). Moreover, only blood pressure was among the abnormal ABI effective risk factors. Conclusion:Female gender, duration of diabetes disease, systolic blood pressure and retinopathy incidence were among the effective factors in the incidence of abnormal ABI and abnormal ABI had a direct and reverse relationship with causing vascular diseases in diabetic type II patients.
https://jkmu.kmu.ac.ir/article_91473_34d471c1e1e1e3322b9e5d35045f6151.pdf
2020-09-01
404
413
10.22062/jkmu.2020.91473
Diabetes mellitus Ankle
brachial index Carotid intima media thickness Diabetes complications
Mohammad Hossein
Gozashti
1
Associate Professor, Endocrinologist, Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mohammad Mehdi
Kafi kang
2
General Practitioner, Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mahdieh
Mashrooteh
mmashrouteh@yahoo.com
3
General Practitioner, Modeling in Health Research Center, Institute for Futures Studies in Health, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Ahmad
Enhesari
a.enhesari@yahoo.com
4
Associate Professor, Radiologist, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Dabelea D, Mayer-Davis EJ, Saydah S, Imperatore G, Linder B, Divers J, et al. Prevalence of type 1 and type 2 diabetes among children and adolescents from 2001 to 2009. JAMA 2014; 311(17):1778-86.
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Sharma M, Nazareth I, Petersen I. Trends in incidence, prevalence and prescribing in type 2 diabetes mellitus between 2000 and 2013 in primary care: a retrospective cohort study. BMJ Open 2016; 6(1):e010210.
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4
Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes Res Clin Pract 2014; 103(2):137-49.
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Brownlee M, Hirsch IB. Glycemic variability: a hemoglobin A1c–independent risk factor for diabetic complications. JAMA 2006; 295(14):1707-8.
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Azimi-Nezhad M, Ghayour-Mobarhan M, Parizadeh MR, Safarian M, Esmaeili H, Parizadeh S, et al. Prevalence of type 2 diabetes mellitus in Iran and its relationship with gender, urbanisation, education, marital status and occupation. Singapore Med J 2008; 49(7):571-6.
8
Esteghamati A, Etemad K, Koohpayehzadeh J, Abbasi M, Meysamie A, Noshad S, et al. Trends in the prevalence of diabetes and impaired fasting glucose in association with obesity in Iran: 2005–2011. Diabetes Research and Clinical Practice 2014; 103(2):319-27.
9
Fowler MJ. Microvascular and macrovascular complications of diabetes. Clinical Diabetes 2008; 26(2):77-82.
10
Mostaza JM, Suarez C, Manzano L, Cairols M, López-Fernández F, Aguilar I, et al. Sub-clinical vascular disease in type 2 diabetic subjects: relationship with chronic complications of diabetes and the presence of cardiovascular disease risk factors. European Journal of Internal Medicine 2008; 19(4):255-60.
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Khammash MR, Obeidat KA, El-Qarqas EA. Screening of hospitalised diabetic patients for lower limb ischaemia: is it necessary? Singapore Medical Journal 2008; 49(2):110.
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Göksan B, Erkol G, Bozluolcay M, Ince B. Diabetes as a determinant of high-grade carotid artery stenosis: evaluation of 1,058 cases by Doppler sonography. J Stroke Cerebrovasc Dis 2001; 10(6):252-6.
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Cheng KS, Mikhailidis DP, Hamilton G, Seifalian AM. A review of the carotid and femoral intima-media thickness as an indicator of the presence of peripheral vascular disease and cardiovascular risk factors. Cardiovasc Res 2002; 54(3):528-38.
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Abramson B, Mannik J, Figol A, Aw J. [PP. 21.39] carotid intima-media thickness screening adds value in a Canadian cohort: implications for patient management. Journal of Hypertension 2017; 35:e277.
17
Baldassarre D, De Jong A, Amato M, Werba PJ, Castelnuovo S, Frigerio B, et al. Carotid intima‐media thickness and markers of inflammation, endothelial damage and hemostasis. Ann Med 2008; 40(1):21-44.
18
American Diabetes Association. Classification and diagnosis of diabetes. Diabetes care 2017; 40(Supplement 1):S11-24.
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Santaguida PL, Balion C, Hunt D, Morrison K, Gerstein H, Raina P, et al. Diagnosis, prognosis, and treatment of impaired glucose tolerance and impaired fasting glucose. Evid Rep Technol Assess (Summ) 2005; 128(1).
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Williams R, Van Gaal L, Lucioni C, CODE-2 Advisory Board. Assessing the impact of complications on the costs of Type II diabetes. Diabetologia 2002; 45(1):S13-S7.
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Lee MY, Hsiao PJ, Huang JC, Hsu WH, Chen SC, Chang JM, et al. Abnormally low or high ankle-brachial index is associated with the development of diabetic retinopathy in type 2 diabetes mellitus. Sci Rep 2018; 8(1):441.
24
Chen SC, Hsiao PJ, Huang JC, Lin KD, Hsu WH, Lee YL, et al. Abnormally low or high ankle-brachial index is associated with proliferative diabetic retinopathy in type 2 diabetic mellitus patients. PloS One 2015; 10(7):e0134718.
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Newman AB, Tyrrell KS, Kuller LH. Mortality over four years in SHEP participants with a low ankle‐arm index. J Am Geriatr Soc 1997; 45(12):1472-8.
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Orchard TJ, Strandness Jr DE. Assessment of peripheral vascular disease in diabetes. Report and recommendations of an international workshop sponsored by the American Diabetes Association and the American Heart Association September 18-20, 1992 New Orleans, Louisiana. Circulation 1993; 88(2):819-28.
27
Abbott JD, Lombardero MS, Barsness GW, Pena-Sing I, Buitrón LV, Singh P, et al. Ankle-brachial index and cardiovascular outcomes in the bypass angioplasty revascularization investigation 2 diabetes trial. Am Heart J 2012; 164(4):585-90.
28
Hayashi C, Ogawa O, Kubo S, Mitsuhashi N, Onuma T, Kawamori R. Ankle brachial pressure index and carotid intima-media thickness as atherosclerosis markers in Japanese diabetics. Diabetes Res Clin Pract 2004; 66(3):269-75.
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Li J, Luo Y, Xu Y, Yang J, Zheng L, Hasimu B, et al. Risk factors of peripheral arterial disease and relationship between low ankle-brachial index and mortality from all-cause and cardiovascular disease in Chinese patients with type 2 diabetes. Circ J 2007; 71(3):377-81.
30
Tseng CH, Chong CK, Tseng CP, Tai TY. The association between urinary albumin excretion and ankle-brachial index in elderly Taiwanese patients with type 2 diabetes mellitus. Age and Ageing 2008; 37(1):77-82.
31
Pignone M, Phillips C, Mulrow C. Use of lipid lowering drugs for primary prevention of coronary heart disease: meta-analysis of randomised trials. BMJ 2000; 321(7267):983-6.
