2024-03-28T16:31:03Z
https://jkmu.kmu.ac.ir/?_action=export&rf=summon&issue=3791
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
The effect of thyroid hoemones on basal and vagally stimulated gastric acid and pepsin secretion in rat
F
Nabavizadeh
S
Zahediasl
M.K
Garib-Naseri
thyroid hoemones effect gastric acid and pepsin secretion.however exact machanism(s) are not clear.this study was performed to compare the effect of vagal stimulation on acid an pepsin secretion in hypothyroid,hyperthyroid and control rars.each group consisted of 8 male and female rats(N-mari) weighing 246+_9 gr.hypo and hyperthyroid states were induced by administretion of methimazol (50mg/l in drinking water)and thyroxine (500mg/l in water) for 20 and 35 days respectively.animals housed in standard conditions (12hr:12hr light/dark) and were deprived of food for 24 hours befour study.under general anesthesia,animale underwent tracheostomy,laparatomy and vagotomy.a cannula was inserted into stomach via duodenum for collection of gastric juice.after 30 minutes of recovery,peripheral and of vagus nerve was stimulated for 15 minutes,and acid and pepsin outputs were measured in collected gastrik samples.acid out put during 15 minutes vagus nerve stimulation were 19.6+_1.4,56.7+_0.8 and 45.1+_0.9 mol,in hypothyroid,hyperthyroid and control groups respectively.similarly ,pepsin secretion during this period was 1.3+_0.09 and 12.4+_0.3 mg.in hypo and hyperthyroid groups respectively.which shows significant differnces with the control group(5.9+_0.4mg).from the results of this study it appears that,thyroid hormones can alter gastric acid and pepsin secretion in response to vagal stimulation.
Thyroid hormones
gastric acid
gastri pepsin
vagal stimulation
Rat
2001
12
01
14
20
https://jkmu.kmu.ac.ir/article_33799_d972c91e8b49a412197242238156ef89.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
The effect of opium addiction on postoperative intraabdominal adhesion in rat
J
Vahedian-Ardakani
H.R
Bahjati
intraperitoneal adhesion formation is a major cause of intestinal obstruction and inferlitity.previous abdominal or pelvic surgery are the most common causes of intraperitoneal adhesion formation.addiction to opium and moephine is not only an important social and individual problem in the world but also affects human physiology and immune system.this randomized double-blind study was designed to investigate the effect of addiction to morphine and opium on postopertive intraperitoneal adhesion formation in rats.63 female rat were divided into three groups and maintained under routinelaboratory condition.there was no addiction in control group.morphine addiction was induced by adding moephine sulfate powder in dirnking water(0.4mg/kg for a duration of 28 days)and in opium group by adding opium tablets in drinking water as powder.after confirmation of addiction by subcutaneous injection of naloxan all rats underwent laparotomy and the serosa of the cecum was scratched over a 5mm*5mm area.the second laparotomy was performed on 30th postoperative day.the extent of intraperitoneal adhesions were quantified based on a scoring system modified by swolin and the informations were analysed by chi-square test.the results showed a significant reduction of intraperitoneal adhesin in addicted group compared with nonaddicted group(p<0.05). it is concluded that addiction to morphine and opium decreases postoperative intraperitoneal adhesion formation in rats.
intraabdominal adhesion
Opium
Morphine
Addiction
laparotomy
2001
12
01
21
26
https://jkmu.kmu.ac.ir/article_33800_9a82c46dbc590d9bb15bb94ce26a3df6.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
Comparison of plasma fibrinogen level in opium addict men with non-addict men
M
Maesomi
H.R
Nasri
F
Farajpour
fibrinogen is one of the plasma proteins synthetzed by the liver.elevated plasma fibrinogen is an independent coronary artery disease(CAD) risk factor and increases the risk of thrombus formation.this study was performed to compare the plasma fibrinogen level in opium addict men with non opium users.each group consisted of 60 males,who didnot smoke cigarettes and were not suffered from diabetes mellitus,hyperlipidemia and hypertension.mean age was 46.6+_3 and 45.7+_3.6 years in opium addict and control group rerespectively.the mean level of plasma fibrinogen for the opium addict group was significantly higher than that of control group(319.1+_58.3 mg/dl vs 295.7+_48.3 mg/dl, p=0.018).there was ni significant difference between two groups regarding other parameters (CBC,Hb,Hct,TC,TG,Cr), but plasma urea in control group was significantly higher than addict group (p=0.008). our study revealed that plasma fibrinogen level in opium addicted men was significantly higher than non-opium users.
