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The Efficacy of Mindfulness-Based Cognitive Therapy on General Health in Patients with Systemic Lupus Erythematosus: A Randomized Controlled Trial

Authors

1 Associate Professor, Department of Psychiatry and Cellular & Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

2 Assistant Professor, Department of Rheumatology and Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran

Abstract

Background & Aims: Systemic lupus erythematosus (SLE) is an autoimmune inflammatory disease, involving multiple organs and producing autoantibodies against different components of the cell. SLE is of unknown etiology with various clinical and laboratory manifestations. Different psychological disorders are seen in patients with SLE, including mood, anxiety, and cognitive disorders. This study was conducted to determine the effectiveness of mindfulness-based cognitive therapy (MBCT) on general health in these patients. Methods: This experimental, randomized, clinical trial was conducted on 46 patients with SLE referring to Imam Ali Clinic in Shahrekord, Southwest Iran within 1 year. The patients were assigned to either of the treatment and control groups (23 patients in each). Both groups underwent routine medical care. The treatment group also underwent 8 group sessions of MBCT. The patients were assessed using the General Health Questionnaire-28 (GHQ-28) prior to, after, and 6 months after the intervention. The data were analyzed using analysis of covariance (ANCOVA). Results: Mean score of general health was significantly lower in the MBCT group compared to the control group in both post-test and follow-up periods. Conclusion: The findings indicated that MBCT contributed to enhancing general health in patients with SLE and that this is a sustainable effect.