32
Makhdoomi K, Mohammadi A, Yekta Z, Aghasi MR, Zamani N, Vossoghian S. Correlation between ankle-brachial index and microalbuminuria in type 2 diabetes mellitus. Iran J Kidney Dis 2013; 7(3):204-9.
33
Lahoz C, Mostaza JM. Ankle-brachial index: a useful tool for stratifying cardiovascular risk. Rev Esp Cardiol 2006; 59(07):647-9. [In Spanish].
34
Lv WS, Sun RX, Gao YY, Wen JP, Pan RF, Li L, et al. Nonalcoholic fatty liver disease and microvascular complications in type 2 diabetes. World J Gastroenterol 2013; 19(20):3134-42.
35
Kim BY, Jung CH, Mok JO, Kang SK, Kim CH. Prevalences of diabetic retinopathy and nephropathy are lower in K orean type 2 diabetic patients with non‐alcoholic fatty liver disease. J Diabetes Investig 2014; 5(2):170-5.
36
Vanjiappan S, Hamide A, Ananthakrishnan R, Periyasamy SG, Mehalingam V. Nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus and its association with cardiovascular disease. Diabetes Metab Syndr 2018; 12(4):479-82.
37
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38
Bosevski M, Stojanovska L. Progression of carotid-artery disease in type 2 diabetic patients: a cohort prospective study. Vasc Health Risk Manag 2015; 11:549-53.
39
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Erzen B, Sabovic M, Sebestjen M, Poredos P. Endothelial dysfunction, intima-media thickness, ankle-brachial pressure index, and pulse pressure in young post-myocardial infarction patients with various expressions of classical risk factors. Heart Vessels 2007; 22(4):215-22.
41
ORIGINAL_ARTICLE
Evaluation of the Cytotoxicity, Antibacterial, Antioxidant, and Anti-inflammatory Effects of Different Extracts of Punica granatum var. pleniflora
Background:Punica granatum var. pleniflora (PGP) has been used for thousands of years as an effective agent to treat various types of diseases. However, there are a few new evidences addressing its therapeutic effects and related mechanisms. Therefore, the aim of this study was to investigate the cytotoxic, antioxidant, antibacterial, and anti-inflammatory effects of ethanolic (ET), dichloromethane (DM), and ethyl acetate (EA) extracts of PGP. Methods: ET, DM, and EA extracts of PGP were first prepared using maceration method. Total phenolic content (TPC) of PGP was then assessed by the Folin-Ciocalteu assay, and its antioxidant capacity was determined by DPPH and FRAP methods. Furthermore, in-vitro antibacterial activity of the PGP extracts was performed. The effect of PGP on the viability of J774A.1, HUVECs, HT29, and MCF-7 cell lines was evaluated by the MTT assay. The anti-inflammatory effect of PGP was assessed in the lipopolysaccharide (LPS)-stimulated J774A.1 cell line using qRT-PCR method. Results: EA extract contained the highest phenolic content (383.3 ± 9.1 mg gallic acid/g extract) and showed the highest antioxidant activity (IC50 = 36.5 ± 2.3 µg/mL). PGP at concentration of 15 µg/mL significantly decreased the expression of COX-2 (ET) and iNOS (ET and EA) in J774A.1 cell. Also, EA showed the highest antibacterial activity. Furthermore, the PGP extracts decreased the viability of all tested cell lines in a concentration-dependent manner. As indicated by IC50, EA demonstrated the lowest IC50 for all tested cell lines. Conclusion: According to the results, antioxidant, anti-inflammatory, antibacterial, and cytotoxic effects of PGP might be driven by its phenolic compounds highly presented in the EA extract.
https://jkmu.kmu.ac.ir/article_91474_96cdafb062c30f332bc1b2f421cc4312.pdf
2020-09-01
414
425
10.22062/jkmu.2020.91474
Punica granatum var. pleniflora Anti
inflammation Antioxidant Antibacterial Cytotoxicity Murine macrophage J774A.1
Mehrnaz
Mehrabani
mehrnaz.mehrabani@yahoo.com
1
Assistant Professor, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mahboobeh
Raeiszadeh
mah.raeiszadeh@gmail.com
2
Assistant Professor, Department of Traditional Pharmacy, Faculty of Traditional Medicine, Kerman University of Medical sciences, Kerman, Iran
AUTHOR
Hamid
Najafipour
3
Professor, Physiology Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mojde
Esmaeli Tarzi
4
Cardiovascular Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Arian
Amirkhosravi
arianamirkhosravi@yahoo.com
5
Ph.D. Student, Pharmaceutical Sciences and Cosmetic Products Research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Alireza
Poustforoosh
alireza110_p@yahoo.com
6
Ph.D. Student, Chemical Engineering Department, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran
AUTHOR
Mohammad Ali
Mohammadi
ali.uk.biotech@gmail.com
7
Ph.D. Student, Research Center for Hydatid Disease in Iran, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Sara
Naghdi
sara_naghdi94@yahoo.com
8
Student Research Committee, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Mitra
Mehrabani
mmehrabani@hotmail.com
9
Professor, Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Karimi A, Majlesi M, Rafieian-Kopaei M. Herbal versus synthetic drugs; beliefs and facts. J Nephropharmacol 2015; 4(1):27-30.
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3
Mehrzadi S, Bahrami N, Mehrabani M, Motevalian M, Mansouri E, Goudarzi M. Ellagic acid: a promising protective remedy against testicular toxicity induced by arsenic. Biomedicine & Pharmacotherapy 2018; 103:1464-72.
4
Raeiszadeh M, Esmaeili-Tarzi M, Bahrampour-Juybari K, Nematollahi-mahani SN, Pardakhty A, Nematollahi MH, et al. Evaluation the effect of Myrtus communis L. extract on several underlying mechanisms involved in wound healing: An in vitro study. South African Journal of Botany 2018; 118:144-50.
5
Gavanji S, Larki B, Bakhtari A. Comparative analysis of extract of Punica granatum var. pleniflora (Golnar-e-farsi) to some antibiotics on pathogens. Journal of Essential Oil Bearing Plants 2015; 18(1):168-78.
6
Sedigh-Rahimabadi M, Fani M, Rostami-Chijan M, Zarshenas MM, Shams M. A traditional mouthwash (Punica granatum var pleniflora) for controlling gingivitis of diabetic patients: a double-blind randomized controlled clinical trial. J Evid Based Complementary Altern Med 2017; 22(1):59-67.
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Gavanji S, Larki B, Bakhtari A. The effect of extract of Punica granatum var. pleniflora for treatment of minor recurrent aphthous stomatitis. Integr Med Res 2014; 3(2):83-90.
8
Mahboubi A, Asgarpanah J, Sadaghiyani PN, Faizi M. Total phenolic and flavonoid content and antibacterial activity of Punica granatum L. var. pleniflora flowers (Golnar) against bacterial strains causing foodborne diseases. BMC Complement Altern Med 2015; 15:366.
