Journal of Kerman University of Medical Sciences

Prevalence of Metabolic Syndrome in Patients with Periodontal Disease

Authors

Fatemeh Safavi 1
Gholamreza Yousefzadeh 2
Mostafa Shokoohi 3
Sadaf Safavi 4
Hamid Najafipour 5
Mitra Shadkam Farokhi 6

1 Student of Dentistry, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

2 Assistant Professor, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

3 Researcher, Research Center for Modeling in health, Institute for Future Studies in Health, Kerman University of Medical Sciences, Kerman, Iran

4 General Practitioner, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

5 Professor, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

6 Research assistant, Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran

Abstract
Background & Aims: Metabolic syndrome is composed of interrelated cardiovascular and cardiometabolic risk factors. Moreover, recent researches have illustrated the association of systemic diseases and periodontitis. Thus, the early diagnosis of this syndrome, as a cardiometabolic risk factor, seems necessary. The aim of this study was to evaluate the prevalence of metabolic syndrome in patients with periodontal disease. Methods: In this cross-sectional study, 900 subjects from the data bank of the Kerman Coronary Artery Disease Risk Study (KERCADRS), Iran, were assessed. The community periodontal index (CPI) was used as the evaluation tool for periodontal treatment needs and health condition . The control group consisted of healthy individuals. Results: The prevalence of metabolic syndrome among patients with periodontal disease was significantly higher than the healthy group (53.6% vs. 33.1%, P < 0.001). High waist circumference, triglyceride disorder, high fasting blood sugar (FBS), and high blood pressure were significantly higher in patients with periodontal disease (P < 0.05). After controlling the effect of confounding variables (age, gender and BMI), the adjusted odds ratio of existence of periodontal pockets were 1.58 (95% CI: 1.1-2.2, P = 0.012) for metabolic syndrome patients. Conclusion: Our results showed a high prevalence of cardiovascular disease risk factors among patients with periodontal disease. Therefore, screening these patients for cardiovascular disease risk factors is suggested.