Keywords

References
  1. Lau CS, Yin G, Mok MY. Ethnic and geographical differences in systemic lupus erythematosus: an overview. Lupus 2006; 15(11): 715-9.
  2. Hahn BH, Kasper DL, Braunwald E, Fauci AS. Systemic lupus erythematosus . In: Longo D, Fauci A, Harrison T, Kasper DL, Hauser SL, Jameson JL, et al., Editors. Harrison's principles of internal medicine. 18th ed. New York, NY: McGraw-Hill Medical; 2012.
  3. Jamshidi AR, Tehrani-Banihashemi A, Dahaghin S, Gholami J, Froozanfar MH, Akhlaghi M, et al. Clinical hand osteoarthritis in Tehran: prevalence, signs, symptoms, and pattern - COPCORD stage I, Iran study. J Rheumatol 2008; 35(7): 1467-8.
  4. Horvath L, Czirjak L, Fekete B, Jakab L, Pozsonyi T, Kalabay L, et al. High levels of antibodies against Clq are associated with disease activity and nephritis but not with other organ manifestations in SLE patients. Clin Exp Rheumatol 2001; 19(6): 667-72.
  5. The American College of Rheumatology. The American College of Rheumatology nomenclature and case definitions for neuropsychiatric lupus syndromes. Arthritis Rheum 1999; 42(4): 599-608.
  6. Bachen EA, Chesney MA, Criswell LA. Prevalence of mood and anxiety disorders in women with systemic lupus erythematosus. Arthritis Rheum 2009; 61(6): 822-9.
  7. Peralta-Ramirez MI, Jimenez-Alonso J, Godoy-Garcia JF, Perez-Garcia M. The effects of daily stress and stressful life events on the clinical symptomatology of patients with lupus erythematosus. Psychosom Med 2004; 66(5): 788-94.
  8. Bricou O, Taieb O, Baubet T, Gal B, Guillevin L, Moro MR. Stress and coping strategies in systemic lupus erythematosus: a review. Neuroimmunomodulation 2006; 13(5-6): 283-93.
  9. Segal ZV, Williams J, Teasdale JD. Mindfulness-based cognitive therapy for depression: a new approach to preventing relapse. New York, NY: Guilford Press; 2002.
  10. Hofmann SG, Sawyer AT, Witt AA, Oh D. The effect of mindfulness-based therapy on anxiety and depression: A meta-analytic review. J Consult Clin Psychol 2010; 78(2): 169-83.
  11. Evans S, Ferrando S, Findler M, Stowell C, Smart C, Haglin D. Mindfulness-based cognitive therapy for generalized anxiety disorder. J Anxiety Disord 2008; 22(4): 716-21.
  12. Kim B, Lee SH, Kim YW, Choi TK, Yook K, Suh SY, et al. Effectiveness of a mindfulness-based cognitive therapy program as an adjunct to pharmacotherapy in patients with panic disorder. J Anxiety Disord 2010; 24(6): 590-5.
  13. Crane C, Williams JMG. Factors associated with attrition from mindfulness-based cognitive therapy in patients with a history of suicidal depression. Mindfulness (N Y) 2010; 1(1): 10-20.
  14. Marchand WR. Mindfulness-based stress reduction, mindfulness-based cognitive therapy, and Zen meditation for depression, anxiety, pain, and psychological distress. J Psychiatr Pract 2012; 18(4): 233-52.
  15. Kulz AK, Landmann S, Cludius B, Hottenrott B, Rose N, Heidenreich T, et al. Mindfulness-based cognitive therapy in obsessive-compulsive disorder: protocol of a randomized controlled trial. BMC Psychiatry 2014; 14: 314.
  16. Wood AW, Gonzalez J, Barden SM. Mindful caring: using mindfulness-based cognitive therapy with caregivers of cancer survivors. J Psychosoc Oncol 2015; 33(1): 66-84.
  17. Serpa JG, Taylor SL, Tillisch K. Mindfulness-based stress reduction (MBSR) reduces anxiety, depression, and suicidal ideation in veterans. Med Care 2014; 52(12 Suppl 5): S19-S24.
  18. Stafford L, Thomas N, Foley E, Judd F, Gibson P, Komiti A, et al. Comparison of the acceptability and benefits of two mindfulness-based interventions in women with breast or gynecologic cancer: a pilot study. Support Care Cancer 2015; 23(4): 1063-71.
  19. Fordham B, Griffiths CE, Bundy C. A pilot study examining mindfulness-based cognitive therapy in psoriasis. Psychol Health Med 2015; 20(1): 121-7.
  20. Zomorodi S, Abdi S, Tabatabaee SK. Comparison of long-term effects of cognitive-behavioral therapy versus mindfulness-based therapy on reduction of symptoms among patients suffering from irritable bowel syndrome. Gastroenterol Hepatol Bed Bench 2014; 7(2): 118-24.
  21. Davis J, Manley A, Goldberg S, Smith S, Jorenby D. Randomized trial comparing mindfulness training for smokers to a matched control. Journal of Substance Abuse Treatment 2014; 47(3): 213-21.
  22. Greco CM, Rudy TE, Manzi S. Effects of a stress-reduction program on psychological function, pain, and physical function of systemic lupus erythematosus patients: a randomized controlled trial. Arthritis Rheum 2004; 51(4): 625-34.
  23. Navarrete-Navarrete N, Peralta-Ramirez MI, Sabio JM, Martinez-Egea I, Santos-Ruiz A, Jimenez-Alonso J. Quality-of-life predictor factors in patients with SLE and their modification after cognitive behavioural therapy. Lupus 2010; 19(14): 1632-9.
  24. Navarrete-Navarrete N, Peralta-Ramirez MI, Sabio-Sanchez JM, Coin MA, Robles-Ortega H, Hidalgo-Tenorio C, et al. Efficacy of cognitive behavioural therapy for the treatment of chronic stress in patients with lupus erythematosus: a randomized controlled trial. Psychother Psychosom 2010; 79(2): 107-15.
  25. Dobkin PL, da Costa D, Dritsa M, Fortin PR, Senecal JL, Goulet JR, et al. Quality of life in systemic lupus erythematosus patients during more and less active disease states: differential contributors to mental and physical health. Arthritis Care Res 1999; 12(6): 401-10.
  26. Ng P, Chan W. Group psychosocial program for enhancing psychological well-being of people with systemic lupus erythematosus. J Soc Work Disabil Rehabil 2007; 6(3): 75-87.
  27. Karlson EW, Liang MH, Eaton H, Huang J, Fitzgerald L, Rogers MP, et al. A randomized clinical trial of a psychoeducational intervention to improve outcomes in systemic lupus erythematosus. Arthritis Rheum 2004; 50(6): 1832-41.
  28. Tovote KA, Fleer J, Snippe E, Peeters ACT, Emmelkamp PMG, Sanderman R, et al. Individual mindfulness-based cognitive therapy and cognitive behavior therapy for treating depressive symptoms in patients with diabetes: results of a randomized controlled trial. Diabetes Care 2014; 37(9): 2427-34.
  29. Davis MC, Zautra AJ, Wolf LD, Tennen H, Yeung EW. Mindfulness and cognitive-behavioral interventions for chronic pain: differential effects on daily pain reactivity and stress reactivity. J Consult Clin Psychol 2015; 83(1): 24-35.
  30. Cramer H, Haller H, Lauche R, Dobos G. Mindfulness-based stress reduction for low back pain. A systematic review. BMC Complementary and Alternative Medicine 2012; 12: 162.
  31. Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, et al. The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1982; 25(11): 1271-7.
  32. Hochberg MC. Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 1997; 40(9): 1725.
  33. Goldberg DP, Hillier VF. A scaled version of the general health questionnaire. Psychol Med 1979; 9(1): 139-45.
  34. Firestein GS, Kelley WN. Kelley's textbook of rheumatology. 8th ed. Philadelphia, PA: Saunders/Elsevier; 2009.


Journal of Kerman University of Medical Sciences
Volume 22, Issue 6
November and December 2015
Pages 499-509
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