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12
Rameshk M, Sharififar F, Mehrabani M, Pardakhty A, Farsinejad A, Mehrabani M. Proliferation and in vitro wound healing effects of the microniosomes containing narcissus tazetta l. bulb extract on primary human fibroblasts (HDFs). Daru 2018; 26(1):31-42.
13
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14
Raeiszadeh M, Pardakhty A, Sharififar F, Mehrabani M, Nejat-mehrab-kermani H, Mehrabani M. Phytoniosome: a novel drug delivery for Myrtle extract. Iran J Pharm Res 2018; 17(3):804-17.
15
Bahrampour-Juybari K, Ebrahimi G, Momeni-Moghaddam MA, Asadikaram G, Torkzadeh-MahaniM, AkbariM, MirzamohammadiS, Karimi A, Nematollahi MH, et al. Evaluation of serum arsenic and its effects on antioxidant alterations in relapsing-remitting multiple sclerosis patients. Mult Scler Relat Disord 2018; 19(1):79-84.
16
Raeiszadeh M, Pardakhty A, Sharififar F, Farsinejad A, Mehrabani M, Hosseini-Nave H, et al. Development, physicochemical characterization, and antimicrobial evaluation of niosomal myrtle essential oil. Res Pharm Sci 2018; 13(3):250-61.
17
Nematollahi MH, Pardakhty A, Torkzadeh-Mahanai M, Mehrabani M, Asadikaram G. Changes in physical and chemical properties of niosome membrane induced by cholesterol: a promising approach for niosome bilayer intervention. RSC Advances 2017; 7(78):49463-72.
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Bekir J, Mars M, Souchard JP, Bouajila J. Assessment of antioxidant, anti-inflammatory, anti-cholinesterase and cytotoxic activities of pomegranate (Punica granatum) leaves. Food Chem Toxicol 2013; 55:470-5.
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Jung KH, Kim MJ, Ha E, Uhm YK, Kim HK, Chung JH, et al. Suppressive effect of Punica granatum on the production of tumor necrosis factor (Tnf) in BV2 microglial cells. Biol Pharm Bull 2006; 29(6):1258-61.
36
ORIGINAL_ARTICLE
Increased Risk of Hypertension in Low aged-carriers with rs2596542 Risk-allele
Background:Hypertension with its related disorders is one of the most common health problems among the Iranian population. Hypertension can be developed by chronic stress and a positive association between stress and rs2596542 has been confirmed. Methods:A Total number of 112 hypertensive patients and 97 healthy individuals were involved in the study. Total blood genomic-DNA was extracted and PASA (PCR amplification of specific alleles) method was used to amplify MICA-rs2596542 polymorphic site. Different genotypes were visualized. The normality of the data was assessed and the binary logistic regression was used for OR and 95%CI calculations. Results:A-risk allele of rs2596542 increased the risk of hypertension development significantly (OR=1.734, p=0.006). Females were significantly more potent to hypertension development than males (OR=2.015, p=0.013). Risk-allele homozygotes (AA) showed a higher risk of hypertension development than GG (OR=2.132, p=0.020) and AG individuals (OR=3.206, p=0.006). Age adjustments at 70 years old, further increased the risk of hypertension development in GG (OR=3.772, p=0.011) and AG (OR=6.531, p=0.009) individuals. Conclusion:A-risk allele of rs2596542 could increase the risk of hypertension up to 3.2 folds and this risk could be upraised after sex and age adjustments.
https://jkmu.kmu.ac.ir/article_91475_db7edcd21cfe8e9b594c6bf7ed996c4f.pdf
2020-09-01
426
435
10.22062/jkmu.2020.91475
Hypertension
rs2596542
PASA
Mohammad Amin
Monsef
1
Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran.
AUTHOR
Seyed-morteza
Javadirad
javadirad@yahoo.com
2
Assistant Professor, Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
LEAD_AUTHOR
Sorour
Eslami
3
Department of Cell and Molecular Biology and Microbiology, Faculty of Biological Science and Technology, University of Isfahan, Isfahan, Iran
AUTHOR
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Mohamed AA, Elsaid OM, Amer EA, Elosaily HH, Sleem MI, Gerges SS, et al. Clinical significance of SNP (rs2596542) in histocompatibility complex class I-related gene A promoter region among hepatitis C virus related hepatocellular carcinoma cases. J Adv Res 2017; 8(4):343-9.
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Yamada Y, Ando F, Shimokata H. Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals. Int J Mol Med 2007; 19(4):675-83.
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Grilo A, Fernandez ML, Beltrán M, Ramirez-Lorca R, González MA, Royo JL, et al. Genetic analysis of CAV1 gene in hypertension and metabolic syndrome. Thromb Haemost 2006; 95(4):696-701.
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Duplain H, Burcelin R, Sartori C, Cook S, Egli M, Lepori M, et al. Insulin resistance, hyperlipidemia, and hypertension in mice lacking endothelial nitric oxide synthase. Circulation 2001; 104(3):342-5.
31
Tabei SM, Nariman A, Daliri K, Roozbeh J, Khezri A, Goodarzi HR, et al. Simple renal cysts and hypertension are associated with angiotensinogen (AGT) gene variant in Shiraz population (Iran). J Renin Angiotensin Aldosterone Syst 2013; 16(2):409-14.
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34
Purkait P, Halder K, Thakur S, Ghosh Roy A, Raychaudhuri P, Bhattacharya S, et al. Association of angiotensinogen gene SNPs and haplotypes with risk of hypertension in eastern Indian population. Clin Hypertens 2017; 23:12.
35
Kurland L, Liljedahl U, Karlsson J, Kahan T, Malmqvist K, Melhus H, et al. Angiotensinogen gene polymorphisms: relationship to blood pressure response to antihypertensive treatment. Results from the Swedish Irbesartan Left Ventricular Hypertrophy Investigation vs Atenolol (SILVHIA) trial. Am J Hypertens 2004; 17(1):8-13.
36
Yu H, Lin S, Zhong J, He M, Jin L, Zhang Y, et al. A core promoter variant of angiotensinogen gene and interindividual variation in response to angiotensin-converting enzyme inhibitors. J Renin Angiotensin Aldosterone Syst 2014; 15(4):540-6.
37
Mansego ML, Redon J, Marín R, González-Albert V, Martin-Escudero JC, Fabia MJ, et al. Renin polymorphisms and haplotypes are associated with blood pressure levels and hypertension risk in postmenopausal women. J Hypertens 2008; 26(2):230-7.
38
Park J, Song K, Jang Y, Yoon SK. A polymorphism of the renin gene rs6682082 is associated with essential hypertension risk and blood pressure levels in Korean women. Yonsei Med J 2015; 56(1):227-34.
39
Goto K, Kato N. MICA SNPs and the NKG2D system in virus-induced HCC. J Gastroenterol 2015; 50(3):261-72.
40
Sharkawy RE, Bayoumi A, Metwally M, Mangia A, Berg T, Romero-Gomez M, et al. A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-β1 dependent mechanisms. Scientific Reports 2019; 9(1):1439.
