Kerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95106119991201Comparison of Adipose tissue fatty acide in CAD and non-CAD patients1634256ENGH.RBahramiAssistant professorZRahimiInstructorM.aMaesomiAssistant professorJournal Article20161019since long term dietary fatty acide intake is reflected in the fatty acide composition of Adipose tissue, this study was aimed to compare the adippose tissue fatty acide profile of angiography documented CAD (test)and non-CAD(control) patients.the first group were 25 patients who underwent coronary artery bypass graft surgery in open heart surgery section of Shahid Beheshti hospital of Kermanshah university of medical sciences.the second group were 2.3 persons who were matched for age and BMI and had aoritic valve replacement(AVR) surgery in the same hospital.small segment of adipost tissue from atrioventricular groove was separated during surgery and stored at -40 until analsis.simultaneous analysis of fatty acide s were carried-out by HPLC thechnique.the results of this study showed that the contents of saturated fatty acides in CAD group were higher,and the unsaturated fatty acids with the exception of linoleic acid were lower than control group.percentage of stearic acid.oleic,acid and linolenic acid in test group were 4.8,20.7, and 6.7 and in control group were 3.8,27.8 and 9.0 respectively (p<0.05).increment of saturated fatty acids along with decrement of unsaturated fatty acids in adipose tissue of CAD patients may have potentiated the atherosclerotic process.no significant difference was seen between other fatty acids in two groups.these findings mey be explained by differences in nutritional habits and or endogenous metabolism of fatty acids between two groups.https://jkmu.kmu.ac.ir/article_34256_f0ee16eb7b92acae888a4601d15a4b63.pdfKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95106119991201effect of thyroid hormoned on distension-induced gastrik and pepsin secretion in the stomach of rat71334257ENFNabavizadeh -Rafsanjaniphd studentSZahediaslprofessorM.KGHarib- NaseriAssistant professorJournal Article20161019thyroid hormoned are known to influence acid and pepsin secretion,though exact mechanism(s) are not fully understood.in this study distention-stimulated acid and pepsin secretionof hypo and hyperthyroid rats were compared with controls.each group consisted of 8 N-mari rats from both sexs,weighing 246.6+_9.2g. hypo and hyper thyroid states were induced by administration of methimazole(500mg/l H20) and thyroxine(200mg/l H20) respectively in drinking water.all animals were deprived of food,but not of water 24 hours before the experiments.after anesthesiation with sodium thiopental (50mg/kg body weight,ip),tracheostomy and laparatomy,gastric secretions were collected through a cannula introduced via duodenum.gastric distension was induced by ringer solution in stomach (1.5cm/100gr body weight).acid secretion which were measured by automatic titrator in the hypothyroid,hyperthyroid and control groups were 8+_0.2,14.6+_1.9,10.2+_0.1 mmol/15min,respectively.pepsin secretion were 4.4+_0.5,9.09+_0.4 and 6.1+_0.1 mg/15 min in respective groups.both series show statistically significant differences between control and the other two groups.the results from the measurements of TSH and T4 hormones show that increased or decreased thyroid function can significantly afeect gastric distension-induced acid and pepsin secretion.https://jkmu.kmu.ac.ir/article_34257_31204bd489e7888c7e05a1d3260890c2.pdfKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95106119991201change in fatty acids composition of milk products during the traditional ghee-making process141934258ENGH.RBahramiAssistant professorHRahiAssociate professorZPyravi-vanakJournal Article20161019seasonal variation of fatty acids composition of milk and various milk products have been subjected to many investigations.however ,most of the researches are concerned with a single product and apparantly there is no inforation about the extent and the factors which contribute to changes in fatty acids composition of lipids in the process of ghee-making by the traditional methods.thus comparative evaluation of quality and quantity of fatty acids in milk and its products which is used in ghee-making bu traditional methods was the subject of this study.sammles of milk,yoghourt,butter, and ghee prepared from the same milk were collected from differnt rural regions of Kermanshah province.the total lipid of each sample was extracted and subjected to fatty acid analysis by HPLC.the results were tabulated and subjected to statistical analysis.starting from milk and ending with Ghee,a statically meaningful changes of fatty acid composition in each sample were observed.the obvious chanes include,a relative increase of short chain fatty acids(C to C12) and a decrease in long chain saturated fatty acids (C14,C16,C18).compared to commercial butter,the cholesterol level was lower in ghee.in conclusion the traditional method of ghee making seems to be beneficial to nutritional values of butter ghee.therefore some aspect of the process may be applied for improvment of the commerial methods of butter processing.https://jkmu.kmu.ac.ir/article_34258_b493d091ec0b7212fce5496bc570bebf.pdfKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95106119991201The role of bronchoscopy in diagnosis of tuberculosis in patients with negative smear & culture202534259ENKhBijhaniAssistant professorBGHaraeliJournal Article20161019tuberculosis (TB) is a serious health problem in the world.in 1990 among 5.5 million population in the world,nearly 7.5 million new cases reported and 3 million patients expired due to this problem.because early detectio of TB is very important ,we decided to evaluate the role of fiberoptic bronchoscopy(FOB) in detection of TB in patients with negative smear and negative culture of sputum.in this cross sectional study,377 patients with supspected TB and negative smear & culture were selected by convenience sampling method.in all patients fob & bronchoaveolar lavage(BAL) and in some patients transbronchial biopsy were performed.specimens were sent to one reference lab in the university Health center.among 377 cases,54.4% were male and 45.6% female.113 cases(30%) were positive for acid-fast bacilli(18% smear positive and 30% culture positive).although BAL study for TB showed 30% positive,transbronchial biopsy plus BAL,raised this figure to 50% in conclusion,it is recommended both FOB&BAL in suspected patients with negative smear and culture to be considered.https://jkmu.kmu.ac.ir/article_34259_ddc6d44ee69c4286a7d82d4536a35268.pdfKerman University of Medical SciencesJournal of Kerman University of Medical Sciences1023-95106119991201Significance of histopathological features of breast carcinoma and its correlation for desision of future therapy263334260ENSHDabiriAssociate professorNMonsefiAssistant professorYNikiyanAssistant professorT.RMirshekariM.RRahimi-MoghadamJournal Article20161019Breast cancer is one of the most common malignancies among women and considered as the first caise of mortality in females suffering from malignant processes.axillary lymph node metastasis (ALNM)is the most important predictor of survival in patient with breast carcinoma.the purpose of this study was to determine the association between the incidence of ALNM and morphologic criteria by univariate and multivariate analysis.the authors reviwed data from 180 patients with breast carcinoma,who have been treated by modified radical mastectomy in hospitals of Kerman during 1989 to 1998.approximately 130 patients (72%) had axillary lymph nodes metastasis,but 30 patients (28%) had no metastasis,multivariate analysis identified four factors as independent predictors of ALNM,such as lymphatic/vascular invasion,perineural invasion,tumoral necrosis and histologic grade,(p=<0.01).there was no independent association between lymphocytic host response or unclear pleomorphism and incidence of axillary lymph node metastasis.tumor diameter can increase the possibility of metastasis,independently of all other main factors(p<0.01),except the histologic grade of tumor may influence this possibility.pathologic features of the primary tumor can be used to estimate the risk of ALNM in patients with breast carcinoma.such a risk assessment might facilitate appropriate management.routine axillary dissection can be omitted in patients at minimal risk of ALNM,if the treatment decision is not influenced by lymph node status.https://jkmu.kmu.ac.ir/article_34260_b4ba06098084bd244871d208048d4524.pdf