Keywords

Metabolic Syndrome
Periodontal disease
Cardiovascular Diseases
risk factors
Iran
  1. Tremblay M, Gaudet D, Brisson D. Metabolic syndrome and oral markers of cardiometabolic risk. J Can Dent Assoc 2011; 77: b125.
  2. Ghezzi AC, Cambri LT, Botezelli JD, Ribeiro C, Dalia RA, de Mello MA. Metabolic syndrome markers in wistar rats of different ages. Diabetol Metab Syndr 2012; 4(1): 16.
  3. LaGuardia HA, Hamm LL, Chen J. The metabolic syndrome and risk of chronic kidney disease: pathophysiology and intervention strategies. J Nutr Metab 2012; 2012: 9.
  4. Emanuela F, Grazia M, Marco dR, Maria PL, Giorgio F, Marco B. Inflammation as a link between obesity and metabolic syndrome. J Nutr Metab 2012; 2012: 476380.
  5. Marjani A, Moghasemi S. The metabolic syndrome among postmenopausal women in Gorgan. International Journal of Endocrinology 2012; 2012: 6.
  6. Pietropaoli D, Monaco A, Del PR, Cifone MG, Marzo G, Giannoni M. Advanced glycation end products: possible link between metabolic syndrome and periodontal diseases. Int J Immunopathol Pharmacol 2012; 25(1): 9-17.
  7. Heidari Z, Hosseinpanah F, Mehrabi Y, Azizi F. Evaluation of power of components of metabolic syndrome for prediction of its development: A 6.5 year longitudinal study in Tehran lipid and glucose study (TLGS). Iran J Endocrinol Metab 2010; 11(5): 530-42. [In Persian].
  8. Nesbitt MJ, Reynolds MA, Shiau H, Choe K, Simonsick EM, Ferrucci L. Association of periodontitis and metabolic syndrome in the Baltimore Longitudinal Study of Aging. Aging Clin Exp Res 2010; 22(3): 238-42.
  9. Roberts CK, Sindhu KK. Oxidative stress and metabolic syndrome. Life Sciences 2009; 84(21-22): 705-12.
  10. Mirmiran P, Bahadoran Z, Golarand M, Azizi F. The association of total oxidized capacity of diet regime with the risk factors of metabolic syndrome among Tehranian adults. Iran J Diabetes Lipid Disord 2012; 11(4): 408-17. [In Persian].
  11. Gunderson EP, Jacobs DR, Jr., Chiang V, Lewis CE, Tsai A, Quesenberry CP, Jr., et al. Childbearing is associated with higher incidence of the metabolic syndrome among women of reproductive age controlling for measurements before pregnancy: the CARDIA study. Am J Obstet Gynecol 2009; 201(2): 177-9.
  12. Saberi HR, Moravveji AR, Fakharian E, Motalebi kashani M, Dehdashti AR. Prevalence of metabolic syndrome in bus and truck drivers in Kashan, Iran. Diabetol Metab Syndr 2011; 3: 8.
  13. Ramezani F, Momenan AA, Bahri M, Azizi F. The relationship between the history and duration breastfeeding with metabolic syndrome in future among women aged 15-50 years participated in Tehran Lipid and Glucose Study (TLGS). Iran J Diabetes Lipid Disord 2012; 12(1): 47-55. [In Persian].
  14. Mohebi S, Azad Bakht L, Feyzi A, Sharifirad GHR, Hozori M, Sherbafchi M. The study of perceived self-efficacy with the rate of dietary intake of macronutrients among women with metabolic syndrome: A pathway analysis. Iran J Diabetes Lipid Disord 2012; 12(1): 56-67. [In Persian].
  15. Yamori M, Njelekela M, Mtabaji J, Yamori Y, Bessho K. Hypertension, periodontal disease, and potassium intake in nonsmoking, nondrinker African women on no medication. International Journal of Hypertension 2011; 2011: 5.
  16. Trevisan M, Dorn J. The relationship between periodontal disease (Pd) and cardiovascular disease (Cvd). Mediterr J Hematol Infect Dis 2010; 14(3): 148-54.
  17. Bhalgat Ranade S, Doiphode S. Is there a relationship between periodontitis and rheumatoid arthritis? J Indian Soc Periodontol 2012; 16(1): 22-7.
  18. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH, Franklin BA, et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005; 112(17): 2735-52.
  19. Jagannathachary S, Kamaraj D. Obesity and periodontal disease. J Indian Soc Periodontol 2010; 14(2): 96-100.
  20. Nagasawa T, Noda M, Katagiri S, Takaichi M, Takahashi Y, Wara-Aswapati N, et al. Relationship between periodontitis and diabetes - importance of a clinical study to prove the vicious cycle. Intern Med 2010; 49(10): 881-5.
  21. Shimazaki Y, Saito T, Yonemoto K, Kiyohara Y, Iida M, Yamashita Y. Relationship of metabolic syndrome to periodontal disease in Japanese women: the Hisayama Study. J Dent Res 2007; 86(3): 271-5.
  22. Gujral DM, Bhattacharyya S, Hargreaves P, Middleton GW. Periodontal disease in a patient receiving Bevacizumab: a case report. J Med Case Reports 2008; 2: 47.
  23. Han DH, Lim SY, Sun BC, Paek D, Kim HD. The association of metabolic syndrome with periodontal disease is confounded by age and smoking in a Korean population: the Shiwha-Banwol Environmental Health Study. J Clin Periodontol 2010; 37(7): 609-16.
  24. D'Aiuto F, Sabbah W, Netuveli G, Donos N, Hingorani AD, Deanfield J, et al. Association of the metabolic syndrome with severe periodontitis in a large U.S. population-based survey. J Clin Endocrinol Metab 2008; 93(10): 3989-94.
  25. Tu YK, D'Aiuto F, Lin HJ, Chen YW, Chien KL. Relationship between metabolic syndrome and diagnoses of periodontal diseases among participants in a large Taiwanese cohort. J Clin Periodontol 2013; 40(11): 994-1000.
  26. Morita T, Yamazaki Y, Mita A, Takada K, Seto M, Nishinoue N, et al. A cohort study on the association between periodontal disease and the development of metabolic syndrome. J Periodontol 2010; 81(4): 512-9.
  27. Kwon YE, Ha JE, Paik DI, Jin BH, Bae KH. The relationship between periodontitis and metabolic syndrome among a Korean nationally representative sample of adults. J Clin Periodontol 2011; 38(9): 781-6.
  28. Andriankaja OM, Sreenivasa S, Dunford R, DeNardin E. Association between metabolic syndrome and periodontal disease. Australian Dental Journal 2010; 55(3): 252-9.
  29. Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, et al. Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study. J Clin Periodontol 2013; 40(8): 743-52.
  30. Morita T, Ogawa Y, Takada K, Nishinoue N, Sasaki Y, Motohashi M, et al. Association between periodontal disease and metabolic syndrome. J Public Health Dent 2009; 69(4): 248-53.
Journal of Kerman University of Medical Sciences
Volume 22, Issue 3
2015
Pages 229-239

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