41
Kumar V, Yi Lo PH, Sawai H, Kato N, Takahashi A, Deng Z, et al. Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma. PLoS One 2012; 7(9):e44743.
42
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Sharkawy RE, Bayoumi A, Metwally M, Mangia A, Berg T, Romero-Gomez M, et al. A variant in the MICA gene is associated with liver fibrosis progression in chronic hepatitis C through TGF-beta1 dependent mechanisms. Sci Rep 2019; 9(1):1439.
46
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50
ORIGINAL_ARTICLE
Breast Cancer Risk Assessment using Gail Model in 35 to 69-year-old Women Referred to the Breast Cancer Screening Center at Omid Hospital in Isfahan, Iran, from 2008 to 2016
Background: Prediction of breast cancer risk and identifying women who are at high risk of breast cancer, would be a great help for planning and conducting screening programs. The aim of this study was to estimate the 5-year breast cancer risk among women in Isfahan. Methods: This cross-sectional study was conducted on 9674 women aged 35-69 years who referred to the Breast Cancer Screening Centre at Omid Hospital in Isfahan from 2008 to 2016. Data were collected using a breast cancer risk assessment tool (Gail model). Any woman with Gail scores greater than 1.67% was considered as a high-risk woman for breast cancer. Using STATA 14, logistic regression was employed to determine the predictors of breast cancer risk at significance level of 5%. Results: The mean 5-year breast cancer risk (BRCA) for all women was 0.62 ± 0.39%, and 2.56% of women had 5 years breast cancer risk greater than or equal to 1.67%. There was a relationship between the 5-year risk of breast cancer and age, age at menarche, age at first live birth, family history of breast cancer, and history of breast biopsy. Conclusion: According to the results, the Gail model can predict the risk of breast cancer and may be employed as a breast cancer risk assessment tool in screening and prevention of breast cancer program.
https://jkmu.kmu.ac.ir/article_91476_44321cfa4bea614825ae79691c4f9a6c.pdf
2020-09-01
436
446
10.22062/jkmu.2020.91476
breast cancer
risk assessment
Gail model
Isfahan
Asiyeh
Kahyani
asiehkahyani@yahoo.com
1
MSc Student, Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Fariborz
Mokarian
frajabi41@gmail.com
2
Professor, Department of Clinical Oncology, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Elham
Moazam
el_moazam@yahoo.com
3
MD, Community Medicine, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Hajar
Karevan
h_karevan@yahoo.com
4
MSc, Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
AUTHOR
Ghasem
Yadegarfar
yadegarfar@gmail.com
5
Associate Professor, Cancer Prevention Research Center, Department of Epidemiology and Biostatistics, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran
LEAD_AUTHOR
World Health Organization. Breast cancer. [cited 2019 Oct 17] Available from: https://www.who.int/cancer/prevention/diagnosis-screening/breast-cancer/en/
1
Panahi G, Shabahang H, Sahebghalam H. Breast cancer risk assessment in Iranian women by Gail model. Medical Journal of The Islamic Republic of Iran (MJIRI) 2008; 22(1):37-9.
2
Worldwide statistics on breast cancer: Diagnosis and risk factors [cited avalilable from:http://www.medicalnewstoday.com/articles/317135.php [
3
Anderson BO, Yip CH, Smith RA, Shyyan R, Sener SF, Eniu A, et al. Guideline implementation for breast healthcare in low-income and middle-income countries: overview of the Breast Health Global Initiative Global Summit 2007. Cancer 2008; 113(8 Suppl):2221-43.
4
Akbari ME, Khayamzadeh M, Khoshnevis S, Nafisi N, Akbari A. Five and ten years survival in breast cancer patients mastectomies vs. breast conserving surgeries personal experience. International Journal of Cancer Management (Iranian Journal of Cancer Prevention) 2008; 1(2):53-6.
5
Alaei Nejad F, Abbasian M, Delvarianzadeh M. Evaluation of the knowledge, attitude and skills among the health volunteers regarding the breast self-examination in Shahroud. Knowledge And Health 2007; 2(2):23-7. [In Persian].
6
Baitchev G, Christova P, Ivanov I. Is the Gail model for breast cancer risk assessment valid for the Bulgarian women? Khirurgiia (Sofiia) 2009; 6:27-30. [In Bulgarian].
7
Ulusoy C, Kepenekci I, Kose K, Aydıntug S, Cam R. Applicability of the Gail model for breast cancer risk assessment in Turkish female population and evaluation of breastfeeding as a risk factor. Breast Cancer Res Treat 2010; 120(2):419-24.
8
Ferrer J, Neyro JL, Estevez A. Identification of risk factors for prevention and early diagnosis of a-symptomatic post-menopausal women. Maturitas 2005; 52(Suppl 1):7-22.
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10
Fisher B, Costantino JP, Wickerham DL, Redmond CK, Kavanah M, Cronin WM, et al. Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. J Natl Cancer Inst 1998; 90(18):1371-88.
11
Howell A, Anderson AS, Clarke RB, Duffy SW, Evans DG, Garcia-Closas M, et al. Risk determination and prevention of breast cancer. Breast Cancer Res 2014; 16(5):446.
12
Augustine P, Jose R, Amrithlal A, Nujum ZT, Peter A, Haran JC. Usefulness of Gail Model breast cancer risk assessment tool in estimating the risk for development of breast cancer in women of Kerala India. Academic Medical Journal of India 2015; 3(4):117-22.
13
Schonberg MA, Li VW, Eliassen AH, Davis RB, LaCroix AZ, McCarthy EP, et al. Performance of the breast cancer risk assessment tool among women aged 75 years and older. J Natl Cancer Inst 2016; 108(3):djv348.
14
Abu-Rustum NR, Herbolsheimer H. Breast cancer risk assessment in indigent women at a public hospital. Gynecologic oncology. Gynecol Oncol 2001; 81(2):287-90.
15
Levine M, Moutquin JM, Walton R, Feightner J, Canadian Task Force on Preventive Health Care, the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care, et al. Chemoprevention of breast cancer. A joint guideline from the Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer. CMAJ 164(12):1681-90.
16
Khazaee-Pool M, Majlessi F, Nedjat S, Montazeri A, Janani L, Pashaei T. Assessing breast cancer risk among Iranian women using the Gail model. Asian Pac J Cancer Prev 2016; 17(8):3759-62.
17
Andreeva VA, Pokhrel P. Breast cancer screening utilization among Eastern European immigrant women worldwide: a systematic literature review and a focus on psychosocial barriers. Psychooncology 2013; 22(12):2664-75.
18
Mirghafourvand M, Mohammad-Alizadeh-Charandabi S, Ahmadpour P, Rahi P. Breast cancer risk based on the Gail model and its predictors in Iranian women. Asian Pac J Cancer Prev 2016; 17(8):3741-5.