fibrinogen
Opium
Addiction
Atherosclerosis
cononary artery disease
2001
12
01
27
31
https://jkmu.kmu.ac.ir/article_33801_f445aa3d1f92a0bbe408ae6651251846.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
Evaluation of antibacterial activity of new N-piperazinyl quinolone derivatives with 1,3,4.thiadiazole group
M.H
Moshafi
A.R
Foromadi
M
Rajaei
quinolones are broad-spectrum antibacterial agents.they have many clinical uses which are increasing.quinolones exert antibacterial activity primarily by inhibiting bacterial DNA gyrase.the inhibition of DNA gyrase by the quinolones are greatly influenced by the nature of the C-7 substituent on the quinolones molecule.substitution of bulky functional groupd is also possible in C-7 position.furthermore,benzylthio and benzylsulfonyl-1,3,4,- thiadiazole derivatives have antibactrial activity.accordingly a series of N-piperazinyl at C-7 position of standard quinolones structure were evaluated for thier antibacterial activity against gram positive and gram negative bacteria using serial dilution test in solid media.the minimum inhibitory concentration (MIC) for each derivative was recorded as microgram per milliliter and compariad with ciprofloxa as standard drug.the results showed that antibacterial activity of these compounds were higher than ciprofloxacin against tested gram positive bacteria(S.aureus,S.epidermidis,B.subtillis),though the potency against tested cgram-negative bavteria (E.coli,E.aeruginosa,K.pneumoniae) was significantly less than that of quinolones as control drugs.in some cases there are selective activities against gram-positive bacteria.meanwhile compounds that have benzylthio -1.3.4- thiadiazole attached to the piperazine group at C-7 position of the quinolone molecule had a stronger antibacterial activity as compaired with that of benzylsulfonyl 1,3,4- thiadizole.furthermore,changing the substitution on the phenyl ring had no significant in the spectrum of antibacterial activity.
quinolones
Antibacterial Activity
1
3
4- thiadiazoly
2001
12
01
32
37
https://jkmu.kmu.ac.ir/article_33802_a95ab5e03d710aa05f6f115cb05b297f.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
Iron serum level and TIBC in porkinson disease
B
Sedighi
G
Mansoori
Parkinson disease is one of the neurodegenetive disease with a prevalence of about 1% in people older than 65.from a pathological point of view,degeneration of neuromelanin cells in pars compacta of substantia nigra has been established.the reason of degeneration is unknouwn.increase in iron concentration in substantia of parkinson,s patients has been established.the increase of iron in this part of brain is due to the altered systemic iron methablism in these patients.in this study the serum levels of iron and TIBC in 34 patients and 102 matched healthy persons were measured.normality of HB,Hct,MCV,MCH were considered as inclusion criterion in both groups.two sample t-test indicated that iron serum level and TIBC in parkinson patients were significantly lower than the controls(p<0.0001).Hct and Hb levels were lower whereas MCV and MCH levels were higher in patients group.a significant difference was observed between the two groups for iron serum level and TIBC.there was no relationship between age,sex,the disease duration and its severity with iron serum level and TIBC,due to iron sedimentation in substantia nigro in patients,this study may prove the role of iron in the pathogenesis or the defect in systematic iron metabolism,in this disease.
Parkinson
s disease
Serum iron
serum TIBC
Kerman
2001
12
01
38
44
https://jkmu.kmu.ac.ir/article_33803_e6dfbfe4f8f2f5a59210b0cda64ace13.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
Extensive necrosis of the nick following dental infection in a diabetic patient
J
Faryabi
Extensive fascial and neel necrosis following diabete is a rare finding ,but if it occurs and left untreated,in can be life threatening due to extension of infection via regional fascia.in this report a 58 years old women is presented who had abscess in chin region due to odontogenic infection.clinical examination showed that,she had an extensive necrotic ulcer in chin and neck region.after laboratory examination and biopsy of lesion with diagnosis of cervical necrotizing fasciitis due to diabetes mellitus and odontogenic infection,she was terated by medical and surgical managements.she was discharged with complete recovery and healing of the ulcerated neck and chin.this patient has an obscure history of diabetes mellitus and was not under treatmant for diabetes at the time of referral.
Netrotizing fasciitis
odontogenic infection
Diabetes Mellitus
2001
12
01
45
50
https://jkmu.kmu.ac.ir/article_33804_20fd0d24119f808ffbe5df8e1f11f3c1.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
A case report of laryngeal small cell carcinoma
M.A
Damghani
M.R
Ahmadi-Mosavi
F
Nabipour
following the first report of laryngeal small cell carcinoma in canada in 1972,only 82 cases of this cancer has been reported in the literature untill 2001.this cancer originates from laryngeal neuroendocrine cells.It,s clinical presentation consists of hoarseness,breathing difficulty:and cigarette smoking is the most important risk factor.this type of cancer is mostly presented after 50 years of age and in subglottic region.the diagnosis of small cell carcinoma of the larynx is essentially based on the light microscopic and immunohistochemical examinations.chemotherapy and rodiotherapy provide better reslts.this is a case report of laryngeal small cell carcinoma in a 27-year-old non-smoker,but oppium addict man.
laryngeal cancer
small cell carcinoma
2001
12
01
51
55
https://jkmu.kmu.ac.ir/article_33805_7bcc29d262857021b455969a304b46bd.pdf
Journal of Kerman University of Medical Sciences
jkmu
1023-9510
1023-9510
2001
8
1
A case of bening bilateral renal Schwannoma
A.A
Ketabchi
M
Ehsan
N
SHadadi
This is a rare case report of bilateral Schwannoma in lower poles of both kindeys in a 36 year old diabetic man.preoperative radiographic evaluations suggested the presence of two solid retroperitoneal tumors attached to the lower poles of both kindeys without any regional or distant extension.the final diagnosis was confirmed by histological and immonohistological studies.
schwannoma
Retroperitoneal
Kidney
2001
12
01
56
59
https://jkmu.kmu.ac.ir/article_33806_4eabf3843ab32ee93b460f609c9bbf30.pdf