TY - JOUR ID - 91865 TI - Lamotrigine-Related Skin Side Effects Were Associated with some HLA-B Alleles in Iranian Epileptic Patients JO - Journal of Kerman University of Medical Sciences JA - JKMU LA - en SN - 1023-9510 AU - Ebrahimi Meimand, Hosseinali AU - Iranmanesh, Farhad AU - Nasiri, Ali AU - Anjomshoa, Ahmad AU - Khosravimashizi, Arezu AU - Jafarzadeh, Abdollah AD - Neurology Research Center, Kerman University of Medical Science, Kerman, Iran AD - Department of Genetics, Kerman University of Medical Science, Kerman, Iran AD - Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran AD - Department of Immunology, Medical School, Kerman University of Medical Sciences, Kerman, Iran & Molecular Medicine Research Center, Research Institute of Basic Medical Sciences, Rafsanjan University of Medical Sciences, Rafsanjan, Iran Y1 - 2022 PY - 2022 VL - 29 IS - 1 SP - 71 EP - 78 KW - Epilepsy KW - Lamotrigine KW - HLA-B alleles KW - Skin reactions DO - 10.22062/jkmu.2022.91865 N2 - Background: Recent evidences revealed that some genetic factors strongly predict occurrence of lamotrigine (LTG)-related skin reactions. The present study aimed to assess the association between some human leukocyte antigen (HLA)-B alleles and risk of LTG-related skin reactions among a sample of epileptic patients.Methods: Totally, 36 epileptic patients expressing LTG-related skin reactions and 70 sex- and age-matched healthy individuals were enrolled into this case-control study. Blood samples were collected from all participants and genomic DNA was extracted by salting-out method. HLA-B alleles were determined using standard sequence specific primer-PCR (SSP-PCR) technique.Results: Of the 31 HLA alleles assessed in our survey, the frequencies of HLA-B*38 and HLA-B*40 were significantly higher in epileptic patients with LTG-related skin reactions when compared to the control group. In term of gender, the frequency of HLA-B*40 allele was significantly higher in the epileptic men with LTG-related skin reactions, whereas the frequency of HLA-B*38 allele was significantly higher in the epileptic women with LTG-related skin reactions than controls with the same gender. Moreover, the frequency of HLA-B*38 allele in patients with high grade of LTG-related skin side effects was significantly higher than patients with low grade of LTG-related skin side effects.Conclusion: These results indicated possible association between HLA-B*40 and HLA-B*38 alleles and LTG-induced skin lesions in Iranian epileptic patients. HLA-B*40 and HLA-B*38 alleles might be differentially expressed in male and female epileptic patients with LTG-induced skin lesions. UR - https://jkmu.kmu.ac.ir/article_91865.html L1 - https://jkmu.kmu.ac.ir/article_91865_146c20561513b53f3c28fe9e36ae3821.pdf ER -