19
Hosseinpour R, Haji Nasrelah E, Ranjpoor F, Sori M, Peyvandi H, Mirhashemi S, et al. Evaluation of the risk of breast cancer, based on the Gail model, in women of more than 35 years old: at health centers of Yasouj during 2010-2011. Iranian Journal of Surgery 2012; 20(3):13-20. [In Persian].
20
Erbil N, Dundar N, Inan C, Bolukbas N. Breast cancer risk assessment using the Gail model: a Turkish study. Asian Pac J Cancer Prev 2015; 16(1):303-6.
21
Ewaid SH, Al-Azzawi LH. Breast cancer risk assessment by Gail Model in women of Baghdad. Alexandria Journal of Medicine 2017; 53(2):183-6.
22
Banks E, Reeves G, Beral V, Bull D, Crossley B, Simmonds M, et al. Influence of personal characteristics of individual women on sensitivity and specificity of mammography in the Million Women Study: cohort study. BMJ 2004; 329(7464):477.
23
Omranipour R, Karbakhsh M, Behforouz A, Neishaboury M, Mahmoodzadeh H, Koma KB, et al. Performance of the gail model for breast cancer risk assessment in Iranian women. Archives of Breast Cancer 2015; 2(1):27-31.
24
Chay WY, Ong WS, Tan PH, Leo NQ, Ho GH, Wong CS, et al. Validation of the Gail model for predicting individual breast cancer risk in a prospective nationwide study of 28,104 Singapore women. Breast Cancer Res 2012; 14(1):R19.
25
Bener A, Çatan F, El Ayoubi HR, Acar A, Ibrahim WH. Assessing breast cancer risk estimates based on the gail model and its predictors in qatari women. J Prim Care Community Health 2017; 8(3):180-7.
26
Vogel VG. Breast cancer prevention: a review of current evidence. CA Cancer J Clin 2000; 50(3):156-70.
27
Sakorafas GH, Krespis E, Pavlakis G. Risk estimation for breast cancer development; a clinical perspective. Surg Oncol 2002; 10(4):183-92.
28
McPherson K, Steel CM, Dixon JM. Breast cancer—epidemiology, risk factors, and genetics. BMJ 2000; 321(7261):624-8.
29
Mohammadbeigi A, Mohammadsalehi N, Valizadeh R, Momtaheni Z, Mokhtari M, Ansari H. Lifetime and 5 years risk of breast cancer and attributable risk factor according to Gail model in Iranian women. J Pharm Bioallied Sci 2015; 7(3):207-11.
30
Parmigiani G, Berry D, Aguilar O. Determining carrier probabilities for breast cancer–susceptibility genes BRCA1 and BRCA2. Am J Hum Genet 1998; 62(1):145-58.
31
Marzbani B, Taymoori P, Nouri B. Assessment of risk factors for breast cancer among women under 50 years old. Journal of School of Public Health and Institute of Public Health Research 2017; 15(1):47-60. [In Persian].
32
Hirose K, Tajima K, Hamajima N, Inoue M, Takezaki T, Kuroishi T, et al. A large‐scale, hospital‐based case‐control study of risk factors of breast cancer according to menopausal status. Jpn J Cancer Res 1995; 86(2):146-54.
33
Augustine P, Jose R, Peter A, Lal AA, Prabhakar J, Sreedharan J, et al. Risk factors of breast cancer in Kerala, India-A case control study. Acad Med J India 2014; 2(1):7-13.
34
ORIGINAL_ARTICLE
Frozen shoulder: Pathogenesis, Diagnosis and Treatment
Frozen shoulder (FS) or adhesive capsulitis is a common disease which causes pain, difficulty and restriction in the movement of the shoulder joint due to unclear complex etiology. The everyday tasks such as bathing, dressing and driving become difficult. It affects both men and women especially in their 40s and 60s. The duration of the disease varies from one patient to another and it may last for up to three years. The symptoms of the disease vary from simple to sever and complex depending on the stage of the disease and the symptoms may vary from patient to patient. Currently, there is no consensus on what the best approach or guidelines can be as the best solution for FS. Our review will discuss the pathogenesis of the disease, early diagnosis, treatment methods and the rehabilitation of the patients during the period of the disease.
https://jkmu.kmu.ac.ir/article_91477_ce10c1588985d1aeeb70b6e59bfa705b.pdf
2020-09-01
447
455
10.22062/jkmu.2020.91477
Synovium
Manipulation
Painkillers
Arthroscopic
Open release
Distension Arthrography
Eman
RABABAH
eaman@hu.edu.jo
1
Master Degree in Anatomy and Histology, Lecturer Hahemite University Faculty of Applied Heath Science, Department of Medical Laboratory Science Hashemite University Jordan
LEAD_AUTHOR
Hashem
Abu Tariah
hashemsalman@hotmail.com
2
PhD in Occupational Therapy, Associated Professor, Faculty of Applied Heath Science, Department of Physical and Occupational Therapy the Hashemite University Jordan
AUTHOR
Raed
Halalsheha
3- halalsheh@hu.edu.jo
3
PhD in Physiology, Assistant Professor, Faculty of Applied Heath Science, Department of Medical Laboratory Science Hashemite University Jordan
AUTHOR
Mohamad
Abo Kebar
4- mohammadak2006@yahoo.com
4
Lab Supervisor, Faculty of Applied Heath Science, Department of Physical and Occupational Therapy, Hashemite University Jordan
AUTHOR
Tamai K, Akutsu M, Yano Y. Primary frozen shoulder: brief review of pathology and imaging abnormalities. J Orthop Sci 2014; 19(1):1-5.
1
Ryan V, Brown H, Minns Lowe CJ, Lewis JS. The pathophysiology associated with primary (idiopathic) frozen shoulder: a systematic review. BMC Musculoskelet Disord 2016; 17(1):340.
2
Manske RC, Prohaska D. Diagnosis and management of adhesive capsulitis. Curr Rev Musculoskelet Med 2008; 1(3-4):180-9.
3
Hagiwara Y, Ando A, Onoda Y, Takemura T, Minowa T, Hanagata N, et al. Coexistence of fibrotic and chondrogenic process in the capsule of idiopathic frozen shoulders. Osteoarthr Cartil 2012; 20(3):241-9.
4
Uppal HS, Evans JP, Smith C. Frozen shoulder: a systematic review of therapeutic options. World J Orthop 2015; 6(2):263-8.
5
van der Windt DA, Koes BW, de Jong BA, Bouter LM. Shoulder disorders in general practice: incidence, patient characteristics, and management. Ann Rheum Dis 1995; 54(12):959-64.
6
Tighe CB, Oakley WS Jr. The prevalence of a diabetic condition and adhesive capsulitis of the shoulder. South Med J 2008; 101(6):591-5.
7
Dias R, Cutts S, Massoud S. Frozen shoulder. BMJ 2005; 331(7530):1453-6.
8
Orthoinfo. Frozen Shoulder. [cited 2017 Feb 16.] Available from: http://orthoinfo.aaos.org/PDFs/A00071.pdf.
9
Zuckerman JD, Rokito A. Frozen shoulder: a consensus definition. J Shoulder Elb Surg 2011; 20(2):322-5.
10
Gerber C, Werner CM, Macy JC, Jacob HA, Nyffeler RW. Effect of selective capsulorrhaphy on the passive range of motion of the glenohumeral joint. J Bone Joint Surg Am 2003; 85(1):48-55.
11
Anton HA. Frozen shoulder. Can Fam Physician 1993; 39:1773–8.
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Hand GC, Athanasou NA, Matthews T, Carr AJ. The pathology of frozen shoulder. J Bone Jt Surg Br 2007; 89(7):928-32.
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Neviaser AS, Hannafin JA. Adhesive capsulitis: a review of current treatment. Am J Sports Med 2010; 38(11):2346-56.
14
Siegel LB, Cohen NJ, Gall EP. Adhesive capsulitis: a sticky issue. Am Fam Physician 1999; 59(7):1843-50.
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Bunker TD, Anthony PP. The pathology of frozen shoulder. A Dupuytren-like disease. J Bone Joint Surg Br 1995; 77(5):677-83.
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Ozaki J, Nakagawa Y, Sakurai G, Tamai S. Recalcitrant chronic adhesive capsulitis of the shoulder. Role of contracture of the coracohumeral ligament and rotator interval in pathogenesis and treatment. J Bone Joint Surg Am 1989; 71(10):1511-5.
18
Hutchinson JW, Tierney GM, Parsons SL, Davis TR. Dupuytren’s disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor. J Bone Joint Surg Br 1998; 80(5):907-8.
19
Bunker TD, Reilly J, Baird KS, Hamblen DL. Expression of growth factors, cytokines and matrix metalloproteinases in frozen shoulder. J Bone Joint Surg Br 2000; 82(5):768-73.
20
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William WR. Repair and Regeneration of Ligaments, Tendons, and Joint Capsule. USA: Humana Press; 2006.
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Matsen F, Lippitt S. Rockwood and Matsen’s The Shoulder. 4th ed. Philadelphia: Saunders 2009. p.1064-112.
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Huang SW, Lin JW, Wang WT, Wu CW, Liou TH, Lin HW. Hyperthyroidism is a risk factor for developing adhesive capsulitis of the shoulder: a nationwide longitudinal population-based study. Sci Rep 2017; 4:4183.
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Lequesne M, Dang N, Bensasson M, Mery C. Increased association of diabetes mellitus with capsulitis of the shoulder and shoulder-hand syndrome. Scand J Rheumatol 1977; 6(1):53-6.
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Harryman DT 2nd. Shoulders: frozen and stiff. Instr Course Lect 1993; 42:247-57.
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Bunker TD, Esler CN. Frozen shoulder and lipids. J Bone Joint Surg Br 1995; 77(5):684-6.
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Emig EW, Schweitzer ME, Karasick D, Lubowitz J. Adhesive capsulitis of the shoulder: MR diagnosis. AJR Am J Roentgenol 1995; 164(6):1457-9.
35
Mengiardi B, Pfirrmann CW, Gerber C, Hodler J, Zanetti M. Frozen shoulder: MR arthrographic findings. Radiology 2004; 233(2):486-92.
36
Gokalp G, Algin O, Yildirim N, Yazici Z. Adhesive capsulitis: contrast-enhanced shoulder MRI findings. J Med Imaging Radiat Oncol 2011; 55(2):119-25.
37
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38
Binder AI, Bulgen DY, Hazleman BL, Tudor J, Wraight P. Frozen shoulder: an arthrographic and radionuclear scan assessment. Ann Rheum 1984; 43(3):365-9.
39
Ryu KN, Lee SW, Rhee YG, Lim JH. Adhesive capsulitis of the shoulder joint: usefulness of dynamic sonography. J Ultrasound Med 1993; 12(8):445-9.
40
Hanchard N, Goodchild L, Thompson J, O’Brien T, Davison D, Richardson C, et al. Evidence-based clinical guidelines for the diagnosis, assessment and physiotherapy management of contracted (frozen) shoulderv.1.6, ‘standard’ physiotherapy. [cited 2017 Feb 16] Available from: http://www.flexphysiotherapy.com.au/upload/pages/info2v2/hanchard-frozen-shoulder-guidelines-2011.pdf.
41
Page P, Labbe A. Adhesive capsulitis: use the evidence to integrate your interventions. N Am J Sports Phys Ther 2010; 5(4):266-73.
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Hannafin JA, Chiaia TA. Adhesive capsulitis. A treatment approach. Clin Orthop Relat Res 2000; (372):95-109.
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Neviaser JS. Adhesive capsulitis and the stiff and painful shoulder. Orthop Clin North Am 1980; 11(2):327-31.
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Bulgen DY, Binder AI, Hazelman BL, Dutton J, Roberts S. Frozen shoulder: prospective clinical study with an evaluation of three treatment regimes. Ann Rheum Dis 1984; 43(3):353-60.
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Watson-Jones R. Simple treatment of stiff shoulders. J Bone Jt Surg [Br]. 1963; 45B:207. https://books.google.jo/books?id=YaFsAAAAQBAJ&pg=PA249&lpg=PA249&dq=49.+WatsonJones+R.+Simple+treatment+of+stiff+shoulders.+J+Bone+Jt+Surg+%5BBr%5D.+1963;+45B:207.&source=bl&ots=g5FakHRp7_&sig=ACfU3U0tLf52_Tq_SWc9jOKFx0HPjbqGng&hl=en&sa=X&ved=2ahUKEwiDnsaa35DoAhVJUxoKHSmMBUUQ6AEwAHoECAoQAQ#v=onepage&q=49.%20Watson-Jones%20R.%20Simple%20treatment%20of%20stiff%20shoulders.%20J%20Bone%20Jt%20Surg%20%5BBr%5D.%201963%3B%2045B%3A207.&f=false
49
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62
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63
ORIGINAL_ARTICLE
A in "ABC" Approach: Systematic Review of Sexual Abstinence education in adolescents
Background: Abstinence is one of the most important aspects of “ABC” approach to prevent the spread of HIV through changing sexual behavior. The purpose of this study was to review the studies conducted in the field of sexual abstinence education. Methods:We investigated the published experimental or quasi-experimental studies from 1998 to 2018 on the impact of sexual abstinence education in the Web of Sciences, PubMed, Scopus, Springer, PsycNET and Sience direct databases. Inclusion criteria were: Randomized Controlled Trials on adolescents receiving abstinence education programs in both English and Persian languages. The outcome measure was sexual behaviors. Of the 1195 articles, 10 papers were evaluated and analyzed by two researchers separately. The quality of the studies was evaluated by Critical Appraisal Skills Program and judged by Cochrane Risk of Bias Tool and divided into three levels of low, high and unclear risk of bias. Results: Seven of the ten included studies in this review reported positive results of abstinence education on sexual behaviors in adolescents. Conclusion: Some evidence supports the efficacy of any particular abstinence education on different aspects of sexual behaviors in adolescents. But, unfortunately, there is no strong evidence in this area. Evaluations of sexual abstinence education using behavioral indicators and long-term follow-up are needed to truly assess its impacts.
https://jkmu.kmu.ac.ir/article_91478_3c6415e93ab3119f3b008137c5ff08ef.pdf
2020-09-01
456
467
10.22062/jkmu.2020.91478
adolescents
Teen
Youth
Abstinence
Education
Sexual behaviors
Maryam
Kabirian
kabirianm1@gmail.com
1
Ph.D. Candidate of Reproductive Health, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Sedigheh
Abdollahpour
abdollahpours961@mums.ac.ir
2
Ph.D. Candidate of Reproductive Health, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Farangis
Sharifi
3
Ph.D. Candidate of Reproductive Health, Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran
AUTHOR
Khadigeh
Mirzaii Najmabadi
mirzaiikh@mums.ac.ir
4
Associate Professor, Nursing and Midwifery Care Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
LEAD_AUTHOR
1. WHO. Adolescent pregnancy. [cited 2019 Sep 18] Available from: https://www.who.int/news-room/fact-sheets/detail/adolescent-pregnancy.
1
2. Karimi L, Mirzaii Najmabadi K, Ebadi A, Makvandi S, Mahdavian M. Exploring educational structure needed for reproductive health in men related to sexually transmitted diseases and HIV / AIDS: a qualitative study. Razi Journal of Medical Sciences 2016; 23(147):82-90. [In Persian].
2
3. Karimi L, Mirzaii Najmabadi K, Ebadi A, Pormehr Yabandeh A. Exploration of reproductive healthcare needs among adult men regarding sexual transmitted diseases and HIV/AIDS. Electron Physician 2017; 9(9):5250-6.
3
4. Larki M, Hadizadeh Tala-Saz Z, Manouchehri-Torshizi E, Vatanchi A, Mirzaii-Najmabadi K. A Review of HIV/AIDS prevention interventions in Iran. Navid No 2018; 21(66):63-76. [In Persian].
4
5. Prevention NCfA. The prevalence of AIDS in Iran availible at http://aids.ir/Febreuary 2018.
5
6. Azadarmaki T, Sharifi Saei MH, Isari M, Talebi S. The typology of premarital sex patterns in Iran. Semi-Annually Jame Pazhuhiy Farhangi 2012; 2(2):1-34. [In Persian].
6
7. Grarmaroudi G, Makarem J, Alavi SS, Abbasi Z. Health related risk behaviors among high school students in Tehran, Iran. Payesh 2010; 9(1):13-9. [In Persian].
7
8. Goya MM AM. Report of the Islamic Republic of Iran on the monitoring of the UN Declaration of Commitment Special United Nations General Assembly on HIV / AIDS. Tehran: Andishmand; 2008. 142 p.
8
9. M V. How to regulate behaviors and sexual relations in the West and Islamic countries based on the comparison of the two German-Austrian societies with the Iranian society. Applied Issues of Islamic Education. 2005;8:4-10.
9
10. Mahdavi P. Passionate Uprisings: Iran Sexual Revolution. California: Stanford University Press; 2008. p.344.
10
11. Bogale A, Seme A. Premarital sexual practices and its predictors among in-school youths of shendi town, west Gojjam zone, North Western Ethiopia. Reprod Health 2014; 11:49.
11
12. Awusabo-Asare K, Abane AM, Kumi-Kyereme A. Adolescent sexual and reproductive health in Ghana: a synthesis of research evidence. New York: Alan Guttmacher Institute; 2004.
12
13. Nzioka C. Dealing with the risks of unwanted pregnancy and sexually transmitted infections among adolescents: some experiences from Kenya. Afr J Reprod Health 2001; 5(3):132-49.
13
14. Z E. Identification and Prioritization messages related to sexual restraint male and female high school students to providing appropriate content. Mashhad: Ferdowsi University; 2015.
14
15. Your Life Counts (YLC). Benefits Of Abstinence. [cited 2019 Oct 20] Available from: http://www.yourlifecounts.org/blog/benefits-abstinence.
15
16. Abstinence sex education.
16
17. Weed SE, Lickona T. Abstinence Education in Context: History, Evidence, Premises, and Comparison to Comprehensive Sexuality Education. New York: Nova Sciences; 2014.
17
18. Santelli J, Ott MA, Lyon M, Rogers J, Summers D, Schleifer R. Abstinence and abstinence-only education: a review of US policies and programs. J Adolesc Health 2006; 38(1):72-81.
18
19. Abel EM, Greco M. A preliminary evaluation of an abstinence-oriented empowerment program for public school youth. Research on Social Work Practice 2008; 18(3):223-30.
19
20. Howard M, McCabe JB. Helping teenagers postpone sexual involvement. Fam Plann Perspect 1990; 22(1):21-6.
20
21. Vigil P, Riquelme R, Rivadeneira R, Aranda W. TeenSTAR: una opción de madurez y libertad: Programa de educación integral de la sexualidad, orientado a adolescentes. Revista Médica de Chile. 2005; 133(10):1173-82.
21
22. Weed SE, Ericksen IH, Lewis A, Grant GE, Wibberly KH. An abstinence program's impact on cognitive mediators and sexual initiation. Am J Health Behav 2008; 32(1):60-73.
22
23. Young M, Core-Gebhart P, Marx D. Abstinence-oriented sexuality education: initial field test results of the Living Smart curriculum. Family Life Educator 1992.
23
24. Kantor LM, Santelli JS, Teitler J, Balmer R. Abstinence-only policies and programs: an overview. Sexuality Research & Social Policy 2008; 5(3):6-17.
24
25. Underhill K, Montgomery P, Operario D. Sexual abstinence only programmes to prevent HIV infection in high income countries: systematic review. Bmj 2007; 335(7613):248.
25
26. Kirby DB. The impact of abstinence and comprehensive sex and STD/HIV education programs on adolescent sexual behavior. Sexuality Research & Social Policy 2008; 5(3):18-27.
26
27. Thomas MH. Abstinence-based programs for prevention of adolescent pregnancies: a review. J Adolesc Health 2000; 26(1):5-17.
27
28. Kim C, Rector R. Abstinence education: assessing the evidence. Heritage Foundation 2008; No 2126.
28
29. Phillips E. Abstinence-only sexual education vs. comprehensive sexual education, with emphasis on knowledge, attitudes, and behaviors of adolescents. [cited 2019 Oct 25] Available from: https://soar.wichita.edu/handle/10057/1097.
29
30. Arnold EM, Smith TE, Harrison DF, Springer DW. The effects of an abstinence-based sex education program on middle school students’ knowledge and beliefs. Research on Social Work Practice 1999; 9(1):10-24.
30
31. Borawski EA, Trapl ES, Lovegreen LD, Colabianchi N, Block T. Effectiveness of abstinence-only intervention in middle school teens. Am J Health Behav 2005; 29(5):423-34.
31
32. Denny G, Young M. An evaluation of an abstinence‐only sex education curriculum: An 18‐month follow‐up. J Sch Health 2006; 76(8):414-22.
32
33. Jemmott 3rd JB, Jemmott LS, Fong GT. Abstinence and safer sex HIV risk-reduction interventions for African American adolescents: a randomized controlled trial. JAMA 1998; 279(19):1529-36.
33
34. Jemmott JB, Jemmott LS, Fong GT. Efficacy of a theory-based abstinence-only intervention over 24 months: a randomized controlled trial with young adolescents. Arch Pediatr Adolesc Med 2010; 164(2):152-9.
34
35. Lieberman LD, Gray H, Wier M, Fiorentino R, Maloney P. Long-term outcomes of an abstinence-based, small-group pregnancy prevention program in New York City schools. Fam Plann Perspect 2000; 32(5):237-45.
35
36. Sather L, Zinn K. Effects of abstinence‐only education on adolescent attitudes and values concerning premarital sexual intercourse. Fam Community Health 2002; 25(2):1-15.
36
37. Trenholm C, Devaney B, Fortson K, Clark M, Quay L, Wheeler J. Impacts of abstinence education on teen sexual activity, risk of pregnancy, and risk of sexually transmitted diseases. J J Policy Anal Manage 2008; 27(2):255-76.
37
38. Weed SE, Ericksen IH, Birch PJ. An evaluation of the heritage keepers abstinence education program. evaluating abstinence education programs: improving implementation and assessing impact Washington DC: Office of Population Affairs and the Administration for Children and Families. Department of Health & Human Services 2005; 2005:88-103.
38
39. Greene VL, Monahan DJ, Ditmar M, Roloson T. Effectiveness of an abstinence-only intervention sited in neighborhood community centers. Journal of Children and Poverty 2011; 17(1):111-24.
39
ORIGINAL_ARTICLE
The Prevalence and Properties of Intracranial Vascular Abnormalities in CT Angiography of Patients with Non-traumatic Intracranial Hemorrhage
Introduction:Intracranial hemorrhage (ICH) is divided into two traumatic and non-traumatic categories. The present study sought to investigate the anatomical properties of non-traumatic intracranial hemorrhage in Kerman, Iran. Method:A total of 305 non-traumatic ICH cases were chosen in Shafa medical center. Data from patients’ files and CT scan images, including demographic factors and type of malformation, aneurysm size and shape, as well as the invovled location and artery were gathered and statistically analyzed. Results:Most cases were 40-60 years old. SAH, ICH and SAH+IVH were 69.5%, 14.4 and 8.5% respectively. From all, 65.2% had arteriovenous malformation and following furthure assessment, aneurysm with 148 cases (74.4%) was the most frequent and 57.4% of aneurysm cases were located in the right hemisphere. In 14.9% of cases, multiple aneurysms were observed. Conclusions: According to the results of this study, non-traumatic intracranial hemorrhages caused by arteriovenous malformation were in the shape of an aneurysm; an increase in age may result in higher probability of aneurysm occurence.
https://jkmu.kmu.ac.ir/article_91479_c07a817e774b8ae168d6441d5ab88204.pdf
2020-09-01
468
473
10.22062/jkmu.2020.91479
Epidemiology
Intracranial hemorrhage
Subarachnoid hemorrhage
Arteriovenous malformations
Intracerebral aneurysms
Mohammad
Saba
1
Assistant professor, Department of Radiology, Neurology Rersearch Center Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Ahmad
Naghibzadeh-tahami
2
Physiology research Center, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Salman
Daneshi
salman_epidemy@yahoo.com
3
Lecturer, Department of Public Health, School of Public Health, Jiroft University of Medical Sciences, Kerman, Iran
AUTHOR
Batool
Labibi
batoolllabibi78@gmail.com
4
Medical student, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
AUTHOR
Fatemeh
Labibi
fatemehlabibi64@gmail.com
5
Resident, Department of Radiology, Shafa Hospital, Afzalipour School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
LEAD_AUTHOR
Fischbein NJ, Wijman CA. Nontraumatic intracranial hemorrhage. Neuroimaging Clinics 2010; 20(4):469-92.
1
Ebrahimi HA, Shafa MA, Saba M. Non-truamatic brain hemorrhage in Kerman Iran. Archive of Iranian Medicine 2000; 2(3):1-3.
2
Caceres JA, Goldstein JN. Intracranial hemorrhage. Emerg Med Clin North Am 2012; 30(3):771-94.
3
Magistris F, Bazak S, Martin J. Intracerebral hemorrhage: pathophysiology, diagnosis and management. MUMJ 2013; 10(1):15-22.
4
Domingues R, Rossi C, Cordonnier C. Diagnostic evaluation for nontraumatic intracerebral hemorrhage. Neurol Clin 2015; 33(2):315-28.
5
Smith SD, Eskey CJ. Hemorrhagic stroke. Radiol Clin North Am 2011; 49(1):27-45.
6
Qureshi AI, Tuhrim S, Broderick JP, Batjer HH, Hondo H, Hanley DF. Spontaneous intracerebral hemorrhage. N Engl J Med 2001; 344(19):1450-60.
7
Aguilar MI, Brott TG. Update in intracerebral hemorrhage. Neurohospitalist 2011; 1(3):148-59.
8
Suarez JI, Tarr RW, Selman WR. Aneurysmal subarachnoid hemorrhage. N Engl J Med 2006; 354(4):387-96.
9
Wong GK, Ng RY, Poon WS. Aneurysmal subarachnoid haemorrhage. Surgical Practice 2008; 12(2):51-5.
10
Kidwell CS, Wintermark M. Imaging of intracranial haemorrhage. Lancet Neurol 2008; 7(3):256-67.
11
Heit JJ, Iv M, Wintermark M. Imaging of intracranial hemorrhage. J Stroke 2017; 19(1):11-27.
12
Song JP, Ni W, Gu YX, Zhu W, Chen L, Xu B, et al. Epidemiological features of nontraumatic spontaneous subarachnoid hemorrhage in China: a nationwide hospital-based multicenter study. Chin Med J (Engl) 2017; 130(7):776-81.
13
Rinkel GJ. Natural history, epidemiology and screening of unruptured intracranial aneurysms. J Neuroradiol 2008; 35(2):99-103.
14
Meisel HJ, Mansmann U, Alvarez H, Rodesch G, Brock M, Lasjaunias P. Cerebral arteriovenous malformations and associated aneurysms: analysis of 305 cases from a series of 662 patients. Neurosurgery 2000; 46(4):793-800.
15
Kaminogo M, Yonekura M, Shibata S. Incidence and outcome of multiple intracranial aneurysms in a defined population. Stroke 2003; 34(1):16-21.
16
Juvela S. Risk factors for multiple intracranial aneurysms. Stroke 2000; 31(2):392-7.
17